Incidental Mutation 'R1670:Coro7'
ID 187577
Institutional Source Beutler Lab
Gene Symbol Coro7
Ensembl Gene ENSMUSG00000039637
Gene Name coronin 7
Synonyms 0610011B16Rik
MMRRC Submission 039706-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R1670 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 4444748-4497584 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 4446097 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Phenylalanine at position 876 (S876F)
Ref Sequence ENSEMBL: ENSMUSP00000048489 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000014445] [ENSMUST00000038552] [ENSMUST00000135823] [ENSMUST00000156889]
AlphaFold Q9D2V7
Predicted Effect probably benign
Transcript: ENSMUST00000014445
SMART Domains Protein: ENSMUSP00000014445
Gene: ENSMUSG00000014301

DomainStartEndE-ValueType
Pfam:Pam16 1 125 4.9e-63 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000038552
AA Change: S876F

PolyPhen 2 Score 0.763 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000048489
Gene: ENSMUSG00000039637
AA Change: S876F

DomainStartEndE-ValueType
DUF1899 3 64 6.41e-15 SMART
WD40 66 106 1.83e-7 SMART
WD40 115 154 4.13e0 SMART
WD40 157 196 1.78e-5 SMART
DUF1900 251 385 4.49e-60 SMART
low complexity region 427 456 N/A INTRINSIC
DUF1899 463 528 1.2e-19 SMART
WD40 531 570 3.64e-2 SMART
WD40 580 620 8.55e-8 SMART
WD40 623 662 1.16e-9 SMART
low complexity region 667 679 N/A INTRINSIC
DUF1900 718 854 6.69e-68 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127120
Predicted Effect probably benign
Transcript: ENSMUST00000135823
SMART Domains Protein: ENSMUSP00000118310
Gene: ENSMUSG00000039637

DomainStartEndE-ValueType
DUF1899 3 64 6.41e-15 SMART
WD40 66 106 1.83e-7 SMART
WD40 115 154 4.13e0 SMART
WD40 157 196 1.78e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139072
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150028
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150724
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151156
Predicted Effect probably benign
Transcript: ENSMUST00000156889
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229767
Meta Mutation Damage Score 0.1300 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 92.3%
Validation Efficiency 97% (74/76)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele are viable and overtly normal but exhibit disruption of the Golgi apparatus. Mutant fibroblasts show increased cell spreading and cellular F-actin content, increased cell polarization and migration, and enhanced wound healing in a scratch-wound assay. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 A G 6: 142,540,448 (GRCm39) V1497A possibly damaging Het
Adam15 T C 3: 89,255,817 (GRCm39) probably benign Het
Angel2 T A 1: 190,674,360 (GRCm39) S371T probably benign Het
Atr T A 9: 95,743,509 (GRCm39) N49K probably benign Het
Bace2 G A 16: 97,213,335 (GRCm39) M228I probably damaging Het
Bdp1 A C 13: 100,163,941 (GRCm39) probably null Het
Calr A T 8: 85,570,748 (GRCm39) D302E probably benign Het
Camta1 T C 4: 151,164,228 (GRCm39) D340G probably benign Het
Car11 C T 7: 45,352,949 (GRCm39) T236I possibly damaging Het
Cfap69 A T 5: 5,636,409 (GRCm39) S275T probably benign Het
Cib2 G A 9: 54,455,653 (GRCm39) R104W probably damaging Het
CN725425 T C 15: 91,130,018 (GRCm39) S294P possibly damaging Het
Cspg4 G A 9: 56,804,687 (GRCm39) V1833M probably damaging Het
Dennd6b C A 15: 89,069,540 (GRCm39) probably benign Het
Dhx30 A T 9: 109,914,341 (GRCm39) Y979N possibly damaging Het
Dnaaf9 G A 2: 130,554,299 (GRCm39) P187S probably damaging Het
Dnah8 A T 17: 30,944,098 (GRCm39) I1772F probably damaging Het
Dync2h1 A T 9: 6,993,942 (GRCm39) I3976N possibly damaging Het
Ebi3 T C 17: 56,261,479 (GRCm39) I125T probably damaging Het
Elfn2 C T 15: 78,556,568 (GRCm39) A660T probably benign Het
F12 C T 13: 55,569,346 (GRCm39) C209Y probably damaging Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fgfr2 T A 7: 129,782,187 (GRCm39) D413V probably damaging Het
Gdf10 T A 14: 33,654,000 (GRCm39) I169N possibly damaging Het
Gdnf T C 15: 7,845,130 (GRCm39) V41A probably benign Het
Gm9857 A T 3: 108,847,478 (GRCm39) probably benign Het
Gpatch11 A G 17: 79,146,529 (GRCm39) E58G possibly damaging Het
Gpr55 A G 1: 85,869,137 (GRCm39) V148A possibly damaging Het
Gucy1b1 A G 3: 81,952,767 (GRCm39) I222T probably benign Het
Hnf4a T C 2: 163,404,496 (GRCm39) S227P probably damaging Het
Hsfy2 A G 1: 56,675,548 (GRCm39) S330P possibly damaging Het
Hycc1 T A 5: 24,204,989 (GRCm39) M1L possibly damaging Het
Ift122 T C 6: 115,900,844 (GRCm39) V1054A probably benign Het
Il27 T A 7: 126,188,647 (GRCm39) E175D probably benign Het
Lactb2 A T 1: 13,730,641 (GRCm39) S12T probably damaging Het
Lrfn2 T C 17: 49,403,605 (GRCm39) V576A probably benign Het
Mansc4 C G 6: 146,976,689 (GRCm39) R309T possibly damaging Het
Med12l AACAGCA AACAGCAACAGCA 3: 59,183,379 (GRCm39) probably benign Het
Mrpl16 C T 19: 11,751,959 (GRCm39) R240* probably null Het
Muc17 A G 5: 137,172,843 (GRCm39) V70A probably benign Het
Ndnf A G 6: 65,680,054 (GRCm39) D111G probably benign Het
Nek4 T C 14: 30,704,384 (GRCm39) F688S probably damaging Het
Nkx2-6 T A 14: 69,412,126 (GRCm39) M98K probably benign Het
Nup188 T C 2: 30,230,667 (GRCm39) S1402P probably benign Het
Or10j2 T A 1: 173,098,467 (GRCm39) S242T probably damaging Het
Or2t48 A T 11: 58,420,237 (GRCm39) S192T probably damaging Het
Or4f14b C T 2: 111,775,264 (GRCm39) C179Y probably damaging Het
Or52i2 A G 7: 102,319,609 (GRCm39) T161A possibly damaging Het
Or5ac23 A T 16: 59,149,607 (GRCm39) N88K probably benign Het
Or5ac24 T C 16: 59,165,790 (GRCm39) I91M possibly damaging Het
Or5m9b T A 2: 85,905,594 (GRCm39) V170D probably benign Het
Parp10 A T 15: 76,126,270 (GRCm39) V306E probably benign Het
Pcnx3 A G 19: 5,723,343 (GRCm39) L1284P probably damaging Het
Pld1 A T 3: 28,103,389 (GRCm39) I365F probably benign Het
Pnisr A G 4: 21,865,893 (GRCm39) D294G probably damaging Het
Pogz C T 3: 94,786,160 (GRCm39) T863I probably benign Het
Ptprn2 A C 12: 116,685,792 (GRCm39) T84P possibly damaging Het
Rln1 C T 19: 29,309,468 (GRCm39) E104K possibly damaging Het
Rnf38 A G 4: 44,138,681 (GRCm39) S271P probably damaging Het
Rngtt A G 4: 33,368,660 (GRCm39) T398A probably benign Het
Rprd2 G T 3: 95,672,115 (GRCm39) T1096K probably damaging Het
Sema3e C T 5: 14,212,199 (GRCm39) probably benign Het
Sema5a T A 15: 32,548,945 (GRCm39) C140S probably damaging Het
Shpk A C 11: 73,113,757 (GRCm39) D390A probably benign Het
Slc22a20 C T 19: 6,022,876 (GRCm39) probably benign Het
Steap2 A G 5: 5,727,393 (GRCm39) V314A possibly damaging Het
Stxbp5l A G 16: 37,111,289 (GRCm39) probably null Het
Tgm3 G T 2: 129,883,688 (GRCm39) E449* probably null Het
Tmem68 A C 4: 3,560,627 (GRCm39) L186V probably damaging Het
Ttc41 T A 10: 86,612,116 (GRCm39) W1130R possibly damaging Het
Ttpal T C 2: 163,457,286 (GRCm39) F253L possibly damaging Het
Vmn2r99 G T 17: 19,582,514 (GRCm39) V40F probably benign Het
Xkr9 G A 1: 13,771,167 (GRCm39) V228M probably damaging Het
Zc3h7b C T 15: 81,661,268 (GRCm39) A369V probably benign Het
Other mutations in Coro7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00428:Coro7 APN 16 4,452,500 (GRCm39) missense possibly damaging 0.83
IGL00885:Coro7 APN 16 4,452,890 (GRCm39) missense probably benign 0.00
IGL02944:Coro7 APN 16 4,453,276 (GRCm39) missense probably benign 0.14
IGL03104:Coro7 APN 16 4,446,990 (GRCm39) missense probably damaging 1.00
IGL03153:Coro7 APN 16 4,453,246 (GRCm39) critical splice donor site probably null
R0022:Coro7 UTSW 16 4,451,168 (GRCm39) missense probably benign 0.01
R0022:Coro7 UTSW 16 4,451,168 (GRCm39) missense probably benign 0.01
R0071:Coro7 UTSW 16 4,488,391 (GRCm39) missense probably damaging 1.00
R0071:Coro7 UTSW 16 4,488,391 (GRCm39) missense probably damaging 1.00
R0080:Coro7 UTSW 16 4,448,328 (GRCm39) missense probably damaging 1.00
R0193:Coro7 UTSW 16 4,445,368 (GRCm39) unclassified probably benign
R0242:Coro7 UTSW 16 4,448,042 (GRCm39) splice site probably benign
R0318:Coro7 UTSW 16 4,493,671 (GRCm39) missense probably benign 0.09
R0554:Coro7 UTSW 16 4,450,121 (GRCm39) missense possibly damaging 0.63
R0666:Coro7 UTSW 16 4,449,775 (GRCm39) missense possibly damaging 0.70
R0835:Coro7 UTSW 16 4,450,118 (GRCm39) missense probably benign 0.12
R0968:Coro7 UTSW 16 4,487,919 (GRCm39) splice site probably benign
R1709:Coro7 UTSW 16 4,452,305 (GRCm39) splice site probably null
R1848:Coro7 UTSW 16 4,448,298 (GRCm39) missense probably damaging 0.99
R1884:Coro7 UTSW 16 4,446,683 (GRCm39) unclassified probably benign
R1935:Coro7 UTSW 16 4,446,596 (GRCm39) missense probably benign
R1937:Coro7 UTSW 16 4,446,596 (GRCm39) missense probably benign
R1939:Coro7 UTSW 16 4,446,596 (GRCm39) missense probably benign
R1967:Coro7 UTSW 16 4,452,753 (GRCm39) missense probably damaging 1.00
R1969:Coro7 UTSW 16 4,451,620 (GRCm39) missense probably benign 0.19
R1970:Coro7 UTSW 16 4,451,620 (GRCm39) missense probably benign 0.19
R3034:Coro7 UTSW 16 4,450,155 (GRCm39) missense probably damaging 0.99
R4638:Coro7 UTSW 16 4,450,151 (GRCm39) missense probably damaging 0.96
R4710:Coro7 UTSW 16 4,452,797 (GRCm39) intron probably benign
R4723:Coro7 UTSW 16 4,449,858 (GRCm39) missense probably benign 0.00
R4789:Coro7 UTSW 16 4,446,085 (GRCm39) missense probably damaging 1.00
R5493:Coro7 UTSW 16 4,450,351 (GRCm39) missense probably damaging 0.99
R5619:Coro7 UTSW 16 4,494,799 (GRCm39) critical splice donor site probably null
R5756:Coro7 UTSW 16 4,450,148 (GRCm39) missense probably damaging 0.97
R5974:Coro7 UTSW 16 4,449,753 (GRCm39) missense possibly damaging 0.83
R6010:Coro7 UTSW 16 4,487,820 (GRCm39) missense possibly damaging 0.68
R6038:Coro7 UTSW 16 4,497,414 (GRCm39) critical splice donor site probably null
R6038:Coro7 UTSW 16 4,497,414 (GRCm39) critical splice donor site probably null
R6906:Coro7 UTSW 16 4,451,168 (GRCm39) missense probably benign 0.00
R6925:Coro7 UTSW 16 4,446,538 (GRCm39) critical splice donor site probably null
R7069:Coro7 UTSW 16 4,497,475 (GRCm39) start codon destroyed probably damaging 0.99
R7326:Coro7 UTSW 16 4,449,912 (GRCm39) missense probably damaging 0.96
R7421:Coro7 UTSW 16 4,486,615 (GRCm39) missense probably benign 0.19
R7521:Coro7 UTSW 16 4,449,346 (GRCm39) missense probably benign 0.00
R7773:Coro7 UTSW 16 4,449,870 (GRCm39) missense probably damaging 1.00
R7846:Coro7 UTSW 16 4,488,400 (GRCm39) missense probably damaging 1.00
R8240:Coro7 UTSW 16 4,486,660 (GRCm39) missense probably damaging 0.96
R8726:Coro7 UTSW 16 4,486,619 (GRCm39) missense possibly damaging 0.95
R8762:Coro7 UTSW 16 4,452,203 (GRCm39) missense probably benign
R9383:Coro7 UTSW 16 4,452,888 (GRCm39) missense probably damaging 1.00
R9451:Coro7 UTSW 16 4,488,402 (GRCm39) missense probably damaging 1.00
R9553:Coro7 UTSW 16 4,486,624 (GRCm39) missense possibly damaging 0.55
Predicted Primers PCR Primer
(F):5'- GCATTGCCTCAAAGGCTCAAGTGG -3'
(R):5'- AACCCCTGGAGAGCAAGTTCTGTG -3'

Sequencing Primer
(F):5'- TCAAGTGGACACCAGGCTG -3'
(R):5'- ttgtatacttaacacatgcagtatcc -3'
Posted On 2014-05-09