Incidental Mutation 'R1671:Mroh2b'
ID 187640
Institutional Source Beutler Lab
Gene Symbol Mroh2b
Ensembl Gene ENSMUSG00000022155
Gene Name maestro heat-like repeat family member 2B
Synonyms 4930455B06Rik, Heatr7b2
MMRRC Submission 039707-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # R1671 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 4928219-4991687 bp(+) (GRCm39)
Type of Mutation splice site (6 bp from exon)
DNA Base Change (assembly) T to C at 4980776 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000036148 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045736]
AlphaFold Q7M6Y6
Predicted Effect probably null
Transcript: ENSMUST00000045736
SMART Domains Protein: ENSMUSP00000036148
Gene: ENSMUSG00000022155

DomainStartEndE-ValueType
low complexity region 124 135 N/A INTRINSIC
low complexity region 824 842 N/A INTRINSIC
SCOP:d1gw5a_ 937 1443 7e-15 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226849
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228458
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.3%
Validation Efficiency 100% (70/70)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930578I06Rik A C 14: 64,210,637 (GRCm39) L197R probably benign Het
Arglu1 A G 8: 8,733,896 (GRCm39) V140A possibly damaging Het
Arhgef28 T C 13: 98,067,542 (GRCm39) E1461G possibly damaging Het
Best3 A T 10: 116,860,573 (GRCm39) D611V possibly damaging Het
Cenpf T C 1: 189,411,341 (GRCm39) probably null Het
Cenpj A C 14: 56,802,502 (GRCm39) M21R probably damaging Het
Cltc A T 11: 86,623,421 (GRCm39) H201Q possibly damaging Het
Col28a1 A T 6: 8,083,773 (GRCm39) N561K possibly damaging Het
Cyp2c70 G A 19: 40,142,081 (GRCm39) P470L probably damaging Het
Cyp4f14 G A 17: 33,135,883 (GRCm39) probably benign Het
Ddi1 A T 9: 6,266,225 (GRCm39) V48D possibly damaging Het
Dnah11 A C 12: 117,880,523 (GRCm39) Y3866D probably damaging Het
Dnah9 A G 11: 65,818,789 (GRCm39) V3183A probably damaging Het
Elmo1 T A 13: 20,472,054 (GRCm39) probably benign Het
Fap T A 2: 62,384,179 (GRCm39) Y9F possibly damaging Het
Fbxo15 T A 18: 84,977,231 (GRCm39) S93T possibly damaging Het
Gal3st2 C T 1: 93,801,400 (GRCm39) R19C probably damaging Het
Gmnn A T 13: 24,936,054 (GRCm39) *207R probably null Het
Gucy1a1 A C 3: 82,013,529 (GRCm39) I371S probably damaging Het
H1f11-ps C A 19: 47,159,294 (GRCm39) V94L possibly damaging Het
Igsf10 G T 3: 59,235,921 (GRCm39) S1420* probably null Het
Itih5 G T 2: 10,191,782 (GRCm39) V106L probably benign Het
Itsn1 T A 16: 91,609,038 (GRCm39) I201K probably damaging Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lars2 C T 9: 123,247,344 (GRCm39) T283I probably benign Het
Loxhd1 T C 18: 77,492,498 (GRCm39) I1313T probably damaging Het
Mamdc4 T A 2: 25,458,235 (GRCm39) R368* probably null Het
Mdga1 A T 17: 30,069,603 (GRCm39) Y422N probably damaging Het
Mro A T 18: 74,003,126 (GRCm39) probably benign Het
Nlrp1b C A 11: 71,092,085 (GRCm39) V14L probably benign Het
Nos3 A G 5: 24,588,838 (GRCm39) D1157G probably damaging Het
Nrxn2 C A 19: 6,523,780 (GRCm39) R598S probably damaging Het
Or2av9 A T 11: 58,381,435 (GRCm39) W49R possibly damaging Het
Or4k1 T C 14: 50,377,290 (GRCm39) K269E probably damaging Het
Or52ae9 C A 7: 103,389,617 (GRCm39) A277S possibly damaging Het
Or8b101 A G 9: 38,020,428 (GRCm39) M144V probably benign Het
Otog A T 7: 45,911,210 (GRCm39) D687V probably damaging Het
Pcsk5 C T 19: 17,432,232 (GRCm39) C1461Y probably damaging Het
Raet1d A G 10: 22,238,614 (GRCm39) M1V probably null Het
Rnf6 A T 5: 146,147,998 (GRCm39) L340* probably null Het
Rsl1d1 T C 16: 11,019,245 (GRCm39) T99A probably damaging Het
Sbno1 A T 5: 124,530,130 (GRCm39) probably null Het
Sipa1l1 A G 12: 82,444,235 (GRCm39) Y982C probably damaging Het
Sorbs3 G T 14: 70,428,915 (GRCm39) R417S possibly damaging Het
Sorl1 A G 9: 41,885,296 (GRCm39) C2102R probably damaging Het
Sp140l2 C T 1: 85,235,106 (GRCm39) probably null Het
Sptbn1 T A 11: 30,092,245 (GRCm39) I494F possibly damaging Het
Tank T A 2: 61,480,097 (GRCm39) V211E probably damaging Het
Tbcd T A 11: 121,488,120 (GRCm39) D840E probably benign Het
Tg T A 15: 66,564,236 (GRCm39) C1146S possibly damaging Het
Tiam2 A T 17: 3,557,109 (GRCm39) E110V probably damaging Het
Tle4 A T 19: 14,431,103 (GRCm39) W560R probably damaging Het
Triml2 G A 8: 43,636,780 (GRCm39) R76H possibly damaging Het
Ttn T C 2: 76,541,964 (GRCm39) E25347G probably damaging Het
Ube2e2 A G 14: 18,586,889 (GRCm38) L124P probably damaging Het
Vmn2r81 A G 10: 79,103,265 (GRCm39) K153E probably benign Het
Wnt16 A T 6: 22,298,178 (GRCm39) Y348F probably damaging Het
Xpo6 A G 7: 125,707,715 (GRCm39) V897A possibly damaging Het
Zbtb26 T C 2: 37,326,377 (GRCm39) T220A probably benign Het
Zik1 A T 7: 10,224,675 (GRCm39) S141T probably damaging Het
Zkscan3 A G 13: 21,580,305 (GRCm39) Y128H possibly damaging Het
Other mutations in Mroh2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00503:Mroh2b APN 15 4,928,679 (GRCm39) missense probably benign
IGL00507:Mroh2b APN 15 4,991,609 (GRCm39) missense probably damaging 1.00
IGL00548:Mroh2b APN 15 4,960,798 (GRCm39) missense probably benign 0.35
IGL00902:Mroh2b APN 15 4,944,704 (GRCm39) missense probably damaging 1.00
IGL00944:Mroh2b APN 15 4,980,609 (GRCm39) splice site probably benign
IGL00954:Mroh2b APN 15 4,932,536 (GRCm39) missense probably damaging 0.99
IGL01015:Mroh2b APN 15 4,971,024 (GRCm39) missense probably damaging 1.00
IGL01134:Mroh2b APN 15 4,944,634 (GRCm39) missense probably benign 0.00
IGL01337:Mroh2b APN 15 4,934,506 (GRCm39) missense probably benign 0.38
IGL01780:Mroh2b APN 15 4,941,482 (GRCm39) missense probably benign 0.01
IGL01919:Mroh2b APN 15 4,953,170 (GRCm39) missense probably benign 0.10
IGL02069:Mroh2b APN 15 4,933,806 (GRCm39) splice site probably benign
IGL02146:Mroh2b APN 15 4,980,776 (GRCm39) splice site probably null
IGL02221:Mroh2b APN 15 4,953,123 (GRCm39) missense probably damaging 1.00
IGL02281:Mroh2b APN 15 4,981,745 (GRCm39) missense probably benign 0.04
IGL02350:Mroh2b APN 15 4,941,482 (GRCm39) missense probably benign 0.01
IGL02357:Mroh2b APN 15 4,941,482 (GRCm39) missense probably benign 0.01
IGL02401:Mroh2b APN 15 4,929,983 (GRCm39) missense possibly damaging 0.71
IGL02427:Mroh2b APN 15 4,981,042 (GRCm39) splice site probably benign
IGL02432:Mroh2b APN 15 4,943,668 (GRCm39) missense probably benign
IGL02582:Mroh2b APN 15 4,937,997 (GRCm39) missense probably damaging 0.98
IGL02632:Mroh2b APN 15 4,960,583 (GRCm39) missense probably damaging 0.99
IGL02741:Mroh2b APN 15 4,935,114 (GRCm39) missense probably benign
IGL02811:Mroh2b APN 15 4,944,718 (GRCm39) missense possibly damaging 0.55
IGL02826:Mroh2b APN 15 4,991,630 (GRCm39) missense probably damaging 0.99
IGL03412:Mroh2b APN 15 4,973,854 (GRCm39) missense probably benign 0.14
PIT4468001:Mroh2b UTSW 15 4,942,294 (GRCm39) missense probably damaging 1.00
R0024:Mroh2b UTSW 15 4,955,109 (GRCm39) missense probably damaging 1.00
R0333:Mroh2b UTSW 15 4,960,600 (GRCm39) missense probably damaging 1.00
R0433:Mroh2b UTSW 15 4,971,116 (GRCm39) missense probably benign 0.01
R0530:Mroh2b UTSW 15 4,963,877 (GRCm39) missense probably damaging 0.97
R1411:Mroh2b UTSW 15 4,947,799 (GRCm39) missense probably damaging 1.00
R1457:Mroh2b UTSW 15 4,955,166 (GRCm39) missense probably damaging 1.00
R1466:Mroh2b UTSW 15 4,955,166 (GRCm39) missense probably damaging 1.00
R1466:Mroh2b UTSW 15 4,955,166 (GRCm39) missense probably damaging 1.00
R1472:Mroh2b UTSW 15 4,978,137 (GRCm39) missense probably benign 0.00
R1525:Mroh2b UTSW 15 4,980,612 (GRCm39) splice site probably null
R1584:Mroh2b UTSW 15 4,955,166 (GRCm39) missense probably damaging 1.00
R1605:Mroh2b UTSW 15 4,974,572 (GRCm39) missense probably benign 0.08
R1657:Mroh2b UTSW 15 4,960,525 (GRCm39) nonsense probably null
R1698:Mroh2b UTSW 15 4,943,622 (GRCm39) missense probably benign 0.02
R2002:Mroh2b UTSW 15 4,955,166 (GRCm39) missense probably damaging 1.00
R2005:Mroh2b UTSW 15 4,946,640 (GRCm39) missense probably damaging 1.00
R2077:Mroh2b UTSW 15 4,974,448 (GRCm39) missense probably damaging 1.00
R2179:Mroh2b UTSW 15 4,950,928 (GRCm39) critical splice donor site probably null
R2183:Mroh2b UTSW 15 4,947,707 (GRCm39) splice site probably null
R3713:Mroh2b UTSW 15 4,973,131 (GRCm39) missense probably benign 0.01
R3714:Mroh2b UTSW 15 4,973,131 (GRCm39) missense probably benign 0.01
R3747:Mroh2b UTSW 15 4,981,728 (GRCm39) nonsense probably null
R3748:Mroh2b UTSW 15 4,981,728 (GRCm39) nonsense probably null
R3749:Mroh2b UTSW 15 4,981,728 (GRCm39) nonsense probably null
R3750:Mroh2b UTSW 15 4,981,728 (GRCm39) nonsense probably null
R3792:Mroh2b UTSW 15 4,953,102 (GRCm39) missense probably damaging 1.00
R3872:Mroh2b UTSW 15 4,954,543 (GRCm39) nonsense probably null
R4021:Mroh2b UTSW 15 4,954,582 (GRCm39) missense possibly damaging 0.75
R4329:Mroh2b UTSW 15 4,960,861 (GRCm39) missense probably damaging 0.99
R4456:Mroh2b UTSW 15 4,977,407 (GRCm39) missense probably benign 0.21
R4592:Mroh2b UTSW 15 4,947,772 (GRCm39) missense probably damaging 1.00
R4836:Mroh2b UTSW 15 4,933,752 (GRCm39) missense probably damaging 1.00
R5050:Mroh2b UTSW 15 4,929,932 (GRCm39) missense possibly damaging 0.82
R5230:Mroh2b UTSW 15 4,971,004 (GRCm39) missense probably benign 0.07
R5342:Mroh2b UTSW 15 4,943,615 (GRCm39) nonsense probably null
R5353:Mroh2b UTSW 15 4,946,660 (GRCm39) missense probably damaging 1.00
R5368:Mroh2b UTSW 15 4,935,054 (GRCm39) missense probably damaging 1.00
R5424:Mroh2b UTSW 15 4,971,094 (GRCm39) missense probably damaging 0.98
R5484:Mroh2b UTSW 15 4,938,463 (GRCm39) missense possibly damaging 0.92
R5999:Mroh2b UTSW 15 4,942,366 (GRCm39) splice site probably null
R6046:Mroh2b UTSW 15 4,980,763 (GRCm39) missense probably benign 0.01
R6081:Mroh2b UTSW 15 4,973,859 (GRCm39) missense probably damaging 1.00
R6162:Mroh2b UTSW 15 4,944,707 (GRCm39) missense probably damaging 1.00
R6165:Mroh2b UTSW 15 4,947,832 (GRCm39) missense probably benign 0.23
R6240:Mroh2b UTSW 15 4,964,126 (GRCm39) missense probably benign 0.38
R6487:Mroh2b UTSW 15 4,976,721 (GRCm39) missense probably damaging 1.00
R6539:Mroh2b UTSW 15 4,935,056 (GRCm39) missense probably damaging 1.00
R6616:Mroh2b UTSW 15 4,982,764 (GRCm39) missense probably benign 0.36
R6663:Mroh2b UTSW 15 4,977,417 (GRCm39) missense probably benign 0.21
R6820:Mroh2b UTSW 15 4,982,756 (GRCm39) missense probably damaging 1.00
R6900:Mroh2b UTSW 15 4,938,469 (GRCm39) missense probably benign 0.00
R6990:Mroh2b UTSW 15 4,942,284 (GRCm39) missense possibly damaging 0.55
R7067:Mroh2b UTSW 15 4,929,986 (GRCm39) missense probably benign 0.35
R7092:Mroh2b UTSW 15 4,964,160 (GRCm39) missense possibly damaging 0.92
R7102:Mroh2b UTSW 15 4,977,485 (GRCm39) missense probably benign 0.06
R7264:Mroh2b UTSW 15 4,950,844 (GRCm39) missense possibly damaging 0.81
R7436:Mroh2b UTSW 15 4,971,036 (GRCm39) missense probably benign 0.21
R7462:Mroh2b UTSW 15 4,938,109 (GRCm39) missense probably damaging 1.00
R7529:Mroh2b UTSW 15 4,978,491 (GRCm39) missense probably damaging 1.00
R7575:Mroh2b UTSW 15 4,964,087 (GRCm39) missense probably damaging 1.00
R7579:Mroh2b UTSW 15 4,960,543 (GRCm39) missense probably benign 0.09
R7605:Mroh2b UTSW 15 4,974,505 (GRCm39) missense probably damaging 1.00
R7624:Mroh2b UTSW 15 4,946,613 (GRCm39) missense probably damaging 1.00
R7797:Mroh2b UTSW 15 4,978,587 (GRCm39) missense probably benign 0.36
R7848:Mroh2b UTSW 15 4,967,861 (GRCm39) nonsense probably null
R7952:Mroh2b UTSW 15 4,980,693 (GRCm39) missense probably damaging 1.00
R7995:Mroh2b UTSW 15 4,950,839 (GRCm39) nonsense probably null
R8088:Mroh2b UTSW 15 4,929,985 (GRCm39) missense possibly damaging 0.57
R8207:Mroh2b UTSW 15 4,967,892 (GRCm39) missense possibly damaging 0.95
R8242:Mroh2b UTSW 15 4,938,522 (GRCm39) missense probably benign 0.04
R8248:Mroh2b UTSW 15 4,960,586 (GRCm39) missense probably benign 0.40
R8258:Mroh2b UTSW 15 4,941,391 (GRCm39) missense probably benign 0.01
R8259:Mroh2b UTSW 15 4,941,391 (GRCm39) missense probably benign 0.01
R8304:Mroh2b UTSW 15 4,955,119 (GRCm39) missense probably damaging 0.99
R8316:Mroh2b UTSW 15 4,980,746 (GRCm39) nonsense probably null
R8345:Mroh2b UTSW 15 4,973,808 (GRCm39) missense probably benign 0.09
R8507:Mroh2b UTSW 15 4,978,572 (GRCm39) missense probably damaging 1.00
R8728:Mroh2b UTSW 15 4,935,122 (GRCm39) missense probably damaging 1.00
R8747:Mroh2b UTSW 15 4,964,782 (GRCm39) missense probably damaging 0.99
R8798:Mroh2b UTSW 15 4,978,191 (GRCm39) missense probably damaging 1.00
R8814:Mroh2b UTSW 15 4,971,107 (GRCm39) missense possibly damaging 0.61
R8856:Mroh2b UTSW 15 4,960,510 (GRCm39) nonsense probably null
R8910:Mroh2b UTSW 15 4,960,855 (GRCm39) missense probably benign 0.01
R8913:Mroh2b UTSW 15 4,947,010 (GRCm39) intron probably benign
R8941:Mroh2b UTSW 15 4,991,606 (GRCm39) missense possibly damaging 0.86
R9014:Mroh2b UTSW 15 4,928,670 (GRCm39) start codon destroyed probably null 0.95
R9086:Mroh2b UTSW 15 4,982,754 (GRCm39) critical splice acceptor site probably null
R9101:Mroh2b UTSW 15 4,929,935 (GRCm39) missense probably benign 0.20
R9118:Mroh2b UTSW 15 4,991,573 (GRCm39) missense possibly damaging 0.86
R9393:Mroh2b UTSW 15 4,980,666 (GRCm39) missense probably benign
R9429:Mroh2b UTSW 15 4,963,907 (GRCm39) missense probably damaging 1.00
R9431:Mroh2b UTSW 15 4,963,952 (GRCm39) missense probably damaging 1.00
R9443:Mroh2b UTSW 15 4,973,821 (GRCm39) missense probably damaging 1.00
R9447:Mroh2b UTSW 15 4,960,823 (GRCm39) missense probably damaging 1.00
R9497:Mroh2b UTSW 15 4,950,845 (GRCm39) missense probably damaging 0.98
R9588:Mroh2b UTSW 15 4,978,130 (GRCm39) missense probably benign 0.00
R9631:Mroh2b UTSW 15 4,946,556 (GRCm39) missense probably damaging 0.97
R9686:Mroh2b UTSW 15 4,974,605 (GRCm39) missense probably benign 0.34
R9774:Mroh2b UTSW 15 4,943,613 (GRCm39) missense probably benign 0.08
X0067:Mroh2b UTSW 15 4,981,073 (GRCm39) missense possibly damaging 0.90
Z1177:Mroh2b UTSW 15 4,934,487 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGATGTGAGACTGACAGCCATCTCC -3'
(R):5'- TGCAGAGTTGCCTGTAGAAGTCCC -3'

Sequencing Primer
(F):5'- AGACTGACAGCCATCTCCTTATTTG -3'
(R):5'- GTGGTCTAATAGCCCATAGAGC -3'
Posted On 2014-05-09