Incidental Mutation 'R1671:Mro'
ID 187647
Institutional Source Beutler Lab
Gene Symbol Mro
Ensembl Gene ENSMUSG00000064036
Gene Name maestro
Synonyms 4930507C04Rik, 4933435E20Rik
MMRRC Submission 039707-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1671 (G1)
Quality Score 225
Status Validated
Chromosome 18
Chromosomal Location 73992465-74014405 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 74003126 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000136775 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000119239] [ENSMUST00000120033] [ENSMUST00000134847] [ENSMUST00000179472]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000119239
SMART Domains Protein: ENSMUSP00000113392
Gene: ENSMUSG00000064036

DomainStartEndE-ValueType
SCOP:d1gw5a_ 23 239 9e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000120033
SMART Domains Protein: ENSMUSP00000113434
Gene: ENSMUSG00000064036

DomainStartEndE-ValueType
SCOP:d1gw5a_ 23 240 3e-10 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000134847
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136473
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139821
Predicted Effect probably benign
Transcript: ENSMUST00000179472
SMART Domains Protein: ENSMUSP00000136775
Gene: ENSMUSG00000064036

DomainStartEndE-ValueType
SCOP:d1gw5a_ 23 240 3e-10 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.3%
Validation Efficiency 100% (70/70)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is specifically transcribed in males before and after differentiation of testis, and the encoded protein may play an important role in a mammalian sex determination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal reproductive morphology and physiology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930578I06Rik A C 14: 64,210,637 (GRCm39) L197R probably benign Het
Arglu1 A G 8: 8,733,896 (GRCm39) V140A possibly damaging Het
Arhgef28 T C 13: 98,067,542 (GRCm39) E1461G possibly damaging Het
Best3 A T 10: 116,860,573 (GRCm39) D611V possibly damaging Het
Cenpf T C 1: 189,411,341 (GRCm39) probably null Het
Cenpj A C 14: 56,802,502 (GRCm39) M21R probably damaging Het
Cltc A T 11: 86,623,421 (GRCm39) H201Q possibly damaging Het
Col28a1 A T 6: 8,083,773 (GRCm39) N561K possibly damaging Het
Cyp2c70 G A 19: 40,142,081 (GRCm39) P470L probably damaging Het
Cyp4f14 G A 17: 33,135,883 (GRCm39) probably benign Het
Ddi1 A T 9: 6,266,225 (GRCm39) V48D possibly damaging Het
Dnah11 A C 12: 117,880,523 (GRCm39) Y3866D probably damaging Het
Dnah9 A G 11: 65,818,789 (GRCm39) V3183A probably damaging Het
Elmo1 T A 13: 20,472,054 (GRCm39) probably benign Het
Fap T A 2: 62,384,179 (GRCm39) Y9F possibly damaging Het
Fbxo15 T A 18: 84,977,231 (GRCm39) S93T possibly damaging Het
Gal3st2 C T 1: 93,801,400 (GRCm39) R19C probably damaging Het
Gmnn A T 13: 24,936,054 (GRCm39) *207R probably null Het
Gucy1a1 A C 3: 82,013,529 (GRCm39) I371S probably damaging Het
H1f11-ps C A 19: 47,159,294 (GRCm39) V94L possibly damaging Het
Igsf10 G T 3: 59,235,921 (GRCm39) S1420* probably null Het
Itih5 G T 2: 10,191,782 (GRCm39) V106L probably benign Het
Itsn1 T A 16: 91,609,038 (GRCm39) I201K probably damaging Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lars2 C T 9: 123,247,344 (GRCm39) T283I probably benign Het
Loxhd1 T C 18: 77,492,498 (GRCm39) I1313T probably damaging Het
Mamdc4 T A 2: 25,458,235 (GRCm39) R368* probably null Het
Mdga1 A T 17: 30,069,603 (GRCm39) Y422N probably damaging Het
Mroh2b T C 15: 4,980,776 (GRCm39) probably null Het
Nlrp1b C A 11: 71,092,085 (GRCm39) V14L probably benign Het
Nos3 A G 5: 24,588,838 (GRCm39) D1157G probably damaging Het
Nrxn2 C A 19: 6,523,780 (GRCm39) R598S probably damaging Het
Or2av9 A T 11: 58,381,435 (GRCm39) W49R possibly damaging Het
Or4k1 T C 14: 50,377,290 (GRCm39) K269E probably damaging Het
Or52ae9 C A 7: 103,389,617 (GRCm39) A277S possibly damaging Het
Or8b101 A G 9: 38,020,428 (GRCm39) M144V probably benign Het
Otog A T 7: 45,911,210 (GRCm39) D687V probably damaging Het
Pcsk5 C T 19: 17,432,232 (GRCm39) C1461Y probably damaging Het
Raet1d A G 10: 22,238,614 (GRCm39) M1V probably null Het
Rnf6 A T 5: 146,147,998 (GRCm39) L340* probably null Het
Rsl1d1 T C 16: 11,019,245 (GRCm39) T99A probably damaging Het
Sbno1 A T 5: 124,530,130 (GRCm39) probably null Het
Sipa1l1 A G 12: 82,444,235 (GRCm39) Y982C probably damaging Het
Sorbs3 G T 14: 70,428,915 (GRCm39) R417S possibly damaging Het
Sorl1 A G 9: 41,885,296 (GRCm39) C2102R probably damaging Het
Sp140l2 C T 1: 85,235,106 (GRCm39) probably null Het
Sptbn1 T A 11: 30,092,245 (GRCm39) I494F possibly damaging Het
Tank T A 2: 61,480,097 (GRCm39) V211E probably damaging Het
Tbcd T A 11: 121,488,120 (GRCm39) D840E probably benign Het
Tg T A 15: 66,564,236 (GRCm39) C1146S possibly damaging Het
Tiam2 A T 17: 3,557,109 (GRCm39) E110V probably damaging Het
Tle4 A T 19: 14,431,103 (GRCm39) W560R probably damaging Het
Triml2 G A 8: 43,636,780 (GRCm39) R76H possibly damaging Het
Ttn T C 2: 76,541,964 (GRCm39) E25347G probably damaging Het
Ube2e2 A G 14: 18,586,889 (GRCm38) L124P probably damaging Het
Vmn2r81 A G 10: 79,103,265 (GRCm39) K153E probably benign Het
Wnt16 A T 6: 22,298,178 (GRCm39) Y348F probably damaging Het
Xpo6 A G 7: 125,707,715 (GRCm39) V897A possibly damaging Het
Zbtb26 T C 2: 37,326,377 (GRCm39) T220A probably benign Het
Zik1 A T 7: 10,224,675 (GRCm39) S141T probably damaging Het
Zkscan3 A G 13: 21,580,305 (GRCm39) Y128H possibly damaging Het
Other mutations in Mro
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0471:Mro UTSW 18 74,009,860 (GRCm39) missense probably benign 0.04
R1720:Mro UTSW 18 74,009,806 (GRCm39) missense probably benign 0.36
R2267:Mro UTSW 18 74,006,368 (GRCm39) missense probably benign 0.19
R4691:Mro UTSW 18 74,006,397 (GRCm39) missense probably benign
R5382:Mro UTSW 18 74,009,893 (GRCm39) missense probably benign 0.00
R6178:Mro UTSW 18 74,006,295 (GRCm39) missense possibly damaging 0.62
R6427:Mro UTSW 18 74,005,104 (GRCm39) missense probably damaging 1.00
R6833:Mro UTSW 18 73,997,003 (GRCm39) start gained probably benign
R7354:Mro UTSW 18 74,006,385 (GRCm39) missense probably benign 0.00
R7686:Mro UTSW 18 74,010,510 (GRCm39) missense probably benign 0.00
R8006:Mro UTSW 18 74,010,577 (GRCm39) missense possibly damaging 0.88
R8277:Mro UTSW 18 73,997,132 (GRCm39) splice site probably benign
R9031:Mro UTSW 18 74,009,911 (GRCm39) critical splice donor site probably null
RF016:Mro UTSW 18 74,003,035 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- AGCGACACTTCAGATGACTGCC -3'
(R):5'- TATGGATGCAGGGTCCAGATCCAG -3'

Sequencing Primer
(F):5'- GGAACAGAAAATCTCGAACCAG -3'
(R):5'- GATCCAGCAGCTCGATCAG -3'
Posted On 2014-05-09