Incidental Mutation 'R1673:Zranb2'
ID 187790
Institutional Source Beutler Lab
Gene Symbol Zranb2
Ensembl Gene ENSMUSG00000028180
Gene Name zinc finger, RAN-binding domain containing 2
Synonyms Zfp265, Zis, Znf265
MMRRC Submission 039709-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1673 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 157239797-157254047 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 157243277 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 91 (P91L)
Ref Sequence ENSEMBL: ENSMUSP00000101673 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029831] [ENSMUST00000106057] [ENSMUST00000106058] [ENSMUST00000184802] [ENSMUST00000198915]
AlphaFold Q9R020
Predicted Effect possibly damaging
Transcript: ENSMUST00000029831
AA Change: P54L

PolyPhen 2 Score 0.906 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000029831
Gene: ENSMUSG00000028180
AA Change: P54L

DomainStartEndE-ValueType
ZnF_RBZ 11 35 1.02e-2 SMART
ZnF_RBZ 36 54 2.09e-1 SMART
low complexity region 70 82 N/A INTRINSIC
low complexity region 108 145 N/A INTRINSIC
low complexity region 156 293 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000106057
AA Change: P91L

PolyPhen 2 Score 0.704 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000101672
Gene: ENSMUSG00000028180
AA Change: P91L

DomainStartEndE-ValueType
ZnF_RBZ 11 37 1.24e-6 SMART
ZnF_RBZ 77 101 3.11e-7 SMART
low complexity region 117 129 N/A INTRINSIC
low complexity region 155 192 N/A INTRINSIC
low complexity region 203 312 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000106058
AA Change: P91L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000101673
Gene: ENSMUSG00000028180
AA Change: P91L

DomainStartEndE-ValueType
ZnF_RBZ 11 37 1.24e-6 SMART
ZnF_RBZ 77 101 3.11e-7 SMART
low complexity region 117 129 N/A INTRINSIC
low complexity region 155 192 N/A INTRINSIC
low complexity region 203 340 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106063
SMART Domains Protein: ENSMUSP00000101678
Gene: ENSMUSG00000028180

DomainStartEndE-ValueType
ZnF_RBZ 11 37 8.79e-7 SMART
ZnF_RBZ 67 91 3.11e-7 SMART
low complexity region 107 119 N/A INTRINSIC
low complexity region 145 182 N/A INTRINSIC
low complexity region 193 330 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152882
Predicted Effect probably benign
Transcript: ENSMUST00000184802
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196791
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196900
Predicted Effect probably benign
Transcript: ENSMUST00000198915
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 91.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 T C 11: 110,103,165 (GRCm39) S809G probably benign Het
Ap4b1 T A 3: 103,725,161 (GRCm39) probably null Het
Aqp12 A G 1: 92,934,606 (GRCm39) Q161R possibly damaging Het
Atp8a2 A G 14: 60,028,689 (GRCm39) I926T probably benign Het
Cacna2d1 A T 5: 16,504,988 (GRCm39) N314I probably damaging Het
Cd209d A G 8: 3,927,113 (GRCm39) S81P probably damaging Het
Cdcp1 T A 9: 123,007,086 (GRCm39) K554* probably null Het
Celsr1 A G 15: 85,816,658 (GRCm39) Y1762H probably benign Het
Cklf A G 8: 104,983,983 (GRCm39) T49A possibly damaging Het
Col12a1 T G 9: 79,600,820 (GRCm39) I755L probably benign Het
Cts3 G A 13: 61,715,368 (GRCm39) Q140* probably null Het
Ddx1 A T 12: 13,294,967 (GRCm39) probably null Het
Dnah3 C A 7: 119,570,402 (GRCm39) E2262* probably null Het
Dnah5 A G 15: 28,290,294 (GRCm39) N1228S probably benign Het
Dsg1a G A 18: 20,464,561 (GRCm39) R352Q probably damaging Het
Efcab5 A G 11: 77,042,679 (GRCm39) F25L probably damaging Het
Efhd1 T A 1: 87,192,404 (GRCm39) V78D probably damaging Het
Eif5a2 T C 3: 28,847,967 (GRCm39) probably null Het
Elp2 T A 18: 24,744,983 (GRCm39) V101D possibly damaging Het
Enpp2 A T 15: 54,773,592 (GRCm39) probably null Het
F5 A G 1: 164,007,089 (GRCm39) T298A probably damaging Het
Fbxo21 G T 5: 118,146,129 (GRCm39) R584L probably benign Het
Fbxw22 G T 9: 109,211,196 (GRCm39) F368L possibly damaging Het
Gcn1 T C 5: 115,720,356 (GRCm39) I409T probably benign Het
Gm12887 T C 4: 121,473,655 (GRCm39) Y65C probably damaging Het
Gria4 G A 9: 4,537,637 (GRCm39) Q224* probably null Het
Hdac5 C T 11: 102,089,631 (GRCm39) V860M probably damaging Het
Ino80 G A 2: 119,212,417 (GRCm39) R1302C probably damaging Het
Kcns2 A T 15: 34,838,966 (GRCm39) I110F probably damaging Het
Lrig3 A G 10: 125,846,036 (GRCm39) T822A probably damaging Het
Mapk6 T C 9: 75,302,851 (GRCm39) D214G probably damaging Het
Mcm2 A T 6: 88,869,060 (GRCm39) L264Q probably benign Het
Mpnd A T 17: 56,317,455 (GRCm39) Y64F probably damaging Het
Muc1 T A 3: 89,139,079 (GRCm39) M520K possibly damaging Het
Muc4 T A 16: 32,577,276 (GRCm39) S189T probably benign Het
Myh13 T C 11: 67,242,945 (GRCm39) S953P possibly damaging Het
Ncf2 A T 1: 152,706,230 (GRCm39) M281L probably benign Het
Nipal2 A G 15: 34,648,841 (GRCm39) I116T probably damaging Het
Nptn T C 9: 58,531,015 (GRCm39) L46P probably benign Het
Or2b6 A T 13: 21,823,214 (GRCm39) S160T probably damaging Het
Or4k77 A G 2: 111,199,552 (GRCm39) T192A probably benign Het
Or51ag1 C A 7: 103,155,896 (GRCm39) V86F probably damaging Het
Or5ae1 T A 7: 84,565,325 (GRCm39) F113I probably damaging Het
Pgr A T 9: 8,902,069 (GRCm39) Y534F possibly damaging Het
Pip4k2a A T 2: 18,877,093 (GRCm39) probably null Het
Pkd1l2 C G 8: 117,767,514 (GRCm39) V1259L probably benign Het
Ppp1r12a A G 10: 108,085,426 (GRCm39) E457G probably damaging Het
Rasa4 T A 5: 136,133,491 (GRCm39) V650D probably benign Het
Rem2 C T 14: 54,713,766 (GRCm39) probably benign Het
Rps18-ps6 A T 13: 97,896,868 (GRCm39) Y77N possibly damaging Het
Sdc1 G A 12: 8,840,409 (GRCm39) R62Q possibly damaging Het
Sdk1 A G 5: 141,934,261 (GRCm39) E366G possibly damaging Het
Setd2 T A 9: 110,433,248 (GRCm39) H2406Q probably damaging Het
Slc30a5 A G 13: 100,949,891 (GRCm39) V397A probably benign Het
Slc36a2 A T 11: 55,075,739 (GRCm39) L16H possibly damaging Het
Slc44a1 T C 4: 53,542,468 (GRCm39) V334A probably benign Het
Sox8 A T 17: 25,786,456 (GRCm39) Y416N possibly damaging Het
Speg T C 1: 75,387,807 (GRCm39) V1416A possibly damaging Het
Stimate T C 14: 30,586,391 (GRCm39) L72S possibly damaging Het
Stk24 T A 14: 121,574,983 (GRCm39) I42F probably damaging Het
Tasor2 A G 13: 3,634,498 (GRCm39) probably null Het
Tcerg1 T A 18: 42,685,646 (GRCm39) L661Q possibly damaging Het
Tpp1 G A 7: 105,396,880 (GRCm39) R417W probably damaging Het
Trim12a T A 7: 103,955,264 (GRCm39) D153V possibly damaging Het
Trpm2 T C 10: 77,778,778 (GRCm39) N396S probably benign Het
Ttn T C 2: 76,637,427 (GRCm39) K5695R probably damaging Het
Ttn G A 2: 76,640,631 (GRCm39) R11960C probably damaging Het
Tulp3 A C 6: 128,310,906 (GRCm39) probably null Het
Uaca T A 9: 60,779,438 (GRCm39) L1273H probably damaging Het
Usp33 A G 3: 152,073,919 (GRCm39) E255G probably damaging Het
Vmn2r54 T G 7: 12,350,138 (GRCm39) probably null Het
Vwa8 C T 14: 79,145,670 (GRCm39) R116C probably damaging Het
Wnt5b A T 6: 119,423,315 (GRCm39) F116L probably benign Het
Zbtb12 CTTCAT CTTCATTCAT 17: 35,115,284 (GRCm39) probably null Het
Zbtb12 TCATC TCATCCATC 17: 35,115,286 (GRCm39) probably null Het
Zfp408 G A 2: 91,476,353 (GRCm39) T367I probably damaging Het
Zfp512b G A 2: 181,230,286 (GRCm39) A480V possibly damaging Het
Zfp560 T C 9: 20,258,949 (GRCm39) T638A probably benign Het
Zfp932 G T 5: 110,156,854 (GRCm39) G151V probably damaging Het
Zpbp T C 11: 11,302,696 (GRCm39) K320E probably damaging Het
Other mutations in Zranb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01115:Zranb2 APN 3 157,252,328 (GRCm39) unclassified probably benign
IGL01528:Zranb2 APN 3 157,250,602 (GRCm39) unclassified probably benign
IGL03008:Zranb2 APN 3 157,252,302 (GRCm39) splice site probably null
R0528:Zranb2 UTSW 3 157,240,096 (GRCm39) missense probably benign 0.26
R0659:Zranb2 UTSW 3 157,247,400 (GRCm39) missense probably benign 0.23
R1170:Zranb2 UTSW 3 157,247,502 (GRCm39) utr 3 prime probably benign
R1885:Zranb2 UTSW 3 157,248,793 (GRCm39) critical splice acceptor site probably null
R4127:Zranb2 UTSW 3 157,243,227 (GRCm39) nonsense probably null
R4610:Zranb2 UTSW 3 157,247,521 (GRCm39) splice site probably benign
R4981:Zranb2 UTSW 3 157,252,378 (GRCm39) unclassified probably benign
R5053:Zranb2 UTSW 3 157,246,796 (GRCm39) missense probably damaging 0.96
R5742:Zranb2 UTSW 3 157,246,340 (GRCm39) nonsense probably null
R5873:Zranb2 UTSW 3 157,242,020 (GRCm39) nonsense probably null
R6086:Zranb2 UTSW 3 157,248,883 (GRCm39) critical splice donor site probably null
R7015:Zranb2 UTSW 3 157,242,370 (GRCm39) critical splice acceptor site probably null
R7547:Zranb2 UTSW 3 157,246,806 (GRCm39) missense possibly damaging 0.93
R7579:Zranb2 UTSW 3 157,246,309 (GRCm39) missense probably damaging 1.00
R8119:Zranb2 UTSW 3 157,241,969 (GRCm39) critical splice acceptor site probably null
R8237:Zranb2 UTSW 3 157,250,677 (GRCm39) missense probably null
R8296:Zranb2 UTSW 3 157,247,412 (GRCm39) missense unknown
R8345:Zranb2 UTSW 3 157,251,731 (GRCm39) missense unknown
R8414:Zranb2 UTSW 3 157,252,312 (GRCm39) missense unknown
R8478:Zranb2 UTSW 3 157,251,745 (GRCm39) makesense probably null
R8768:Zranb2 UTSW 3 157,247,327 (GRCm39) splice site probably benign
R9021:Zranb2 UTSW 3 157,250,720 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TGGTCCTGTAGACAGACCTTGAACC -3'
(R):5'- GTGTAAGGCTGCCTAGCACTACTTC -3'

Sequencing Primer
(F):5'- CCTTGAACCTTTACAGGAAAGCTG -3'
(R):5'- cagcatacaggatgaggcag -3'
Posted On 2014-05-09