Incidental Mutation 'R1680:Or7g12'
ID 188422
Institutional Source Beutler Lab
Gene Symbol Or7g12
Ensembl Gene ENSMUSG00000095525
Gene Name olfactory receptor family 7 subfamily G member 12
Synonyms GA_x6K02T2PVTD-12724921-12725859, MOR153-2, Olfr834, MOR153-4_p
MMRRC Submission 039716-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.312) question?
Stock # R1680 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 18899286-18900224 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 18899812 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 176 (H176R)
Ref Sequence ENSEMBL: ENSMUSP00000083680 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086492]
AlphaFold Q7TRG8
Predicted Effect possibly damaging
Transcript: ENSMUST00000086492
AA Change: H176R

PolyPhen 2 Score 0.808 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000083680
Gene: ENSMUSG00000095525
AA Change: H176R

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 7.2e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 305 7e-6 PFAM
Pfam:7tm_1 41 290 2.9e-20 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik C G 10: 100,439,390 (GRCm39) P187R probably damaging Het
Ahnak T A 19: 8,987,327 (GRCm39) H2870Q probably benign Het
Arhgef33 C T 17: 80,655,080 (GRCm39) S95F probably damaging Het
Atp1a2 T A 1: 172,106,521 (GRCm39) D827V probably damaging Het
Bcat1 T G 6: 144,985,354 (GRCm39) D96A probably damaging Het
Birc6 A T 17: 74,855,741 (GRCm39) I184L probably benign Het
Clca3b A T 3: 144,543,585 (GRCm39) L415M probably damaging Het
Clstn1 T C 4: 149,728,183 (GRCm39) V617A probably benign Het
Col22a1 G A 15: 71,671,210 (GRCm39) A1050V unknown Het
Col5a3 C T 9: 20,695,964 (GRCm39) probably null Het
Csmd3 G A 15: 47,604,566 (GRCm39) T1059I probably damaging Het
Dclk2 C T 3: 86,712,946 (GRCm39) R503Q possibly damaging Het
Dnm3 A G 1: 161,838,545 (GRCm39) V272A probably benign Het
Dnmt3a A G 12: 3,923,361 (GRCm39) Q187R probably damaging Het
Dpp9 A G 17: 56,497,103 (GRCm39) Y710H probably benign Het
Eef1a2 A T 2: 180,794,734 (GRCm39) M155K possibly damaging Het
Entpd8 G A 2: 24,974,036 (GRCm39) C331Y probably damaging Het
Erc1 A C 6: 119,552,722 (GRCm39) L1072R probably damaging Het
Fhip2b T C 14: 70,824,291 (GRCm39) Y482C probably damaging Het
Gtf3c2 A G 5: 31,331,212 (GRCm39) S155P probably damaging Het
Gucy2c A G 6: 136,699,491 (GRCm39) S617P probably damaging Het
Ice1 T C 13: 70,753,567 (GRCm39) R840G probably benign Het
Il1rl2 T C 1: 40,390,953 (GRCm39) Y299H possibly damaging Het
Ints7 T G 1: 191,353,274 (GRCm39) probably null Het
Ireb2 C T 9: 54,788,802 (GRCm39) T92I probably damaging Het
Itprid1 C T 6: 55,945,751 (GRCm39) T824I probably damaging Het
Kcnj8 A T 6: 142,515,915 (GRCm39) L64* probably null Het
Mapk8ip3 A G 17: 25,119,985 (GRCm39) V983A probably damaging Het
Mertk A G 2: 128,643,556 (GRCm39) D985G probably benign Het
Mical3 A T 6: 120,936,604 (GRCm39) S1307R probably benign Het
Mtcl3 A T 10: 29,072,835 (GRCm39) Q709L probably damaging Het
Ncaph2 A G 15: 89,248,825 (GRCm39) D222G probably benign Het
Nf1 C A 11: 79,441,824 (GRCm39) S295* probably null Het
Nlrp12 T A 7: 3,289,804 (GRCm39) D236V probably damaging Het
Npnt A G 3: 132,612,563 (GRCm39) V74A probably benign Het
Oasl1 A G 5: 115,074,003 (GRCm39) D304G probably damaging Het
Or52i2 A G 7: 102,319,940 (GRCm39) D271G possibly damaging Het
Or8g22 T C 9: 38,958,296 (GRCm39) I140V probably benign Het
Or8h8 C T 2: 86,753,505 (GRCm39) V124I probably benign Het
Patz1 A G 11: 3,257,812 (GRCm39) K604E probably damaging Het
Pcsk6 T A 7: 65,684,998 (GRCm39) V793E probably benign Het
Pla2g4d C T 2: 120,108,231 (GRCm39) probably null Het
Plxnc1 A C 10: 94,677,413 (GRCm39) L938R probably benign Het
Pou4f2 G T 8: 79,161,460 (GRCm39) A381D probably damaging Het
Prdm4 A G 10: 85,735,087 (GRCm39) L685P possibly damaging Het
Pxn T A 5: 115,690,206 (GRCm39) V383E probably damaging Het
Rbl1 A G 2: 157,016,703 (GRCm39) L632P probably damaging Het
Rnf135 T A 11: 80,087,707 (GRCm39) S219T possibly damaging Het
Sdk2 T C 11: 113,682,262 (GRCm39) D2039G possibly damaging Het
Sdk2 C T 11: 113,729,472 (GRCm39) silent Het
Slc5a6 A G 5: 31,199,988 (GRCm39) Y131H probably damaging Het
Slc9a1 T C 4: 133,145,391 (GRCm39) I492T probably damaging Het
Spag5 A G 11: 78,211,442 (GRCm39) K993E probably damaging Het
Sptbn1 T G 11: 30,109,371 (GRCm39) I75L possibly damaging Het
Syngap1 T C 17: 27,171,553 (GRCm39) S46P possibly damaging Het
Tfcp2l1 T A 1: 118,603,335 (GRCm39) F458I probably damaging Het
Tmem67 A G 4: 12,087,840 (GRCm39) V102A probably benign Het
Tomm70a T C 16: 56,942,324 (GRCm39) S34P unknown Het
Txlnb G T 10: 17,718,981 (GRCm39) G604V probably benign Het
Ube2q1 A G 3: 89,683,483 (GRCm39) T143A probably benign Het
Unc80 C T 1: 66,542,828 (GRCm39) R361* probably null Het
Vcan T C 13: 89,851,666 (GRCm39) D1098G probably benign Het
Vmn1r176 T A 7: 23,534,806 (GRCm39) T116S probably damaging Het
Wdr81 C T 11: 75,345,249 (GRCm39) R6K probably benign Het
Zan T A 5: 137,401,312 (GRCm39) T4136S unknown Het
Zbtb14 C A 17: 69,695,497 (GRCm39) F398L probably damaging Het
Zfp606 A T 7: 12,227,898 (GRCm39) H615L probably damaging Het
Zp3r A T 1: 130,510,617 (GRCm39) N433K probably benign Het
Other mutations in Or7g12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01804:Or7g12 APN 9 18,900,136 (GRCm39) missense probably benign 0.16
IGL02073:Or7g12 APN 9 18,899,621 (GRCm39) missense possibly damaging 0.89
IGL02119:Or7g12 APN 9 18,899,908 (GRCm39) missense probably benign 0.00
IGL02705:Or7g12 APN 9 18,899,696 (GRCm39) missense probably benign 0.03
R0462:Or7g12 UTSW 9 18,900,198 (GRCm39) missense probably benign
R0466:Or7g12 UTSW 9 18,899,551 (GRCm39) missense probably benign 0.00
R0709:Or7g12 UTSW 9 18,899,422 (GRCm39) missense probably damaging 0.98
R0711:Or7g12 UTSW 9 18,899,447 (GRCm39) missense probably benign 0.04
R1268:Or7g12 UTSW 9 18,899,652 (GRCm39) missense probably damaging 0.98
R1663:Or7g12 UTSW 9 18,900,006 (GRCm39) missense probably damaging 0.99
R1686:Or7g12 UTSW 9 18,899,839 (GRCm39) missense probably damaging 1.00
R1903:Or7g12 UTSW 9 18,900,192 (GRCm39) nonsense probably null
R1907:Or7g12 UTSW 9 18,899,737 (GRCm39) missense possibly damaging 0.82
R1911:Or7g12 UTSW 9 18,900,196 (GRCm39) missense probably damaging 0.99
R2143:Or7g12 UTSW 9 18,900,099 (GRCm39) missense probably benign 0.06
R2431:Or7g12 UTSW 9 18,899,299 (GRCm39) missense probably damaging 1.00
R4014:Or7g12 UTSW 9 18,900,178 (GRCm39) missense probably benign 0.08
R4515:Or7g12 UTSW 9 18,899,278 (GRCm39) splice site probably null
R4575:Or7g12 UTSW 9 18,900,001 (GRCm39) nonsense probably null
R6974:Or7g12 UTSW 9 18,899,689 (GRCm39) missense probably damaging 0.99
R7394:Or7g12 UTSW 9 18,900,006 (GRCm39) missense probably damaging 0.99
R7455:Or7g12 UTSW 9 18,900,150 (GRCm39) missense possibly damaging 0.92
R7828:Or7g12 UTSW 9 18,900,216 (GRCm39) missense probably benign
R7962:Or7g12 UTSW 9 18,899,952 (GRCm39) missense probably damaging 0.97
R8360:Or7g12 UTSW 9 18,900,139 (GRCm39) missense probably benign 0.28
R8812:Or7g12 UTSW 9 18,899,812 (GRCm39) missense possibly damaging 0.81
R8905:Or7g12 UTSW 9 18,899,494 (GRCm39) missense possibly damaging 0.92
R8973:Or7g12 UTSW 9 18,899,974 (GRCm39) nonsense probably null
R8980:Or7g12 UTSW 9 18,899,423 (GRCm39) missense probably damaging 1.00
R9013:Or7g12 UTSW 9 18,899,874 (GRCm39) missense possibly damaging 0.94
R9058:Or7g12 UTSW 9 18,900,222 (GRCm39) makesense probably null
R9614:Or7g12 UTSW 9 18,899,526 (GRCm39) missense possibly damaging 0.75
R9779:Or7g12 UTSW 9 18,900,135 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- GGTGAACATACAGGCTCAGGTCAAC -3'
(R):5'- TTCTGGAGCTATGAGTGCCAGCAG -3'

Sequencing Primer
(F):5'- ACTCGATCAGTTATACAGGCTGC -3'
(R):5'- CTACTAAATGTGATGCACATATCGAG -3'
Posted On 2014-05-09