Incidental Mutation 'R1405:Tafa5'
ID 188708
Institutional Source Beutler Lab
Gene Symbol Tafa5
Ensembl Gene ENSMUSG00000054863
Gene Name TAFA chemokine like family member 5
Synonyms Tara-5, Fam19a5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # R1405 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 87428500-87643565 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) C to T at 87565678 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000155322 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068088] [ENSMUST00000230414]
AlphaFold Q91WE9
Predicted Effect probably benign
Transcript: ENSMUST00000068088
SMART Domains Protein: ENSMUSP00000064808
Gene: ENSMUSG00000054863

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Pfam:TAFA 35 124 1.1e-47 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000230414
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.2%
Validation Efficiency
MGI Phenotype FUNCTION: This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 G A 4: 53,059,253 (GRCm39) probably benign Het
AC163020.1 A G 7: 46,959,305 (GRCm39) S229P possibly damaging Het
Arap1 G A 7: 101,047,643 (GRCm39) probably null Het
Asb8 G A 15: 98,039,248 (GRCm39) H51Y possibly damaging Het
Capn10 T G 1: 92,872,744 (GRCm39) V490G probably benign Het
Ccdc138 T A 10: 58,380,939 (GRCm39) probably benign Het
Ccdc146 G A 5: 21,604,730 (GRCm39) S36L probably benign Het
Celsr1 C T 15: 85,789,635 (GRCm39) probably null Het
Clvs2 C A 10: 33,389,256 (GRCm39) *328L probably null Het
Cul9 C G 17: 46,833,101 (GRCm39) A1326P probably damaging Het
D6Wsu163e G A 6: 126,951,446 (GRCm39) probably benign Het
Dstn A G 2: 143,780,356 (GRCm39) K19E probably damaging Het
Ehmt2 T A 17: 35,125,553 (GRCm39) H134Q probably benign Het
Faah G A 4: 115,858,345 (GRCm39) P411S probably damaging Het
Fn1 A G 1: 71,681,237 (GRCm39) F364L probably damaging Het
Gm5828 T C 1: 16,839,768 (GRCm39) noncoding transcript Het
Gmnc A T 16: 26,779,196 (GRCm39) N270K possibly damaging Het
Grip2 A T 6: 91,765,133 (GRCm39) probably null Het
Hmg20a A T 9: 56,384,587 (GRCm39) Q119L possibly damaging Het
Ipo7 T C 7: 109,629,048 (GRCm39) I106T probably benign Het
Ipo7 C T 7: 109,638,456 (GRCm39) P241L probably damaging Het
Katnb1 T C 8: 95,824,801 (GRCm39) Y574H probably damaging Het
Larp6 A C 9: 60,644,849 (GRCm39) M330L probably benign Het
Lrrc8e T C 8: 4,281,754 (GRCm39) Y30H probably damaging Het
Nav3 A T 10: 109,606,194 (GRCm39) probably benign Het
Nop56 T C 2: 130,119,868 (GRCm39) V420A probably benign Het
Nrg1 T C 8: 32,407,855 (GRCm39) D126G probably benign Het
Prdm1 T A 10: 44,315,961 (GRCm39) N725I probably damaging Het
Prl3a1 A G 13: 27,459,051 (GRCm39) probably null Het
Psmd2 T C 16: 20,471,034 (GRCm39) L59P possibly damaging Het
Ptgdr2 T C 19: 10,918,395 (GRCm39) V304A probably benign Het
Ptp4a2 T A 4: 129,738,851 (GRCm39) probably benign Het
Rasa3 A G 8: 13,638,027 (GRCm39) V339A possibly damaging Het
Sec24c G A 14: 20,742,593 (GRCm39) probably null Het
Serpinb9e A G 13: 33,444,009 (GRCm39) D343G probably benign Het
Sptbn5 A T 2: 119,881,097 (GRCm39) noncoding transcript Het
Stab1 A C 14: 30,870,958 (GRCm39) V1297G probably benign Het
Stk4 C T 2: 163,942,448 (GRCm39) T360M probably benign Het
Tmprss2 G A 16: 97,398,005 (GRCm39) T57I probably benign Het
Tnrc6a A G 7: 122,770,301 (GRCm39) D697G probably damaging Het
Vwa5b2 T A 16: 20,423,066 (GRCm39) D1021E probably benign Het
Wdr46 C A 17: 34,168,057 (GRCm39) P543Q probably damaging Het
Zfp1005 T A 2: 150,109,620 (GRCm39) Y103* probably null Het
Zfp287 T A 11: 62,619,137 (GRCm39) D119V probably damaging Het
Zxdc A G 6: 90,361,225 (GRCm39) S737G possibly damaging Het
Other mutations in Tafa5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0227:Tafa5 UTSW 15 87,604,691 (GRCm39) splice site probably benign
R0305:Tafa5 UTSW 15 87,604,709 (GRCm39) missense probably damaging 1.00
R4646:Tafa5 UTSW 15 87,604,783 (GRCm39) missense probably damaging 0.99
R4647:Tafa5 UTSW 15 87,604,783 (GRCm39) missense probably damaging 0.99
R4841:Tafa5 UTSW 15 87,509,637 (GRCm39) intron probably benign
R9147:Tafa5 UTSW 15 87,428,775 (GRCm39) missense probably benign 0.05
R9148:Tafa5 UTSW 15 87,428,775 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- ACTGGAATCCCTGGCAGAGCATAC -3'
(R):5'- ATACCTCAGAGTCTTGGCCTCAGAG -3'

Sequencing Primer
(F):5'- GCATACAGGAGATGGTTTGC -3'
(R):5'- CCTCAGAGCATTCTGGAGATG -3'
Posted On 2014-05-09