Incidental Mutation 'R1652:Or10d3'
ID 188791
Institutional Source Beutler Lab
Gene Symbol Or10d3
Ensembl Gene ENSMUSG00000050853
Gene Name olfactory receptor family 10 subfamily D member 3
Synonyms GA_x6K02T2PVTD-33247839-33246901, MOR224-9, Olfr958
MMRRC Submission 039688-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.153) question?
Stock # R1652 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 39461227-39462165 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 39461591 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 192 (T192I)
Ref Sequence ENSEMBL: ENSMUSP00000149788 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062545] [ENSMUST00000215505] [ENSMUST00000217227]
AlphaFold Q8VEY3
Predicted Effect probably benign
Transcript: ENSMUST00000062545
AA Change: T192I

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000049930
Gene: ENSMUSG00000050853
AA Change: T192I

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 1.1e-49 PFAM
Pfam:7TM_GPCR_Srsx 36 236 1.5e-6 PFAM
Pfam:7tm_1 41 288 3.4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215505
AA Change: T192I

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000217227
AA Change: T192I

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.2%
  • 20x: 92.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam2 T A 14: 66,314,700 (GRCm39) E37V probably benign Het
Adamts7 A G 9: 90,071,697 (GRCm39) D664G probably damaging Het
Adamtsl5 A G 10: 80,178,011 (GRCm39) V256A probably benign Het
Adrb1 C T 19: 56,711,705 (GRCm39) S301L possibly damaging Het
Akap9 A G 5: 4,127,210 (GRCm39) Y3686C probably damaging Het
Ap3b2 A G 7: 81,123,147 (GRCm39) S456P probably damaging Het
Atp1a4 T C 1: 172,082,470 (GRCm39) Y124C probably damaging Het
Bdkrb1 A T 12: 105,570,502 (GRCm39) T23S probably damaging Het
Cacna1g A G 11: 94,318,230 (GRCm39) Y1468H probably damaging Het
Cep170b A G 12: 112,699,947 (GRCm39) D152G probably damaging Het
Cers4 T A 8: 4,566,908 (GRCm39) probably null Het
Cplane1 G T 15: 8,230,630 (GRCm39) R969L probably damaging Het
Cyp2t4 A T 7: 26,856,815 (GRCm39) D285V possibly damaging Het
Ddx56 A T 11: 6,217,679 (GRCm39) L14Q probably damaging Het
Dennd2d C A 3: 106,394,317 (GRCm39) R63S probably benign Het
Dnah7b T A 1: 46,214,550 (GRCm39) L1105* probably null Het
Eef1e1 A T 13: 38,840,081 (GRCm39) L75I possibly damaging Het
Eif1ad11 T A 12: 87,993,853 (GRCm39) V27E probably benign Het
Fam76b A G 9: 13,747,188 (GRCm39) S191G probably benign Het
Fat1 T A 8: 45,478,215 (GRCm39) Y2420* probably null Het
Fbxw18 T A 9: 109,519,695 (GRCm39) L270F probably benign Het
Fech T A 18: 64,591,269 (GRCm39) H385L probably benign Het
Fkbp4 A T 6: 128,413,637 (GRCm39) I2N probably damaging Het
Gda A T 19: 21,378,042 (GRCm39) M339K probably damaging Het
Gdpgp1 T A 7: 79,889,112 (GRCm39) M381K probably benign Het
Glyctk C A 9: 106,034,356 (GRCm39) V173L probably damaging Het
Gtf2ird1 G A 5: 134,424,567 (GRCm39) P393L probably damaging Het
Kat2a T C 11: 100,599,437 (GRCm39) N517D probably damaging Het
Krt84 G A 15: 101,434,398 (GRCm39) S523F possibly damaging Het
Lama1 G A 17: 68,114,841 (GRCm39) R2330Q probably damaging Het
Lamc1 C T 1: 153,125,392 (GRCm39) G597E probably damaging Het
Lekr1 A T 3: 65,591,508 (GRCm39) S82C probably benign Het
Lgi3 T C 14: 70,768,656 (GRCm39) F51S probably damaging Het
Lrba T C 3: 86,447,245 (GRCm39) S2030P probably damaging Het
Map4k5 A G 12: 69,877,201 (GRCm39) probably null Het
Mcoln2 C A 3: 145,869,390 (GRCm39) R32S possibly damaging Het
Metap1 A T 3: 138,168,151 (GRCm39) F324L probably damaging Het
Moxd2 C T 6: 40,864,337 (GRCm39) R31H probably damaging Het
Ncf4 T A 15: 78,145,234 (GRCm39) M274K possibly damaging Het
Nup205 T G 6: 35,215,901 (GRCm39) V1747G probably benign Het
Or52r1c A G 7: 102,735,013 (GRCm39) D91G probably benign Het
Or5ae1 T C 7: 84,565,728 (GRCm39) V247A probably damaging Het
Pbx3 C T 2: 34,114,568 (GRCm39) G122D probably damaging Het
Plcb3 A G 19: 6,932,664 (GRCm39) F1034L probably benign Het
Ppp2r1a G A 17: 21,176,236 (GRCm39) V153I probably benign Het
Prss33 C G 17: 24,054,115 (GRCm39) M30I probably benign Het
Prss33 A T 17: 24,054,116 (GRCm39) M30K probably benign Het
R3hdm2 G A 10: 127,330,960 (GRCm39) S793N probably benign Het
Rab11fip5 C T 6: 85,325,279 (GRCm39) V343M probably damaging Het
Rere A G 4: 150,696,522 (GRCm39) probably benign Het
Rims1 G T 1: 22,363,090 (GRCm39) P52Q probably damaging Het
Scpep1 G T 11: 88,843,260 (GRCm39) S66* probably null Het
Setd2 A G 9: 110,378,932 (GRCm39) S632G probably benign Het
Shc3 A T 13: 51,626,875 (GRCm39) H129Q probably damaging Het
Slc22a20 A T 19: 6,022,970 (GRCm39) M391K probably damaging Het
Smurf1 A T 5: 144,817,474 (GRCm39) I712K probably damaging Het
Snx25 T A 8: 46,502,510 (GRCm39) I629L probably damaging Het
Supt16 A C 14: 52,414,637 (GRCm39) V425G probably benign Het
Tnik G A 3: 28,658,442 (GRCm39) V576I probably benign Het
Trcg1 A C 9: 57,152,856 (GRCm39) D551A probably damaging Het
Ubald2 A G 11: 116,325,178 (GRCm39) N15S probably damaging Het
Usf1 T C 1: 171,245,317 (GRCm39) I243T probably damaging Het
Vmn2r19 A T 6: 123,292,656 (GRCm39) I233F possibly damaging Het
Vmn2r63 T C 7: 42,577,635 (GRCm39) N301S probably benign Het
Wdr27 A G 17: 15,137,532 (GRCm39) F419L probably benign Het
Other mutations in Or10d3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0446:Or10d3 UTSW 9 39,461,747 (GRCm39) missense probably damaging 0.96
R0539:Or10d3 UTSW 9 39,461,593 (GRCm39) missense probably damaging 0.99
R1512:Or10d3 UTSW 9 39,461,390 (GRCm39) missense probably damaging 1.00
R1521:Or10d3 UTSW 9 39,462,080 (GRCm39) missense possibly damaging 0.65
R2099:Or10d3 UTSW 9 39,461,963 (GRCm39) missense probably benign 0.17
R2252:Or10d3 UTSW 9 39,461,273 (GRCm39) missense probably damaging 0.99
R2911:Or10d3 UTSW 9 39,462,117 (GRCm39) missense possibly damaging 0.76
R3722:Or10d3 UTSW 9 39,461,418 (GRCm39) missense probably damaging 1.00
R5745:Or10d3 UTSW 9 39,461,987 (GRCm39) missense probably damaging 1.00
R6460:Or10d3 UTSW 9 39,462,088 (GRCm39) frame shift probably null
R6504:Or10d3 UTSW 9 39,461,574 (GRCm39) missense probably damaging 1.00
R7063:Or10d3 UTSW 9 39,461,411 (GRCm39) missense possibly damaging 0.87
R7162:Or10d3 UTSW 9 39,461,525 (GRCm39) missense probably damaging 1.00
R8674:Or10d3 UTSW 9 39,461,675 (GRCm39) missense probably damaging 1.00
R8748:Or10d3 UTSW 9 39,461,712 (GRCm39) nonsense probably null
R8748:Or10d3 UTSW 9 39,461,711 (GRCm39) missense possibly damaging 0.95
R8822:Or10d3 UTSW 9 39,461,812 (GRCm39) missense probably benign 0.11
R9529:Or10d3 UTSW 9 39,461,723 (GRCm39) missense probably benign 0.28
R9631:Or10d3 UTSW 9 39,461,508 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACAGTTCCCAGCATGGGGTTTG -3'
(R):5'- ATGACCGCTTTGCTGCCATTTG -3'

Sequencing Primer
(F):5'- TGATTATAGGTCCATAGGCACAG -3'
(R):5'- CGGTACTCGGTCATCATGAAC -3'
Posted On 2014-05-09