Incidental Mutation 'R1703:Adgra3'
ID 189875
Institutional Source Beutler Lab
Gene Symbol Adgra3
Ensembl Gene ENSMUSG00000029090
Gene Name adhesion G protein-coupled receptor A3
Synonyms Tem5-like, 3830613O22Rik, Gpr125
MMRRC Submission 039736-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1703 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 50117293-50216338 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 50164117 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 287 (M287I)
Ref Sequence ENSEMBL: ENSMUSP00000030971 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030971]
AlphaFold Q7TT36
Predicted Effect probably benign
Transcript: ENSMUST00000030971
AA Change: M287I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000030971
Gene: ENSMUSG00000029090
AA Change: M287I

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
low complexity region 36 48 N/A INTRINSIC
LRR 68 92 1.71e1 SMART
LRR_TYP 93 116 2.27e-4 SMART
LRR_TYP 117 140 4.11e-2 SMART
LRR_TYP 141 164 3.89e-3 SMART
LRRCT 176 225 5.24e-5 SMART
IG 238 331 8.26e-5 SMART
GPS 686 738 4.81e-3 SMART
Pfam:7tm_2 746 1031 1.6e-16 PFAM
low complexity region 1251 1262 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196229
Meta Mutation Damage Score 0.0651 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.2%
  • 20x: 92.4%
Validation Efficiency 99% (86/87)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]
PHENOTYPE: Homozygous mutant mice are fertile and grossly normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057M21Rik A T 7: 130,945,431 (GRCm39) Y401* probably null Het
4932415M13Rik C A 17: 54,032,065 (GRCm39) noncoding transcript Het
Abtb3 A G 10: 85,223,248 (GRCm39) D19G unknown Het
Acoxl T A 2: 127,820,692 (GRCm39) S81R probably damaging Het
Adamtsl4 A G 3: 95,584,924 (GRCm39) C915R probably damaging Het
Afg1l T G 10: 42,276,395 (GRCm39) D250A probably damaging Het
Akap8l C T 17: 32,551,457 (GRCm39) R511H probably damaging Het
Amfr T C 8: 94,700,871 (GRCm39) T530A probably benign Het
Ank2 C T 3: 126,723,415 (GRCm39) V971M probably damaging Het
App A G 16: 84,762,656 (GRCm39) S656P probably damaging Het
Arid5a T A 1: 36,358,656 (GRCm39) probably null Het
Asic5 T A 3: 81,907,029 (GRCm39) V60D possibly damaging Het
Atm G T 9: 53,412,000 (GRCm39) H1019N probably benign Het
Cep250 A G 2: 155,807,466 (GRCm39) K277R probably benign Het
Chrna7 C T 7: 62,749,255 (GRCm39) R409H probably damaging Het
Chrng A T 1: 87,138,628 (GRCm39) N419I possibly damaging Het
Ciao1 T C 2: 127,087,739 (GRCm39) S199G probably benign Het
Clstn2 A T 9: 97,340,290 (GRCm39) M694K possibly damaging Het
Cpeb2 A G 5: 43,391,181 (GRCm39) probably benign Het
Cyp2c69 T A 19: 39,864,810 (GRCm39) I223F probably benign Het
Dennd1b A T 1: 139,097,492 (GRCm39) probably null Het
Dnah17 A T 11: 117,917,575 (GRCm39) L4162Q probably damaging Het
Dnm1 T C 2: 32,213,463 (GRCm39) M506V probably benign Het
Ecsit A G 9: 21,986,107 (GRCm39) V173A probably damaging Het
Fam13b T C 18: 34,584,492 (GRCm39) probably null Het
Fgl2 T A 5: 21,577,730 (GRCm39) W6R possibly damaging Het
Galnt9 G A 5: 110,767,038 (GRCm39) R503H probably damaging Het
Gramd1a C T 7: 30,838,959 (GRCm39) V247M possibly damaging Het
Grip2 A T 6: 91,754,379 (GRCm39) I632N probably damaging Het
Hspg2 T C 4: 137,286,462 (GRCm39) V3627A probably damaging Het
Ipo8 T C 6: 148,691,390 (GRCm39) Y660C probably benign Het
Isg15 T C 4: 156,284,265 (GRCm39) R88G possibly damaging Het
Itgb5 T A 16: 33,730,870 (GRCm39) D388E probably benign Het
Jhy T C 9: 40,856,133 (GRCm39) Y118C probably damaging Het
Kalrn G A 16: 34,025,696 (GRCm39) T931M probably damaging Het
Kif21a A G 15: 90,833,250 (GRCm39) probably null Het
Lama2 A T 10: 27,142,667 (GRCm39) Y604N probably damaging Het
Lrp3 T G 7: 34,912,586 (GRCm39) S34R possibly damaging Het
Lrrc37 C T 11: 103,431,700 (GRCm39) V1372I probably benign Het
Lyn T C 4: 3,738,867 (GRCm39) probably null Het
Mroh8 C T 2: 157,113,896 (GRCm39) V132I probably benign Het
Mthfd1l T C 10: 4,098,093 (GRCm39) F977L probably damaging Het
Nol8 C T 13: 49,820,933 (GRCm39) T912M possibly damaging Het
Nrxn1 A T 17: 90,515,845 (GRCm39) N169K probably damaging Het
Oplah A G 15: 76,180,867 (GRCm39) Y1279H probably benign Het
Or10ag56 T C 2: 87,139,754 (GRCm39) V207A probably benign Het
Or4c101 T A 2: 88,390,599 (GRCm39) M262K possibly damaging Het
Pcsk5 T C 19: 17,729,458 (GRCm39) N129S probably benign Het
Pcyt2 G T 11: 120,503,894 (GRCm39) P185T probably benign Het
Pdlim2 A G 14: 70,411,784 (GRCm39) probably null Het
Pgs1 T C 11: 117,905,554 (GRCm39) probably benign Het
Qprt A G 7: 126,707,343 (GRCm39) V251A probably benign Het
Rasal2 A C 1: 156,985,170 (GRCm39) L834R probably damaging Het
Reg1 T C 6: 78,405,432 (GRCm39) C161R probably damaging Het
Rp1 T A 1: 4,415,392 (GRCm39) I1907F probably damaging Het
S1pr5 T C 9: 21,155,346 (GRCm39) D360G possibly damaging Het
Sart3 C A 5: 113,890,280 (GRCm39) V482F probably benign Het
Scarf2 A G 16: 17,620,713 (GRCm39) E127G probably damaging Het
Serinc5 T C 13: 92,825,305 (GRCm39) S245P probably damaging Het
Serpinc1 G T 1: 160,821,087 (GRCm39) R57L probably damaging Het
Setd2 A G 9: 110,378,932 (GRCm39) S632G probably benign Het
Sgca A T 11: 94,860,217 (GRCm39) L307M probably damaging Het
Slc7a9 C A 7: 35,154,000 (GRCm39) Q208K probably benign Het
Slfn10-ps C T 11: 82,920,869 (GRCm39) noncoding transcript Het
Spam1 A T 6: 24,796,256 (GRCm39) D69V probably damaging Het
Tanc1 A G 2: 59,673,365 (GRCm39) E1490G probably benign Het
Tbc1d22a G T 15: 86,123,416 (GRCm39) D150Y probably benign Het
Tex10 C T 4: 48,456,800 (GRCm39) R637Q probably benign Het
Tlx1 A G 19: 45,144,443 (GRCm39) D55G possibly damaging Het
Tram2 G T 1: 21,074,458 (GRCm39) N241K probably damaging Het
Ttc23l T C 15: 10,523,744 (GRCm39) Y325C probably damaging Het
Ubac2 T A 14: 122,142,582 (GRCm39) S27T probably benign Het
Utrn G A 10: 12,603,473 (GRCm39) probably benign Het
Vnn3 A T 10: 23,741,828 (GRCm39) M378L probably benign Het
Vps18 T A 2: 119,119,538 (GRCm39) D6E probably benign Het
Xkr5 T A 8: 18,989,134 (GRCm39) I253F probably benign Het
Yeats4 A T 10: 117,051,628 (GRCm39) C210S probably benign Het
Zdhhc20 A G 14: 58,076,545 (GRCm39) probably null Het
Other mutations in Adgra3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00777:Adgra3 APN 5 50,183,100 (GRCm39) missense probably damaging 1.00
IGL00848:Adgra3 APN 5 50,159,291 (GRCm39) missense probably damaging 1.00
IGL01455:Adgra3 APN 5 50,144,899 (GRCm39) nonsense probably null
IGL01665:Adgra3 APN 5 50,164,272 (GRCm39) missense possibly damaging 0.64
IGL02151:Adgra3 APN 5 50,136,484 (GRCm39) missense probably benign
IGL02239:Adgra3 APN 5 50,118,054 (GRCm39) missense probably damaging 1.00
IGL02351:Adgra3 APN 5 50,215,900 (GRCm39) missense probably benign 0.19
IGL02358:Adgra3 APN 5 50,215,900 (GRCm39) missense probably benign 0.19
IGL02938:Adgra3 APN 5 50,118,659 (GRCm39) missense probably benign 0.01
IGL03028:Adgra3 APN 5 50,174,194 (GRCm39) missense probably benign 0.30
aperture UTSW 5 50,156,487 (GRCm39) nonsense probably null
saltatory UTSW 5 50,117,901 (GRCm39) missense probably benign 0.09
ANU74:Adgra3 UTSW 5 50,118,380 (GRCm39) missense probably benign 0.16
R0041:Adgra3 UTSW 5 50,117,901 (GRCm39) missense probably benign 0.09
R0041:Adgra3 UTSW 5 50,117,901 (GRCm39) missense probably benign 0.09
R0121:Adgra3 UTSW 5 50,183,128 (GRCm39) splice site probably benign
R0125:Adgra3 UTSW 5 50,159,194 (GRCm39) splice site probably benign
R0137:Adgra3 UTSW 5 50,121,182 (GRCm39) splice site probably benign
R0415:Adgra3 UTSW 5 50,119,099 (GRCm39) splice site probably benign
R0479:Adgra3 UTSW 5 50,147,607 (GRCm39) missense probably benign 0.00
R0505:Adgra3 UTSW 5 50,166,676 (GRCm39) critical splice donor site probably null
R0831:Adgra3 UTSW 5 50,128,144 (GRCm39) missense probably damaging 1.00
R0883:Adgra3 UTSW 5 50,118,065 (GRCm39) missense probably damaging 1.00
R0920:Adgra3 UTSW 5 50,118,503 (GRCm39) missense probably benign 0.19
R1139:Adgra3 UTSW 5 50,119,097 (GRCm39) splice site probably null
R1211:Adgra3 UTSW 5 50,164,218 (GRCm39) missense possibly damaging 0.88
R1370:Adgra3 UTSW 5 50,118,129 (GRCm39) missense possibly damaging 0.56
R1530:Adgra3 UTSW 5 50,118,479 (GRCm39) missense probably benign 0.00
R1782:Adgra3 UTSW 5 50,129,404 (GRCm39) missense probably benign 0.02
R1843:Adgra3 UTSW 5 50,118,834 (GRCm39) missense probably damaging 1.00
R2157:Adgra3 UTSW 5 50,159,283 (GRCm39) missense possibly damaging 0.87
R2281:Adgra3 UTSW 5 50,159,222 (GRCm39) missense probably benign 0.04
R2385:Adgra3 UTSW 5 50,136,908 (GRCm39) missense possibly damaging 0.95
R2426:Adgra3 UTSW 5 50,166,791 (GRCm39) missense possibly damaging 0.61
R3084:Adgra3 UTSW 5 50,170,733 (GRCm39) critical splice donor site probably null
R3086:Adgra3 UTSW 5 50,170,733 (GRCm39) critical splice donor site probably null
R3409:Adgra3 UTSW 5 50,159,272 (GRCm39) missense probably damaging 1.00
R3410:Adgra3 UTSW 5 50,159,272 (GRCm39) missense probably damaging 1.00
R3411:Adgra3 UTSW 5 50,159,272 (GRCm39) missense probably damaging 1.00
R4301:Adgra3 UTSW 5 50,118,420 (GRCm39) missense possibly damaging 0.94
R4360:Adgra3 UTSW 5 50,147,552 (GRCm39) missense possibly damaging 0.92
R4475:Adgra3 UTSW 5 50,159,240 (GRCm39) missense probably damaging 1.00
R4569:Adgra3 UTSW 5 50,117,905 (GRCm39) missense probably damaging 1.00
R4607:Adgra3 UTSW 5 50,128,081 (GRCm39) missense probably damaging 0.98
R4667:Adgra3 UTSW 5 50,136,298 (GRCm39) missense possibly damaging 0.94
R4671:Adgra3 UTSW 5 50,136,710 (GRCm39) missense probably damaging 1.00
R4886:Adgra3 UTSW 5 50,156,537 (GRCm39) missense probably benign 0.07
R5197:Adgra3 UTSW 5 50,118,096 (GRCm39) missense probably benign 0.01
R5208:Adgra3 UTSW 5 50,168,857 (GRCm39) missense probably damaging 0.99
R5313:Adgra3 UTSW 5 50,118,651 (GRCm39) missense probably benign 0.24
R5435:Adgra3 UTSW 5 50,147,468 (GRCm39) missense probably damaging 0.99
R5663:Adgra3 UTSW 5 50,156,627 (GRCm39) missense probably benign 0.14
R6038:Adgra3 UTSW 5 50,156,487 (GRCm39) nonsense probably null
R6038:Adgra3 UTSW 5 50,156,487 (GRCm39) nonsense probably null
R6064:Adgra3 UTSW 5 50,117,667 (GRCm39) missense probably damaging 0.97
R6259:Adgra3 UTSW 5 50,156,483 (GRCm39) missense possibly damaging 0.63
R6272:Adgra3 UTSW 5 50,166,791 (GRCm39) missense possibly damaging 0.61
R6293:Adgra3 UTSW 5 50,118,189 (GRCm39) missense probably benign 0.21
R6296:Adgra3 UTSW 5 50,118,189 (GRCm39) missense probably benign 0.21
R6297:Adgra3 UTSW 5 50,118,189 (GRCm39) missense probably benign 0.21
R6352:Adgra3 UTSW 5 50,147,592 (GRCm39) missense probably benign 0.01
R6352:Adgra3 UTSW 5 50,136,478 (GRCm39) missense probably benign
R6989:Adgra3 UTSW 5 50,164,226 (GRCm39) missense probably damaging 1.00
R7026:Adgra3 UTSW 5 50,118,083 (GRCm39) missense probably benign
R7147:Adgra3 UTSW 5 50,118,587 (GRCm39) missense probably damaging 1.00
R7206:Adgra3 UTSW 5 50,164,238 (GRCm39) missense probably damaging 1.00
R7381:Adgra3 UTSW 5 50,216,116 (GRCm39) start codon destroyed probably null
R7508:Adgra3 UTSW 5 50,174,209 (GRCm39) missense probably benign 0.10
R7538:Adgra3 UTSW 5 50,118,792 (GRCm39) missense probably benign 0.01
R7579:Adgra3 UTSW 5 50,144,977 (GRCm39) missense probably benign
R7951:Adgra3 UTSW 5 50,121,126 (GRCm39) missense probably damaging 1.00
R8269:Adgra3 UTSW 5 50,121,079 (GRCm39) missense probably damaging 0.98
R8458:Adgra3 UTSW 5 50,145,013 (GRCm39) missense probably damaging 0.99
R8486:Adgra3 UTSW 5 50,147,621 (GRCm39) missense probably damaging 0.98
R8912:Adgra3 UTSW 5 50,118,273 (GRCm39) missense possibly damaging 0.61
R8955:Adgra3 UTSW 5 50,118,731 (GRCm39) missense probably benign 0.05
R9108:Adgra3 UTSW 5 50,136,295 (GRCm39) missense probably damaging 1.00
R9112:Adgra3 UTSW 5 50,118,395 (GRCm39) missense probably damaging 1.00
R9191:Adgra3 UTSW 5 50,145,006 (GRCm39) missense possibly damaging 0.88
R9267:Adgra3 UTSW 5 50,155,618 (GRCm39) missense possibly damaging 0.87
R9312:Adgra3 UTSW 5 50,117,900 (GRCm39) missense probably damaging 1.00
R9537:Adgra3 UTSW 5 50,118,207 (GRCm39) missense possibly damaging 0.82
R9614:Adgra3 UTSW 5 50,164,250 (GRCm39) missense probably damaging 1.00
RF005:Adgra3 UTSW 5 50,170,729 (GRCm39) splice site probably null
RF024:Adgra3 UTSW 5 50,170,729 (GRCm39) splice site probably null
RF036:Adgra3 UTSW 5 50,215,983 (GRCm39) small deletion probably benign
X0065:Adgra3 UTSW 5 50,129,304 (GRCm39) missense probably benign
Z1187:Adgra3 UTSW 5 50,136,421 (GRCm39) missense probably damaging 1.00
Z1192:Adgra3 UTSW 5 50,156,623 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ATGGTGAAAGGGCGGTGATTCC -3'
(R):5'- TCTCTGTGTGGTGCATGAACAGC -3'

Sequencing Primer
(F):5'- TCTTCCAAAACTAGATGAGGAGATAG -3'
(R):5'- GGGCTTCTGTTCACTCGGTC -3'
Posted On 2014-05-14