Incidental Mutation 'R1706:Ago3'
ID 190061
Institutional Source Beutler Lab
Gene Symbol Ago3
Ensembl Gene ENSMUSG00000028842
Gene Name argonaute RISC catalytic subunit 3
Synonyms eIF2C3, C130014L07Rik, argonaute 3
MMRRC Submission 039739-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1706 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 126225497-126323349 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 126264085 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 374 (P374S)
Ref Sequence ENSEMBL: ENSMUSP00000066633 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069097]
AlphaFold Q8CJF9
Predicted Effect probably damaging
Transcript: ENSMUST00000069097
AA Change: P374S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000066633
Gene: ENSMUSG00000028842
AA Change: P374S

DomainStartEndE-ValueType
Pfam:ArgoN 20 167 9.4e-26 PFAM
DUF1785 176 228 3.48e-25 SMART
PAZ 236 371 4.18e-4 SMART
Pfam:ArgoL2 376 421 1.3e-14 PFAM
Pfam:ArgoMid 430 512 1.4e-34 PFAM
Piwi 518 819 2.96e-136 SMART
Blast:Piwi 826 852 5e-7 BLAST
Meta Mutation Damage Score 0.2203 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 93.6%
Validation Efficiency 100% (60/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI

All alleles(22) : Gene trapped(22)

Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921524L21Rik T C 18: 6,624,059 (GRCm39) probably benign Het
4931406C07Rik G A 9: 15,209,153 (GRCm39) T47I probably damaging Het
Adcy2 T A 13: 68,868,865 (GRCm39) N558I probably damaging Het
Ak8 T C 2: 28,650,007 (GRCm39) C345R possibly damaging Het
Akap8l C T 17: 32,551,457 (GRCm39) R511H probably damaging Het
BC005624 T C 2: 30,868,922 (GRCm39) E84G possibly damaging Het
Cav1 T C 6: 17,339,181 (GRCm39) F89L probably damaging Het
Cfap206 G A 4: 34,688,875 (GRCm39) P593L probably damaging Het
Clcn6 G A 4: 148,102,025 (GRCm39) T353I probably benign Het
Cstl1 G A 2: 148,593,079 (GRCm39) probably null Het
Cyp2d10 A C 15: 82,289,783 (GRCm39) S140A probably damaging Het
D130052B06Rik G A 11: 33,566,230 (GRCm39) R18H unknown Het
Ddi2 A G 4: 141,411,308 (GRCm39) F535L probably benign Het
Dop1a C T 9: 86,436,133 (GRCm39) T2383M possibly damaging Het
Duox1 A G 2: 122,149,953 (GRCm39) T115A probably benign Het
Ercc6l2 T A 13: 64,020,272 (GRCm39) probably benign Het
Gm7052 A G 17: 22,258,823 (GRCm39) probably benign Het
Gm9925 G A 18: 74,198,573 (GRCm39) probably benign Het
Gnas T A 2: 174,141,768 (GRCm39) S646T possibly damaging Het
Gpatch3 T A 4: 133,302,484 (GRCm39) C138* probably null Het
Igsf8 C T 1: 172,144,972 (GRCm39) R100C probably damaging Het
Kcnh3 A G 15: 99,135,959 (GRCm39) K652R possibly damaging Het
Kcnn4 T A 7: 24,074,167 (GRCm39) V77E probably damaging Het
Kif13b T A 14: 64,998,115 (GRCm39) probably benign Het
Lca5l T C 16: 95,977,164 (GRCm39) N214S probably benign Het
Luc7l3 T C 11: 94,188,582 (GRCm39) probably benign Het
Lypd3 T C 7: 24,339,755 (GRCm39) I274T probably benign Het
Macf1 A G 4: 123,264,377 (GRCm39) probably null Het
Mchr1 A G 15: 81,121,364 (GRCm39) Y38C probably damaging Het
Mia2 T A 12: 59,191,552 (GRCm39) L716* probably null Het
Mki67 A G 7: 135,302,295 (GRCm39) L913P probably benign Het
Mug2 T A 6: 122,013,191 (GRCm39) probably benign Het
Neu3 A G 7: 99,472,563 (GRCm39) L58P probably damaging Het
Or4p23 G A 2: 88,576,482 (GRCm39) P250L probably damaging Het
Or8h9 A T 2: 86,789,424 (GRCm39) I126N probably damaging Het
Pak1ip1 T C 13: 41,166,164 (GRCm39) V363A probably benign Het
Pcdhb16 A G 18: 37,612,705 (GRCm39) D555G probably benign Het
Pygb G A 2: 150,669,067 (GRCm39) G671D probably damaging Het
Rab30 A T 7: 92,478,875 (GRCm39) I79L possibly damaging Het
Rab44 C A 17: 29,357,080 (GRCm39) T70K probably damaging Het
Rccd1 C G 7: 79,970,411 (GRCm39) G69R possibly damaging Het
Sema5b T C 16: 35,470,125 (GRCm39) V329A probably damaging Het
Setd2 A G 9: 110,378,932 (GRCm39) S632G probably benign Het
Slc22a14 T C 9: 119,010,050 (GRCm39) N15S probably benign Het
Smurf2 G A 11: 106,715,573 (GRCm39) H632Y probably damaging Het
Syt10 C T 15: 89,674,979 (GRCm39) D456N probably damaging Het
Tex10 C T 4: 48,456,800 (GRCm39) R637Q probably benign Het
Tgm6 T C 2: 129,987,079 (GRCm39) C516R possibly damaging Het
Tmprss9 T C 10: 80,734,021 (GRCm39) probably benign Het
Trim67 A G 8: 125,521,160 (GRCm39) N174S probably damaging Het
Ttc8 C A 12: 98,910,142 (GRCm39) T123K probably benign Het
Ugt1a7c T A 1: 88,023,447 (GRCm39) M202K probably damaging Het
Vmn2r7 T A 3: 64,598,880 (GRCm39) H559L possibly damaging Het
Zfp511 A G 7: 139,617,192 (GRCm39) D96G probably benign Het
Zfp868 A G 8: 70,065,060 (GRCm39) Y92H probably benign Het
Zzz3 T A 3: 152,154,735 (GRCm39) D633E probably damaging Het
Other mutations in Ago3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00090:Ago3 APN 4 126,265,334 (GRCm39) missense probably damaging 1.00
IGL01826:Ago3 APN 4 126,297,075 (GRCm39) missense probably damaging 1.00
IGL02285:Ago3 APN 4 126,244,670 (GRCm39) missense possibly damaging 0.88
IGL02869:Ago3 APN 4 126,261,580 (GRCm39) splice site probably benign
IGL03068:Ago3 APN 4 126,311,171 (GRCm39) missense probably damaging 0.99
D4043:Ago3 UTSW 4 126,244,796 (GRCm39) missense probably damaging 1.00
R0506:Ago3 UTSW 4 126,311,045 (GRCm39) missense possibly damaging 0.79
R0545:Ago3 UTSW 4 126,311,025 (GRCm39) missense probably damaging 1.00
R0764:Ago3 UTSW 4 126,248,885 (GRCm39) missense possibly damaging 0.82
R1445:Ago3 UTSW 4 126,265,580 (GRCm39) missense probably benign
R1909:Ago3 UTSW 4 126,240,530 (GRCm39) missense probably damaging 1.00
R1944:Ago3 UTSW 4 126,247,520 (GRCm39) missense probably damaging 1.00
R1974:Ago3 UTSW 4 126,240,544 (GRCm39) missense probably damaging 1.00
R2239:Ago3 UTSW 4 126,262,315 (GRCm39) missense probably damaging 1.00
R2380:Ago3 UTSW 4 126,262,315 (GRCm39) missense probably damaging 1.00
R2424:Ago3 UTSW 4 126,298,040 (GRCm39) missense probably damaging 1.00
R2571:Ago3 UTSW 4 126,257,604 (GRCm39) missense probably damaging 1.00
R3121:Ago3 UTSW 4 126,311,165 (GRCm39) missense probably benign
R3122:Ago3 UTSW 4 126,311,165 (GRCm39) missense probably benign
R4022:Ago3 UTSW 4 126,262,386 (GRCm39) missense probably benign 0.31
R4079:Ago3 UTSW 4 126,247,473 (GRCm39) critical splice donor site probably null
R4272:Ago3 UTSW 4 126,248,884 (GRCm39) missense possibly damaging 0.95
R4533:Ago3 UTSW 4 126,239,356 (GRCm39) missense probably damaging 1.00
R4575:Ago3 UTSW 4 126,240,475 (GRCm39) missense probably benign 0.06
R4656:Ago3 UTSW 4 126,257,545 (GRCm39) nonsense probably null
R4782:Ago3 UTSW 4 126,241,665 (GRCm39) splice site probably null
R4783:Ago3 UTSW 4 126,262,296 (GRCm39) missense probably benign 0.31
R4784:Ago3 UTSW 4 126,262,296 (GRCm39) missense probably benign 0.31
R4785:Ago3 UTSW 4 126,262,296 (GRCm39) missense probably benign 0.31
R4799:Ago3 UTSW 4 126,241,665 (GRCm39) splice site probably null
R5013:Ago3 UTSW 4 126,262,391 (GRCm39) missense probably benign 0.18
R5180:Ago3 UTSW 4 126,261,544 (GRCm39) missense probably benign 0.01
R5692:Ago3 UTSW 4 126,248,862 (GRCm39) splice site probably null
R5801:Ago3 UTSW 4 126,265,561 (GRCm39) missense possibly damaging 0.53
R5955:Ago3 UTSW 4 126,248,843 (GRCm39) missense probably damaging 1.00
R6730:Ago3 UTSW 4 126,265,338 (GRCm39) missense probably null 0.04
R7077:Ago3 UTSW 4 126,265,325 (GRCm39) missense probably null 0.01
R7123:Ago3 UTSW 4 126,248,798 (GRCm39) critical splice donor site probably null
R7125:Ago3 UTSW 4 126,264,145 (GRCm39) missense probably null 0.89
R7354:Ago3 UTSW 4 126,311,099 (GRCm39) missense possibly damaging 0.72
R7472:Ago3 UTSW 4 126,239,310 (GRCm39) missense probably damaging 1.00
R7522:Ago3 UTSW 4 126,257,600 (GRCm39) missense probably benign 0.00
R7863:Ago3 UTSW 4 126,243,990 (GRCm39) missense possibly damaging 0.53
R8163:Ago3 UTSW 4 126,262,377 (GRCm39) missense probably benign 0.10
R8225:Ago3 UTSW 4 126,247,532 (GRCm39) missense probably damaging 1.00
R8266:Ago3 UTSW 4 126,270,721 (GRCm39) nonsense probably null
R8269:Ago3 UTSW 4 126,270,721 (GRCm39) nonsense probably null
R8343:Ago3 UTSW 4 126,270,721 (GRCm39) nonsense probably null
R8344:Ago3 UTSW 4 126,270,721 (GRCm39) nonsense probably null
R8345:Ago3 UTSW 4 126,270,721 (GRCm39) nonsense probably null
R8547:Ago3 UTSW 4 126,264,109 (GRCm39) missense probably null 0.82
R8948:Ago3 UTSW 4 126,244,115 (GRCm39) critical splice acceptor site probably null
R8962:Ago3 UTSW 4 126,241,595 (GRCm39) missense probably damaging 1.00
R8989:Ago3 UTSW 4 126,298,191 (GRCm39) missense probably damaging 1.00
R9110:Ago3 UTSW 4 126,248,829 (GRCm39) missense probably damaging 1.00
R9356:Ago3 UTSW 4 126,264,144 (GRCm39) missense probably damaging 1.00
T0722:Ago3 UTSW 4 126,298,098 (GRCm39) missense probably benign
T0722:Ago3 UTSW 4 126,298,089 (GRCm39) missense probably benign 0.21
T0722:Ago3 UTSW 4 126,298,056 (GRCm39) missense probably benign
T0722:Ago3 UTSW 4 126,298,103 (GRCm39) missense probably benign 0.00
T0975:Ago3 UTSW 4 126,298,103 (GRCm39) missense probably benign 0.00
T0975:Ago3 UTSW 4 126,298,098 (GRCm39) missense probably benign
T0975:Ago3 UTSW 4 126,298,056 (GRCm39) missense probably benign
Predicted Primers
Posted On 2014-05-14