Incidental Mutation 'R1707:Rasgrp1'
| ID |
190117 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rasgrp1
|
| Ensembl Gene |
ENSMUSG00000027347 |
| Gene Name |
RAS guanyl releasing protein 1 |
| Synonyms |
|
| MMRRC Submission |
039740-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.264)
|
| Stock # |
R1707 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
117110464-117173358 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 117129028 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 197
(V197E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000136423
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000102534]
[ENSMUST00000172901]
[ENSMUST00000173252]
[ENSMUST00000173541]
[ENSMUST00000174770]
[ENSMUST00000178884]
|
| AlphaFold |
Q9Z1S3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000102534
AA Change: V197E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000099593
Gene: ENSMUSG00000027347
AA Change: V197E
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_5
|
474 |
499 |
3.2e-6 |
PFAM |
|
Pfam:EF-hand_6
|
474 |
502 |
5e-6 |
PFAM |
|
C1
|
542 |
591 |
5.77e-16 |
SMART |
|
PDB:4L9U|B
|
740 |
791 |
2e-23 |
PDB |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000110898
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000172901
AA Change: V197E
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000133449
Gene: ENSMUSG00000027347
AA Change: V197E
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_6
|
442 |
467 |
1.2e-5 |
PFAM |
|
C1
|
507 |
556 |
5.77e-16 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000173252
AA Change: V197E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000134592
Gene: ENSMUSG00000027347
AA Change: V197E
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_6
|
442 |
467 |
1.1e-5 |
PFAM |
|
Pfam:C1_1
|
507 |
539 |
3.4e-8 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000173541
AA Change: V197E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000134027
Gene: ENSMUSG00000027347
AA Change: V197E
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_5
|
441 |
464 |
1.6e-5 |
PFAM |
|
Pfam:EF-hand_6
|
442 |
467 |
1.6e-5 |
PFAM |
|
C1
|
507 |
556 |
5.77e-16 |
SMART |
|
PDB:4L9U|B
|
705 |
756 |
2e-23 |
PDB |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000174770
AA Change: V197E
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000134167
Gene: ENSMUSG00000027347
AA Change: V197E
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000178884
AA Change: V197E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000136423
Gene: ENSMUSG00000027347
AA Change: V197E
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_5
|
474 |
499 |
3.2e-6 |
PFAM |
|
C1
|
542 |
591 |
5.77e-16 |
SMART |
|
PDB:4L9U|B
|
740 |
791 |
2e-23 |
PDB |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.4%
- 20x: 92.9%
|
| Validation Efficiency |
96% (82/85) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for spontaneous and targeted null mutations exhibit a lymphoproliferative autoimmune syndrome in which T cells fail to activate Ras or proliferate after antigen exposure, defects in positive selection, and enlarged spleen and lymph nodes. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930523C07Rik |
A |
T |
1: 159,898,372 (GRCm39) |
|
probably benign |
Het |
| 4931429P17Rik |
A |
G |
13: 48,114,481 (GRCm39) |
|
noncoding transcript |
Het |
| Acox3 |
T |
A |
5: 35,758,908 (GRCm39) |
I373N |
possibly damaging |
Het |
| Adgrb1 |
G |
T |
15: 74,401,192 (GRCm39) |
A63S |
probably damaging |
Het |
| Alkbh2 |
C |
T |
5: 114,262,287 (GRCm39) |
E148K |
probably damaging |
Het |
| Aplp2 |
A |
T |
9: 31,062,215 (GRCm39) |
H692Q |
probably damaging |
Het |
| Arhgap24 |
T |
C |
5: 103,039,953 (GRCm39) |
S297P |
probably benign |
Het |
| Arhgap9 |
C |
T |
10: 127,164,758 (GRCm39) |
P561S |
probably benign |
Het |
| Arhgef10l |
T |
G |
4: 140,291,600 (GRCm39) |
D62A |
probably damaging |
Het |
| Asb14 |
T |
G |
14: 26,623,079 (GRCm39) |
F150L |
probably benign |
Het |
| Atp8b3 |
A |
T |
10: 80,357,635 (GRCm39) |
|
probably null |
Het |
| Atrnl1 |
A |
G |
19: 57,675,169 (GRCm39) |
D686G |
probably benign |
Het |
| Bmpr1a |
A |
T |
14: 34,147,098 (GRCm39) |
|
probably benign |
Het |
| Cc2d2a |
T |
A |
5: 43,881,030 (GRCm39) |
|
probably null |
Het |
| Ccin |
T |
A |
4: 43,983,947 (GRCm39) |
I118N |
probably benign |
Het |
| Cd8b1 |
G |
A |
6: 71,303,168 (GRCm39) |
G81D |
probably damaging |
Het |
| Cep126 |
G |
A |
9: 8,100,383 (GRCm39) |
S717L |
probably benign |
Het |
| Cip2a |
A |
C |
16: 48,838,767 (GRCm39) |
Q861H |
probably damaging |
Het |
| Colgalt2 |
C |
T |
1: 152,276,114 (GRCm39) |
R76W |
probably damaging |
Het |
| Copg1 |
A |
T |
6: 87,882,192 (GRCm39) |
T596S |
probably benign |
Het |
| Cpb1 |
G |
A |
3: 20,329,655 (GRCm39) |
R24W |
probably damaging |
Het |
| Csad |
T |
A |
15: 102,088,407 (GRCm39) |
D134V |
probably damaging |
Het |
| Dchs2 |
A |
G |
3: 83,034,912 (GRCm39) |
|
probably benign |
Het |
| Ddb2 |
A |
G |
2: 91,064,554 (GRCm39) |
W119R |
probably damaging |
Het |
| Dhx57 |
A |
T |
17: 80,582,655 (GRCm39) |
S317T |
probably damaging |
Het |
| Dlc1 |
A |
G |
8: 37,404,763 (GRCm39) |
V342A |
probably benign |
Het |
| Dpp4 |
G |
A |
2: 62,189,679 (GRCm39) |
|
probably benign |
Het |
| Dst |
G |
T |
1: 34,206,727 (GRCm39) |
W1005L |
probably damaging |
Het |
| Ehmt1 |
T |
C |
2: 24,695,150 (GRCm39) |
M989V |
probably benign |
Het |
| Entr1 |
T |
A |
2: 26,277,618 (GRCm39) |
N69Y |
probably damaging |
Het |
| Gm5422 |
G |
A |
10: 31,124,458 (GRCm39) |
|
noncoding transcript |
Het |
| Gm9944 |
A |
G |
4: 144,179,833 (GRCm39) |
|
probably benign |
Het |
| Gtf2ird2 |
T |
C |
5: 134,245,829 (GRCm39) |
Y696H |
probably damaging |
Het |
| H2-M11 |
T |
G |
17: 36,859,658 (GRCm39) |
V217G |
probably damaging |
Het |
| Hunk |
C |
T |
16: 90,183,295 (GRCm39) |
|
probably benign |
Het |
| Impg1 |
T |
C |
9: 80,285,799 (GRCm39) |
|
probably null |
Het |
| Ints11 |
T |
G |
4: 155,959,655 (GRCm39) |
D87E |
probably benign |
Het |
| Intu |
T |
A |
3: 40,595,073 (GRCm39) |
S21T |
probably benign |
Het |
| Intu |
C |
A |
3: 40,637,931 (GRCm39) |
D472E |
possibly damaging |
Het |
| Kbtbd3 |
T |
A |
9: 4,316,985 (GRCm39) |
N45K |
probably benign |
Het |
| Kif1c |
C |
T |
11: 70,619,223 (GRCm39) |
L953F |
probably damaging |
Het |
| Klrg2 |
C |
G |
6: 38,613,729 (GRCm39) |
E91D |
possibly damaging |
Het |
| Lamc3 |
T |
C |
2: 31,802,141 (GRCm39) |
|
probably null |
Het |
| Magi2 |
T |
G |
5: 20,420,491 (GRCm39) |
M309R |
probably damaging |
Het |
| Magohb |
G |
A |
6: 131,261,600 (GRCm39) |
P147S |
probably damaging |
Het |
| Mdn1 |
A |
G |
4: 32,693,504 (GRCm39) |
D1043G |
probably damaging |
Het |
| Mtmr3 |
T |
C |
11: 4,454,095 (GRCm39) |
D203G |
probably damaging |
Het |
| Mvp |
C |
T |
7: 126,600,744 (GRCm39) |
V86I |
probably benign |
Het |
| Naip5 |
A |
T |
13: 100,379,363 (GRCm39) |
F226I |
probably damaging |
Het |
| Nasp |
T |
A |
4: 116,476,133 (GRCm39) |
Q51L |
probably damaging |
Het |
| Nf1 |
T |
A |
11: 79,426,430 (GRCm39) |
F1594I |
probably damaging |
Het |
| Nod2 |
A |
C |
8: 89,397,104 (GRCm39) |
E816A |
possibly damaging |
Het |
| Nom1 |
G |
A |
5: 29,640,316 (GRCm39) |
S214N |
probably damaging |
Het |
| Or2l13b |
T |
C |
16: 19,348,927 (GRCm39) |
T248A |
probably benign |
Het |
| Or8c9 |
T |
A |
9: 38,241,197 (GRCm39) |
F105I |
probably damaging |
Het |
| Parp14 |
A |
C |
16: 35,678,219 (GRCm39) |
L583R |
probably damaging |
Het |
| Pclo |
T |
C |
5: 14,763,238 (GRCm39) |
S3904P |
unknown |
Het |
| Pkhd1 |
T |
A |
1: 20,621,064 (GRCm39) |
|
probably benign |
Het |
| Plaat1 |
A |
G |
16: 29,046,978 (GRCm39) |
K166E |
probably damaging |
Het |
| Polr1e |
A |
C |
4: 45,027,469 (GRCm39) |
D233A |
probably damaging |
Het |
| Prr29 |
T |
C |
11: 106,267,509 (GRCm39) |
V124A |
probably damaging |
Het |
| Rgma |
A |
T |
7: 73,067,707 (GRCm39) |
T415S |
unknown |
Het |
| Sacs |
G |
T |
14: 61,447,211 (GRCm39) |
V3086L |
probably benign |
Het |
| Sash1 |
A |
G |
10: 8,606,141 (GRCm39) |
S750P |
probably benign |
Het |
| Scpppq1 |
T |
A |
5: 104,222,099 (GRCm39) |
|
probably benign |
Het |
| Sema6a |
A |
T |
18: 47,416,512 (GRCm39) |
S372T |
probably benign |
Het |
| Sis |
A |
G |
3: 72,816,420 (GRCm39) |
|
probably benign |
Het |
| Skint8 |
T |
A |
4: 111,796,769 (GRCm39) |
V291D |
probably damaging |
Het |
| Slc12a8 |
A |
G |
16: 33,371,377 (GRCm39) |
N171S |
probably damaging |
Het |
| Slc25a40 |
G |
A |
5: 8,490,793 (GRCm39) |
|
probably null |
Het |
| Spag6l |
A |
T |
16: 16,598,492 (GRCm39) |
I333N |
probably benign |
Het |
| Sspo |
T |
A |
6: 48,454,811 (GRCm39) |
F2999L |
probably damaging |
Het |
| Stambpl1 |
A |
C |
19: 34,216,221 (GRCm39) |
T363P |
probably damaging |
Het |
| Tenm4 |
A |
T |
7: 96,537,892 (GRCm39) |
N1785Y |
probably damaging |
Het |
| Tln2 |
C |
T |
9: 67,283,089 (GRCm39) |
S293N |
probably benign |
Het |
| Tmed3 |
G |
A |
9: 89,584,833 (GRCm39) |
L141F |
probably damaging |
Het |
| Tmem30c |
G |
T |
16: 57,086,843 (GRCm39) |
T320K |
possibly damaging |
Het |
| Tnn |
T |
C |
1: 159,972,714 (GRCm39) |
Y296C |
probably damaging |
Het |
| Ttn |
C |
T |
2: 76,620,430 (GRCm39) |
A15802T |
probably damaging |
Het |
| Usp53 |
T |
C |
3: 122,741,049 (GRCm39) |
M734V |
probably benign |
Het |
| Vmn1r24 |
A |
G |
6: 57,933,497 (GRCm39) |
I7T |
probably benign |
Het |
| Vmn1r74 |
T |
A |
7: 11,581,504 (GRCm39) |
V268E |
probably damaging |
Het |
| Xirp1 |
A |
T |
9: 119,847,841 (GRCm39) |
H347Q |
possibly damaging |
Het |
|
| Other mutations in Rasgrp1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00504:Rasgrp1
|
APN |
2 |
117,136,272 (GRCm39) |
nonsense |
probably null |
|
|
IGL00901:Rasgrp1
|
APN |
2 |
117,115,611 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01083:Rasgrp1
|
APN |
2 |
117,115,549 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01325:Rasgrp1
|
APN |
2 |
117,129,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01520:Rasgrp1
|
APN |
2 |
117,119,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01776:Rasgrp1
|
APN |
2 |
117,117,321 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01780:Rasgrp1
|
APN |
2 |
117,115,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01859:Rasgrp1
|
APN |
2 |
117,119,899 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01892:Rasgrp1
|
APN |
2 |
117,124,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02068:Rasgrp1
|
APN |
2 |
117,131,059 (GRCm39) |
splice site |
probably benign |
|
|
IGL02684:Rasgrp1
|
APN |
2 |
117,113,057 (GRCm39) |
missense |
probably benign |
0.03 |
|
bukhansan
|
UTSW |
2 |
117,122,178 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
Commendatore
|
UTSW |
2 |
117,113,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
dragged
|
UTSW |
2 |
117,129,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
grouper
|
UTSW |
2 |
117,132,485 (GRCm39) |
nonsense |
probably null |
|
|
Gyeryandsan
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Haddock
|
UTSW |
2 |
117,122,376 (GRCm39) |
missense |
probably damaging |
0.99 |
|
jovial
|
UTSW |
2 |
117,119,158 (GRCm39) |
missense |
probably benign |
0.01 |
|
mercurial
|
UTSW |
2 |
117,118,314 (GRCm39) |
nonsense |
probably null |
|
|
naejangsan
|
UTSW |
2 |
117,122,273 (GRCm39) |
nonsense |
probably null |
|
|
sea_bass
|
UTSW |
2 |
117,113,135 (GRCm39) |
missense |
probably benign |
0.02 |
|
venutian
|
UTSW |
2 |
117,115,410 (GRCm39) |
nonsense |
probably null |
|
|
R0067:Rasgrp1
|
UTSW |
2 |
117,125,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0067:Rasgrp1
|
UTSW |
2 |
117,125,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0538:Rasgrp1
|
UTSW |
2 |
117,115,428 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0786:Rasgrp1
|
UTSW |
2 |
117,130,980 (GRCm39) |
missense |
probably benign |
|
|
R1068:Rasgrp1
|
UTSW |
2 |
117,113,057 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1165:Rasgrp1
|
UTSW |
2 |
117,115,420 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1491:Rasgrp1
|
UTSW |
2 |
117,113,100 (GRCm39) |
nonsense |
probably null |
|
|
R1869:Rasgrp1
|
UTSW |
2 |
117,120,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2214:Rasgrp1
|
UTSW |
2 |
117,115,646 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2425:Rasgrp1
|
UTSW |
2 |
117,119,931 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3236:Rasgrp1
|
UTSW |
2 |
117,122,293 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3915:Rasgrp1
|
UTSW |
2 |
117,119,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4079:Rasgrp1
|
UTSW |
2 |
117,115,510 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4163:Rasgrp1
|
UTSW |
2 |
117,113,135 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4781:Rasgrp1
|
UTSW |
2 |
117,122,190 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4782:Rasgrp1
|
UTSW |
2 |
117,115,356 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5028:Rasgrp1
|
UTSW |
2 |
117,132,485 (GRCm39) |
nonsense |
probably null |
|
|
R6019:Rasgrp1
|
UTSW |
2 |
117,122,376 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6220:Rasgrp1
|
UTSW |
2 |
117,115,410 (GRCm39) |
nonsense |
probably null |
|
|
R6294:Rasgrp1
|
UTSW |
2 |
117,122,273 (GRCm39) |
nonsense |
probably null |
|
|
R6335:Rasgrp1
|
UTSW |
2 |
117,124,351 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6948:Rasgrp1
|
UTSW |
2 |
117,129,085 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7165:Rasgrp1
|
UTSW |
2 |
117,168,885 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7246:Rasgrp1
|
UTSW |
2 |
117,168,835 (GRCm39) |
nonsense |
probably null |
|
|
R7372:Rasgrp1
|
UTSW |
2 |
117,115,635 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7400:Rasgrp1
|
UTSW |
2 |
117,129,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7432:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7448:Rasgrp1
|
UTSW |
2 |
117,122,178 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7448:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7449:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7450:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7475:Rasgrp1
|
UTSW |
2 |
117,116,589 (GRCm39) |
missense |
probably benign |
|
|
R7487:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7573:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7672:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8016:Rasgrp1
|
UTSW |
2 |
117,118,314 (GRCm39) |
nonsense |
probably null |
|
|
R8199:Rasgrp1
|
UTSW |
2 |
117,124,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8527:Rasgrp1
|
UTSW |
2 |
117,168,785 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8692:Rasgrp1
|
UTSW |
2 |
117,115,353 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8725:Rasgrp1
|
UTSW |
2 |
117,119,158 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8727:Rasgrp1
|
UTSW |
2 |
117,119,158 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8880:Rasgrp1
|
UTSW |
2 |
117,115,425 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9280:Rasgrp1
|
UTSW |
2 |
117,113,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9675:Rasgrp1
|
UTSW |
2 |
117,173,190 (GRCm39) |
start codon destroyed |
probably benign |
0.00 |
|
R9792:Rasgrp1
|
UTSW |
2 |
117,118,429 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9793:Rasgrp1
|
UTSW |
2 |
117,118,429 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9795:Rasgrp1
|
UTSW |
2 |
117,118,429 (GRCm39) |
missense |
probably benign |
0.32 |
|
Z1176:Rasgrp1
|
UTSW |
2 |
117,132,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGAAACTGCCTGCTGACTTTCTCTG -3'
(R):5'- ACCACATGTTGCCTGCAATTTCTTG -3'
Sequencing Primer
(F):5'- GCTCATATTCCTAAGTTCCCTGG -3'
(R):5'- TGCCAAATGGAGCTTGCTAAC -3'
|
| Posted On |
2014-05-14 |
Incidental Mutation