Incidental Mutation 'R1709:Setd2'
| ID |
190337 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Setd2
|
| Ensembl Gene |
ENSMUSG00000044791 |
| Gene Name |
SET domain containing 2 |
| Synonyms |
KMT3A, 4921524K10Rik |
| MMRRC Submission |
039742-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.948)
|
| Stock # |
R1709 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
110361665-110447701 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 110378925 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 913
(D913E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000116313
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000153838]
|
| AlphaFold |
E9Q5F9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000153838
AA Change: D913E
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000116313
Gene: ENSMUSG00000044791
AA Change: D913E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
156 |
176 |
N/A |
INTRINSIC |
|
low complexity region
|
185 |
207 |
N/A |
INTRINSIC |
|
low complexity region
|
297 |
313 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
419 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
809 |
N/A |
INTRINSIC |
|
low complexity region
|
867 |
883 |
N/A |
INTRINSIC |
|
low complexity region
|
1015 |
1039 |
N/A |
INTRINSIC |
|
low complexity region
|
1066 |
1077 |
N/A |
INTRINSIC |
|
low complexity region
|
1384 |
1395 |
N/A |
INTRINSIC |
|
AWS
|
1468 |
1523 |
8.39e-30 |
SMART |
|
SET
|
1524 |
1647 |
3.07e-41 |
SMART |
|
PostSET
|
1648 |
1664 |
1.27e-5 |
SMART |
|
Blast:SET
|
1689 |
1714 |
2e-6 |
BLAST |
|
low complexity region
|
1884 |
1909 |
N/A |
INTRINSIC |
|
low complexity region
|
1956 |
1967 |
N/A |
INTRINSIC |
|
coiled coil region
|
2090 |
2113 |
N/A |
INTRINSIC |
|
low complexity region
|
2189 |
2211 |
N/A |
INTRINSIC |
|
low complexity region
|
2248 |
2265 |
N/A |
INTRINSIC |
|
WW
|
2363 |
2395 |
2.1e-11 |
SMART |
|
Pfam:SRI
|
2440 |
2530 |
6e-30 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000196814
AA Change: D629E
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000198823
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000199595
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.4%
- 20x: 92.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired embryonic vascular remodeling in the embryo proper, yolk sac, and placenta that leads to death around E10.5. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aacs |
A |
G |
5: 125,566,942 (GRCm39) |
K152E |
probably benign |
Het |
| Adgrd1 |
T |
C |
5: 129,256,292 (GRCm39) |
V641A |
possibly damaging |
Het |
| Adgrv1 |
A |
T |
13: 81,741,179 (GRCm39) |
V95E |
probably damaging |
Het |
| Agbl5 |
G |
A |
5: 31,063,585 (GRCm39) |
C872Y |
probably damaging |
Het |
| Aldh1a7 |
G |
T |
19: 20,693,316 (GRCm39) |
T201K |
probably damaging |
Het |
| Aox1 |
C |
T |
1: 58,116,633 (GRCm39) |
A788V |
probably benign |
Het |
| Apob |
T |
C |
12: 8,059,306 (GRCm39) |
V2563A |
probably damaging |
Het |
| Atcay |
G |
A |
10: 81,049,065 (GRCm39) |
T179I |
probably damaging |
Het |
| Atf5 |
A |
T |
7: 44,462,707 (GRCm39) |
L139Q |
probably benign |
Het |
| Atp13a3 |
T |
C |
16: 30,134,659 (GRCm39) |
T1205A |
probably benign |
Het |
| Atr |
C |
T |
9: 95,753,129 (GRCm39) |
T656I |
probably benign |
Het |
| Bloc1s3 |
T |
C |
7: 19,241,453 (GRCm39) |
E25G |
possibly damaging |
Het |
| Brap |
T |
C |
5: 121,803,353 (GRCm39) |
|
probably null |
Het |
| C6 |
G |
T |
15: 4,820,452 (GRCm39) |
A488S |
probably benign |
Het |
| Ccin |
T |
C |
4: 43,984,133 (GRCm39) |
F180S |
probably damaging |
Het |
| Cd207 |
T |
C |
6: 83,649,818 (GRCm39) |
I256V |
possibly damaging |
Het |
| Cdc42bpa |
G |
T |
1: 179,894,789 (GRCm39) |
C323F |
probably damaging |
Het |
| Cfap57 |
T |
C |
4: 118,428,901 (GRCm39) |
T1022A |
probably benign |
Het |
| Cmtr2 |
A |
T |
8: 110,948,581 (GRCm39) |
Q297L |
probably benign |
Het |
| Coro7 |
A |
T |
16: 4,452,305 (GRCm39) |
|
probably null |
Het |
| Cpsf2 |
T |
A |
12: 101,965,801 (GRCm39) |
Y589N |
probably damaging |
Het |
| Cpxm2 |
T |
C |
7: 131,661,563 (GRCm39) |
Y408C |
probably damaging |
Het |
| Crocc |
A |
G |
4: 140,753,410 (GRCm39) |
|
probably null |
Het |
| Cryzl1 |
A |
C |
16: 91,509,124 (GRCm39) |
F59C |
probably damaging |
Het |
| Csmd2 |
T |
C |
4: 128,389,988 (GRCm39) |
V2241A |
probably damaging |
Het |
| Cxcl15 |
C |
A |
5: 90,949,275 (GRCm39) |
H147N |
unknown |
Het |
| Dennd4a |
A |
G |
9: 64,796,887 (GRCm39) |
T860A |
possibly damaging |
Het |
| Dnah10 |
C |
T |
5: 124,837,155 (GRCm39) |
P966L |
probably damaging |
Het |
| Dpp9 |
T |
A |
17: 56,501,431 (GRCm39) |
M594L |
probably benign |
Het |
| Dspp |
C |
A |
5: 104,323,590 (GRCm39) |
N244K |
probably damaging |
Het |
| Efcab8 |
T |
A |
2: 153,656,290 (GRCm39) |
|
probably null |
Het |
| Elapor2 |
C |
T |
5: 9,490,726 (GRCm39) |
R579* |
probably null |
Het |
| Fabp3 |
C |
T |
4: 130,206,180 (GRCm39) |
T57I |
probably benign |
Het |
| Fbxw17 |
A |
G |
13: 50,585,693 (GRCm39) |
M299V |
probably benign |
Het |
| Fbxw7 |
T |
A |
3: 84,883,659 (GRCm39) |
I530N |
probably damaging |
Het |
| Gp2 |
C |
A |
7: 119,050,808 (GRCm39) |
D308Y |
probably null |
Het |
| Gpd2 |
G |
A |
2: 57,247,667 (GRCm39) |
V537M |
probably damaging |
Het |
| Gpr18 |
T |
A |
14: 122,149,404 (GRCm39) |
Y207F |
probably damaging |
Het |
| Grip1 |
A |
T |
10: 119,733,620 (GRCm39) |
D20V |
probably damaging |
Het |
| Gzmf |
A |
C |
14: 56,444,397 (GRCm39) |
F59V |
probably damaging |
Het |
| H3c1 |
T |
A |
13: 23,945,964 (GRCm39) |
I125F |
probably damaging |
Het |
| Igfn1 |
T |
C |
1: 135,883,311 (GRCm39) |
I2732V |
probably benign |
Het |
| Ipo8 |
A |
T |
6: 148,684,226 (GRCm39) |
D855E |
probably benign |
Het |
| Klrk1 |
A |
T |
6: 129,591,682 (GRCm39) |
|
probably null |
Het |
| Megf11 |
A |
G |
9: 64,602,694 (GRCm39) |
Y876C |
probably damaging |
Het |
| Mettl8 |
G |
T |
2: 70,812,495 (GRCm39) |
Q12K |
probably benign |
Het |
| Mrgprf |
T |
C |
7: 144,861,954 (GRCm39) |
F172S |
probably benign |
Het |
| Mycbp2 |
G |
A |
14: 103,461,852 (GRCm39) |
T1432I |
probably damaging |
Het |
| Nek11 |
A |
C |
9: 105,225,260 (GRCm39) |
L84R |
probably damaging |
Het |
| Nlrp1b |
T |
C |
11: 71,092,099 (GRCm39) |
E9G |
probably benign |
Het |
| Nrxn1 |
T |
C |
17: 90,344,615 (GRCm39) |
I433V |
probably damaging |
Het |
| Nup153 |
A |
G |
13: 46,847,450 (GRCm39) |
C660R |
probably damaging |
Het |
| Or1o11 |
T |
A |
17: 37,757,091 (GRCm39) |
Y226* |
probably null |
Het |
| Or2a25 |
T |
C |
6: 42,889,078 (GRCm39) |
V207A |
possibly damaging |
Het |
| Or4z4 |
G |
T |
19: 12,076,245 (GRCm39) |
P253T |
probably damaging |
Het |
| Or5h26 |
T |
A |
16: 58,988,264 (GRCm39) |
M81L |
probably benign |
Het |
| P2rx7 |
T |
A |
5: 122,808,528 (GRCm39) |
N303K |
possibly damaging |
Het |
| Pank4 |
T |
C |
4: 155,054,504 (GRCm39) |
L159P |
probably damaging |
Het |
| Pcdhb22 |
A |
T |
18: 37,651,553 (GRCm39) |
H7L |
probably benign |
Het |
| Pdzd8 |
A |
T |
19: 59,289,771 (GRCm39) |
I543N |
probably benign |
Het |
| Pramel25 |
T |
C |
4: 143,520,116 (GRCm39) |
V120A |
possibly damaging |
Het |
| Prrc2b |
C |
A |
2: 32,084,473 (GRCm39) |
R313S |
probably damaging |
Het |
| Rbm12b1 |
T |
C |
4: 12,145,827 (GRCm39) |
C600R |
probably benign |
Het |
| Rem1 |
G |
A |
2: 152,476,455 (GRCm39) |
V238M |
probably damaging |
Het |
| Rfx6 |
T |
A |
10: 51,554,498 (GRCm39) |
M113K |
possibly damaging |
Het |
| Rlf |
A |
T |
4: 121,007,020 (GRCm39) |
D653E |
probably benign |
Het |
| Rnf130 |
A |
G |
11: 49,978,213 (GRCm39) |
D258G |
possibly damaging |
Het |
| Robo2 |
A |
G |
16: 73,753,411 (GRCm39) |
V822A |
possibly damaging |
Het |
| Rps6kc1 |
G |
T |
1: 190,532,533 (GRCm39) |
Q490K |
possibly damaging |
Het |
| Scn9a |
T |
C |
2: 66,313,850 (GRCm39) |
Y1945C |
probably damaging |
Het |
| Sfr1 |
G |
T |
19: 47,723,442 (GRCm39) |
E315D |
possibly damaging |
Het |
| Smarca5 |
G |
A |
8: 81,435,849 (GRCm39) |
R763* |
probably null |
Het |
| Sugct |
A |
C |
13: 17,847,151 (GRCm39) |
I44S |
probably damaging |
Het |
| Syce1l |
A |
G |
8: 114,380,662 (GRCm39) |
|
probably null |
Het |
| Tbc1d8b |
A |
G |
X: 138,634,829 (GRCm39) |
I654V |
probably benign |
Het |
| Tcf23 |
T |
A |
5: 31,130,852 (GRCm39) |
Y163* |
probably null |
Het |
| Terf2ip |
TG |
T |
8: 112,738,238 (GRCm39) |
|
probably null |
Het |
| Tmem158 |
T |
C |
9: 123,088,950 (GRCm39) |
S221G |
possibly damaging |
Het |
| Tnrc6a |
A |
G |
7: 122,769,205 (GRCm39) |
T332A |
probably benign |
Het |
| Trappc4 |
T |
C |
9: 44,318,508 (GRCm39) |
T31A |
probably benign |
Het |
| Trim27 |
T |
C |
13: 21,372,235 (GRCm39) |
|
probably null |
Het |
| Ttyh2 |
T |
A |
11: 114,599,301 (GRCm39) |
L330Q |
probably damaging |
Het |
| Tubgcp3 |
A |
T |
8: 12,689,532 (GRCm39) |
L578* |
probably null |
Het |
| Txndc11 |
C |
A |
16: 10,946,565 (GRCm39) |
E83* |
probably null |
Het |
| Utp20 |
T |
C |
10: 88,585,159 (GRCm39) |
K2635R |
probably benign |
Het |
| V1ra8 |
C |
T |
6: 90,180,304 (GRCm39) |
T169I |
probably damaging |
Het |
| Vcl |
G |
A |
14: 21,069,441 (GRCm39) |
V706I |
probably benign |
Het |
| Vmn2r106 |
A |
T |
17: 20,499,373 (GRCm39) |
D179E |
probably benign |
Het |
| Vmn2r80 |
T |
C |
10: 79,030,223 (GRCm39) |
M683T |
probably benign |
Het |
| Xirp2 |
A |
G |
2: 67,340,215 (GRCm39) |
I819V |
probably benign |
Het |
| Zfp735 |
T |
C |
11: 73,602,589 (GRCm39) |
F511S |
probably benign |
Het |
| Zfp831 |
T |
C |
2: 174,487,683 (GRCm39) |
V786A |
probably benign |
Het |
| Zfp992 |
T |
A |
4: 146,550,949 (GRCm39) |
H223Q |
probably benign |
Het |
| Zfyve19 |
A |
C |
2: 119,041,300 (GRCm39) |
Q72P |
probably damaging |
Het |
|
| Other mutations in Setd2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00722:Setd2
|
APN |
9 |
110,380,204 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01023:Setd2
|
APN |
9 |
110,376,581 (GRCm39) |
nonsense |
probably null |
|
|
IGL01063:Setd2
|
APN |
9 |
110,402,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01745:Setd2
|
APN |
9 |
110,423,779 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01911:Setd2
|
APN |
9 |
110,446,499 (GRCm39) |
splice site |
probably null |
|
|
IGL01955:Setd2
|
APN |
9 |
110,378,386 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02023:Setd2
|
APN |
9 |
110,423,704 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02080:Setd2
|
APN |
9 |
110,376,518 (GRCm39) |
splice site |
probably null |
|
|
IGL02412:Setd2
|
APN |
9 |
110,379,842 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02519:Setd2
|
APN |
9 |
110,382,184 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02631:Setd2
|
APN |
9 |
110,379,644 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02754:Setd2
|
APN |
9 |
110,379,124 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02828:Setd2
|
APN |
9 |
110,390,282 (GRCm39) |
missense |
probably benign |
0.31 |
|
IGL03033:Setd2
|
APN |
9 |
110,380,343 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL03140:Setd2
|
APN |
9 |
110,444,020 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03378:Setd2
|
APN |
9 |
110,382,220 (GRCm39) |
missense |
unknown |
|
|
American_samoa
|
UTSW |
9 |
110,396,826 (GRCm39) |
nonsense |
probably null |
|
|
slingshot
|
UTSW |
9 |
110,378,575 (GRCm39) |
missense |
probably benign |
0.00 |
|
P0028:Setd2
|
UTSW |
9 |
110,403,022 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4544001:Setd2
|
UTSW |
9 |
110,380,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0058:Setd2
|
UTSW |
9 |
110,423,494 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0058:Setd2
|
UTSW |
9 |
110,423,494 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0167:Setd2
|
UTSW |
9 |
110,402,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0408:Setd2
|
UTSW |
9 |
110,423,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0452:Setd2
|
UTSW |
9 |
110,382,168 (GRCm39) |
splice site |
probably null |
|
|
R0541:Setd2
|
UTSW |
9 |
110,402,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0947:Setd2
|
UTSW |
9 |
110,377,579 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1249:Setd2
|
UTSW |
9 |
110,402,948 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1294:Setd2
|
UTSW |
9 |
110,378,575 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1518:Setd2
|
UTSW |
9 |
110,431,306 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1585:Setd2
|
UTSW |
9 |
110,380,464 (GRCm39) |
missense |
unknown |
|
|
R1647:Setd2
|
UTSW |
9 |
110,378,932 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1649:Setd2
|
UTSW |
9 |
110,378,932 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1651:Setd2
|
UTSW |
9 |
110,378,932 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1652:Setd2
|
UTSW |
9 |
110,378,932 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1673:Setd2
|
UTSW |
9 |
110,433,248 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1703:Setd2
|
UTSW |
9 |
110,378,932 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1706:Setd2
|
UTSW |
9 |
110,378,932 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1752:Setd2
|
UTSW |
9 |
110,423,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1796:Setd2
|
UTSW |
9 |
110,446,884 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1796:Setd2
|
UTSW |
9 |
110,379,413 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1812:Setd2
|
UTSW |
9 |
110,379,170 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1884:Setd2
|
UTSW |
9 |
110,385,486 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2024:Setd2
|
UTSW |
9 |
110,378,201 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2051:Setd2
|
UTSW |
9 |
110,379,958 (GRCm39) |
missense |
probably benign |
|
|
R2117:Setd2
|
UTSW |
9 |
110,433,212 (GRCm39) |
frame shift |
probably null |
|
|
R2120:Setd2
|
UTSW |
9 |
110,378,932 (GRCm39) |
missense |
probably benign |
0.12 |
|
R2124:Setd2
|
UTSW |
9 |
110,378,932 (GRCm39) |
missense |
probably benign |
0.12 |
|
R2172:Setd2
|
UTSW |
9 |
110,378,912 (GRCm39) |
missense |
probably benign |
0.10 |
|
R2179:Setd2
|
UTSW |
9 |
110,423,756 (GRCm39) |
nonsense |
probably null |
|
|
R2262:Setd2
|
UTSW |
9 |
110,390,311 (GRCm39) |
intron |
probably benign |
|
|
R2411:Setd2
|
UTSW |
9 |
110,379,497 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R2413:Setd2
|
UTSW |
9 |
110,376,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2419:Setd2
|
UTSW |
9 |
110,378,065 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R2424:Setd2
|
UTSW |
9 |
110,446,590 (GRCm39) |
missense |
probably benign |
0.37 |
|
R3757:Setd2
|
UTSW |
9 |
110,402,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3765:Setd2
|
UTSW |
9 |
110,423,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3796:Setd2
|
UTSW |
9 |
110,378,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3797:Setd2
|
UTSW |
9 |
110,378,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3799:Setd2
|
UTSW |
9 |
110,378,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3899:Setd2
|
UTSW |
9 |
110,421,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3900:Setd2
|
UTSW |
9 |
110,421,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3913:Setd2
|
UTSW |
9 |
110,380,114 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4010:Setd2
|
UTSW |
9 |
110,428,263 (GRCm39) |
missense |
probably null |
1.00 |
|
R4580:Setd2
|
UTSW |
9 |
110,403,311 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4614:Setd2
|
UTSW |
9 |
110,398,881 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4651:Setd2
|
UTSW |
9 |
110,423,200 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4652:Setd2
|
UTSW |
9 |
110,423,200 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4855:Setd2
|
UTSW |
9 |
110,401,022 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4970:Setd2
|
UTSW |
9 |
110,377,226 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5112:Setd2
|
UTSW |
9 |
110,377,226 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5123:Setd2
|
UTSW |
9 |
110,446,595 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5140:Setd2
|
UTSW |
9 |
110,380,197 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5202:Setd2
|
UTSW |
9 |
110,380,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5290:Setd2
|
UTSW |
9 |
110,446,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5560:Setd2
|
UTSW |
9 |
110,378,907 (GRCm39) |
nonsense |
probably null |
|
|
R5604:Setd2
|
UTSW |
9 |
110,433,284 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5678:Setd2
|
UTSW |
9 |
110,431,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5708:Setd2
|
UTSW |
9 |
110,377,891 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R5763:Setd2
|
UTSW |
9 |
110,385,343 (GRCm39) |
splice site |
probably null |
|
|
R5814:Setd2
|
UTSW |
9 |
110,396,826 (GRCm39) |
nonsense |
probably null |
|
|
R5924:Setd2
|
UTSW |
9 |
110,403,112 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6244:Setd2
|
UTSW |
9 |
110,377,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6313:Setd2
|
UTSW |
9 |
110,385,434 (GRCm39) |
missense |
unknown |
|
|
R6431:Setd2
|
UTSW |
9 |
110,379,453 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6526:Setd2
|
UTSW |
9 |
110,361,785 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6579:Setd2
|
UTSW |
9 |
110,378,846 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6996:Setd2
|
UTSW |
9 |
110,379,640 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7012:Setd2
|
UTSW |
9 |
110,376,751 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7105:Setd2
|
UTSW |
9 |
110,377,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7134:Setd2
|
UTSW |
9 |
110,377,865 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7222:Setd2
|
UTSW |
9 |
110,380,530 (GRCm39) |
missense |
|
|
|
R7359:Setd2
|
UTSW |
9 |
110,392,012 (GRCm39) |
missense |
|
|
|
R7492:Setd2
|
UTSW |
9 |
110,423,700 (GRCm39) |
missense |
|
|
|
R7643:Setd2
|
UTSW |
9 |
110,396,908 (GRCm39) |
splice site |
probably null |
|
|
R7869:Setd2
|
UTSW |
9 |
110,379,082 (GRCm39) |
nonsense |
probably null |
|
|
R7903:Setd2
|
UTSW |
9 |
110,446,905 (GRCm39) |
missense |
|
|
|
R8004:Setd2
|
UTSW |
9 |
110,421,613 (GRCm39) |
missense |
|
|
|
R8017:Setd2
|
UTSW |
9 |
110,431,255 (GRCm39) |
missense |
|
|
|
R8019:Setd2
|
UTSW |
9 |
110,431,255 (GRCm39) |
missense |
|
|
|
R8366:Setd2
|
UTSW |
9 |
110,377,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8460:Setd2
|
UTSW |
9 |
110,423,338 (GRCm39) |
missense |
|
|
|
R8498:Setd2
|
UTSW |
9 |
110,378,989 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8725:Setd2
|
UTSW |
9 |
110,402,912 (GRCm39) |
missense |
|
|
|
R8870:Setd2
|
UTSW |
9 |
110,423,321 (GRCm39) |
missense |
|
|
|
R8878:Setd2
|
UTSW |
9 |
110,421,467 (GRCm39) |
missense |
probably benign |
|
|
R9132:Setd2
|
UTSW |
9 |
110,374,385 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9159:Setd2
|
UTSW |
9 |
110,374,385 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9198:Setd2
|
UTSW |
9 |
110,378,168 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R9277:Setd2
|
UTSW |
9 |
110,379,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9326:Setd2
|
UTSW |
9 |
110,378,671 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9558:Setd2
|
UTSW |
9 |
110,376,628 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9664:Setd2
|
UTSW |
9 |
110,377,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9673:Setd2
|
UTSW |
9 |
110,378,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF009:Setd2
|
UTSW |
9 |
110,379,779 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Setd2
|
UTSW |
9 |
110,376,343 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Setd2
|
UTSW |
9 |
110,361,794 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Z1176:Setd2
|
UTSW |
9 |
110,376,647 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Z1177:Setd2
|
UTSW |
9 |
110,376,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTGATAATAGGGAGCCGACAGACC -3'
(R):5'- TCGCTTGAACTTGCAGAAGATCCAG -3'
Sequencing Primer
(F):5'- GCATTGGTAGCACTAGTTCAGC -3'
(R):5'- CATGGACAGTAGATACAATCTCTGG -3'
|
| Posted On |
2014-05-14 |
Incidental Mutation