Mutagenetix > Incidental Mutation

Incidental Mutation 'R1711:Arid3c'

190533

Institutional Source

Beutler Lab

Gene Symbol

Arid3c

Ensembl Gene

ENSMUSG00000066224

Gene Name

AT-rich interaction domain 3C

Synonyms

OTTMUSG00000006683

MMRRC Submission

039744-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.283) question?

Stock #

R1711 (G1)

Quality Score

193

Status

Not validated

Chromosome

Chromosomal Location

41723836-41731142 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 41725947 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Serine at position 219 (R219S)

Ref Sequence

ENSEMBL: ENSMUSP00000127678 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030158] [ENSMUST00000084698] [ENSMUST00000108041] [ENSMUST00000150809] [ENSMUST00000159930] [ENSMUST00000171251] [ENSMUST00000171641]

AlphaFold

A6PWV5

Predicted Effect

probably benign
Transcript: ENSMUST00000030158

SMART Domains

Protein: ENSMUSP00000030158
Gene: ENSMUSG00000028447

Domain	Start	End	E-Value	Type
Pfam:Dynactin_p22	6	170	2.8e-61	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000084698
AA Change: R219S

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000081748
Gene: ENSMUSG00000066224
AA Change: R219S

Domain	Start	End	E-Value	Type
low complexity region	3	14	N/A	INTRINSIC
low complexity region	18	32	N/A	INTRINSIC
low complexity region	41	71	N/A	INTRINSIC
ARID	107	198	5.47e-35	SMART
BRIGHT	111	203	3.7e-39	SMART
low complexity region	235	257	N/A	INTRINSIC
Blast:ARID	283	327	2e-12	BLAST
low complexity region	387	409	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108041

SMART Domains

Protein: ENSMUSP00000103676
Gene: ENSMUSG00000073889

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
IG	33	108	5.75e-4	SMART
FN3	112	204	2.18e-2	SMART
FN3	218	304	4.93e-1	SMART
low complexity region	354	365	N/A	INTRINSIC
transmembrane domain	369	391	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147120

Predicted Effect

possibly damaging
Transcript: ENSMUST00000150809
AA Change: R219S

PolyPhen 2 Score 0.858 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000116411
Gene: ENSMUSG00000066224
AA Change: R219S

Domain	Start	End	E-Value	Type
low complexity region	3	14	N/A	INTRINSIC
low complexity region	18	32	N/A	INTRINSIC
low complexity region	41	71	N/A	INTRINSIC
ARID	107	198	5.47e-35	SMART
BRIGHT	111	203	3.7e-39	SMART
low complexity region	235	257	N/A	INTRINSIC
Blast:ARID	283	327	2e-12	BLAST
low complexity region	357	379	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000159930

SMART Domains

Protein: ENSMUSP00000124563
Gene: ENSMUSG00000066224

Domain	Start	End	E-Value	Type
low complexity region	3	14	N/A	INTRINSIC
low complexity region	18	32	N/A	INTRINSIC
low complexity region	41	71	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000171251
AA Change: R219S

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000127678
Gene: ENSMUSG00000066224
AA Change: R219S

Domain	Start	End	E-Value	Type
low complexity region	3	14	N/A	INTRINSIC
low complexity region	18	32	N/A	INTRINSIC
low complexity region	41	71	N/A	INTRINSIC
ARID	107	198	5.47e-35	SMART
BRIGHT	111	203	3.7e-39	SMART
low complexity region	235	257	N/A	INTRINSIC
Blast:ARID	283	327	2e-12	BLAST
low complexity region	387	409	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000171641

SMART Domains

Protein: ENSMUSP00000130988
Gene: ENSMUSG00000028447

Domain	Start	End	E-Value	Type
Pfam:Dynactin_p22	1	149	1.4e-63	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.6%
20x: 93.6%

Validation Efficiency

MGI Phenotype

FUNCTION: This gene is a member of the ARID (AT-rich interaction domain) family of proteins. The ARID domain is a helix-turn-helix motif-based DNA-binding domain. ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 111 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210408I21Rik	C	T	13: 77,418,039 (GRCm39)	T741I	possibly damaging	Het
Aadacl4fm2	A	T	4: 144,281,976 (GRCm39)	I272K	probably damaging	Het
Acot3	A	T	12: 84,100,347 (GRCm39)	Q41L	probably damaging	Het
Actl7b	G	A	4: 56,740,165 (GRCm39)	Q398*	probably null	Het
Adgrb2	C	A	4: 129,886,417 (GRCm39)	Q186K	probably damaging	Het
Akr1a1	A	G	4: 116,495,171 (GRCm39)		probably null	Het
Ap3s2	A	T	7: 79,530,238 (GRCm39)	F192L	probably damaging	Het
Apobr	T	G	7: 126,184,151 (GRCm39)		probably null	Het
Arhgap5	A	G	12: 52,566,128 (GRCm39)	N1033S	probably damaging	Het
Bves	C	T	10: 45,223,961 (GRCm39)	T207M	probably damaging	Het
Cacna1d	T	C	14: 29,788,013 (GRCm39)	K1619R	probably damaging	Het
Caps2	A	T	10: 112,026,883 (GRCm39)	D223V	possibly damaging	Het
Cd3g	A	C	9: 44,885,640 (GRCm39)	L35R	probably damaging	Het
Cdh23	A	T	10: 60,359,315 (GRCm39)	V261E	probably benign	Het
Cfap54	T	G	10: 92,846,882 (GRCm39)	T1028P	probably damaging	Het
Ch25h	C	A	19: 34,451,686 (GRCm39)	V281L	probably benign	Het
Cip2a	A	C	16: 48,837,849 (GRCm39)	I850L	probably benign	Het
Clu	G	T	14: 66,218,354 (GRCm39)	V405L	possibly damaging	Het
Col6a3	A	T	1: 90,757,935 (GRCm39)	H6Q	probably damaging	Het
Cps1	G	A	1: 67,207,533 (GRCm39)		probably null	Het
Ctr9	T	C	7: 110,654,870 (GRCm39)	S1134P	unknown	Het
Cts7	C	T	13: 61,500,624 (GRCm39)	G308S	probably damaging	Het
Cyp2c39	C	A	19: 39,555,335 (GRCm39)	T385K	probably damaging	Het
Dennd5a	A	T	7: 109,517,919 (GRCm39)	D596E	probably benign	Het
Disc1	T	A	8: 125,851,349 (GRCm39)	I413K	probably benign	Het
Dll3	C	T	7: 27,993,922 (GRCm39)	G505D	probably damaging	Het
Dnah3	A	G	7: 119,677,794 (GRCm39)	W377R	probably damaging	Het
Dop1b	A	G	16: 93,596,814 (GRCm39)	D1792G	probably damaging	Het
Dpep3	T	A	8: 106,700,325 (GRCm39)	R460S	probably benign	Het
Ebf4	A	G	2: 130,200,751 (GRCm39)	N302S	probably damaging	Het
Efcab3	A	G	11: 104,611,514 (GRCm39)	K452R	probably benign	Het
Egflam	T	C	15: 7,319,396 (GRCm39)	E194G	possibly damaging	Het
Ep400	A	T	5: 110,841,174 (GRCm39)		probably benign	Het
Ercc6	T	C	14: 32,248,133 (GRCm39)	M228T	probably damaging	Het
Fbxo9	T	C	9: 77,994,529 (GRCm39)	T264A	probably damaging	Het
Fcrl5	C	A	3: 87,364,721 (GRCm39)	P486T	possibly damaging	Het
Fyb1	T	C	15: 6,609,960 (GRCm39)	F178L	probably damaging	Het
Gaa	T	A	11: 119,171,286 (GRCm39)	I646N	probably damaging	Het
Gm5431	A	T	11: 48,785,853 (GRCm39)	V174E	possibly damaging	Het
Gnpat	T	G	8: 125,613,691 (GRCm39)		probably null	Het
Gucy1a2	G	T	9: 3,759,622 (GRCm39)	R476I	probably benign	Het
Hars1	A	G	18: 36,904,156 (GRCm39)	L241P	probably damaging	Het
Haus5	G	A	7: 30,357,328 (GRCm39)	Q399*	probably null	Het
Hephl1	T	C	9: 14,970,542 (GRCm39)	E984G	probably damaging	Het
Hmces	C	T	6: 87,898,574 (GRCm39)	Q132*	probably null	Het
Hsp90b1	G	T	10: 86,530,389 (GRCm39)	T490K	probably damaging	Het
Idh2	T	G	7: 79,748,906 (GRCm39)	E125A	probably damaging	Het
Ipo13	G	T	4: 117,761,719 (GRCm39)	H465Q	probably benign	Het
Isca2	C	A	12: 84,820,393 (GRCm39)	T31K	probably damaging	Het
Itga9	T	C	9: 118,527,529 (GRCm39)	V560A	probably benign	Het
Jhy	G	A	9: 40,822,453 (GRCm39)	Q562*	probably null	Het
Kcnj5	A	G	9: 32,233,865 (GRCm39)	I150T	probably damaging	Het
Kmt2a	A	G	9: 44,752,918 (GRCm39)	I1419T	unknown	Het
Lix1	T	C	17: 17,666,320 (GRCm39)	F160L	possibly damaging	Het
Lonrf2	G	A	1: 38,852,357 (GRCm39)	P165S	probably benign	Het
Map4k1	A	T	7: 28,688,777 (GRCm39)	Q276L	possibly damaging	Het
Mmp9	G	A	2: 164,791,342 (GRCm39)	G171S	probably damaging	Het
Mvp	C	A	7: 126,594,907 (GRCm39)		probably null	Het
Mylk3	T	A	8: 86,091,460 (GRCm39)	E115V	probably damaging	Het
Nebl	T	A	2: 17,393,565 (GRCm39)	T603S	probably damaging	Het
Nudt15	T	C	14: 73,760,776 (GRCm39)	D105G	probably benign	Het
Or12j2	A	C	7: 139,915,912 (GRCm39)	T46P	possibly damaging	Het
Or2w1b	G	A	13: 21,300,476 (GRCm39)	V205I	probably benign	Het
Or51b6	T	A	7: 103,555,906 (GRCm39)	W87R	probably damaging	Het
Or52i2	G	T	7: 102,319,369 (GRCm39)	V81L	probably damaging	Het
Or52l1	A	T	7: 104,829,967 (GRCm39)	H199Q	probably damaging	Het
Or8g2b	A	G	9: 39,751,581 (GRCm39)	M284V	probably benign	Het
Osbpl9	A	T	4: 108,923,415 (GRCm39)	C495S	probably damaging	Het
Pamr1	A	G	2: 102,471,197 (GRCm39)	T507A	probably benign	Het
Pcdhb9	T	A	18: 37,536,380 (GRCm39)	C791*	probably null	Het
Pcgf6	T	C	19: 47,038,957 (GRCm39)	E101G	probably damaging	Het
Pdgfrl	A	T	8: 41,438,831 (GRCm39)	I256F	probably benign	Het
Pdzd7	T	C	19: 45,033,950 (GRCm39)	R45G	possibly damaging	Het
Pecr	C	T	1: 72,316,568 (GRCm39)	V46I	possibly damaging	Het
Pgr	A	G	9: 8,922,715 (GRCm39)		probably null	Het
Pik3c2a	A	T	7: 116,017,162 (GRCm39)	Y198*	probably null	Het
Pp2d1	T	A	17: 53,822,338 (GRCm39)	M243L	possibly damaging	Het
Ppp1r1a	T	A	15: 103,441,919 (GRCm39)	I50L	possibly damaging	Het
Proc	T	C	18: 32,260,459 (GRCm39)	D222G	probably benign	Het
Ptprq	T	A	10: 107,370,560 (GRCm39)	R2044*	probably null	Het
Ranbp2	T	C	10: 58,296,341 (GRCm39)	V326A	probably benign	Het
Reep6	T	A	10: 80,169,815 (GRCm39)	F122I	possibly damaging	Het
Rubcn	C	A	16: 32,663,471 (GRCm39)	R388S	probably damaging	Het
Rusc1	A	G	3: 88,996,600 (GRCm39)	L62P	probably damaging	Het
Satb2	T	C	1: 56,889,448 (GRCm39)	N423S	probably damaging	Het
Scart1	G	T	7: 139,800,522 (GRCm39)	C101F	probably damaging	Het
Serpinb9d	A	G	13: 33,384,731 (GRCm39)	K236R	probably benign	Het
Slc4a7	A	G	14: 14,765,709 (GRCm38)	R680G	probably benign	Het
Slitrk1	T	A	14: 109,150,528 (GRCm39)	Y61F	probably benign	Het
Son	A	G	16: 91,457,114 (GRCm39)		probably benign	Het
Sparc	T	A	11: 55,286,602 (GRCm39)		probably null	Het
Spon2	A	G	5: 33,373,729 (GRCm39)	F194S	probably damaging	Het
Spta1	A	G	1: 174,068,608 (GRCm39)	E2136G	probably damaging	Het
Stat4	T	C	1: 52,146,084 (GRCm39)	S746P	probably damaging	Het
Stk31	T	A	6: 49,446,238 (GRCm39)	S958R	probably benign	Het
Stom	T	A	2: 35,205,929 (GRCm39)	I267F	probably damaging	Het
Stx12	A	T	4: 132,585,788 (GRCm39)	D197E	probably damaging	Het
Taok3	A	T	5: 117,393,991 (GRCm39)	N588I	possibly damaging	Het
Tgs1	A	G	4: 3,598,658 (GRCm39)	D657G	probably damaging	Het
Trim6	A	G	7: 103,882,044 (GRCm39)	T432A	probably damaging	Het
Trim72	C	G	7: 127,603,757 (GRCm39)	C34W	probably damaging	Het
Trpc4ap	A	T	2: 155,499,664 (GRCm39)	I286N	probably benign	Het
Ttn	A	G	2: 76,693,905 (GRCm39)	V321A	possibly damaging	Het
Utp4	T	A	8: 107,645,352 (GRCm39)	I583N	probably damaging	Het
Wdfy2	G	T	14: 63,181,546 (GRCm39)	M225I	probably benign	Het
Wfdc1	A	G	8: 120,407,776 (GRCm39)	T134A	probably benign	Het
Wnt9b	A	G	11: 103,622,954 (GRCm39)	S150P	probably damaging	Het
Zbtb46	A	T	2: 181,053,477 (GRCm39)	F412I	probably damaging	Het
Zc3h15	G	A	2: 83,491,492 (GRCm39)	R240H	probably benign	Het
Zfp11	A	T	5: 129,733,737 (GRCm39)	Y575N	probably benign	Het
Zfp687	T	C	3: 94,919,200 (GRCm39)	M191V	probably benign	Het

Other mutations in Arid3c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02297:Arid3c	APN	4	41,730,021 (GRCm39)	missense	possibly damaging	0.72
R0445:Arid3c	UTSW	4	41,725,172 (GRCm39)	missense	probably benign	0.00
R0675:Arid3c	UTSW	4	41,725,958 (GRCm39)	missense	probably damaging	1.00
R1617:Arid3c	UTSW	4	41,725,103 (GRCm39)	missense	probably damaging	1.00
R1929:Arid3c	UTSW	4	41,724,744 (GRCm39)	missense	probably damaging	1.00
R2270:Arid3c	UTSW	4	41,724,744 (GRCm39)	missense	probably damaging	1.00
R2271:Arid3c	UTSW	4	41,724,744 (GRCm39)	missense	probably damaging	1.00
R2272:Arid3c	UTSW	4	41,724,744 (GRCm39)	missense	probably damaging	1.00
R2867:Arid3c	UTSW	4	41,725,958 (GRCm39)	missense	probably damaging	1.00
R2867:Arid3c	UTSW	4	41,725,958 (GRCm39)	missense	probably damaging	1.00
R4818:Arid3c	UTSW	4	41,730,072 (GRCm39)	missense	possibly damaging	0.72
R5622:Arid3c	UTSW	4	41,729,959 (GRCm39)	missense	probably benign	0.02
R6289:Arid3c	UTSW	4	41,724,285 (GRCm39)	unclassified	probably benign
R6995:Arid3c	UTSW	4	41,725,087 (GRCm39)	missense	probably damaging	1.00
R7339:Arid3c	UTSW	4	41,729,883 (GRCm39)	critical splice donor site	probably null
R8244:Arid3c	UTSW	4	41,729,997 (GRCm39)	missense	possibly damaging	0.61
R9009:Arid3c	UTSW	4	41,729,925 (GRCm39)	missense	probably benign	0.00
R9324:Arid3c	UTSW	4	41,730,138 (GRCm39)	missense	possibly damaging	0.86
R9573:Arid3c	UTSW	4	41,726,003 (GRCm39)	missense	probably benign	0.42
R9772:Arid3c	UTSW	4	41,724,723 (GRCm39)	missense	probably damaging	1.00
Z1177:Arid3c	UTSW	4	41,730,177 (GRCm39)	missense	possibly damaging	0.91

Predicted Primers

PCR Primer
(F):5'- CTGGTAAACCAGAAGCAGAACCCTG -3'
(R):5'- TCATCAACCGAAAAGTGTGGCGAG -3'

Sequencing Primer
(F):5'- AGAACCCTGGGTGGGAC -3'
(R):5'- CTCCGTACACAGTGAGGACAG -3'

Posted On

2014-05-14