Incidental Mutation 'R1711:Apobr'
ID 190563
Institutional Source Beutler Lab
Gene Symbol Apobr
Ensembl Gene ENSMUSG00000042759
Gene Name apolipoprotein B receptor
Synonyms Apob48r, Apob-48r
MMRRC Submission 039744-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R1711 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 126184114-126188284 bp(+) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) T to G at 126184151 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000042028 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032962] [ENSMUST00000039522] [ENSMUST00000058429] [ENSMUST00000084589] [ENSMUST00000098036] [ENSMUST00000116269] [ENSMUST00000144173] [ENSMUST00000138558] [ENSMUST00000137646] [ENSMUST00000131860] [ENSMUST00000125508] [ENSMUST00000128970] [ENSMUST00000147086] [ENSMUST00000150917] [ENSMUST00000150587] [ENSMUST00000150311]
AlphaFold Q8VBT6
Predicted Effect probably benign
Transcript: ENSMUST00000032962
SMART Domains Protein: ENSMUSP00000032962
Gene: ENSMUSG00000030720

DomainStartEndE-ValueType
Pfam:CLN3 37 438 3.5e-215 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000039522
SMART Domains Protein: ENSMUSP00000042028
Gene: ENSMUSG00000042759

DomainStartEndE-ValueType
low complexity region 45 59 N/A INTRINSIC
low complexity region 171 181 N/A INTRINSIC
low complexity region 351 363 N/A INTRINSIC
low complexity region 381 396 N/A INTRINSIC
low complexity region 465 476 N/A INTRINSIC
low complexity region 588 608 N/A INTRINSIC
low complexity region 837 862 N/A INTRINSIC
low complexity region 869 881 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000058429
SMART Domains Protein: ENSMUSP00000054637
Gene: ENSMUSG00000044701

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
low complexity region 137 148 N/A INTRINSIC
low complexity region 160 177 N/A INTRINSIC
low complexity region 210 228 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000084589
SMART Domains Protein: ENSMUSP00000081636
Gene: ENSMUSG00000030720

DomainStartEndE-ValueType
Pfam:CLN3 37 438 3.5e-215 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000098036
SMART Domains Protein: ENSMUSP00000095644
Gene: ENSMUSG00000030720

DomainStartEndE-ValueType
Pfam:CLN3 37 414 4.3e-191 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000116269
SMART Domains Protein: ENSMUSP00000111973
Gene: ENSMUSG00000030720

DomainStartEndE-ValueType
Pfam:CLN3 39 437 1.6e-140 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000144173
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134406
Predicted Effect probably benign
Transcript: ENSMUST00000138558
Predicted Effect probably benign
Transcript: ENSMUST00000137646
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134498
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128049
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128225
Predicted Effect probably benign
Transcript: ENSMUST00000131860
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134246
Predicted Effect probably benign
Transcript: ENSMUST00000125508
SMART Domains Protein: ENSMUSP00000117561
Gene: ENSMUSG00000030720

DomainStartEndE-ValueType
Pfam:CLN3 37 76 1.2e-17 PFAM
Pfam:CLN3 73 151 2.8e-38 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000128970
SMART Domains Protein: ENSMUSP00000114901
Gene: ENSMUSG00000030720

DomainStartEndE-ValueType
Pfam:CLN3 37 196 1.2e-87 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000147086
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153790
Predicted Effect probably benign
Transcript: ENSMUST00000150917
SMART Domains Protein: ENSMUSP00000138688
Gene: ENSMUSG00000030720

DomainStartEndE-ValueType
Pfam:CLN3 37 77 1.6e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000150587
SMART Domains Protein: ENSMUSP00000118054
Gene: ENSMUSG00000030720

DomainStartEndE-ValueType
Pfam:CLN3 37 70 4.1e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000150311
SMART Domains Protein: ENSMUSP00000116160
Gene: ENSMUSG00000030720

DomainStartEndE-ValueType
Pfam:CLN3 37 69 1.5e-14 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.6%
  • 20x: 93.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 111 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik C T 13: 77,418,039 (GRCm39) T741I possibly damaging Het
Aadacl4fm2 A T 4: 144,281,976 (GRCm39) I272K probably damaging Het
Acot3 A T 12: 84,100,347 (GRCm39) Q41L probably damaging Het
Actl7b G A 4: 56,740,165 (GRCm39) Q398* probably null Het
Adgrb2 C A 4: 129,886,417 (GRCm39) Q186K probably damaging Het
Akr1a1 A G 4: 116,495,171 (GRCm39) probably null Het
Ap3s2 A T 7: 79,530,238 (GRCm39) F192L probably damaging Het
Arhgap5 A G 12: 52,566,128 (GRCm39) N1033S probably damaging Het
Arid3c G T 4: 41,725,947 (GRCm39) R219S probably damaging Het
Bves C T 10: 45,223,961 (GRCm39) T207M probably damaging Het
Cacna1d T C 14: 29,788,013 (GRCm39) K1619R probably damaging Het
Caps2 A T 10: 112,026,883 (GRCm39) D223V possibly damaging Het
Cd3g A C 9: 44,885,640 (GRCm39) L35R probably damaging Het
Cdh23 A T 10: 60,359,315 (GRCm39) V261E probably benign Het
Cfap54 T G 10: 92,846,882 (GRCm39) T1028P probably damaging Het
Ch25h C A 19: 34,451,686 (GRCm39) V281L probably benign Het
Cip2a A C 16: 48,837,849 (GRCm39) I850L probably benign Het
Clu G T 14: 66,218,354 (GRCm39) V405L possibly damaging Het
Col6a3 A T 1: 90,757,935 (GRCm39) H6Q probably damaging Het
Cps1 G A 1: 67,207,533 (GRCm39) probably null Het
Ctr9 T C 7: 110,654,870 (GRCm39) S1134P unknown Het
Cts7 C T 13: 61,500,624 (GRCm39) G308S probably damaging Het
Cyp2c39 C A 19: 39,555,335 (GRCm39) T385K probably damaging Het
Dennd5a A T 7: 109,517,919 (GRCm39) D596E probably benign Het
Disc1 T A 8: 125,851,349 (GRCm39) I413K probably benign Het
Dll3 C T 7: 27,993,922 (GRCm39) G505D probably damaging Het
Dnah3 A G 7: 119,677,794 (GRCm39) W377R probably damaging Het
Dop1b A G 16: 93,596,814 (GRCm39) D1792G probably damaging Het
Dpep3 T A 8: 106,700,325 (GRCm39) R460S probably benign Het
Ebf4 A G 2: 130,200,751 (GRCm39) N302S probably damaging Het
Efcab3 A G 11: 104,611,514 (GRCm39) K452R probably benign Het
Egflam T C 15: 7,319,396 (GRCm39) E194G possibly damaging Het
Ep400 A T 5: 110,841,174 (GRCm39) probably benign Het
Ercc6 T C 14: 32,248,133 (GRCm39) M228T probably damaging Het
Fbxo9 T C 9: 77,994,529 (GRCm39) T264A probably damaging Het
Fcrl5 C A 3: 87,364,721 (GRCm39) P486T possibly damaging Het
Fyb1 T C 15: 6,609,960 (GRCm39) F178L probably damaging Het
Gaa T A 11: 119,171,286 (GRCm39) I646N probably damaging Het
Gm5431 A T 11: 48,785,853 (GRCm39) V174E possibly damaging Het
Gnpat T G 8: 125,613,691 (GRCm39) probably null Het
Gucy1a2 G T 9: 3,759,622 (GRCm39) R476I probably benign Het
Hars1 A G 18: 36,904,156 (GRCm39) L241P probably damaging Het
Haus5 G A 7: 30,357,328 (GRCm39) Q399* probably null Het
Hephl1 T C 9: 14,970,542 (GRCm39) E984G probably damaging Het
Hmces C T 6: 87,898,574 (GRCm39) Q132* probably null Het
Hsp90b1 G T 10: 86,530,389 (GRCm39) T490K probably damaging Het
Idh2 T G 7: 79,748,906 (GRCm39) E125A probably damaging Het
Ipo13 G T 4: 117,761,719 (GRCm39) H465Q probably benign Het
Isca2 C A 12: 84,820,393 (GRCm39) T31K probably damaging Het
Itga9 T C 9: 118,527,529 (GRCm39) V560A probably benign Het
Jhy G A 9: 40,822,453 (GRCm39) Q562* probably null Het
Kcnj5 A G 9: 32,233,865 (GRCm39) I150T probably damaging Het
Kmt2a A G 9: 44,752,918 (GRCm39) I1419T unknown Het
Lix1 T C 17: 17,666,320 (GRCm39) F160L possibly damaging Het
Lonrf2 G A 1: 38,852,357 (GRCm39) P165S probably benign Het
Map4k1 A T 7: 28,688,777 (GRCm39) Q276L possibly damaging Het
Mmp9 G A 2: 164,791,342 (GRCm39) G171S probably damaging Het
Mvp C A 7: 126,594,907 (GRCm39) probably null Het
Mylk3 T A 8: 86,091,460 (GRCm39) E115V probably damaging Het
Nebl T A 2: 17,393,565 (GRCm39) T603S probably damaging Het
Nudt15 T C 14: 73,760,776 (GRCm39) D105G probably benign Het
Or12j2 A C 7: 139,915,912 (GRCm39) T46P possibly damaging Het
Or2w1b G A 13: 21,300,476 (GRCm39) V205I probably benign Het
Or51b6 T A 7: 103,555,906 (GRCm39) W87R probably damaging Het
Or52i2 G T 7: 102,319,369 (GRCm39) V81L probably damaging Het
Or52l1 A T 7: 104,829,967 (GRCm39) H199Q probably damaging Het
Or8g2b A G 9: 39,751,581 (GRCm39) M284V probably benign Het
Osbpl9 A T 4: 108,923,415 (GRCm39) C495S probably damaging Het
Pamr1 A G 2: 102,471,197 (GRCm39) T507A probably benign Het
Pcdhb9 T A 18: 37,536,380 (GRCm39) C791* probably null Het
Pcgf6 T C 19: 47,038,957 (GRCm39) E101G probably damaging Het
Pdgfrl A T 8: 41,438,831 (GRCm39) I256F probably benign Het
Pdzd7 T C 19: 45,033,950 (GRCm39) R45G possibly damaging Het
Pecr C T 1: 72,316,568 (GRCm39) V46I possibly damaging Het
Pgr A G 9: 8,922,715 (GRCm39) probably null Het
Pik3c2a A T 7: 116,017,162 (GRCm39) Y198* probably null Het
Pp2d1 T A 17: 53,822,338 (GRCm39) M243L possibly damaging Het
Ppp1r1a T A 15: 103,441,919 (GRCm39) I50L possibly damaging Het
Proc T C 18: 32,260,459 (GRCm39) D222G probably benign Het
Ptprq T A 10: 107,370,560 (GRCm39) R2044* probably null Het
Ranbp2 T C 10: 58,296,341 (GRCm39) V326A probably benign Het
Reep6 T A 10: 80,169,815 (GRCm39) F122I possibly damaging Het
Rubcn C A 16: 32,663,471 (GRCm39) R388S probably damaging Het
Rusc1 A G 3: 88,996,600 (GRCm39) L62P probably damaging Het
Satb2 T C 1: 56,889,448 (GRCm39) N423S probably damaging Het
Scart1 G T 7: 139,800,522 (GRCm39) C101F probably damaging Het
Serpinb9d A G 13: 33,384,731 (GRCm39) K236R probably benign Het
Slc4a7 A G 14: 14,765,709 (GRCm38) R680G probably benign Het
Slitrk1 T A 14: 109,150,528 (GRCm39) Y61F probably benign Het
Son A G 16: 91,457,114 (GRCm39) probably benign Het
Sparc T A 11: 55,286,602 (GRCm39) probably null Het
Spon2 A G 5: 33,373,729 (GRCm39) F194S probably damaging Het
Spta1 A G 1: 174,068,608 (GRCm39) E2136G probably damaging Het
Stat4 T C 1: 52,146,084 (GRCm39) S746P probably damaging Het
Stk31 T A 6: 49,446,238 (GRCm39) S958R probably benign Het
Stom T A 2: 35,205,929 (GRCm39) I267F probably damaging Het
Stx12 A T 4: 132,585,788 (GRCm39) D197E probably damaging Het
Taok3 A T 5: 117,393,991 (GRCm39) N588I possibly damaging Het
Tgs1 A G 4: 3,598,658 (GRCm39) D657G probably damaging Het
Trim6 A G 7: 103,882,044 (GRCm39) T432A probably damaging Het
Trim72 C G 7: 127,603,757 (GRCm39) C34W probably damaging Het
Trpc4ap A T 2: 155,499,664 (GRCm39) I286N probably benign Het
Ttn A G 2: 76,693,905 (GRCm39) V321A possibly damaging Het
Utp4 T A 8: 107,645,352 (GRCm39) I583N probably damaging Het
Wdfy2 G T 14: 63,181,546 (GRCm39) M225I probably benign Het
Wfdc1 A G 8: 120,407,776 (GRCm39) T134A probably benign Het
Wnt9b A G 11: 103,622,954 (GRCm39) S150P probably damaging Het
Zbtb46 A T 2: 181,053,477 (GRCm39) F412I probably damaging Het
Zc3h15 G A 2: 83,491,492 (GRCm39) R240H probably benign Het
Zfp11 A T 5: 129,733,737 (GRCm39) Y575N probably benign Het
Zfp687 T C 3: 94,919,200 (GRCm39) M191V probably benign Het
Other mutations in Apobr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01812:Apobr APN 7 126,187,094 (GRCm39) missense probably damaging 1.00
IGL02373:Apobr APN 7 126,184,563 (GRCm39) missense probably damaging 1.00
IGL02383:Apobr APN 7 126,185,779 (GRCm39) missense probably benign 0.35
R0626:Apobr UTSW 7 126,185,827 (GRCm39) missense possibly damaging 0.73
R1142:Apobr UTSW 7 126,186,654 (GRCm39) missense probably benign 0.01
R1672:Apobr UTSW 7 126,186,723 (GRCm39) missense probably benign 0.31
R1865:Apobr UTSW 7 126,185,140 (GRCm39) missense probably benign 0.00
R1971:Apobr UTSW 7 126,185,397 (GRCm39) missense probably benign 0.00
R1985:Apobr UTSW 7 126,186,903 (GRCm39) missense possibly damaging 0.66
R2130:Apobr UTSW 7 126,186,378 (GRCm39) missense probably benign 0.15
R2143:Apobr UTSW 7 126,186,288 (GRCm39) missense probably benign 0.01
R4497:Apobr UTSW 7 126,186,694 (GRCm39) splice site probably null
R4693:Apobr UTSW 7 126,186,019 (GRCm39) missense probably damaging 0.96
R4797:Apobr UTSW 7 126,186,756 (GRCm39) missense probably benign 0.30
R4814:Apobr UTSW 7 126,185,859 (GRCm39) missense probably benign 0.03
R5000:Apobr UTSW 7 126,185,729 (GRCm39) missense possibly damaging 0.53
R5153:Apobr UTSW 7 126,186,904 (GRCm39) missense possibly damaging 0.92
R5176:Apobr UTSW 7 126,184,188 (GRCm39) missense probably damaging 1.00
R5285:Apobr UTSW 7 126,184,175 (GRCm39) unclassified probably benign
R5296:Apobr UTSW 7 126,187,196 (GRCm39) missense probably damaging 0.96
R5579:Apobr UTSW 7 126,186,847 (GRCm39) missense probably benign 0.00
R9025:Apobr UTSW 7 126,185,629 (GRCm39) missense possibly damaging 0.94
R9063:Apobr UTSW 7 126,185,920 (GRCm39) missense probably benign 0.00
R9245:Apobr UTSW 7 126,186,507 (GRCm39) nonsense probably null
R9405:Apobr UTSW 7 126,184,704 (GRCm39) missense possibly damaging 0.95
R9444:Apobr UTSW 7 126,185,140 (GRCm39) missense probably benign 0.00
R9688:Apobr UTSW 7 126,186,663 (GRCm39) missense probably benign 0.08
Z1088:Apobr UTSW 7 126,184,203 (GRCm39) missense probably benign 0.00
Z1176:Apobr UTSW 7 126,186,436 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AAATGGGAACCCAGAACTTCCAGTG -3'
(R):5'- TCAGGCTTCAGGAGAGGCTGTAAG -3'

Sequencing Primer
(F):5'- AGAACTTCCAGTGGCCTTATC -3'
(R):5'- TAAGGGAGAGGAAAGGTGAGACTAC -3'
Posted On 2014-05-14