Mutagenetix > Incidental Mutation

Incidental Mutation 'R0016:Trgv5'

19082

Institutional Source

Beutler Lab

Gene Symbol

Trgv5

Ensembl Gene

ENSMUSG00000076747

Gene Name

T cell receptor gamma, variable 5

Synonyms

Tcrg-V5

MMRRC Submission

038311-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.099) question?

Stock #

R0016 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

19376448-19376895 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 19376889 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Stop codon at position 112 (W112*)

Ref Sequence

ENSEMBL: ENSMUSP00000143714 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103555] [ENSMUST00000103556] [ENSMUST00000198330] [ENSMUST00000199017]

AlphaFold

A0A075B5Y9

Predicted Effect

probably benign
Transcript: ENSMUST00000103555

SMART Domains

Protein: ENSMUSP00000100336
Gene: ENSMUSG00000076746

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
IG	40	134	2.94e-1	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000103556
AA Change: W96*

SMART Domains

Protein: ENSMUSP00000100337
Gene: ENSMUSG00000076747
AA Change: W96*

Domain	Start	End	E-Value	Type
IGv	18	95	3.3e-13	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000197661

Predicted Effect

probably benign
Transcript: ENSMUST00000198330

SMART Domains

Protein: ENSMUSP00000142811
Gene: ENSMUSG00000076746

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
IG	27	121	1.2e-3	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000199017
AA Change: W112*

SMART Domains

Protein: ENSMUSP00000143714
Gene: ENSMUSG00000076747
AA Change: W112*

Domain	Start	End	E-Value	Type
signal peptide	1	16	N/A	INTRINSIC
IGv	34	111	1.4e-15	SMART

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 81.7%
3x: 74.6%
10x: 53.6%
20x: 32.4%

Validation Efficiency

93% (85/91)

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	A	C	1: 71,333,959 (GRCm39)	V1181G	probably benign	Het
Adamts12	A	T	15: 11,217,915 (GRCm39)	I291F	probably damaging	Het
Aspm	G	C	1: 139,407,282 (GRCm39)	Q2056H	probably benign	Het
C7	A	T	15: 5,076,406 (GRCm39)	V122E	probably benign	Het
Casp12	A	T	9: 5,352,844 (GRCm39)	Q152L	probably null	Het
Cpne8	A	G	15: 90,385,608 (GRCm39)		probably benign	Het
Cspg4b	T	C	13: 113,502,639 (GRCm39)	Y115H	probably damaging	Het
Cyp2j7	T	A	4: 96,090,384 (GRCm39)	I347F	probably damaging	Het
Dync2h1	A	G	9: 7,144,346 (GRCm39)		probably benign	Het
Echdc1	A	T	10: 29,198,417 (GRCm39)		probably benign	Het
Elovl3	T	A	19: 46,120,597 (GRCm39)	F30Y	probably damaging	Het
Fgd3	C	T	13: 49,450,085 (GRCm39)	D55N	probably benign	Het
Fhod1	T	C	8: 106,058,287 (GRCm39)	E823G	possibly damaging	Het
Gapvd1	A	G	2: 34,589,925 (GRCm39)		probably benign	Het
Helz2	C	A	2: 180,874,552 (GRCm39)	G1981C	probably damaging	Het
Kif27	A	G	13: 58,502,528 (GRCm39)	V50A	probably damaging	Het
Lrp2bp	T	A	8: 46,465,068 (GRCm39)	F62L	probably damaging	Het
Marf1	G	A	16: 13,970,129 (GRCm39)	H197Y	probably damaging	Het
Mon2	C	T	10: 122,871,451 (GRCm39)	V389M	probably damaging	Het
Myh8	A	G	11: 67,189,351 (GRCm39)	K1176E	probably damaging	Het
Nckap1l	A	G	15: 103,384,063 (GRCm39)	T554A	probably benign	Het
Oog3	A	G	4: 143,884,641 (GRCm39)	Y432H	probably damaging	Het
Sorbs1	A	G	19: 40,303,182 (GRCm39)		probably benign	Het
Srgap2	A	G	1: 131,277,200 (GRCm39)	M349T	possibly damaging	Het
Stc2	A	T	11: 31,310,177 (GRCm39)	D286E	probably benign	Het
Stk31	T	C	6: 49,414,311 (GRCm39)	Y482H	probably damaging	Het
Sycp2l	A	G	13: 41,310,976 (GRCm39)		probably benign	Het
Tasor2	A	C	13: 3,635,170 (GRCm39)		probably null	Het
Trim27	A	T	13: 21,375,399 (GRCm39)	E310V	probably benign	Het
Uvrag	T	C	7: 98,641,188 (GRCm39)	K284R	probably benign	Het
Xylt2	A	G	11: 94,560,466 (GRCm39)	S270P	probably damaging	Het
Zwint	T	C	10: 72,493,030 (GRCm39)		probably benign	Het

Other mutations in Trgv5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R3794:Trgv5	UTSW	13	19,376,694 (GRCm39)	missense	probably benign	0.31
R4788:Trgv5	UTSW	13	19,376,724 (GRCm39)	missense	probably benign	0.35
R5099:Trgv5	UTSW	13	19,376,886 (GRCm39)	missense	probably damaging	0.99
R5397:Trgv5	UTSW	13	19,376,728 (GRCm39)	missense	possibly damaging	0.85
R5735:Trgv5	UTSW	13	19,376,695 (GRCm39)	missense	probably benign	0.18
R7848:Trgv5	UTSW	13	19,376,849 (GRCm39)	missense	probably damaging	1.00
R9525:Trgv5	UTSW	13	19,376,885 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-03-25