Incidental Mutation 'R1714:Ydjc'
ID 190899
Institutional Source Beutler Lab
Gene Symbol Ydjc
Ensembl Gene ENSMUSG00000041774
Gene Name YdjC homolog (bacterial)
Synonyms 4930521M19Rik, 1810015A11Rik
MMRRC Submission 039747-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R1714 (G1)
Quality Score 157
Status Not validated
Chromosome 16
Chromosomal Location 16964813-16966721 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 16965663 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 143 (V143M)
Ref Sequence ENSEMBL: ENSMUSP00000156140 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023452] [ENSMUST00000069064] [ENSMUST00000090192] [ENSMUST00000115702] [ENSMUST00000115706] [ENSMUST00000115711] [ENSMUST00000231726] [ENSMUST00000231708] [ENSMUST00000231493] [ENSMUST00000231597] [ENSMUST00000232479] [ENSMUST00000232139] [ENSMUST00000232033] [ENSMUST00000232540] [ENSMUST00000232344]
AlphaFold Q14BV6
Predicted Effect probably benign
Transcript: ENSMUST00000023452
SMART Domains Protein: ENSMUSP00000023452
Gene: ENSMUSG00000022768

DomainStartEndE-ValueType
low complexity region 116 127 N/A INTRINSIC
low complexity region 150 161 N/A INTRINSIC
low complexity region 190 206 N/A INTRINSIC
low complexity region 488 503 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000069064
AA Change: V143M

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000069864
Gene: ENSMUSG00000041774
AA Change: V143M

DomainStartEndE-ValueType
Pfam:YdjC 7 288 1.3e-68 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000090192
SMART Domains Protein: ENSMUSP00000087658
Gene: ENSMUSG00000038965

DomainStartEndE-ValueType
UBCc 5 149 1.43e-64 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000115702
AA Change: V143M

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000111366
Gene: ENSMUSG00000041774
AA Change: V143M

DomainStartEndE-ValueType
Pfam:YdjC 6 229 9.2e-59 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000115706
AA Change: V143M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000111371
Gene: ENSMUSG00000041774
AA Change: V143M

DomainStartEndE-ValueType
Pfam:YdjC 6 229 1.3e-59 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115711
SMART Domains Protein: ENSMUSP00000111376
Gene: ENSMUSG00000022768

DomainStartEndE-ValueType
Pfam:DUF4702 18 411 6.3e-223 PFAM
low complexity region 488 503 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137267
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145198
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142576
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145792
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157013
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149681
Predicted Effect probably damaging
Transcript: ENSMUST00000231726
AA Change: V143M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231502
Predicted Effect probably benign
Transcript: ENSMUST00000231708
Predicted Effect probably benign
Transcript: ENSMUST00000231493
Predicted Effect probably benign
Transcript: ENSMUST00000231597
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231539
Predicted Effect probably damaging
Transcript: ENSMUST00000232479
AA Change: V143M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000232668
Predicted Effect probably benign
Transcript: ENSMUST00000232139
Predicted Effect probably benign
Transcript: ENSMUST00000232033
Predicted Effect probably benign
Transcript: ENSMUST00000232540
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231975
Predicted Effect probably benign
Transcript: ENSMUST00000232344
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 93.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik C T 13: 77,464,479 (GRCm39) T892I possibly damaging Het
Abcb11 A C 2: 69,136,925 (GRCm39) F179V probably damaging Het
Adgrg6 G T 10: 14,315,514 (GRCm39) Q597K possibly damaging Het
Ankmy1 G T 1: 92,812,916 (GRCm39) Y464* probably null Het
Apba1 G A 19: 23,922,316 (GRCm39) E795K possibly damaging Het
Aqp12 T A 1: 92,934,681 (GRCm39) V186D possibly damaging Het
Brd8 A T 18: 34,742,886 (GRCm39) S253R probably damaging Het
Cdc42se2 A T 11: 54,631,112 (GRCm39) S2R possibly damaging Het
Chd9 A C 8: 91,760,853 (GRCm39) probably benign Het
Clk4 C T 11: 51,171,245 (GRCm39) H219Y probably damaging Het
Cngb1 A G 8: 95,984,559 (GRCm39) Y417H probably damaging Het
Cr2 A T 1: 194,833,994 (GRCm39) F932I possibly damaging Het
Cxxc1 C A 18: 74,352,934 (GRCm39) R415S probably damaging Het
Dclk2 G A 3: 86,813,400 (GRCm39) A182V probably benign Het
Ddx11 T G 17: 66,455,754 (GRCm39) W718G probably damaging Het
Dmd A C X: 83,008,356 (GRCm39) T2069P probably benign Het
Dnai1 T C 4: 41,632,164 (GRCm39) F533L probably benign Het
Dnajc5b A T 3: 19,633,265 (GRCm39) R163* probably null Het
Dynll2 T A 11: 87,874,838 (GRCm39) probably null Het
Ercc5 A G 1: 44,206,499 (GRCm39) T471A probably benign Het
Fan1 T C 7: 64,016,435 (GRCm39) D563G probably benign Het
Fbxo34 A G 14: 47,766,658 (GRCm39) Y6C probably damaging Het
Fcrl5 T A 3: 87,353,713 (GRCm39) S353T probably damaging Het
Gabrb3 A T 7: 57,415,176 (GRCm39) Y82F probably damaging Het
Gm20939 C A 17: 95,183,234 (GRCm39) P157T probably damaging Het
H2bc1 T C 13: 24,117,935 (GRCm39) T69A probably benign Het
Haus3 A T 5: 34,321,041 (GRCm39) H468Q probably benign Het
Il20ra T C 10: 19,631,576 (GRCm39) V259A probably damaging Het
Isg15 A T 4: 156,284,414 (GRCm39) V38E probably damaging Het
Kcnq3 A G 15: 65,871,912 (GRCm39) S586P probably benign Het
Kl A T 5: 150,876,798 (GRCm39) Y206F probably benign Het
Klk1b24 C A 7: 43,840,939 (GRCm39) D122E probably damaging Het
Kmt2d A C 15: 98,760,831 (GRCm39) S840A unknown Het
Krt34 A G 11: 99,930,953 (GRCm39) S150P possibly damaging Het
Lamc3 A G 2: 31,830,769 (GRCm39) K1502R probably benign Het
Letm1 G T 5: 33,918,228 (GRCm39) R306S possibly damaging Het
Lnx1 C T 5: 74,768,398 (GRCm39) G397S probably null Het
Lrrc8c A G 5: 105,755,157 (GRCm39) T311A possibly damaging Het
Mpeg1 A T 19: 12,440,198 (GRCm39) D552V probably damaging Het
Myh11 C T 16: 14,054,232 (GRCm39) probably null Het
Ndufa9 T C 6: 126,799,154 (GRCm39) probably null Het
Or4e5 A C 14: 52,727,871 (GRCm39) probably null Het
Or4f4b A T 2: 111,314,008 (GRCm39) I78F probably damaging Het
Or8s8 G A 15: 98,354,614 (GRCm39) C141Y probably damaging Het
Polr3d A C 14: 70,678,755 (GRCm39) M117R possibly damaging Het
Ppp5c T C 7: 16,742,628 (GRCm39) I237V probably benign Het
Prrc2c G A 1: 162,504,945 (GRCm39) T2632M probably damaging Het
Ptprg C A 14: 12,213,697 (GRCm38) Q1022K probably damaging Het
Pus10 T A 11: 23,675,542 (GRCm39) H471Q probably damaging Het
Ralgapa1 A G 12: 55,689,174 (GRCm39) V1928A probably damaging Het
Rbpms2 CACT CACTACT 9: 65,558,947 (GRCm39) probably benign Het
Rbpms2 ACTGCTGCTGCTGCTGC ACTGCTGCTGCTGCTGCTGC 9: 65,558,948 (GRCm39) probably benign Het
Rfpl4 T G 7: 5,113,357 (GRCm39) T269P probably benign Het
Rgs10 A G 7: 128,004,946 (GRCm39) V72A probably damaging Het
Rsph1 T C 17: 31,474,190 (GRCm39) N289S probably benign Het
Sbk2 T C 7: 4,966,121 (GRCm39) D21G probably benign Het
Shbg A T 11: 69,507,983 (GRCm39) D127E possibly damaging Het
Spag16 A G 1: 69,882,164 (GRCm39) E52G probably damaging Het
Ssh2 G A 11: 77,344,850 (GRCm39) G945D possibly damaging Het
Sstr3 A T 15: 78,424,473 (GRCm39) D91E probably damaging Het
Syne2 C A 12: 76,101,713 (GRCm39) A669E probably benign Het
Traf3 A G 12: 111,208,907 (GRCm39) I109V probably benign Het
Ube2j1 A G 4: 33,049,886 (GRCm39) T295A probably damaging Het
Usp46 A G 5: 74,163,828 (GRCm39) V276A probably benign Het
Vmn1r200 T C 13: 22,579,640 (GRCm39) S139P possibly damaging Het
Zfp169 T C 13: 48,652,330 (GRCm39) E29G probably benign Het
Zfp292 A G 4: 34,808,935 (GRCm39) S1370P probably damaging Het
Zfp763 C T 17: 33,238,591 (GRCm39) D185N probably damaging Het
Zfp827 A T 8: 79,787,202 (GRCm39) N123Y probably damaging Het
Zfp979 A T 4: 147,698,442 (GRCm39) I89N probably damaging Het
Zfr2 T C 10: 81,080,583 (GRCm39) L419P probably damaging Het
Other mutations in Ydjc
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02834:Ydjc APN 16 16,965,153 (GRCm39) missense probably benign 0.08
IGL02878:Ydjc APN 16 16,965,469 (GRCm39) missense possibly damaging 0.74
R1659:Ydjc UTSW 16 16,965,703 (GRCm39) missense possibly damaging 0.73
R2328:Ydjc UTSW 16 16,964,986 (GRCm39) missense possibly damaging 0.93
R4857:Ydjc UTSW 16 16,966,002 (GRCm39) unclassified probably benign
R6182:Ydjc UTSW 16 16,964,943 (GRCm39) missense probably benign 0.00
R6444:Ydjc UTSW 16 16,965,545 (GRCm39) missense probably damaging 1.00
R7341:Ydjc UTSW 16 16,968,762 (GRCm39) missense probably benign 0.00
R7565:Ydjc UTSW 16 16,964,869 (GRCm39) missense probably damaging 1.00
R8769:Ydjc UTSW 16 16,968,732 (GRCm39) missense probably benign 0.00
R9170:Ydjc UTSW 16 16,965,666 (GRCm39) missense probably benign
R9642:Ydjc UTSW 16 16,966,073 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TAGTTCAAAGGCTGGAGCAGTCGC -3'
(R):5'- GTAGTTGGGAAGGCTGATGCTCAC -3'

Sequencing Primer
(F):5'- CGAAGCTCATAGTATCTGTGCC -3'
(R):5'- CTGATGCTCACCGCAGG -3'
Posted On 2014-05-14