Incidental Mutation 'R1718:Or5ak25'
ID 191180
Institutional Source Beutler Lab
Gene Symbol Or5ak25
Ensembl Gene ENSMUSG00000075218
Gene Name olfactory receptor family 5 subfamily AK member 25
Synonyms MOR203-3, GA_x6K02T2Q125-46915844-46914897, Olfr995
MMRRC Submission 039751-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.148) question?
Stock # R1718 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 85268553-85269500 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 85269149 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 118 (M118V)
Ref Sequence ENSEMBL: ENSMUSP00000149952 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099924] [ENSMUST00000214679] [ENSMUST00000216933] [ENSMUST00000217218]
AlphaFold Q8VF74
Predicted Effect probably benign
Transcript: ENSMUST00000099924
AA Change: M118V

PolyPhen 2 Score 0.394 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000097508
Gene: ENSMUSG00000075218
AA Change: M118V

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.1e-50 PFAM
Pfam:7tm_1 41 290 2.3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214679
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215758
Predicted Effect probably benign
Transcript: ENSMUST00000216933
AA Change: M118V

PolyPhen 2 Score 0.394 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000217218
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.6%
  • 20x: 93.5%
Validation Efficiency 100% (69/69)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik G T 13: 77,393,489 (GRCm39) probably benign Het
Acot3 T G 12: 84,100,717 (GRCm39) probably null Het
Acox1 A T 11: 116,065,508 (GRCm39) C523* probably null Het
Adamts19 G A 18: 59,105,897 (GRCm39) C764Y probably damaging Het
Agrn GCTCT GCTCTCT 4: 156,250,976 (GRCm39) probably null Het
Apob A G 12: 8,066,087 (GRCm39) K4319R probably benign Het
AU016765 A C 17: 64,862,433 (GRCm39) noncoding transcript Het
Bpifb1 T A 2: 154,055,903 (GRCm39) probably null Het
Btn2a2 A G 13: 23,666,106 (GRCm39) V242A probably benign Het
Camta1 A G 4: 151,168,481 (GRCm39) S1281P probably benign Het
Ccdc116 T C 16: 16,959,772 (GRCm39) K306E probably benign Het
Cemip A G 7: 83,584,866 (GRCm39) V1350A probably benign Het
Clip2 A T 5: 134,531,783 (GRCm39) L674* probably null Het
Cyp2d12 T A 15: 82,442,251 (GRCm39) D244E probably benign Het
Cyp4x1 A G 4: 114,968,867 (GRCm39) V379A possibly damaging Het
Dnah9 T A 11: 66,058,905 (GRCm39) H130L possibly damaging Het
Enpp7 A G 11: 118,881,809 (GRCm39) Y318C probably damaging Het
Fras1 A T 5: 96,702,748 (GRCm39) probably null Het
Glra3 G T 8: 56,393,942 (GRCm39) A18S probably benign Het
Gm28042 T A 2: 119,866,872 (GRCm39) S172T possibly damaging Het
Gm7808 T A 9: 19,839,299 (GRCm39) probably benign Het
Gpr61 C T 3: 108,057,696 (GRCm39) V322M possibly damaging Het
H2-T5 A G 17: 36,472,676 (GRCm39) probably benign Het
Hapln3 A G 7: 78,773,198 (GRCm39) V15A unknown Het
Ip6k1 G A 9: 107,918,195 (GRCm39) E77K possibly damaging Het
Klk1b4 A G 7: 43,859,096 (GRCm39) Y38C probably damaging Het
Lrrfip1 A G 1: 91,043,277 (GRCm39) K561E probably damaging Het
Map3k1 A G 13: 111,891,953 (GRCm39) C1101R probably benign Het
Mcoln2 A G 3: 145,896,229 (GRCm39) probably benign Het
Mfsd2b G A 12: 4,919,037 (GRCm39) T73I probably damaging Het
Mfsd4b5 C T 10: 39,851,199 (GRCm39) V19I probably benign Het
Mgme1 T A 2: 144,114,238 (GRCm39) D113E probably benign Het
Mki67 A G 7: 135,297,223 (GRCm39) S2604P probably damaging Het
Mob3c A G 4: 115,688,841 (GRCm39) I125V probably benign Het
Mrps9 G A 1: 42,942,559 (GRCm39) R339H probably damaging Het
Ndst1 T C 18: 60,840,875 (GRCm39) D269G probably damaging Het
Nedd9 T C 13: 41,492,402 (GRCm39) N30S probably damaging Het
Notch4 G A 17: 34,795,737 (GRCm39) probably benign Het
Or5t15 A T 2: 86,681,531 (GRCm39) N170K probably benign Het
Or8b9 G A 9: 37,766,749 (GRCm39) V212I probably benign Het
Or8c10 A G 9: 38,278,890 (GRCm39) D6G probably benign Het
Papss1 C A 3: 131,324,946 (GRCm39) R447S probably damaging Het
Pla2g4a C T 1: 149,747,274 (GRCm39) probably benign Het
Rab11fip2 A G 19: 59,924,081 (GRCm39) F266L probably damaging Het
Ralgapb T A 2: 158,285,200 (GRCm39) Y554* probably null Het
Rem2 T C 14: 54,716,607 (GRCm39) V240A probably damaging Het
Retsat T C 6: 72,579,654 (GRCm39) V143A probably benign Het
Rnf141 G T 7: 110,420,480 (GRCm39) Q175K probably damaging Het
Rtcb C A 10: 85,777,881 (GRCm39) G431V probably damaging Het
Slc7a6os A G 8: 106,930,971 (GRCm39) W222R probably damaging Het
Smarcc2 T C 10: 128,304,867 (GRCm39) probably benign Het
Smchd1 A T 17: 71,755,828 (GRCm39) Y218N possibly damaging Het
Sp110 G A 1: 85,522,106 (GRCm39) H66Y probably benign Het
Speg G A 1: 75,394,507 (GRCm39) E1739K probably benign Het
Speg A G 1: 75,398,388 (GRCm39) Q1945R possibly damaging Het
Sprtn T C 8: 125,625,096 (GRCm39) V67A probably damaging Het
Tktl2 G A 8: 66,964,999 (GRCm39) V186M probably damaging Het
Tnks1bp1 G T 2: 84,902,082 (GRCm39) E997D probably benign Het
Tti1 A T 2: 157,850,144 (GRCm39) V365E probably benign Het
Tulp4 A G 17: 6,272,715 (GRCm39) I590V probably benign Het
Vmn2r61 A G 7: 41,950,121 (GRCm39) D847G probably benign Het
Zfp184 A G 13: 22,143,442 (GRCm39) T383A possibly damaging Het
Zik1 T A 7: 10,226,268 (GRCm39) E33V probably damaging Het
Zik1 C A 7: 10,226,269 (GRCm39) E33* probably null Het
Other mutations in Or5ak25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02102:Or5ak25 APN 2 85,268,611 (GRCm39) missense probably damaging 1.00
IGL02540:Or5ak25 APN 2 85,269,259 (GRCm39) missense probably benign 0.05
IGL02687:Or5ak25 APN 2 85,268,930 (GRCm39) missense possibly damaging 0.93
IGL02713:Or5ak25 APN 2 85,268,981 (GRCm39) missense probably damaging 0.99
R0318:Or5ak25 UTSW 2 85,268,581 (GRCm39) missense possibly damaging 0.91
R0463:Or5ak25 UTSW 2 85,268,630 (GRCm39) missense probably damaging 1.00
R0638:Or5ak25 UTSW 2 85,268,845 (GRCm39) missense probably benign 0.03
R1668:Or5ak25 UTSW 2 85,269,220 (GRCm39) missense probably benign 0.00
R4981:Or5ak25 UTSW 2 85,268,813 (GRCm39) missense probably damaging 1.00
R5261:Or5ak25 UTSW 2 85,269,241 (GRCm39) missense probably benign
R7036:Or5ak25 UTSW 2 85,268,774 (GRCm39) missense probably damaging 1.00
R7899:Or5ak25 UTSW 2 85,268,741 (GRCm39) missense probably benign 0.39
R8209:Or5ak25 UTSW 2 85,268,981 (GRCm39) missense probably damaging 0.99
R8226:Or5ak25 UTSW 2 85,268,981 (GRCm39) missense probably damaging 0.99
R8803:Or5ak25 UTSW 2 85,268,981 (GRCm39) missense probably damaging 0.99
R9037:Or5ak25 UTSW 2 85,269,139 (GRCm39) missense possibly damaging 0.88
R9541:Or5ak25 UTSW 2 85,269,025 (GRCm39) missense possibly damaging 0.65
Predicted Primers PCR Primer
(F):5'- AGGCTGATGATTGGGACAACATCAC -3'
(R):5'- GGCAACACTGGGATGATCCTCCTC -3'

Sequencing Primer
(F):5'- TTGGGACAACATCACAGAAAAAGTG -3'
(R):5'- GGGATGATCCTCCTCATTAACAC -3'
Posted On 2014-05-14