Incidental Mutation 'R1718:Zik1'
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ID191198
Institutional Source Beutler Lab
Gene Symbol Zik1
Ensembl Gene ENSMUSG00000030393
Gene Namezinc finger protein interacting with K protein 1
Synonyms
MMRRC Submission 039751-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.054) question?
Stock #R1718 (G1)
Quality Score225
Status Validated
Chromosome7
Chromosomal Location10487229-10495394 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to A at 10492342 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 33 (E33*)
Ref Sequence ENSEMBL: ENSMUSP00000032551 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032551]
Predicted Effect probably null
Transcript: ENSMUST00000032551
AA Change: E33*
SMART Domains Protein: ENSMUSP00000032551
Gene: ENSMUSG00000030393
AA Change: E33*

DomainStartEndE-ValueType
KRAB 14 74 1.41e-9 SMART
ZnF_C2H2 215 237 1.3e-4 SMART
ZnF_C2H2 243 265 1.56e-2 SMART
ZnF_C2H2 271 293 7.37e-4 SMART
ZnF_C2H2 299 321 5.67e-5 SMART
ZnF_C2H2 327 349 3.89e-3 SMART
ZnF_C2H2 355 377 6.52e-5 SMART
ZnF_C2H2 383 405 4.54e-4 SMART
ZnF_C2H2 411 433 1.84e-4 SMART
ZnF_C2H2 439 461 8.67e-1 SMART
Meta Mutation Damage Score 0.592 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.6%
  • 20x: 93.5%
Validation Efficiency 100% (69/69)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik G T 13: 77,245,370 probably benign Het
Acot3 T G 12: 84,053,943 probably null Het
Acox1 A T 11: 116,174,682 C523* probably null Het
Adamts19 G A 18: 58,972,825 C764Y probably damaging Het
Agrn GCTCT GCTCTCT 4: 156,166,519 probably null Het
Apob A G 12: 8,016,087 K4319R probably benign Het
AU016765 A C 17: 64,555,438 noncoding transcript Het
Bpifb1 T A 2: 154,213,983 probably null Het
Btn2a2 A G 13: 23,481,936 V242A probably benign Het
Camta1 A G 4: 151,084,024 S1281P probably benign Het
Ccdc116 T C 16: 17,141,908 K306E probably benign Het
Cemip A G 7: 83,935,658 V1350A probably benign Het
Clip2 A T 5: 134,502,929 L674* probably null Het
Cyp2d12 T A 15: 82,558,050 D244E probably benign Het
Cyp4x1 A G 4: 115,111,670 V379A possibly damaging Het
Dnah9 T A 11: 66,168,079 H130L possibly damaging Het
Enpp7 A G 11: 118,990,983 Y318C probably damaging Het
Fras1 A T 5: 96,554,889 probably null Het
Glra3 G T 8: 55,940,907 A18S probably benign Het
Gm28042 T A 2: 120,036,391 S172T possibly damaging Het
Gm7808 T A 9: 19,928,003 probably benign Het
Gm8909 A G 17: 36,161,784 probably benign Het
Gpr61 C T 3: 108,150,380 V322M possibly damaging Het
Hapln3 A G 7: 79,123,450 V15A unknown Het
Ip6k1 G A 9: 108,040,996 E77K possibly damaging Het
Klk1b4 A G 7: 44,209,672 Y38C probably damaging Het
Lrrfip1 A G 1: 91,115,555 K561E probably damaging Het
Map3k1 A G 13: 111,755,419 C1101R probably benign Het
Mcoln2 A G 3: 146,190,474 probably benign Het
Mfsd2b G A 12: 4,869,037 T73I probably damaging Het
Mfsd4b5 C T 10: 39,975,203 V19I probably benign Het
Mgme1 T A 2: 144,272,318 D113E probably benign Het
Mki67 A G 7: 135,695,494 S2604P probably damaging Het
Mob3c A G 4: 115,831,644 I125V probably benign Het
Mrps9 G A 1: 42,903,399 R339H probably damaging Het
Ndst1 T C 18: 60,707,803 D269G probably damaging Het
Nedd9 T C 13: 41,338,926 N30S probably damaging Het
Notch4 G A 17: 34,576,763 probably benign Het
Olfr1095 A T 2: 86,851,187 N170K probably benign Het
Olfr250 A G 9: 38,367,594 D6G probably benign Het
Olfr877 G A 9: 37,855,453 V212I probably benign Het
Olfr995 T C 2: 85,438,805 M118V probably benign Het
Papss1 C A 3: 131,619,185 R447S probably damaging Het
Pla2g4a C T 1: 149,871,523 probably benign Het
Rab11fip2 A G 19: 59,935,649 F266L probably damaging Het
Ralgapb T A 2: 158,443,280 Y554* probably null Het
Rem2 T C 14: 54,479,150 V240A probably damaging Het
Retsat T C 6: 72,602,671 V143A probably benign Het
Rnf141 G T 7: 110,821,273 Q175K probably damaging Het
Rtcb C A 10: 85,942,017 G431V probably damaging Het
Slc7a6os A G 8: 106,204,339 W222R probably damaging Het
Smarcc2 T C 10: 128,468,998 probably benign Het
Smchd1 A T 17: 71,448,833 Y218N possibly damaging Het
Sp110 G A 1: 85,594,385 H66Y probably benign Het
Speg G A 1: 75,417,863 E1739K probably benign Het
Speg A G 1: 75,421,744 Q1945R possibly damaging Het
Sprtn T C 8: 124,898,357 V67A probably damaging Het
Tktl2 G A 8: 66,512,347 V186M probably damaging Het
Tnks1bp1 G T 2: 85,071,738 E997D probably benign Het
Tti1 A T 2: 158,008,224 V365E probably benign Het
Tulp4 A G 17: 6,222,440 I590V probably benign Het
Vmn2r61 A G 7: 42,300,697 D847G probably benign Het
Zfp184 A G 13: 21,959,272 T383A possibly damaging Het
Other mutations in Zik1
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4791001:Zik1 UTSW 7 10492329 missense probably benign 0.01
R1105:Zik1 UTSW 7 10490385 missense probably damaging 1.00
R1106:Zik1 UTSW 7 10490385 missense probably damaging 1.00
R1107:Zik1 UTSW 7 10490385 missense probably damaging 1.00
R1108:Zik1 UTSW 7 10490385 missense probably damaging 1.00
R1533:Zik1 UTSW 7 10490126 missense possibly damaging 0.90
R1671:Zik1 UTSW 7 10490748 missense probably damaging 0.99
R1713:Zik1 UTSW 7 10490384 missense possibly damaging 0.89
R1718:Zik1 UTSW 7 10492341 missense probably damaging 0.97
R1921:Zik1 UTSW 7 10490016 missense probably damaging 1.00
R4356:Zik1 UTSW 7 10490341 nonsense probably null
R4466:Zik1 UTSW 7 10490966 missense probably benign 0.09
R5763:Zik1 UTSW 7 10492366 missense probably benign 0.18
R5950:Zik1 UTSW 7 10490571 nonsense probably null
Y4336:Zik1 UTSW 7 10490385 missense probably damaging 1.00
Y4338:Zik1 UTSW 7 10490385 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCACTGCTAAGCACTTGTCATGCC -3'
(R):5'- TCTGCCAAGAACAGATGCAGCC -3'

Sequencing Primer
(F):5'- CTTGAGGTAGTAGACACAGTTCAGC -3'
(R):5'- TGGTGCTATGACAACAATACTGG -3'
Posted On2014-05-14