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|Institutional Source||Beutler Lab|
|Gene Name||glycine receptor, alpha 3 subunit|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R1718 (G1)|
|Chromosomal Location||55940460-56130070 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to T at 55940907 bp|
|Amino Acid Change||Alanine to Serine at position 18 (A18S)|
|Ref Sequence||ENSEMBL: ENSMUSP00000000275 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000000275]|
|Predicted Effect||probably benign
AA Change: A18S
PolyPhen 2 Score 0.068 (Sensitivity: 0.94; Specificity: 0.84)
AA Change: A18S
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.07|
|Coding Region Coverage||
|Validation Efficiency||100% (69/69)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the glycine receptor subfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
PHENOTYPE: Homozygous null mice are fertile and display decreased inflammatory pain sensitization without any gross abnormalities in the brain or spinal cord. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Glra3||
(F):5'- AACTGTTGCTCAGGACCTCTGCAC -3'
(R):5'- GTGGGAAGAGCCCAACTACTCAAAC -3'
(F):5'- GTAGCTTCACTGTGAAATCACTCG -3'
(R):5'- GTTTCAGTAAGTCAGAACACAGTCC -3'