Mutagenetix > Incidental Mutation

Incidental Mutation 'R0010:Scgb2b26'

19136

Institutional Source

Beutler Lab

Gene Symbol

Scgb2b26

Ensembl Gene

ENSMUSG00000066586

Gene Name

secretoglobin, family 2B, member 26

Synonyms

Abpbg4, Abpbg26, C2d, Abpg, Scgb2b4

MMRRC Submission

038305-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

R0010 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

33642422-33644410 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 33643774 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Aspartic acid at position 55 (E55D)

Ref Sequence

ENSEMBL: ENSMUSP00000082763 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000085623]

AlphaFold

Q8JZX1

Predicted Effect

probably damaging
Transcript: ENSMUST00000085623
AA Change: E55D

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000082763
Gene: ENSMUSG00000066586
AA Change: E55D

Domain	Start	End	E-Value	Type
low complexity region	5	11	N/A	INTRINSIC
Pfam:Feld-I_B	24	90	2.9e-29	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 79.6%
3x: 70.9%
10x: 47.0%
20x: 26.4%

Validation Efficiency

91% (78/86)

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl3	C	T	5: 81,940,250 (GRCm39)	A1320V	possibly damaging	Het
Ahrr	G	A	13: 74,431,143 (GRCm39)		probably benign	Het
Cd74	A	T	18: 60,942,143 (GRCm39)	H124L	probably benign	Het
Cdk5rap2	T	C	4: 70,161,696 (GRCm39)	E270G	probably benign	Het
Cldnd1	T	A	16: 58,551,622 (GRCm39)		probably benign	Het
Dennd4a	T	C	9: 64,803,997 (GRCm39)	L1112P	probably benign	Het
Evc2	T	A	5: 37,574,793 (GRCm39)	L1016Q	probably damaging	Het
Fam135b	T	C	15: 71,493,881 (GRCm39)	K16R	probably damaging	Het
Frem1	T	C	4: 82,918,335 (GRCm39)	I536V	probably benign	Het
Ginm1	T	C	10: 7,651,138 (GRCm39)		probably benign	Het
Glrb	A	T	3: 80,767,622 (GRCm39)		probably benign	Het
Glt6d1	C	A	2: 25,684,739 (GRCm39)		probably null	Het
Gm10320	T	C	13: 98,626,054 (GRCm39)	Y110C	probably damaging	Het
Intu	T	C	3: 40,608,702 (GRCm39)		probably benign	Het
Ltbp1	A	G	17: 75,670,386 (GRCm39)	T1476A	probably damaging	Het
Mcoln2	C	T	3: 145,889,316 (GRCm39)	T374M	probably damaging	Het
Mitf	A	G	6: 97,784,242 (GRCm39)	K33R	probably benign	Het
Nlgn1	G	T	3: 25,490,006 (GRCm39)		probably benign	Het
Nup133	A	T	8: 124,631,318 (GRCm39)	I1072N	probably damaging	Het
Rock1	T	A	18: 10,084,380 (GRCm39)	D951V	probably damaging	Het
Scn8a	T	C	15: 100,911,454 (GRCm39)	V958A	probably damaging	Het
Sgk1	G	A	10: 21,873,337 (GRCm39)		probably null	Het
Shprh	C	T	10: 11,027,675 (GRCm39)	T94I	probably benign	Het
Smg1	A	T	7: 117,771,082 (GRCm39)		probably benign	Het
Spta1	G	A	1: 174,045,509 (GRCm39)	V1556I	probably benign	Het
Trappc14	T	C	5: 138,258,555 (GRCm39)		probably null	Het
Trappc4	G	A	9: 44,316,528 (GRCm39)		probably benign	Het
Txlna	T	G	4: 129,522,879 (GRCm39)	D487A	probably benign	Het
Ube2d2b	T	C	5: 107,978,502 (GRCm39)	F51S	possibly damaging	Het
Wdfy3	T	C	5: 101,996,215 (GRCm39)	T3234A	probably damaging	Het
Zbtb41	T	G	1: 139,351,268 (GRCm39)	V127G	probably damaging	Het
Zfp608	A	T	18: 55,028,286 (GRCm39)		probably benign	Het

Other mutations in Scgb2b26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02061:Scgb2b26	APN	7	33,642,610 (GRCm39)	missense	probably benign	0.16
R0010:Scgb2b26	UTSW	7	33,643,774 (GRCm39)	missense	probably damaging	0.98
R6768:Scgb2b26	UTSW	7	33,644,379 (GRCm39)	missense	probably damaging	1.00
R7188:Scgb2b26	UTSW	7	33,644,379 (GRCm39)	missense	probably damaging	1.00
R7325:Scgb2b26	UTSW	7	33,643,782 (GRCm39)	missense	probably benign	0.14
R8205:Scgb2b26	UTSW	7	33,643,833 (GRCm39)	missense	probably benign	0.03
R8679:Scgb2b26	UTSW	7	33,643,784 (GRCm39)	missense	probably damaging	0.99
Z1088:Scgb2b26	UTSW	7	33,643,792 (GRCm39)	missense	probably benign	0.00

Posted On

2013-03-25