Incidental Mutation 'R1724:Tle7'
ID 191681
Institutional Source Beutler Lab
Gene Symbol Tle7
Ensembl Gene ENSMUSG00000095941
Gene Name TLE family member 7
Synonyms Gm21964
MMRRC Submission 039756-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.120) question?
Stock # R1724 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 110827964-110838646 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 110836795 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Asparagine at position 227 (T227N)
Ref Sequence ENSEMBL: ENSMUSP00000151787 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000178785] [ENSMUST00000213641] [ENSMUST00000219454]
AlphaFold A0A1W2P7S4
Predicted Effect probably damaging
Transcript: ENSMUST00000178785
AA Change: T101N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000136968
Gene: ENSMUSG00000095941
AA Change: T101N

DomainStartEndE-ValueType
WD40 18 55 3.9e-2 SMART
WD40 65 104 2.3e0 SMART
WD40 108 146 4.13e0 SMART
WD40 149 186 7.92e1 SMART
Blast:WD40 189 227 3e-12 BLAST
WD40 269 308 1.49e0 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000213641
AA Change: T220N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000219454
AA Change: T227N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.1420 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 93.0%
Validation Efficiency 98% (50/51)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts13 T C 2: 26,881,306 (GRCm39) V761A probably benign Het
Arap1 G T 7: 101,049,733 (GRCm39) A1032S possibly damaging Het
Atg4d C T 9: 21,179,741 (GRCm39) H230Y probably damaging Het
Auh G A 13: 52,989,532 (GRCm39) P308L probably benign Het
Bcdin3d T A 15: 99,368,561 (GRCm39) K213* probably null Het
Cep295nl T A 11: 118,223,854 (GRCm39) E330V probably benign Het
Col10a1 A G 10: 34,271,714 (GRCm39) Y562C probably damaging Het
Col9a2 G A 4: 120,911,099 (GRCm39) R578Q probably damaging Het
Creld1 A G 6: 113,461,535 (GRCm39) D85G possibly damaging Het
Cth A T 3: 157,619,364 (GRCm39) V153D probably damaging Het
Dazap2 T A 15: 100,515,884 (GRCm39) Y71N probably damaging Het
Ddah1 A C 3: 145,597,261 (GRCm39) D269A probably damaging Het
Dhx9 A C 1: 153,334,234 (GRCm39) D975E probably benign Het
Erich3 T A 3: 154,467,964 (GRCm39) D805E possibly damaging Het
Fam83f T G 15: 80,576,468 (GRCm39) V373G possibly damaging Het
Gabpb2 T C 3: 95,113,826 (GRCm39) D19G probably damaging Het
Gabrr1 T A 4: 33,161,651 (GRCm39) M325K probably damaging Het
Galntl5 T G 5: 25,425,120 (GRCm39) N379K possibly damaging Het
Gm10277 TC T 11: 77,676,828 (GRCm39) probably null Het
Gm42791 C A 5: 148,896,311 (GRCm39) probably benign Het
Gm5356 G A 8: 89,913,684 (GRCm39) noncoding transcript Het
Kifap3 C T 1: 163,610,666 (GRCm39) R49* probably null Het
Kmt2c C T 5: 25,520,003 (GRCm39) G2036R probably damaging Het
Lce1l A T 3: 92,757,726 (GRCm39) V44E unknown Het
Lmbr1 T A 5: 29,566,081 (GRCm39) E48D probably benign Het
Nes C A 3: 87,884,748 (GRCm39) N958K probably benign Het
Nwd1 A C 8: 73,438,248 (GRCm39) H1432P probably damaging Het
Or2d2b G A 7: 106,705,409 (GRCm39) H220Y probably benign Het
Or52h9 T C 7: 104,202,435 (GRCm39) F103S probably damaging Het
Osgepl1 A G 1: 53,357,062 (GRCm39) T75A probably benign Het
Perm1 T C 4: 156,302,529 (GRCm39) S358P possibly damaging Het
Pramel14 C T 4: 143,720,002 (GRCm39) G121D probably benign Het
Ptk2 A G 15: 73,114,255 (GRCm39) V701A possibly damaging Het
Sdc4 G T 2: 164,273,206 (GRCm39) Q35K probably benign Het
Secisbp2 A G 13: 51,824,882 (GRCm39) S377G probably benign Het
Spag16 G C 1: 70,532,941 (GRCm39) G540A probably damaging Het
Sun1 T A 5: 139,221,480 (GRCm39) D517E probably benign Het
Taf3 A G 2: 9,957,177 (GRCm39) V177A probably benign Het
Thbs2 A G 17: 14,906,162 (GRCm39) L246P possibly damaging Het
Trpm1 G T 7: 63,885,569 (GRCm39) G862* probably null Het
Trpm8 A T 1: 88,278,578 (GRCm39) T584S possibly damaging Het
Ythdc2 T C 18: 44,961,757 (GRCm39) S2P probably benign Het
Zc2hc1c G T 12: 85,336,586 (GRCm39) R81L probably benign Het
Zfp292 C A 4: 34,811,237 (GRCm39) L602F probably damaging Het
Other mutations in Tle7
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4761:Tle7 UTSW 8 110,836,753 (GRCm39) missense probably damaging 1.00
R5247:Tle7 UTSW 8 110,837,209 (GRCm39) missense probably damaging 1.00
R5451:Tle7 UTSW 8 110,836,503 (GRCm39) missense probably damaging 0.97
R7148:Tle7 UTSW 8 110,836,048 (GRCm39) missense probably benign 0.42
R8077:Tle7 UTSW 8 110,836,735 (GRCm39) missense probably damaging 1.00
R8157:Tle7 UTSW 8 110,835,493 (GRCm39) missense probably benign 0.00
R8891:Tle7 UTSW 8 110,836,763 (GRCm39) missense possibly damaging 0.74
R9649:Tle7 UTSW 8 110,837,580 (GRCm39) missense probably damaging 1.00
R9686:Tle7 UTSW 8 110,836,563 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCAGGTTTAGAGAAGTCAGCCAGGG -3'
(R):5'- CCTACTGCCATGAAGGGAAAGTGAG -3'

Sequencing Primer
(F):5'- CAGCCAGGGCCTCTGTC -3'
(R):5'- CTTTCCCAAGAGAGACCTGAGTG -3'
Posted On 2014-05-14