Incidental Mutation 'R1692:Fbxw20'
ID 191873
Institutional Source Beutler Lab
Gene Symbol Fbxw20
Ensembl Gene ENSMUSG00000061701
Gene Name F-box and WD-40 domain protein 20
Synonyms
MMRRC Submission 039725-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R1692 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 109046500-109063822 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 109050777 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 377 (T377K)
Ref Sequence ENSEMBL: ENSMUSP00000078503 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079548] [ENSMUST00000197329]
AlphaFold Q5U467
Predicted Effect possibly damaging
Transcript: ENSMUST00000079548
AA Change: T377K

PolyPhen 2 Score 0.725 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000078503
Gene: ENSMUSG00000061701
AA Change: T377K

DomainStartEndE-ValueType
FBOX 5 45 2.37e-6 SMART
SCOP:d1tbga_ 116 249 5e-8 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000197329
SMART Domains Protein: ENSMUSP00000143126
Gene: ENSMUSG00000061701

DomainStartEndE-ValueType
FBOX 5 45 1.5e-8 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198261
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.6%
  • 20x: 93.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam12 A T 7: 133,489,673 (GRCm39) *582R probably null Het
Agfg2 A G 5: 137,662,633 (GRCm39) Y145H probably damaging Het
Aldh1a1 C T 19: 20,608,182 (GRCm39) P335S probably damaging Het
Amotl1 T C 9: 14,463,018 (GRCm39) R732G possibly damaging Het
Ankef1 A T 2: 136,392,346 (GRCm39) I512F probably benign Het
Atg9a A T 1: 75,166,999 (GRCm39) D17E probably benign Het
Atpsckmt T C 15: 31,602,297 (GRCm39) probably null Het
Brd8 A T 18: 34,742,886 (GRCm39) S253R probably damaging Het
Ccnq T C 11: 78,642,157 (GRCm39) E111G probably benign Het
Cd79a T A 7: 24,600,881 (GRCm39) M192K probably damaging Het
Clcn1 T G 6: 42,290,032 (GRCm39) F822L possibly damaging Het
Dnajb12 A G 10: 59,732,199 (GRCm39) Y346C probably damaging Het
Erbb3 A G 10: 128,407,594 (GRCm39) I918T probably benign Het
Fry A G 5: 150,293,692 (GRCm39) I462V probably damaging Het
Gmip A G 8: 70,266,553 (GRCm39) N251S probably benign Het
Gpx1 A G 9: 108,216,674 (GRCm39) T55A possibly damaging Het
Hmcn2 T C 2: 31,340,856 (GRCm39) V4443A possibly damaging Het
Kdm4d A T 9: 14,375,807 (GRCm39) I17K probably benign Het
Lamc3 A G 2: 31,811,793 (GRCm39) S927G probably null Het
Map7d1 G A 4: 126,136,101 (GRCm39) P36S probably damaging Het
Mfsd13a C A 19: 46,360,515 (GRCm39) H356N probably benign Het
Mtap C T 4: 89,095,151 (GRCm39) R268C probably benign Het
Myo1a C T 10: 127,555,203 (GRCm39) probably null Het
Myom3 T C 4: 135,502,862 (GRCm39) L313P probably benign Het
Nrxn2 T A 19: 6,569,298 (GRCm39) V1391E probably damaging Het
Otoa A C 7: 120,690,774 (GRCm39) Q3P probably damaging Het
Phldb1 T C 9: 44,626,717 (GRCm39) E576G probably damaging Het
Pigw A C 11: 84,767,892 (GRCm39) L479R probably damaging Het
Pip5k1a A G 3: 94,971,041 (GRCm39) I507T probably benign Het
Ppp4r3b T A 11: 29,138,123 (GRCm39) I157N probably benign Het
Rrm2b G A 15: 37,927,566 (GRCm39) R115* probably null Het
Sall1 C T 8: 89,755,028 (GRCm39) S1317N probably benign Het
Serpinb6b T G 13: 33,158,978 (GRCm39) F179V probably damaging Het
Slc4a8 T A 15: 100,698,454 (GRCm39) F648I probably damaging Het
Slc5a7 T C 17: 54,588,754 (GRCm39) T298A probably damaging Het
Slit3 T C 11: 35,550,171 (GRCm39) L830P probably damaging Het
Smarcc1 T A 9: 110,003,072 (GRCm39) N387K possibly damaging Het
Tanc2 C T 11: 105,748,326 (GRCm39) T486I probably benign Het
Tdp1 C T 12: 99,921,260 (GRCm39) P599S probably damaging Het
Tmem33 A G 5: 67,425,897 (GRCm39) D38G probably null Het
Uvrag C T 7: 98,653,870 (GRCm39) R247Q probably benign Het
Vars1 T C 17: 35,232,701 (GRCm39) V875A probably damaging Het
Vcl A G 14: 21,074,250 (GRCm39) E879G probably damaging Het
Vmn1r231 C T 17: 21,110,871 (GRCm39) V15I probably benign Het
Zfp609 T C 9: 65,702,593 (GRCm39) T20A probably damaging Het
Zfp747l1 G T 7: 126,983,652 (GRCm39) H483Q possibly damaging Het
Zfp959 T A 17: 56,205,299 (GRCm39) H445Q probably damaging Het
Zmiz2 T A 11: 6,350,795 (GRCm39) V515E probably damaging Het
Zmym5 G A 14: 57,041,650 (GRCm39) T151M probably damaging Het
Zxdc C T 6: 90,355,933 (GRCm39) Q481* probably null Het
Other mutations in Fbxw20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00228:Fbxw20 APN 9 109,063,770 (GRCm39) start codon destroyed probably damaging 0.97
IGL01764:Fbxw20 APN 9 109,052,427 (GRCm39) missense possibly damaging 0.71
IGL02149:Fbxw20 APN 9 109,062,886 (GRCm39) critical splice donor site probably null
IGL02307:Fbxw20 APN 9 109,062,601 (GRCm39) missense possibly damaging 0.70
IGL02335:Fbxw20 APN 9 109,052,377 (GRCm39) missense possibly damaging 0.91
IGL02338:Fbxw20 APN 9 109,055,046 (GRCm39) missense probably benign 0.00
PIT4377001:Fbxw20 UTSW 9 109,050,795 (GRCm39) missense probably benign 0.00
PIT4434001:Fbxw20 UTSW 9 109,052,500 (GRCm39) missense probably damaging 1.00
R0652:Fbxw20 UTSW 9 109,061,400 (GRCm39) missense probably damaging 1.00
R1018:Fbxw20 UTSW 9 109,050,404 (GRCm39) missense probably benign 0.03
R1114:Fbxw20 UTSW 9 109,052,550 (GRCm39) missense probably damaging 1.00
R1596:Fbxw20 UTSW 9 109,050,368 (GRCm39) missense probably damaging 1.00
R1967:Fbxw20 UTSW 9 109,046,578 (GRCm39) missense probably benign 0.00
R2055:Fbxw20 UTSW 9 109,050,442 (GRCm39) missense probably damaging 0.99
R2224:Fbxw20 UTSW 9 109,062,650 (GRCm39) missense possibly damaging 0.50
R4394:Fbxw20 UTSW 9 109,061,398 (GRCm39) missense probably benign 0.00
R4617:Fbxw20 UTSW 9 109,046,631 (GRCm39) missense probably damaging 1.00
R4858:Fbxw20 UTSW 9 109,063,763 (GRCm39) missense possibly damaging 0.54
R5794:Fbxw20 UTSW 9 109,062,668 (GRCm39) missense possibly damaging 0.95
R5794:Fbxw20 UTSW 9 109,052,358 (GRCm39) missense probably damaging 0.97
R6090:Fbxw20 UTSW 9 109,052,431 (GRCm39) missense probably benign 0.03
R7161:Fbxw20 UTSW 9 109,055,048 (GRCm39) missense probably damaging 1.00
R7328:Fbxw20 UTSW 9 109,061,383 (GRCm39) missense probably damaging 1.00
R8004:Fbxw20 UTSW 9 109,050,449 (GRCm39) missense probably damaging 1.00
R8258:Fbxw20 UTSW 9 109,063,763 (GRCm39) missense probably benign 0.18
R8259:Fbxw20 UTSW 9 109,063,763 (GRCm39) missense probably benign 0.18
R8770:Fbxw20 UTSW 9 109,046,596 (GRCm39) missense probably benign 0.00
R9006:Fbxw20 UTSW 9 109,062,530 (GRCm39) splice site probably benign
R9090:Fbxw20 UTSW 9 109,050,423 (GRCm39) missense probably benign 0.02
R9131:Fbxw20 UTSW 9 109,052,514 (GRCm39) missense probably damaging 1.00
R9271:Fbxw20 UTSW 9 109,050,423 (GRCm39) missense probably benign 0.02
R9464:Fbxw20 UTSW 9 109,050,399 (GRCm39) missense probably damaging 1.00
Z1177:Fbxw20 UTSW 9 109,054,955 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- ACACTTTCTGAGCAGCAGGCTTC -3'
(R):5'- GGACATGGACTTGTCAGGACATGG -3'

Sequencing Primer
(F):5'- agcccatgtaaaggtggaaag -3'
(R):5'- TTGTCAGACCAATGGACTGC -3'
Posted On 2014-05-14