Mutagenetix > Incidental Mutation

Incidental Mutation 'R1696:Foxp1'

192217

Institutional Source

Beutler Lab

Gene Symbol

Foxp1

Ensembl Gene

ENSMUSG00000030067

Gene Name

forkhead box P1

Synonyms

3110052D19Rik, 4932443N09Rik

MMRRC Submission

039729-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1696 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

98902299-99499682 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 98922663 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Alanine at position 391 (S391A)

Ref Sequence

ENSEMBL: ENSMUSP00000135635 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074346] [ENSMUST00000113322] [ENSMUST00000113324] [ENSMUST00000113326] [ENSMUST00000113328] [ENSMUST00000113329] [ENSMUST00000124058] [ENSMUST00000177307] [ENSMUST00000176632] [ENSMUST00000176850] [ENSMUST00000176565] [ENSMUST00000177229] [ENSMUST00000177230] [ENSMUST00000177437]

AlphaFold

P58462

Predicted Effect

probably benign
Transcript: ENSMUST00000074346
AA Change: S422A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000073953
Gene: ENSMUSG00000030067
AA Change: S422A

Domain	Start	End	E-Value	Type
coiled coil region	62	113	N/A	INTRINSIC
low complexity region	140	191	N/A	INTRINSIC
low complexity region	200	233	N/A	INTRINSIC
low complexity region	236	250	N/A	INTRINSIC
low complexity region	264	275	N/A	INTRINSIC
low complexity region	317	330	N/A	INTRINSIC
ZnF_C2H2	334	359	8.67e-1	SMART
low complexity region	371	383	N/A	INTRINSIC
low complexity region	432	446	N/A	INTRINSIC
FH	491	572	2.07e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000113322
AA Change: S422A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000108948
Gene: ENSMUSG00000030067
AA Change: S422A

Domain	Start	End	E-Value	Type
coiled coil region	62	113	N/A	INTRINSIC
low complexity region	140	191	N/A	INTRINSIC
low complexity region	200	233	N/A	INTRINSIC
low complexity region	236	250	N/A	INTRINSIC
low complexity region	264	275	N/A	INTRINSIC
low complexity region	317	330	N/A	INTRINSIC
ZnF_C2H2	334	359	8.67e-1	SMART
low complexity region	371	383	N/A	INTRINSIC
low complexity region	432	446	N/A	INTRINSIC
FH	491	572	2.07e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000113324
AA Change: S423A

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000108950
Gene: ENSMUSG00000030067
AA Change: S423A

Domain	Start	End	E-Value	Type
coiled coil region	62	113	N/A	INTRINSIC
low complexity region	140	192	N/A	INTRINSIC
low complexity region	201	234	N/A	INTRINSIC
low complexity region	237	251	N/A	INTRINSIC
low complexity region	265	276	N/A	INTRINSIC
low complexity region	318	331	N/A	INTRINSIC
ZnF_C2H2	335	360	8.67e-1	SMART
low complexity region	372	384	N/A	INTRINSIC
low complexity region	433	447	N/A	INTRINSIC
FH	492	573	2.07e-39	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000113326
AA Change: S390A

SMART Domains

Protein: ENSMUSP00000108952
Gene: ENSMUSG00000030067
AA Change: S390A

Domain	Start	End	E-Value	Type
low complexity region	108	159	N/A	INTRINSIC
low complexity region	168	201	N/A	INTRINSIC
low complexity region	204	218	N/A	INTRINSIC
low complexity region	232	243	N/A	INTRINSIC
low complexity region	285	298	N/A	INTRINSIC
ZnF_C2H2	302	327	8.67e-1	SMART
low complexity region	339	351	N/A	INTRINSIC
low complexity region	400	414	N/A	INTRINSIC
FH	459	540	2.07e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000113328
AA Change: S423A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000108954
Gene: ENSMUSG00000030067
AA Change: S423A

Domain	Start	End	E-Value	Type
coiled coil region	62	113	N/A	INTRINSIC
low complexity region	140	191	N/A	INTRINSIC
low complexity region	200	234	N/A	INTRINSIC
low complexity region	237	251	N/A	INTRINSIC
low complexity region	265	276	N/A	INTRINSIC
low complexity region	318	331	N/A	INTRINSIC
ZnF_C2H2	335	360	8.67e-1	SMART
low complexity region	372	384	N/A	INTRINSIC
low complexity region	433	447	N/A	INTRINSIC
FH	492	573	2.07e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000113329
AA Change: S422A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000108955
Gene: ENSMUSG00000030067
AA Change: S422A

Domain	Start	End	E-Value	Type
coiled coil region	62	113	N/A	INTRINSIC
low complexity region	140	191	N/A	INTRINSIC
low complexity region	200	233	N/A	INTRINSIC
low complexity region	236	250	N/A	INTRINSIC
low complexity region	264	275	N/A	INTRINSIC
low complexity region	317	330	N/A	INTRINSIC
ZnF_C2H2	334	359	8.67e-1	SMART
low complexity region	371	383	N/A	INTRINSIC
low complexity region	432	446	N/A	INTRINSIC
FH	491	579	1.76e-10	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000124058
AA Change: S293A

PolyPhen 2 Score 0.045 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000120244
Gene: ENSMUSG00000030067
AA Change: S293A

Domain	Start	End	E-Value	Type
low complexity region	10	62	N/A	INTRINSIC
low complexity region	71	104	N/A	INTRINSIC
low complexity region	107	121	N/A	INTRINSIC
low complexity region	135	146	N/A	INTRINSIC
low complexity region	188	201	N/A	INTRINSIC
ZnF_C2H2	205	230	8.67e-1	SMART
low complexity region	242	254	N/A	INTRINSIC
low complexity region	303	317	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000177307
AA Change: S424A

SMART Domains

Protein: ENSMUSP00000135764
Gene: ENSMUSG00000030067
AA Change: S424A

Domain	Start	End	E-Value	Type
coiled coil region	62	113	N/A	INTRINSIC
low complexity region	140	192	N/A	INTRINSIC
low complexity region	201	235	N/A	INTRINSIC
low complexity region	238	252	N/A	INTRINSIC
low complexity region	266	277	N/A	INTRINSIC
low complexity region	319	332	N/A	INTRINSIC
ZnF_C2H2	336	361	8.67e-1	SMART
low complexity region	373	385	N/A	INTRINSIC
low complexity region	434	448	N/A	INTRINSIC
FH	492	573	2.07e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000176632
AA Change: S391A

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000135635
Gene: ENSMUSG00000030067
AA Change: S391A

Domain	Start	End	E-Value	Type
low complexity region	108	159	N/A	INTRINSIC
low complexity region	168	202	N/A	INTRINSIC
low complexity region	205	219	N/A	INTRINSIC
low complexity region	233	244	N/A	INTRINSIC
low complexity region	286	299	N/A	INTRINSIC
ZnF_C2H2	303	328	8.67e-1	SMART
low complexity region	340	352	N/A	INTRINSIC
low complexity region	401	415	N/A	INTRINSIC
FH	460	541	2.07e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000176850
AA Change: S392A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000135041
Gene: ENSMUSG00000030067
AA Change: S392A

Domain	Start	End	E-Value	Type
low complexity region	108	160	N/A	INTRINSIC
low complexity region	169	203	N/A	INTRINSIC
low complexity region	206	220	N/A	INTRINSIC
low complexity region	234	245	N/A	INTRINSIC
low complexity region	287	300	N/A	INTRINSIC
ZnF_C2H2	304	329	8.67e-1	SMART
low complexity region	341	353	N/A	INTRINSIC
low complexity region	402	416	N/A	INTRINSIC
FH	461	542	2.07e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000176565
AA Change: S423A

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000135181
Gene: ENSMUSG00000030067
AA Change: S423A

Domain	Start	End	E-Value	Type
coiled coil region	62	113	N/A	INTRINSIC
low complexity region	140	191	N/A	INTRINSIC
low complexity region	200	234	N/A	INTRINSIC
low complexity region	237	251	N/A	INTRINSIC
low complexity region	265	276	N/A	INTRINSIC
low complexity region	318	331	N/A	INTRINSIC
ZnF_C2H2	335	360	8.67e-1	SMART
low complexity region	372	384	N/A	INTRINSIC
low complexity region	433	447	N/A	INTRINSIC
FH	491	572	2.07e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000177229
AA Change: S294A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

SMART Domains

Protein: ENSMUSP00000134817
Gene: ENSMUSG00000030067
AA Change: S294A

Domain	Start	End	E-Value	Type
low complexity region	10	62	N/A	INTRINSIC
low complexity region	71	105	N/A	INTRINSIC
low complexity region	108	122	N/A	INTRINSIC
low complexity region	136	147	N/A	INTRINSIC
low complexity region	189	202	N/A	INTRINSIC
ZnF_C2H2	206	231	8.67e-1	SMART
low complexity region	243	255	N/A	INTRINSIC
low complexity region	304	318	N/A	INTRINSIC
FH	363	444	2.07e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000177230
AA Change: S392A

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000135098
Gene: ENSMUSG00000030067
AA Change: S392A

Domain	Start	End	E-Value	Type
low complexity region	108	160	N/A	INTRINSIC
low complexity region	169	203	N/A	INTRINSIC
low complexity region	206	220	N/A	INTRINSIC
low complexity region	234	245	N/A	INTRINSIC
low complexity region	287	300	N/A	INTRINSIC
ZnF_C2H2	304	329	8.67e-1	SMART
low complexity region	341	353	N/A	INTRINSIC
low complexity region	402	416	N/A	INTRINSIC
FH	461	542	2.07e-39	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000177437
AA Change: S293A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

SMART Domains

Protein: ENSMUSP00000135809
Gene: ENSMUSG00000030067
AA Change: S293A

Domain	Start	End	E-Value	Type
low complexity region	10	61	N/A	INTRINSIC
low complexity region	70	104	N/A	INTRINSIC
low complexity region	107	121	N/A	INTRINSIC
low complexity region	135	146	N/A	INTRINSIC
low complexity region	188	201	N/A	INTRINSIC
ZnF_C2H2	205	230	8.67e-1	SMART
low complexity region	242	254	N/A	INTRINSIC
low complexity region	303	317	N/A	INTRINSIC
FH	362	443	2.07e-39	SMART

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.5%
20x: 92.9%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous null mice display embryonic lethality with abnormal outflow tract septation, ventricular septal defects, abnormal cardiac valve morphology, decreased and irregular heart rate, thin ventricular compact zone, and edema. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 106 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310022A10Rik	A	G	7: 27,260,022 (GRCm39)	T25A	possibly damaging	Het
Abca17	T	C	17: 24,486,632 (GRCm39)	Y1465C	possibly damaging	Het
Adgrb1	C	T	15: 74,459,956 (GRCm39)	R530W	probably damaging	Het
Ak9	A	G	10: 41,203,585 (GRCm39)	T159A	possibly damaging	Het
Akap13	G	A	7: 75,259,340 (GRCm39)	G655S	possibly damaging	Het
Amer2	T	A	14: 60,617,123 (GRCm39)	D439E	possibly damaging	Het
Anxa2	TCCC	TCC	9: 69,397,036 (GRCm39)		probably null	Het
Arfgef2	T	A	2: 166,703,558 (GRCm39)	M870K	probably damaging	Het
Arhgef33	T	C	17: 80,656,935 (GRCm39)	F150S	probably damaging	Het
Arid2	A	T	15: 96,268,064 (GRCm39)	T726S	probably benign	Het
Atf7ip2	G	A	16: 10,052,195 (GRCm39)	V225I	probably damaging	Het
Atp12a	A	T	14: 56,603,545 (GRCm39)	E50V	probably damaging	Het
Bdkrb1	A	G	12: 105,570,761 (GRCm39)	N109S	probably benign	Het
Cald1	A	G	6: 34,722,646 (GRCm39)	E104G	probably damaging	Het
Capn15	A	G	17: 26,183,878 (GRCm39)	V267A	probably benign	Het
Ccng2	A	T	5: 93,421,241 (GRCm39)	K250N	possibly damaging	Het
Ccr10	T	A	11: 101,065,210 (GRCm39)	N107Y	probably benign	Het
Cntn2	T	C	1: 132,449,017 (GRCm39)	N664S	probably damaging	Het
Cyp24a1	T	G	2: 170,327,963 (GRCm39)	E426D	probably benign	Het
Cyp26a1	A	G	19: 37,689,626 (GRCm39)	S441G	probably benign	Het
Cyp4f14	T	A	17: 33,128,145 (GRCm39)	K290M	possibly damaging	Het
Dcp2	T	A	18: 44,533,391 (GRCm39)	L114Q	probably damaging	Het
Dhrs7	A	G	12: 72,699,894 (GRCm39)	F246S	possibly damaging	Het
Dlg1	T	C	16: 31,600,616 (GRCm39)	V167A	probably damaging	Het
Dnmt3b	A	T	2: 153,518,630 (GRCm39)	K598*	probably null	Het
Dph7	T	C	2: 24,859,692 (GRCm39)		probably null	Het
Ehbp1	T	C	11: 22,003,441 (GRCm39)	M1103V	probably damaging	Het
Ell2	T	C	13: 75,917,677 (GRCm39)	S536P	probably damaging	Het
Ero1a	A	T	14: 45,537,392 (GRCm39)	V178E	probably damaging	Het
Faf2	T	A	13: 54,786,067 (GRCm39)	*50R	probably null	Het
Fbxl14	A	T	6: 119,457,107 (GRCm39)	N96I	probably damaging	Het
Fcrl2	T	C	3: 87,166,825 (GRCm39)	Y56C	possibly damaging	Het
Foxc1	T	A	13: 31,992,782 (GRCm39)	M531K	unknown	Het
Frem2	A	T	3: 53,563,463 (GRCm39)	L348*	probably null	Het
Fsd1	T	A	17: 56,295,257 (GRCm39)		probably null	Het
Gab2	A	G	7: 96,872,840 (GRCm39)	E81G	probably damaging	Het
Gcat	G	A	15: 78,919,995 (GRCm39)	V196M	probably damaging	Het
Gfy	T	C	7: 44,827,470 (GRCm39)	T209A	possibly damaging	Het
Ggt7	T	C	2: 155,336,899 (GRCm39)	N531S	possibly damaging	Het
Gnai3	A	G	3: 108,016,775 (GRCm39)	I343T	probably damaging	Het
H2-DMa	A	T	17: 34,357,387 (GRCm39)	Q220L	probably benign	Het
Heatr1	A	G	13: 12,438,602 (GRCm39)	I1346V	possibly damaging	Het
Igfbp1	T	A	11: 7,147,978 (GRCm39)	V7D	probably benign	Het
Igfbp1	T	C	11: 7,151,922 (GRCm39)	W242R	probably damaging	Het
Kbtbd2	T	G	6: 56,756,326 (GRCm39)	K470T	probably benign	Het
Klb	G	C	5: 65,506,089 (GRCm39)	R112P	possibly damaging	Het
Klhl25	G	T	7: 75,516,591 (GRCm39)	G499V	probably damaging	Het
Krt7	A	T	15: 101,321,307 (GRCm39)	T375S	probably benign	Het
Krt73	G	A	15: 101,708,344 (GRCm39)	L238F	probably damaging	Het
Lama5	G	T	2: 179,844,279 (GRCm39)	H331Q	probably damaging	Het
Leng8	T	G	7: 4,148,135 (GRCm39)	F663V	probably damaging	Het
Lrp12	G	T	15: 39,741,757 (GRCm39)	H338Q	probably damaging	Het
Lrp6	T	A	6: 134,445,686 (GRCm39)	R1042S	probably damaging	Het
Map6	T	A	7: 98,966,664 (GRCm39)		probably null	Het
Mdn1	T	C	4: 32,700,417 (GRCm39)	F1459L	possibly damaging	Het
Mmp1b	T	C	9: 7,386,699 (GRCm39)	T142A	probably damaging	Het
Mmp23	T	A	4: 155,735,166 (GRCm39)	*392C	probably null	Het
Nlrp4a	C	T	7: 26,149,959 (GRCm39)	S522F	probably damaging	Het
Nup93	T	G	8: 95,023,183 (GRCm39)	F254V	probably benign	Het
Oas1h	G	T	5: 121,000,885 (GRCm39)		probably null	Het
Ocstamp	A	G	2: 165,238,094 (GRCm39)	L390P	probably damaging	Het
Olfm1	C	A	2: 28,098,128 (GRCm39)	Y20*	probably null	Het
Or10ac1	C	T	6: 42,515,537 (GRCm39)	V140M	probably benign	Het
Or13a26	A	T	7: 140,284,409 (GRCm39)	K82*	probably null	Het
Or52ae7	T	C	7: 103,119,384 (GRCm39)	V46A	probably benign	Het
Or5as1	A	G	2: 86,980,724 (GRCm39)	F94L	probably benign	Het
Or7g33	A	G	9: 19,449,190 (GRCm39)	F12S	probably damaging	Het
Pgghg	T	C	7: 140,525,224 (GRCm39)	V410A	possibly damaging	Het
Polr2b	T	A	5: 77,490,495 (GRCm39)	D878E	probably benign	Het
Pspc1	T	C	14: 57,001,700 (GRCm39)	T225A	probably benign	Het
Rad21l	A	T	2: 151,510,447 (GRCm39)	Y3N	probably damaging	Het
Rbl2	A	G	8: 91,812,352 (GRCm39)	N280S	probably benign	Het
Rdm1	C	A	11: 101,521,694 (GRCm39)	Q150K	probably benign	Het
Ro60	T	A	1: 143,633,575 (GRCm39)	I508F	probably damaging	Het
Rrp12	A	T	19: 41,862,188 (GRCm39)	F932I	probably damaging	Het
Ryr2	A	T	13: 11,746,543 (GRCm39)	M2003K	probably benign	Het
Scfd2	T	C	5: 74,691,539 (GRCm39)	T248A	probably benign	Het
Slc22a16	G	A	10: 40,460,923 (GRCm39)	A242T	possibly damaging	Het
Slit3	C	A	11: 35,566,750 (GRCm39)	N1007K	probably damaging	Het
Sntg2	C	A	12: 30,317,062 (GRCm39)	G187C	probably damaging	Het
Spag5	T	C	11: 78,212,152 (GRCm39)	V1060A	probably damaging	Het
Spg7	G	A	8: 123,816,964 (GRCm39)	V552I	probably benign	Het
Spns2	T	A	11: 72,347,173 (GRCm39)	T434S	probably benign	Het
Srpk2	C	T	5: 23,753,492 (GRCm39)	W87*	probably null	Het
St3gal3	T	C	4: 117,797,589 (GRCm39)	I268V	possibly damaging	Het
Stat6	T	C	10: 127,488,918 (GRCm39)	C356R	probably damaging	Het
Stx8	A	G	11: 67,902,248 (GRCm39)	Q144R	probably damaging	Het
Tcn2	C	A	11: 3,872,169 (GRCm39)	L319F	probably damaging	Het
Tex14	T	C	11: 87,402,371 (GRCm39)	I486T	possibly damaging	Het
Thtpa	T	C	14: 55,333,242 (GRCm39)	V109A	probably benign	Het
Tmem127	C	A	2: 127,090,627 (GRCm39)	L48I	probably damaging	Het
Tnfaip8	A	T	18: 50,223,290 (GRCm39)	K9*	probably null	Het
Tnfrsf1b	T	A	4: 144,954,044 (GRCm39)	T102S	probably benign	Het
Tor1aip1	A	T	1: 155,893,262 (GRCm39)	M110K	possibly damaging	Het
Trim10	A	T	17: 37,188,073 (GRCm39)	K430*	probably null	Het
Trpv6	A	G	6: 41,598,702 (GRCm39)	V641A	possibly damaging	Het
Ttf1	T	G	2: 28,960,014 (GRCm39)	Y541D	probably damaging	Het
Ttn	A	G	2: 76,594,750 (GRCm39)	V20432A	probably damaging	Het
Vac14	A	T	8: 111,359,079 (GRCm39)		probably null	Het
Vipr2	G	T	12: 116,102,777 (GRCm39)	A296S	probably benign	Het
Vmn1r1	T	C	1: 181,985,624 (GRCm39)	R14G	probably benign	Het
Vmn1r178	T	A	7: 23,593,625 (GRCm39)	N151K	probably damaging	Het
Vmn1r58	T	A	7: 5,413,727 (GRCm39)	I168F	possibly damaging	Het
Vmn1r77	C	T	7: 11,775,547 (GRCm39)	Q40*	probably null	Het
Vmn2r76	T	C	7: 85,880,464 (GRCm39)	N74S	possibly damaging	Het
Zc2hc1c	T	A	12: 85,337,555 (GRCm39)	M404K	possibly damaging	Het

Other mutations in Foxp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02191:Foxp1	APN	6	98,922,561 (GRCm39)	missense	probably damaging	0.99
IGL02330:Foxp1	APN	6	98,922,373 (GRCm39)	missense	probably damaging	1.00
IGL02869:Foxp1	APN	6	98,907,044 (GRCm39)	utr 3 prime	probably benign
IGL02968:Foxp1	APN	6	99,052,822 (GRCm39)	missense	probably damaging	1.00
Foxy	UTSW	6	98,992,471 (GRCm39)	nonsense	probably null
Moxie	UTSW	6	98,992,475 (GRCm39)	critical splice acceptor site	probably null
Roxie	UTSW	6	98,918,595 (GRCm39)	missense	unknown
R0037:Foxp1	UTSW	6	99,139,930 (GRCm39)	missense	probably damaging	1.00
R0063:Foxp1	UTSW	6	98,921,684 (GRCm39)	splice site	probably benign
R0063:Foxp1	UTSW	6	98,921,684 (GRCm39)	splice site	probably benign
R0427:Foxp1	UTSW	6	98,907,164 (GRCm39)	missense	probably damaging	1.00
R0601:Foxp1	UTSW	6	98,907,083 (GRCm39)	missense	probably damaging	1.00
R1356:Foxp1	UTSW	6	98,993,637 (GRCm39)	splice site	probably benign
R1468:Foxp1	UTSW	6	98,955,181 (GRCm39)	missense	possibly damaging	0.62
R1468:Foxp1	UTSW	6	98,955,181 (GRCm39)	missense	possibly damaging	0.62
R1548:Foxp1	UTSW	6	98,922,381 (GRCm39)	missense	probably damaging	1.00
R1933:Foxp1	UTSW	6	99,052,926 (GRCm39)	small deletion	probably benign
R2152:Foxp1	UTSW	6	98,993,502 (GRCm39)	missense	probably damaging	0.99
R2338:Foxp1	UTSW	6	98,980,254 (GRCm39)	missense	possibly damaging	0.61
R3896:Foxp1	UTSW	6	99,052,897 (GRCm39)	missense	probably benign	0.33
R5006:Foxp1	UTSW	6	99,139,819 (GRCm39)	missense	probably damaging	0.98
R5143:Foxp1	UTSW	6	98,922,493 (GRCm39)	critical splice donor site	probably null
R5428:Foxp1	UTSW	6	98,993,592 (GRCm39)	missense	probably damaging	1.00
R5765:Foxp1	UTSW	6	98,992,423 (GRCm39)	missense	probably damaging	0.99
R5816:Foxp1	UTSW	6	99,052,926 (GRCm39)	small deletion	probably benign
R6172:Foxp1	UTSW	6	98,992,475 (GRCm39)	critical splice acceptor site	probably null
R6172:Foxp1	UTSW	6	98,992,471 (GRCm39)	nonsense	probably null
R6173:Foxp1	UTSW	6	98,992,475 (GRCm39)	critical splice acceptor site	probably null
R6173:Foxp1	UTSW	6	98,992,471 (GRCm39)	nonsense	probably null
R6175:Foxp1	UTSW	6	98,943,037 (GRCm39)	missense	probably damaging	1.00
R6776:Foxp1	UTSW	6	99,052,926 (GRCm39)	small deletion	probably benign
R6782:Foxp1	UTSW	6	98,907,106 (GRCm39)	missense	probably damaging	1.00
R7229:Foxp1	UTSW	6	98,912,373 (GRCm39)	missense	unknown
R7559:Foxp1	UTSW	6	98,922,521 (GRCm39)	missense	unknown
R7715:Foxp1	UTSW	6	98,922,621 (GRCm39)	missense	unknown
R8007:Foxp1	UTSW	6	98,918,595 (GRCm39)	missense	unknown
R8099:Foxp1	UTSW	6	98,922,510 (GRCm39)	missense	unknown
R8317:Foxp1	UTSW	6	99,052,866 (GRCm39)	small deletion	probably benign
R8408:Foxp1	UTSW	6	98,922,543 (GRCm39)	missense	unknown
R8704:Foxp1	UTSW	6	98,993,507 (GRCm39)	missense	unknown
R8705:Foxp1	UTSW	6	98,993,507 (GRCm39)	missense	unknown
R9014:Foxp1	UTSW	6	99,052,866 (GRCm39)	small deletion	probably benign
R9147:Foxp1	UTSW	6	99,052,866 (GRCm39)	small deletion	probably benign
R9399:Foxp1	UTSW	6	99,052,866 (GRCm39)	small deletion	probably benign
R9604:Foxp1	UTSW	6	99,052,926 (GRCm39)	small deletion	probably benign
X0066:Foxp1	UTSW	6	99,052,976 (GRCm39)	nonsense	probably null
Z1177:Foxp1	UTSW	6	98,955,122 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- ACGTTGTATTTGTCTGAGTACCGCC -3'
(R):5'- CTTGCTGCTGTGCAAAGGAGAATC -3'

Sequencing Primer
(F):5'- AGTACCGCCTGCGGATAG -3'
(R):5'- TGTGTCCCGTGTAAACATACCAG -3'

Posted On

2014-05-14