Incidental Mutation 'R1696:Ccr10'
ID 192261
Institutional Source Beutler Lab
Gene Symbol Ccr10
Ensembl Gene ENSMUSG00000044052
Gene Name C-C motif chemokine receptor 10
Synonyms GPR2, Cmkbr9, CCR10
MMRRC Submission 039729-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1696 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 101063824-101066269 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 101065210 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Tyrosine at position 107 (N107Y)
Ref Sequence ENSEMBL: ENSMUSP00000062588 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043397] [ENSMUST00000062759] [ENSMUST00000103109] [ENSMUST00000123864] [ENSMUST00000129895] [ENSMUST00000164474]
AlphaFold Q9JL21
Predicted Effect probably benign
Transcript: ENSMUST00000043397
SMART Domains Protein: ENSMUSP00000046044
Gene: ENSMUSG00000035172

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
low complexity region 23 40 N/A INTRINSIC
PH 96 201 1.9e-5 SMART
low complexity region 241 251 N/A INTRINSIC
Pfam:MyTH4 285 398 4.2e-21 PFAM
B41 400 664 2.91e-4 SMART
low complexity region 750 766 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000062759
AA Change: N107Y

PolyPhen 2 Score 0.251 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000062588
Gene: ENSMUSG00000044052
AA Change: N107Y

DomainStartEndE-ValueType
Pfam:7tm_1 58 310 4.8e-43 PFAM
low complexity region 313 329 N/A INTRINSIC
low complexity region 336 349 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000103109
SMART Domains Protein: ENSMUSP00000099398
Gene: ENSMUSG00000017167

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
FA58C 25 169 7.49e-36 SMART
LamG 196 333 2.86e-32 SMART
LamG 382 516 3.49e-27 SMART
EGF 544 578 2.28e0 SMART
Blast:FBG 580 777 1e-133 BLAST
LamG 806 940 1.95e-25 SMART
EGF_like 961 997 6.03e1 SMART
low complexity region 1032 1044 N/A INTRINSIC
low complexity region 1047 1058 N/A INTRINSIC
low complexity region 1063 1078 N/A INTRINSIC
LamG 1081 1219 2.59e-30 SMART
4.1m 1305 1323 7.85e-7 SMART
low complexity region 1333 1370 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000123864
SMART Domains Protein: ENSMUSP00000120865
Gene: ENSMUSG00000035172

DomainStartEndE-ValueType
PH 95 200 1.9e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000129895
SMART Domains Protein: ENSMUSP00000137841
Gene: ENSMUSG00000035172

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
low complexity region 23 40 N/A INTRINSIC
PH 96 201 1.9e-5 SMART
low complexity region 241 251 N/A INTRINSIC
Pfam:MyTH4 281 399 2.7e-16 PFAM
B41 400 664 5.17e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138942
Predicted Effect probably benign
Transcript: ENSMUST00000164474
SMART Domains Protein: ENSMUSP00000127088
Gene: ENSMUSG00000035172

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
low complexity region 23 40 N/A INTRINSIC
PH 96 201 1.9e-5 SMART
low complexity region 241 251 N/A INTRINSIC
Pfam:MyTH4 281 399 3.3e-16 PFAM
B41 400 661 6.14e-4 SMART
low complexity region 747 763 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 92.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for null mutation are viable and fertile, without any detectable neurological abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 106 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310022A10Rik A G 7: 27,260,022 (GRCm39) T25A possibly damaging Het
Abca17 T C 17: 24,486,632 (GRCm39) Y1465C possibly damaging Het
Adgrb1 C T 15: 74,459,956 (GRCm39) R530W probably damaging Het
Ak9 A G 10: 41,203,585 (GRCm39) T159A possibly damaging Het
Akap13 G A 7: 75,259,340 (GRCm39) G655S possibly damaging Het
Amer2 T A 14: 60,617,123 (GRCm39) D439E possibly damaging Het
Anxa2 TCCC TCC 9: 69,397,036 (GRCm39) probably null Het
Arfgef2 T A 2: 166,703,558 (GRCm39) M870K probably damaging Het
Arhgef33 T C 17: 80,656,935 (GRCm39) F150S probably damaging Het
Arid2 A T 15: 96,268,064 (GRCm39) T726S probably benign Het
Atf7ip2 G A 16: 10,052,195 (GRCm39) V225I probably damaging Het
Atp12a A T 14: 56,603,545 (GRCm39) E50V probably damaging Het
Bdkrb1 A G 12: 105,570,761 (GRCm39) N109S probably benign Het
Cald1 A G 6: 34,722,646 (GRCm39) E104G probably damaging Het
Capn15 A G 17: 26,183,878 (GRCm39) V267A probably benign Het
Ccng2 A T 5: 93,421,241 (GRCm39) K250N possibly damaging Het
Cntn2 T C 1: 132,449,017 (GRCm39) N664S probably damaging Het
Cyp24a1 T G 2: 170,327,963 (GRCm39) E426D probably benign Het
Cyp26a1 A G 19: 37,689,626 (GRCm39) S441G probably benign Het
Cyp4f14 T A 17: 33,128,145 (GRCm39) K290M possibly damaging Het
Dcp2 T A 18: 44,533,391 (GRCm39) L114Q probably damaging Het
Dhrs7 A G 12: 72,699,894 (GRCm39) F246S possibly damaging Het
Dlg1 T C 16: 31,600,616 (GRCm39) V167A probably damaging Het
Dnmt3b A T 2: 153,518,630 (GRCm39) K598* probably null Het
Dph7 T C 2: 24,859,692 (GRCm39) probably null Het
Ehbp1 T C 11: 22,003,441 (GRCm39) M1103V probably damaging Het
Ell2 T C 13: 75,917,677 (GRCm39) S536P probably damaging Het
Ero1a A T 14: 45,537,392 (GRCm39) V178E probably damaging Het
Faf2 T A 13: 54,786,067 (GRCm39) *50R probably null Het
Fbxl14 A T 6: 119,457,107 (GRCm39) N96I probably damaging Het
Fcrl2 T C 3: 87,166,825 (GRCm39) Y56C possibly damaging Het
Foxc1 T A 13: 31,992,782 (GRCm39) M531K unknown Het
Foxp1 A C 6: 98,922,663 (GRCm39) S391A probably benign Het
Frem2 A T 3: 53,563,463 (GRCm39) L348* probably null Het
Fsd1 T A 17: 56,295,257 (GRCm39) probably null Het
Gab2 A G 7: 96,872,840 (GRCm39) E81G probably damaging Het
Gcat G A 15: 78,919,995 (GRCm39) V196M probably damaging Het
Gfy T C 7: 44,827,470 (GRCm39) T209A possibly damaging Het
Ggt7 T C 2: 155,336,899 (GRCm39) N531S possibly damaging Het
Gnai3 A G 3: 108,016,775 (GRCm39) I343T probably damaging Het
H2-DMa A T 17: 34,357,387 (GRCm39) Q220L probably benign Het
Heatr1 A G 13: 12,438,602 (GRCm39) I1346V possibly damaging Het
Igfbp1 T A 11: 7,147,978 (GRCm39) V7D probably benign Het
Igfbp1 T C 11: 7,151,922 (GRCm39) W242R probably damaging Het
Kbtbd2 T G 6: 56,756,326 (GRCm39) K470T probably benign Het
Klb G C 5: 65,506,089 (GRCm39) R112P possibly damaging Het
Klhl25 G T 7: 75,516,591 (GRCm39) G499V probably damaging Het
Krt7 A T 15: 101,321,307 (GRCm39) T375S probably benign Het
Krt73 G A 15: 101,708,344 (GRCm39) L238F probably damaging Het
Lama5 G T 2: 179,844,279 (GRCm39) H331Q probably damaging Het
Leng8 T G 7: 4,148,135 (GRCm39) F663V probably damaging Het
Lrp12 G T 15: 39,741,757 (GRCm39) H338Q probably damaging Het
Lrp6 T A 6: 134,445,686 (GRCm39) R1042S probably damaging Het
Map6 T A 7: 98,966,664 (GRCm39) probably null Het
Mdn1 T C 4: 32,700,417 (GRCm39) F1459L possibly damaging Het
Mmp1b T C 9: 7,386,699 (GRCm39) T142A probably damaging Het
Mmp23 T A 4: 155,735,166 (GRCm39) *392C probably null Het
Nlrp4a C T 7: 26,149,959 (GRCm39) S522F probably damaging Het
Nup93 T G 8: 95,023,183 (GRCm39) F254V probably benign Het
Oas1h G T 5: 121,000,885 (GRCm39) probably null Het
Ocstamp A G 2: 165,238,094 (GRCm39) L390P probably damaging Het
Olfm1 C A 2: 28,098,128 (GRCm39) Y20* probably null Het
Or10ac1 C T 6: 42,515,537 (GRCm39) V140M probably benign Het
Or13a26 A T 7: 140,284,409 (GRCm39) K82* probably null Het
Or52ae7 T C 7: 103,119,384 (GRCm39) V46A probably benign Het
Or5as1 A G 2: 86,980,724 (GRCm39) F94L probably benign Het
Or7g33 A G 9: 19,449,190 (GRCm39) F12S probably damaging Het
Pgghg T C 7: 140,525,224 (GRCm39) V410A possibly damaging Het
Polr2b T A 5: 77,490,495 (GRCm39) D878E probably benign Het
Pspc1 T C 14: 57,001,700 (GRCm39) T225A probably benign Het
Rad21l A T 2: 151,510,447 (GRCm39) Y3N probably damaging Het
Rbl2 A G 8: 91,812,352 (GRCm39) N280S probably benign Het
Rdm1 C A 11: 101,521,694 (GRCm39) Q150K probably benign Het
Ro60 T A 1: 143,633,575 (GRCm39) I508F probably damaging Het
Rrp12 A T 19: 41,862,188 (GRCm39) F932I probably damaging Het
Ryr2 A T 13: 11,746,543 (GRCm39) M2003K probably benign Het
Scfd2 T C 5: 74,691,539 (GRCm39) T248A probably benign Het
Slc22a16 G A 10: 40,460,923 (GRCm39) A242T possibly damaging Het
Slit3 C A 11: 35,566,750 (GRCm39) N1007K probably damaging Het
Sntg2 C A 12: 30,317,062 (GRCm39) G187C probably damaging Het
Spag5 T C 11: 78,212,152 (GRCm39) V1060A probably damaging Het
Spg7 G A 8: 123,816,964 (GRCm39) V552I probably benign Het
Spns2 T A 11: 72,347,173 (GRCm39) T434S probably benign Het
Srpk2 C T 5: 23,753,492 (GRCm39) W87* probably null Het
St3gal3 T C 4: 117,797,589 (GRCm39) I268V possibly damaging Het
Stat6 T C 10: 127,488,918 (GRCm39) C356R probably damaging Het
Stx8 A G 11: 67,902,248 (GRCm39) Q144R probably damaging Het
Tcn2 C A 11: 3,872,169 (GRCm39) L319F probably damaging Het
Tex14 T C 11: 87,402,371 (GRCm39) I486T possibly damaging Het
Thtpa T C 14: 55,333,242 (GRCm39) V109A probably benign Het
Tmem127 C A 2: 127,090,627 (GRCm39) L48I probably damaging Het
Tnfaip8 A T 18: 50,223,290 (GRCm39) K9* probably null Het
Tnfrsf1b T A 4: 144,954,044 (GRCm39) T102S probably benign Het
Tor1aip1 A T 1: 155,893,262 (GRCm39) M110K possibly damaging Het
Trim10 A T 17: 37,188,073 (GRCm39) K430* probably null Het
Trpv6 A G 6: 41,598,702 (GRCm39) V641A possibly damaging Het
Ttf1 T G 2: 28,960,014 (GRCm39) Y541D probably damaging Het
Ttn A G 2: 76,594,750 (GRCm39) V20432A probably damaging Het
Vac14 A T 8: 111,359,079 (GRCm39) probably null Het
Vipr2 G T 12: 116,102,777 (GRCm39) A296S probably benign Het
Vmn1r1 T C 1: 181,985,624 (GRCm39) R14G probably benign Het
Vmn1r178 T A 7: 23,593,625 (GRCm39) N151K probably damaging Het
Vmn1r58 T A 7: 5,413,727 (GRCm39) I168F possibly damaging Het
Vmn1r77 C T 7: 11,775,547 (GRCm39) Q40* probably null Het
Vmn2r76 T C 7: 85,880,464 (GRCm39) N74S possibly damaging Het
Zc2hc1c T A 12: 85,337,555 (GRCm39) M404K possibly damaging Het
Other mutations in Ccr10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02887:Ccr10 APN 11 101,065,492 (GRCm39) missense probably benign 0.01
R1523:Ccr10 UTSW 11 101,064,501 (GRCm39) missense probably damaging 0.98
R5275:Ccr10 UTSW 11 101,065,111 (GRCm39) missense possibly damaging 0.92
R5295:Ccr10 UTSW 11 101,065,111 (GRCm39) missense possibly damaging 0.92
R5418:Ccr10 UTSW 11 101,064,904 (GRCm39) missense probably benign 0.16
R6219:Ccr10 UTSW 11 101,065,375 (GRCm39) missense possibly damaging 0.85
R7161:Ccr10 UTSW 11 101,065,104 (GRCm39) missense probably benign 0.02
R7674:Ccr10 UTSW 11 101,065,475 (GRCm39) missense probably benign
R8458:Ccr10 UTSW 11 101,064,982 (GRCm39) missense probably damaging 1.00
R9596:Ccr10 UTSW 11 101,065,018 (GRCm39) missense probably benign
Z1176:Ccr10 UTSW 11 101,065,166 (GRCm39) frame shift probably null
Z1176:Ccr10 UTSW 11 101,065,149 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCACAGTCTGCGTGAGGCTTTC -3'
(R):5'- ACAAGGCTGATGTCCAGGCTTTC -3'

Sequencing Primer
(F):5'- AATGAGCCGACAGCGTC -3'
(R):5'- ATGTCCAGGCTTTCAGTCG -3'
Posted On 2014-05-14