Incidental Mutation 'R1698:Mprip'
| ID |
192429 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mprip
|
| Ensembl Gene |
ENSMUSG00000005417 |
| Gene Name |
myosin phosphatase Rho interacting protein |
| Synonyms |
p116 Rho interacting protein, p116Rip, Gm34094, RIP3, Rhoip3 |
| MMRRC Submission |
039731-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.669)
|
| Stock # |
R1698 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
59552973-59671686 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 59651084 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Glutamine
at position 1596
(L1596Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000071081
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000066330]
[ENSMUST00000072031]
[ENSMUST00000108751]
[ENSMUST00000116371]
[ENSMUST00000133861]
|
| AlphaFold |
P97434 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000066330
AA Change: L1596Q
PolyPhen 2
Score 0.753 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000071081
Gene: ENSMUSG00000005417
AA Change: L1596Q
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
44 |
152 |
3.33e-10 |
SMART |
|
low complexity region
|
179 |
190 |
N/A |
INTRINSIC |
|
low complexity region
|
221 |
234 |
N/A |
INTRINSIC |
|
Blast:PH
|
249 |
320 |
1e-10 |
BLAST |
|
PH
|
351 |
448 |
3.76e-18 |
SMART |
|
low complexity region
|
492 |
501 |
N/A |
INTRINSIC |
|
low complexity region
|
536 |
555 |
N/A |
INTRINSIC |
|
coiled coil region
|
636 |
671 |
N/A |
INTRINSIC |
|
Blast:PAC
|
806 |
848 |
2e-10 |
BLAST |
|
low complexity region
|
1005 |
1023 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1059 |
N/A |
INTRINSIC |
|
low complexity region
|
1114 |
1128 |
N/A |
INTRINSIC |
|
low complexity region
|
1183 |
1200 |
N/A |
INTRINSIC |
|
coiled coil region
|
1267 |
1300 |
N/A |
INTRINSIC |
|
coiled coil region
|
1617 |
1642 |
N/A |
INTRINSIC |
|
coiled coil region
|
1729 |
1779 |
N/A |
INTRINSIC |
|
coiled coil region
|
1899 |
1936 |
N/A |
INTRINSIC |
|
coiled coil region
|
1960 |
2110 |
N/A |
INTRINSIC |
|
coiled coil region
|
2132 |
2206 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000072031
|
| SMART Domains |
Protein: ENSMUSP00000071914
Gene: ENSMUSG00000005417
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
44 |
152 |
3.33e-10 |
SMART |
|
low complexity region
|
179 |
190 |
N/A |
INTRINSIC |
|
low complexity region
|
221 |
234 |
N/A |
INTRINSIC |
|
Blast:PH
|
254 |
320 |
1e-10 |
BLAST |
|
PH
|
387 |
484 |
3.76e-18 |
SMART |
|
low complexity region
|
528 |
537 |
N/A |
INTRINSIC |
|
low complexity region
|
572 |
591 |
N/A |
INTRINSIC |
|
coiled coil region
|
672 |
707 |
N/A |
INTRINSIC |
|
coiled coil region
|
728 |
878 |
N/A |
INTRINSIC |
|
coiled coil region
|
900 |
974 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108751
|
| SMART Domains |
Protein: ENSMUSP00000104382
Gene: ENSMUSG00000005417
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
44 |
152 |
3.33e-10 |
SMART |
|
low complexity region
|
183 |
196 |
N/A |
INTRINSIC |
|
Blast:PH
|
216 |
282 |
1e-10 |
BLAST |
|
PH
|
349 |
446 |
3.76e-18 |
SMART |
|
low complexity region
|
490 |
499 |
N/A |
INTRINSIC |
|
low complexity region
|
534 |
553 |
N/A |
INTRINSIC |
|
coiled coil region
|
634 |
669 |
N/A |
INTRINSIC |
|
coiled coil region
|
690 |
840 |
N/A |
INTRINSIC |
|
coiled coil region
|
862 |
936 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000116371
|
| SMART Domains |
Protein: ENSMUSP00000112072
Gene: ENSMUSG00000005417
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
44 |
152 |
3.33e-10 |
SMART |
|
low complexity region
|
179 |
190 |
N/A |
INTRINSIC |
|
low complexity region
|
221 |
234 |
N/A |
INTRINSIC |
|
Blast:PH
|
254 |
320 |
1e-10 |
BLAST |
|
PH
|
387 |
484 |
3.76e-18 |
SMART |
|
low complexity region
|
528 |
537 |
N/A |
INTRINSIC |
|
low complexity region
|
572 |
591 |
N/A |
INTRINSIC |
|
coiled coil region
|
672 |
707 |
N/A |
INTRINSIC |
|
coiled coil region
|
728 |
878 |
N/A |
INTRINSIC |
|
coiled coil region
|
900 |
974 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000132620
|
| SMART Domains |
Protein: ENSMUSP00000119422
Gene: ENSMUSG00000005417
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
26 |
37 |
N/A |
INTRINSIC |
|
low complexity region
|
68 |
81 |
N/A |
INTRINSIC |
|
Blast:PH
|
101 |
167 |
9e-11 |
BLAST |
|
PH
|
198 |
295 |
3.76e-18 |
SMART |
|
low complexity region
|
339 |
348 |
N/A |
INTRINSIC |
|
low complexity region
|
383 |
402 |
N/A |
INTRINSIC |
|
coiled coil region
|
482 |
517 |
N/A |
INTRINSIC |
|
coiled coil region
|
538 |
688 |
N/A |
INTRINSIC |
|
coiled coil region
|
710 |
784 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000133861
|
| SMART Domains |
Protein: ENSMUSP00000119562
Gene: ENSMUSG00000005417
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
18 |
29 |
N/A |
INTRINSIC |
|
low complexity region
|
47 |
58 |
N/A |
INTRINSIC |
|
low complexity region
|
89 |
102 |
N/A |
INTRINSIC |
|
low complexity region
|
152 |
162 |
N/A |
INTRINSIC |
|
low complexity region
|
259 |
269 |
N/A |
INTRINSIC |
|
PH
|
373 |
470 |
3.76e-18 |
SMART |
|
low complexity region
|
514 |
523 |
N/A |
INTRINSIC |
|
low complexity region
|
558 |
577 |
N/A |
INTRINSIC |
|
coiled coil region
|
658 |
693 |
N/A |
INTRINSIC |
|
coiled coil region
|
714 |
864 |
N/A |
INTRINSIC |
|
coiled coil region
|
886 |
960 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156111
|
| SMART Domains |
Protein: ENSMUSP00000114446
Gene: ENSMUSG00000005417
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
5 |
38 |
1.61e-7 |
PROSPERO |
|
internal_repeat_2
|
9 |
51 |
2.4e-6 |
PROSPERO |
|
internal_repeat_1
|
59 |
92 |
1.61e-7 |
PROSPERO |
|
internal_repeat_2
|
85 |
129 |
2.4e-6 |
PROSPERO |
|
coiled coil region
|
140 |
177 |
N/A |
INTRINSIC |
|
coiled coil region
|
201 |
351 |
N/A |
INTRINSIC |
|
coiled coil region
|
373 |
447 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.6%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A2m |
A |
C |
6: 121,622,117 (GRCm39) |
E340A |
possibly damaging |
Het |
| Abca13 |
A |
G |
11: 9,264,507 (GRCm39) |
D2963G |
probably benign |
Het |
| Actn3 |
T |
C |
19: 4,912,235 (GRCm39) |
D783G |
possibly damaging |
Het |
| Adamtsl2 |
A |
G |
2: 26,993,139 (GRCm39) |
E723G |
possibly damaging |
Het |
| Agrn |
G |
T |
4: 156,251,015 (GRCm39) |
Q1931K |
probably benign |
Het |
| Ankrd27 |
G |
A |
7: 35,313,946 (GRCm39) |
A426T |
probably benign |
Het |
| Atg9b |
C |
A |
5: 24,593,186 (GRCm39) |
G406C |
probably damaging |
Het |
| C1ra |
A |
T |
6: 124,499,725 (GRCm39) |
Q637L |
probably benign |
Het |
| Cdhr2 |
A |
T |
13: 54,867,394 (GRCm39) |
M438L |
probably benign |
Het |
| Cep350 |
T |
C |
1: 155,829,104 (GRCm39) |
I267V |
possibly damaging |
Het |
| Chrna5 |
A |
G |
9: 54,911,926 (GRCm39) |
Y138C |
probably damaging |
Het |
| Chst3 |
T |
A |
10: 60,021,525 (GRCm39) |
M441L |
probably benign |
Het |
| Cmya5 |
G |
A |
13: 93,200,027 (GRCm39) |
P3434S |
probably benign |
Het |
| Cog2 |
T |
A |
8: 125,252,422 (GRCm39) |
L42Q |
probably damaging |
Het |
| Cpq |
A |
T |
15: 33,250,272 (GRCm39) |
I210F |
probably benign |
Het |
| Crnn |
C |
A |
3: 93,055,765 (GRCm39) |
Q184K |
probably damaging |
Het |
| Csnka2ip |
A |
T |
16: 64,298,422 (GRCm39) |
Y647* |
probably null |
Het |
| D5Ertd579e |
C |
T |
5: 36,761,874 (GRCm39) |
R1331H |
probably benign |
Het |
| Dennd5a |
C |
T |
7: 109,516,587 (GRCm39) |
|
probably null |
Het |
| Dync1h1 |
A |
G |
12: 110,593,426 (GRCm39) |
Q1231R |
possibly damaging |
Het |
| Erbin |
T |
A |
13: 103,970,239 (GRCm39) |
I1126F |
possibly damaging |
Het |
| Fastkd1 |
T |
C |
2: 69,532,813 (GRCm39) |
D518G |
probably benign |
Het |
| Gcc1 |
A |
G |
6: 28,421,110 (GRCm39) |
L69P |
possibly damaging |
Het |
| Gkn1 |
T |
C |
6: 87,324,151 (GRCm39) |
Y119C |
probably damaging |
Het |
| Gmpr |
T |
G |
13: 45,670,520 (GRCm39) |
W81G |
probably benign |
Het |
| Gyg1 |
T |
A |
3: 20,192,215 (GRCm39) |
I236F |
probably benign |
Het |
| Hcrtr2 |
T |
C |
9: 76,153,735 (GRCm39) |
Y219C |
probably damaging |
Het |
| Hmcn1 |
G |
A |
1: 150,441,120 (GRCm39) |
Q5379* |
probably null |
Het |
| Kank1 |
T |
C |
19: 25,388,681 (GRCm39) |
C785R |
probably benign |
Het |
| Lrp1b |
A |
T |
2: 40,741,818 (GRCm39) |
C3036* |
probably null |
Het |
| Mdga2 |
T |
C |
12: 66,736,109 (GRCm39) |
D373G |
probably damaging |
Het |
| Mgat2 |
A |
T |
12: 69,232,493 (GRCm39) |
I356F |
probably benign |
Het |
| Miga2 |
A |
G |
2: 30,268,009 (GRCm39) |
D346G |
probably damaging |
Het |
| Mroh2b |
G |
A |
15: 4,943,622 (GRCm39) |
R386Q |
probably benign |
Het |
| Mst1r |
T |
A |
9: 107,797,179 (GRCm39) |
S1349R |
probably benign |
Het |
| Mtmr3 |
C |
T |
11: 4,442,825 (GRCm39) |
R403H |
possibly damaging |
Het |
| Mycbpap |
G |
A |
11: 94,398,969 (GRCm39) |
Q460* |
probably null |
Het |
| Myo9a |
T |
C |
9: 59,775,464 (GRCm39) |
V1025A |
probably benign |
Het |
| Ncapd2 |
C |
T |
6: 125,145,553 (GRCm39) |
E1365K |
probably null |
Het |
| Nkiras2 |
C |
A |
11: 100,515,989 (GRCm39) |
D105E |
probably damaging |
Het |
| Nolc1 |
T |
G |
19: 46,069,870 (GRCm39) |
|
probably null |
Het |
| Nos1 |
T |
C |
5: 118,005,297 (GRCm39) |
F6L |
probably benign |
Het |
| Or10j3 |
A |
T |
1: 173,030,938 (GRCm39) |
N5I |
probably damaging |
Het |
| Or12e1 |
G |
T |
2: 87,022,081 (GRCm39) |
V17L |
probably benign |
Het |
| Or2t46 |
T |
C |
11: 58,472,077 (GRCm39) |
Y136H |
probably damaging |
Het |
| Or2w1b |
C |
T |
13: 21,300,735 (GRCm39) |
T291I |
probably benign |
Het |
| Or4f54 |
T |
A |
2: 111,122,905 (GRCm39) |
C97* |
probably null |
Het |
| Or8b46 |
T |
A |
9: 38,450,552 (GRCm39) |
Y120* |
probably null |
Het |
| Pfkm |
A |
G |
15: 98,026,199 (GRCm39) |
E598G |
possibly damaging |
Het |
| Phf2 |
A |
T |
13: 48,961,106 (GRCm39) |
D861E |
unknown |
Het |
| Polr2a |
A |
G |
11: 69,630,703 (GRCm39) |
|
probably null |
Het |
| Popdc2 |
G |
A |
16: 38,189,853 (GRCm39) |
V167M |
probably damaging |
Het |
| Ptpn22 |
T |
C |
3: 103,793,114 (GRCm39) |
S422P |
probably benign |
Het |
| Rasa2 |
T |
C |
9: 96,450,428 (GRCm39) |
K490R |
possibly damaging |
Het |
| Rbfox3 |
T |
A |
11: 118,386,047 (GRCm39) |
D286V |
probably damaging |
Het |
| Rdh13 |
A |
G |
7: 4,430,790 (GRCm39) |
W223R |
probably damaging |
Het |
| Riok3 |
T |
C |
18: 12,261,986 (GRCm39) |
S7P |
probably benign |
Het |
| Rnaseh2b |
A |
G |
14: 62,591,081 (GRCm39) |
E144G |
probably benign |
Het |
| Rnf20 |
C |
T |
4: 49,651,498 (GRCm39) |
Q655* |
probably null |
Het |
| Rpap2 |
T |
C |
5: 107,751,416 (GRCm39) |
Y8H |
probably damaging |
Het |
| Slc5a10 |
T |
C |
11: 61,600,428 (GRCm39) |
Y181C |
probably benign |
Het |
| Snd1 |
G |
T |
6: 28,888,252 (GRCm39) |
G896* |
probably null |
Het |
| Spast |
C |
T |
17: 74,663,155 (GRCm39) |
Q158* |
probably null |
Het |
| Tas2r104 |
G |
A |
6: 131,662,547 (GRCm39) |
S54F |
probably damaging |
Het |
| Tcaf2 |
C |
T |
6: 42,604,951 (GRCm39) |
W611* |
probably null |
Het |
| Thoc2l |
C |
T |
5: 104,668,376 (GRCm39) |
A966V |
probably benign |
Het |
| Timp4 |
G |
A |
6: 115,227,364 (GRCm39) |
|
probably null |
Het |
| Tmem45a |
G |
A |
16: 56,643,933 (GRCm39) |
S72L |
probably benign |
Het |
| Tnrc18 |
T |
C |
5: 142,774,458 (GRCm39) |
T124A |
possibly damaging |
Het |
| Tns2 |
C |
T |
15: 102,017,369 (GRCm39) |
R281C |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,773,259 (GRCm39) |
D2381G |
probably damaging |
Het |
| Uevld |
T |
C |
7: 46,605,372 (GRCm39) |
T41A |
possibly damaging |
Het |
| Ugcg |
C |
T |
4: 59,207,798 (GRCm39) |
P46S |
probably benign |
Het |
| Unc5d |
T |
C |
8: 29,186,506 (GRCm39) |
E527G |
probably damaging |
Het |
| Vmn2r125 |
C |
T |
4: 156,703,333 (GRCm39) |
T237I |
probably benign |
Het |
| Vmn2r63 |
A |
C |
7: 42,583,038 (GRCm39) |
I59S |
probably benign |
Het |
| Vps72 |
G |
A |
3: 95,026,006 (GRCm39) |
S106N |
probably benign |
Het |
| Zan |
A |
C |
5: 137,407,931 (GRCm39) |
|
probably benign |
Het |
| Zbtb38 |
T |
C |
9: 96,567,515 (GRCm39) |
K1190E |
probably benign |
Het |
| Zc3h6 |
T |
C |
2: 128,859,278 (GRCm39) |
V1103A |
probably benign |
Het |
| Zfp407 |
G |
A |
18: 84,580,282 (GRCm39) |
T277I |
probably damaging |
Het |
| Zfp804b |
A |
G |
5: 6,819,509 (GRCm39) |
S1149P |
probably damaging |
Het |
|
| Other mutations in Mprip |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00334:Mprip
|
APN |
11 |
59,639,417 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL00563:Mprip
|
APN |
11 |
59,643,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00905:Mprip
|
APN |
11 |
59,662,994 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL00928:Mprip
|
APN |
11 |
59,635,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01161:Mprip
|
APN |
11 |
59,622,399 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01991:Mprip
|
APN |
11 |
59,645,838 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02491:Mprip
|
APN |
11 |
59,660,857 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL03030:Mprip
|
APN |
11 |
59,631,941 (GRCm39) |
splice site |
probably null |
|
|
IGL03056:Mprip
|
APN |
11 |
59,662,518 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03293:Mprip
|
APN |
11 |
59,586,989 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0049:Mprip
|
UTSW |
11 |
59,657,571 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0097:Mprip
|
UTSW |
11 |
59,649,317 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0097:Mprip
|
UTSW |
11 |
59,649,317 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0147:Mprip
|
UTSW |
11 |
59,627,899 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0319:Mprip
|
UTSW |
11 |
59,587,864 (GRCm39) |
splice site |
probably benign |
|
|
R0471:Mprip
|
UTSW |
11 |
59,650,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0539:Mprip
|
UTSW |
11 |
59,631,943 (GRCm39) |
splice site |
probably benign |
|
|
R0627:Mprip
|
UTSW |
11 |
59,660,798 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0864:Mprip
|
UTSW |
11 |
59,649,587 (GRCm39) |
missense |
probably benign |
|
|
R1218:Mprip
|
UTSW |
11 |
59,634,640 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Mprip
|
UTSW |
11 |
59,650,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Mprip
|
UTSW |
11 |
59,650,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1695:Mprip
|
UTSW |
11 |
59,643,357 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1802:Mprip
|
UTSW |
11 |
59,645,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1837:Mprip
|
UTSW |
11 |
59,657,571 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1862:Mprip
|
UTSW |
11 |
59,649,047 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2094:Mprip
|
UTSW |
11 |
59,640,334 (GRCm39) |
splice site |
probably benign |
|
|
R2107:Mprip
|
UTSW |
11 |
59,660,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2108:Mprip
|
UTSW |
11 |
59,660,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2510:Mprip
|
UTSW |
11 |
59,640,334 (GRCm39) |
splice site |
probably benign |
|
|
R3003:Mprip
|
UTSW |
11 |
59,618,381 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3115:Mprip
|
UTSW |
11 |
59,656,229 (GRCm39) |
splice site |
probably null |
|
|
R3941:Mprip
|
UTSW |
11 |
59,622,328 (GRCm39) |
splice site |
probably benign |
|
|
R4347:Mprip
|
UTSW |
11 |
59,650,279 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4603:Mprip
|
UTSW |
11 |
59,622,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4807:Mprip
|
UTSW |
11 |
59,648,846 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5011:Mprip
|
UTSW |
11 |
59,650,721 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R5338:Mprip
|
UTSW |
11 |
59,651,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5549:Mprip
|
UTSW |
11 |
59,651,644 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5569:Mprip
|
UTSW |
11 |
59,651,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5604:Mprip
|
UTSW |
11 |
59,649,293 (GRCm39) |
missense |
probably benign |
|
|
R5615:Mprip
|
UTSW |
11 |
59,649,313 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5846:Mprip
|
UTSW |
11 |
59,649,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5970:Mprip
|
UTSW |
11 |
59,648,547 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6054:Mprip
|
UTSW |
11 |
59,649,251 (GRCm39) |
missense |
probably benign |
|
|
R6452:Mprip
|
UTSW |
11 |
59,643,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6457:Mprip
|
UTSW |
11 |
59,649,815 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6544:Mprip
|
UTSW |
11 |
59,648,552 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6750:Mprip
|
UTSW |
11 |
59,586,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6843:Mprip
|
UTSW |
11 |
59,650,554 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R6851:Mprip
|
UTSW |
11 |
59,649,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6867:Mprip
|
UTSW |
11 |
59,640,456 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7002:Mprip
|
UTSW |
11 |
59,652,016 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7023:Mprip
|
UTSW |
11 |
59,628,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7764:Mprip
|
UTSW |
11 |
59,655,242 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7765:Mprip
|
UTSW |
11 |
59,649,047 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7828:Mprip
|
UTSW |
11 |
59,627,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7866:Mprip
|
UTSW |
11 |
59,643,756 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R7911:Mprip
|
UTSW |
11 |
59,651,681 (GRCm39) |
missense |
|
|
|
R7979:Mprip
|
UTSW |
11 |
59,657,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8292:Mprip
|
UTSW |
11 |
59,650,340 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8481:Mprip
|
UTSW |
11 |
59,648,982 (GRCm39) |
nonsense |
probably null |
|
|
R8717:Mprip
|
UTSW |
11 |
59,650,526 (GRCm39) |
missense |
probably benign |
|
|
R8810:Mprip
|
UTSW |
11 |
59,587,851 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R8981:Mprip
|
UTSW |
11 |
59,622,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9214:Mprip
|
UTSW |
11 |
59,650,901 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R9245:Mprip
|
UTSW |
11 |
59,628,403 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R9748:Mprip
|
UTSW |
11 |
59,656,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Mprip
|
UTSW |
11 |
59,650,310 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1176:Mprip
|
UTSW |
11 |
59,628,230 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
Z1177:Mprip
|
UTSW |
11 |
59,648,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCAGAGCATACAGGAGACCCTAC -3'
(R):5'- TATGAGAGATGCTGGGACATCCGC -3'
Sequencing Primer
(F):5'- CTACAAGGGACCCAGGCAG -3'
(R):5'- GCAGAAGCCTCTGGCAAC -3'
|
| Posted On |
2014-05-14 |
Incidental Mutation