Incidental Mutation 'R1699:Usp24'
| ID |
192494 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Usp24
|
| Ensembl Gene |
ENSMUSG00000028514 |
| Gene Name |
ubiquitin specific peptidase 24 |
| Synonyms |
2700066K03Rik, 2810030C21Rik |
| MMRRC Submission |
039732-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1699 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
106173410-106298519 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 106296024 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 2615
(D2615E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133095
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000049507]
[ENSMUST00000094933]
[ENSMUST00000165709]
|
| AlphaFold |
B1AY13 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000049507
|
| SMART Domains |
Protein: ENSMUSP00000055757
Gene: ENSMUSG00000044254
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
12 |
27 |
N/A |
INTRINSIC |
|
Pfam:Peptidase_S8
|
180 |
438 |
3.1e-34 |
PFAM |
|
low complexity region
|
471 |
481 |
N/A |
INTRINSIC |
|
low complexity region
|
490 |
500 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000094933
AA Change: D2614E
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000092538
Gene: ENSMUSG00000028514
AA Change: D2614E
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:UBA
|
5 |
43 |
2e-16 |
BLAST |
|
low complexity region
|
57 |
96 |
N/A |
INTRINSIC |
|
SCOP:d1gw5a_
|
348 |
882 |
6e-7 |
SMART |
|
low complexity region
|
1031 |
1059 |
N/A |
INTRINSIC |
|
low complexity region
|
1124 |
1150 |
N/A |
INTRINSIC |
|
low complexity region
|
1365 |
1378 |
N/A |
INTRINSIC |
|
Pfam:UCH
|
1685 |
2036 |
3.7e-54 |
PFAM |
|
Pfam:UCH_1
|
1686 |
1993 |
1.8e-27 |
PFAM |
|
low complexity region
|
2066 |
2081 |
N/A |
INTRINSIC |
|
low complexity region
|
2256 |
2267 |
N/A |
INTRINSIC |
|
low complexity region
|
2576 |
2592 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000165709
AA Change: D2615E
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000133095
Gene: ENSMUSG00000028514
AA Change: D2615E
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:UBA
|
5 |
43 |
2e-16 |
BLAST |
|
low complexity region
|
57 |
96 |
N/A |
INTRINSIC |
|
SCOP:d1gw5a_
|
348 |
883 |
8e-7 |
SMART |
|
low complexity region
|
1032 |
1060 |
N/A |
INTRINSIC |
|
low complexity region
|
1125 |
1151 |
N/A |
INTRINSIC |
|
low complexity region
|
1366 |
1379 |
N/A |
INTRINSIC |
|
Pfam:UCH
|
1686 |
2037 |
2e-49 |
PFAM |
|
Pfam:UCH_1
|
1687 |
1994 |
4e-24 |
PFAM |
|
low complexity region
|
2067 |
2082 |
N/A |
INTRINSIC |
|
low complexity region
|
2257 |
2268 |
N/A |
INTRINSIC |
|
low complexity region
|
2577 |
2593 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 101 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca2 |
A |
G |
2: 25,337,363 (GRCm39) |
E2406G |
possibly damaging |
Het |
| Adam6b |
T |
A |
12: 113,454,205 (GRCm39) |
F341I |
probably benign |
Het |
| Adam8 |
A |
T |
7: 139,563,224 (GRCm39) |
N767K |
possibly damaging |
Het |
| Aig1 |
T |
C |
10: 13,744,366 (GRCm39) |
D46G |
possibly damaging |
Het |
| Alms1 |
A |
G |
6: 85,599,862 (GRCm39) |
I2032V |
possibly damaging |
Het |
| Ankrd16 |
A |
G |
2: 11,789,204 (GRCm39) |
I264V |
probably benign |
Het |
| Areg |
T |
G |
5: 91,291,357 (GRCm39) |
V100G |
probably damaging |
Het |
| Bcan |
A |
G |
3: 87,896,543 (GRCm39) |
Y718H |
probably damaging |
Het |
| Brsk2 |
T |
A |
7: 141,539,200 (GRCm39) |
I188N |
probably damaging |
Het |
| Cdt1 |
T |
C |
8: 123,296,722 (GRCm39) |
Y203H |
probably damaging |
Het |
| Cfap119 |
A |
T |
7: 127,186,028 (GRCm39) |
|
probably null |
Het |
| Chil3 |
A |
C |
3: 106,067,682 (GRCm39) |
|
probably null |
Het |
| Ciao2b |
A |
G |
8: 105,366,718 (GRCm39) |
V132A |
probably damaging |
Het |
| Cimip2c |
A |
G |
5: 30,641,210 (GRCm39) |
|
probably null |
Het |
| Cth |
A |
G |
3: 157,613,073 (GRCm39) |
L253P |
probably damaging |
Het |
| Cyp11b1 |
A |
G |
15: 74,712,666 (GRCm39) |
F132L |
possibly damaging |
Het |
| Dab1 |
C |
T |
4: 104,588,948 (GRCm39) |
A524V |
probably benign |
Het |
| Dnah11 |
A |
G |
12: 118,154,603 (GRCm39) |
S226P |
probably damaging |
Het |
| Egfr |
A |
T |
11: 16,809,019 (GRCm39) |
Q71L |
probably benign |
Het |
| Eml6 |
T |
A |
11: 29,696,282 (GRCm39) |
K1940* |
probably null |
Het |
| Epn2 |
T |
A |
11: 61,414,014 (GRCm39) |
K391* |
probably null |
Het |
| Erich1 |
A |
T |
8: 14,140,259 (GRCm39) |
S2T |
possibly damaging |
Het |
| Evi5 |
A |
C |
5: 107,966,786 (GRCm39) |
L245R |
probably damaging |
Het |
| Evpl |
T |
C |
11: 116,118,414 (GRCm39) |
Y731C |
probably damaging |
Het |
| Exoc3l |
G |
A |
8: 106,021,645 (GRCm39) |
H128Y |
probably benign |
Het |
| Extl1 |
G |
A |
4: 134,091,894 (GRCm39) |
Q320* |
probably null |
Het |
| Fam91a1 |
T |
A |
15: 58,304,797 (GRCm39) |
S416T |
probably benign |
Het |
| Fat3 |
A |
T |
9: 15,849,694 (GRCm39) |
S3903T |
probably damaging |
Het |
| Fer1l4 |
A |
G |
2: 155,871,605 (GRCm39) |
F1392L |
probably benign |
Het |
| Fstl4 |
T |
C |
11: 53,059,005 (GRCm39) |
I488T |
possibly damaging |
Het |
| Gak |
A |
T |
5: 108,752,243 (GRCm39) |
Y338* |
probably null |
Het |
| Garin4 |
T |
A |
1: 190,896,018 (GRCm39) |
E208D |
probably benign |
Het |
| Glp2r |
T |
C |
11: 67,648,367 (GRCm39) |
T112A |
probably benign |
Het |
| Glrb |
G |
A |
3: 80,769,081 (GRCm39) |
T180I |
probably damaging |
Het |
| Gm10118 |
C |
T |
10: 63,762,671 (GRCm39) |
|
probably benign |
Het |
| Gpr19 |
A |
T |
6: 134,847,192 (GRCm39) |
F72I |
possibly damaging |
Het |
| Grin3b |
C |
A |
10: 79,811,716 (GRCm39) |
N740K |
probably damaging |
Het |
| Gstk1 |
A |
T |
6: 42,223,535 (GRCm39) |
T42S |
probably benign |
Het |
| Hoxd1 |
G |
A |
2: 74,594,626 (GRCm39) |
A294T |
probably benign |
Het |
| Hspg2 |
T |
A |
4: 137,275,323 (GRCm39) |
|
probably null |
Het |
| Ift74 |
A |
T |
4: 94,573,940 (GRCm39) |
N472I |
probably benign |
Het |
| Il1a |
C |
T |
2: 129,144,813 (GRCm39) |
D202N |
probably damaging |
Het |
| Islr |
T |
C |
9: 58,064,778 (GRCm39) |
D243G |
probably damaging |
Het |
| Kif21a |
C |
T |
15: 90,843,946 (GRCm39) |
E1098K |
probably damaging |
Het |
| Krtap16-1 |
T |
C |
11: 99,876,852 (GRCm39) |
E184G |
probably damaging |
Het |
| Lrp1b |
A |
G |
2: 41,075,974 (GRCm39) |
I1889T |
possibly damaging |
Het |
| Mcpt4 |
A |
G |
14: 56,297,416 (GRCm39) |
*247Q |
probably null |
Het |
| Megf10 |
T |
C |
18: 57,410,802 (GRCm39) |
|
probably null |
Het |
| Mettl2 |
T |
A |
11: 105,030,544 (GRCm39) |
H373Q |
probably benign |
Het |
| Mocos |
A |
G |
18: 24,816,273 (GRCm39) |
K617E |
probably damaging |
Het |
| Ms4a8a |
A |
G |
19: 11,053,761 (GRCm39) |
I115T |
probably damaging |
Het |
| Ndst1 |
T |
C |
18: 60,828,580 (GRCm39) |
Y658C |
probably damaging |
Het |
| Nin |
G |
A |
12: 70,077,712 (GRCm39) |
A1031V |
probably benign |
Het |
| Nin |
C |
A |
12: 70,092,337 (GRCm39) |
K657N |
possibly damaging |
Het |
| Noc4l |
G |
A |
5: 110,797,713 (GRCm39) |
R344* |
probably null |
Het |
| Notch2 |
T |
C |
3: 98,052,443 (GRCm39) |
S1980P |
probably damaging |
Het |
| Npat |
C |
T |
9: 53,473,960 (GRCm39) |
S584L |
probably benign |
Het |
| Nphp4 |
A |
G |
4: 152,581,121 (GRCm39) |
T102A |
probably damaging |
Het |
| Olfml2b |
A |
G |
1: 170,472,642 (GRCm39) |
N51S |
possibly damaging |
Het |
| Or2n1e |
A |
G |
17: 38,585,932 (GRCm39) |
K90R |
probably benign |
Het |
| Or2y16 |
T |
A |
11: 49,335,116 (GRCm39) |
I146N |
possibly damaging |
Het |
| Or5al1 |
T |
C |
2: 85,990,280 (GRCm39) |
I145V |
probably benign |
Het |
| Or5w22 |
A |
G |
2: 87,362,427 (GRCm39) |
T17A |
probably benign |
Het |
| Pced1b |
T |
A |
15: 97,282,758 (GRCm39) |
W266R |
probably damaging |
Het |
| Pdcd6ip |
A |
G |
9: 113,507,422 (GRCm39) |
V378A |
probably damaging |
Het |
| Pde8b |
T |
A |
13: 95,169,374 (GRCm39) |
K683N |
probably damaging |
Het |
| Pfas |
T |
G |
11: 68,888,872 (GRCm39) |
|
probably null |
Het |
| Pirb |
A |
T |
7: 3,720,637 (GRCm39) |
L287Q |
probably benign |
Het |
| Plcd4 |
T |
G |
1: 74,587,394 (GRCm39) |
S51R |
probably benign |
Het |
| Plekhh2 |
T |
A |
17: 84,884,612 (GRCm39) |
Y775* |
probably null |
Het |
| Polr3a |
G |
A |
14: 24,534,232 (GRCm39) |
P91L |
probably damaging |
Het |
| Ppp4r3b |
C |
T |
11: 29,163,765 (GRCm39) |
T47I |
possibly damaging |
Het |
| Pter |
A |
T |
2: 12,999,572 (GRCm39) |
D169V |
probably damaging |
Het |
| Ptpn12 |
A |
G |
5: 21,203,168 (GRCm39) |
S537P |
probably benign |
Het |
| Ptpru |
T |
A |
4: 131,506,361 (GRCm39) |
D1067V |
probably damaging |
Het |
| Rcn1 |
A |
T |
2: 105,229,350 (GRCm39) |
D67E |
probably damaging |
Het |
| Rfc4 |
T |
C |
16: 22,932,983 (GRCm39) |
E318G |
probably benign |
Het |
| Samd13 |
C |
A |
3: 146,368,469 (GRCm39) |
R41L |
probably benign |
Het |
| Shoc1 |
T |
C |
4: 59,113,926 (GRCm39) |
K13R |
unknown |
Het |
| Slc6a2 |
T |
C |
8: 93,699,440 (GRCm39) |
I156T |
possibly damaging |
Het |
| Spag16 |
T |
C |
1: 70,036,015 (GRCm39) |
F348L |
probably benign |
Het |
| Spag4 |
T |
C |
2: 155,907,342 (GRCm39) |
Y21H |
probably damaging |
Het |
| Stam2 |
G |
A |
2: 52,593,187 (GRCm39) |
A368V |
possibly damaging |
Het |
| Stc1 |
A |
T |
14: 69,275,776 (GRCm39) |
M190L |
probably benign |
Het |
| Stxbp1 |
A |
G |
2: 32,690,629 (GRCm39) |
L475P |
probably damaging |
Het |
| Syn3 |
A |
T |
10: 85,916,075 (GRCm39) |
Y304N |
probably damaging |
Het |
| Tbc1d15 |
G |
T |
10: 115,056,219 (GRCm39) |
T251K |
probably benign |
Het |
| Tbpl2 |
A |
T |
2: 23,985,057 (GRCm39) |
M29K |
probably benign |
Het |
| Tead3 |
T |
G |
17: 28,553,698 (GRCm39) |
Q170H |
possibly damaging |
Het |
| Tpbpb |
T |
C |
13: 61,049,977 (GRCm39) |
N51D |
probably benign |
Het |
| Tstd3 |
A |
G |
4: 21,759,400 (GRCm39) |
M124T |
probably benign |
Het |
| Ttyh1 |
T |
A |
7: 4,122,695 (GRCm39) |
H14Q |
possibly damaging |
Het |
| Tubgcp4 |
G |
A |
2: 121,020,374 (GRCm39) |
W449* |
probably null |
Het |
| Txndc11 |
A |
G |
16: 10,905,639 (GRCm39) |
|
probably null |
Het |
| Vars1 |
A |
G |
17: 35,233,734 (GRCm39) |
E1020G |
possibly damaging |
Het |
| Vmn2r58 |
A |
G |
7: 41,509,951 (GRCm39) |
I542T |
probably benign |
Het |
| Vwf |
A |
G |
6: 125,620,032 (GRCm39) |
Y1570C |
probably damaging |
Het |
| Vwf |
A |
T |
6: 125,662,863 (GRCm39) |
Y2749F |
possibly damaging |
Het |
| Zfand1 |
A |
C |
3: 10,406,115 (GRCm39) |
V198G |
possibly damaging |
Het |
| Zfp536 |
G |
A |
7: 37,268,879 (GRCm39) |
T179I |
probably damaging |
Het |
| Zfp599 |
T |
C |
9: 22,161,700 (GRCm39) |
Y155C |
probably benign |
Het |
|
| Other mutations in Usp24 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00329:Usp24
|
APN |
4 |
106,216,288 (GRCm39) |
missense |
probably benign |
|
|
IGL00340:Usp24
|
APN |
4 |
106,258,336 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00480:Usp24
|
APN |
4 |
106,225,303 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00548:Usp24
|
APN |
4 |
106,198,495 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00655:Usp24
|
APN |
4 |
106,247,515 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00674:Usp24
|
APN |
4 |
106,229,876 (GRCm39) |
splice site |
probably benign |
|
|
IGL00718:Usp24
|
APN |
4 |
106,266,901 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL00803:Usp24
|
APN |
4 |
106,242,723 (GRCm39) |
splice site |
probably benign |
|
|
IGL01161:Usp24
|
APN |
4 |
106,294,041 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01344:Usp24
|
APN |
4 |
106,236,582 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL01374:Usp24
|
APN |
4 |
106,237,296 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL01485:Usp24
|
APN |
4 |
106,219,429 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01736:Usp24
|
APN |
4 |
106,280,658 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01737:Usp24
|
APN |
4 |
106,244,931 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01862:Usp24
|
APN |
4 |
106,266,095 (GRCm39) |
splice site |
probably benign |
|
|
IGL01981:Usp24
|
APN |
4 |
106,232,965 (GRCm39) |
splice site |
probably benign |
|
|
IGL02090:Usp24
|
APN |
4 |
106,268,623 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL02275:Usp24
|
APN |
4 |
106,244,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02352:Usp24
|
APN |
4 |
106,261,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02359:Usp24
|
APN |
4 |
106,261,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02391:Usp24
|
APN |
4 |
106,264,326 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
IGL02418:Usp24
|
APN |
4 |
106,293,557 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02537:Usp24
|
APN |
4 |
106,249,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02638:Usp24
|
APN |
4 |
106,295,969 (GRCm39) |
splice site |
probably benign |
|
|
IGL02638:Usp24
|
APN |
4 |
106,295,967 (GRCm39) |
splice site |
probably benign |
|
|
IGL02830:Usp24
|
APN |
4 |
106,204,584 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL03125:Usp24
|
APN |
4 |
106,249,599 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03280:Usp24
|
APN |
4 |
106,237,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03350:Usp24
|
APN |
4 |
106,228,276 (GRCm39) |
nonsense |
probably null |
|
|
BB010:Usp24
|
UTSW |
4 |
106,285,686 (GRCm39) |
missense |
probably benign |
|
|
BB020:Usp24
|
UTSW |
4 |
106,285,686 (GRCm39) |
missense |
probably benign |
|
|
IGL03098:Usp24
|
UTSW |
4 |
106,228,230 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0035:Usp24
|
UTSW |
4 |
106,225,224 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0044:Usp24
|
UTSW |
4 |
106,269,281 (GRCm39) |
splice site |
probably benign |
|
|
R0086:Usp24
|
UTSW |
4 |
106,249,557 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0125:Usp24
|
UTSW |
4 |
106,254,496 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R0197:Usp24
|
UTSW |
4 |
106,264,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0240:Usp24
|
UTSW |
4 |
106,271,601 (GRCm39) |
nonsense |
probably null |
|
|
R0240:Usp24
|
UTSW |
4 |
106,271,601 (GRCm39) |
nonsense |
probably null |
|
|
R0491:Usp24
|
UTSW |
4 |
106,259,302 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0687:Usp24
|
UTSW |
4 |
106,277,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0973:Usp24
|
UTSW |
4 |
106,270,875 (GRCm39) |
splice site |
probably null |
|
|
R0973:Usp24
|
UTSW |
4 |
106,228,276 (GRCm39) |
nonsense |
probably null |
|
|
R0973:Usp24
|
UTSW |
4 |
106,228,276 (GRCm39) |
nonsense |
probably null |
|
|
R0974:Usp24
|
UTSW |
4 |
106,270,875 (GRCm39) |
splice site |
probably null |
|
|
R0974:Usp24
|
UTSW |
4 |
106,228,276 (GRCm39) |
nonsense |
probably null |
|
|
R1163:Usp24
|
UTSW |
4 |
106,278,157 (GRCm39) |
missense |
probably benign |
|
|
R1293:Usp24
|
UTSW |
4 |
106,280,750 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1333:Usp24
|
UTSW |
4 |
106,199,550 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R1476:Usp24
|
UTSW |
4 |
106,219,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1728:Usp24
|
UTSW |
4 |
106,217,618 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1729:Usp24
|
UTSW |
4 |
106,217,618 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1753:Usp24
|
UTSW |
4 |
106,234,756 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1917:Usp24
|
UTSW |
4 |
106,267,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2045:Usp24
|
UTSW |
4 |
106,258,177 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R2424:Usp24
|
UTSW |
4 |
106,256,310 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2436:Usp24
|
UTSW |
4 |
106,266,842 (GRCm39) |
nonsense |
probably null |
|
|
R2513:Usp24
|
UTSW |
4 |
106,236,602 (GRCm39) |
splice site |
probably null |
|
|
R3824:Usp24
|
UTSW |
4 |
106,236,263 (GRCm39) |
missense |
probably benign |
|
|
R3831:Usp24
|
UTSW |
4 |
106,219,209 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3833:Usp24
|
UTSW |
4 |
106,219,209 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3982:Usp24
|
UTSW |
4 |
106,245,080 (GRCm39) |
missense |
probably benign |
0.38 |
|
R4022:Usp24
|
UTSW |
4 |
106,236,421 (GRCm39) |
splice site |
probably benign |
|
|
R4067:Usp24
|
UTSW |
4 |
106,216,286 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4175:Usp24
|
UTSW |
4 |
106,173,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4766:Usp24
|
UTSW |
4 |
106,273,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Usp24
|
UTSW |
4 |
106,219,377 (GRCm39) |
splice site |
probably null |
|
|
R4798:Usp24
|
UTSW |
4 |
106,217,359 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4809:Usp24
|
UTSW |
4 |
106,270,873 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4822:Usp24
|
UTSW |
4 |
106,273,244 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4906:Usp24
|
UTSW |
4 |
106,245,834 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4934:Usp24
|
UTSW |
4 |
106,283,743 (GRCm39) |
missense |
probably benign |
0.29 |
|
R5074:Usp24
|
UTSW |
4 |
106,277,644 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5151:Usp24
|
UTSW |
4 |
106,256,309 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5220:Usp24
|
UTSW |
4 |
106,239,500 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5279:Usp24
|
UTSW |
4 |
106,242,621 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5280:Usp24
|
UTSW |
4 |
106,198,411 (GRCm39) |
missense |
probably benign |
0.18 |
|
R5285:Usp24
|
UTSW |
4 |
106,264,230 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5292:Usp24
|
UTSW |
4 |
106,275,460 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5294:Usp24
|
UTSW |
4 |
106,219,554 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5394:Usp24
|
UTSW |
4 |
106,265,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5517:Usp24
|
UTSW |
4 |
106,232,871 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5522:Usp24
|
UTSW |
4 |
106,229,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5546:Usp24
|
UTSW |
4 |
106,273,244 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5756:Usp24
|
UTSW |
4 |
106,219,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5910:Usp24
|
UTSW |
4 |
106,237,665 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5972:Usp24
|
UTSW |
4 |
106,225,264 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6285:Usp24
|
UTSW |
4 |
106,231,297 (GRCm39) |
splice site |
probably null |
|
|
R6370:Usp24
|
UTSW |
4 |
106,237,718 (GRCm39) |
missense |
probably null |
0.20 |
|
R6630:Usp24
|
UTSW |
4 |
106,245,032 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6754:Usp24
|
UTSW |
4 |
106,217,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7027:Usp24
|
UTSW |
4 |
106,219,441 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7088:Usp24
|
UTSW |
4 |
106,244,743 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7129:Usp24
|
UTSW |
4 |
106,219,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7131:Usp24
|
UTSW |
4 |
106,239,500 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R7156:Usp24
|
UTSW |
4 |
106,245,116 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7174:Usp24
|
UTSW |
4 |
106,219,878 (GRCm39) |
splice site |
probably null |
|
|
R7236:Usp24
|
UTSW |
4 |
106,263,502 (GRCm39) |
splice site |
probably null |
|
|
R7403:Usp24
|
UTSW |
4 |
106,264,232 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7424:Usp24
|
UTSW |
4 |
106,236,304 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7475:Usp24
|
UTSW |
4 |
106,199,550 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R7505:Usp24
|
UTSW |
4 |
106,236,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7782:Usp24
|
UTSW |
4 |
106,173,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7900:Usp24
|
UTSW |
4 |
106,266,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7933:Usp24
|
UTSW |
4 |
106,285,686 (GRCm39) |
missense |
probably benign |
|
|
R7940:Usp24
|
UTSW |
4 |
106,287,741 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8271:Usp24
|
UTSW |
4 |
106,285,711 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8348:Usp24
|
UTSW |
4 |
106,225,933 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8448:Usp24
|
UTSW |
4 |
106,225,933 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8483:Usp24
|
UTSW |
4 |
106,230,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8546:Usp24
|
UTSW |
4 |
106,259,326 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8798:Usp24
|
UTSW |
4 |
106,236,436 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8822:Usp24
|
UTSW |
4 |
106,269,410 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8992:Usp24
|
UTSW |
4 |
106,234,762 (GRCm39) |
missense |
probably benign |
0.36 |
|
R9002:Usp24
|
UTSW |
4 |
106,275,412 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9037:Usp24
|
UTSW |
4 |
106,236,251 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9068:Usp24
|
UTSW |
4 |
106,232,875 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9096:Usp24
|
UTSW |
4 |
106,254,508 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9180:Usp24
|
UTSW |
4 |
106,216,247 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9199:Usp24
|
UTSW |
4 |
106,244,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9201:Usp24
|
UTSW |
4 |
106,277,727 (GRCm39) |
missense |
probably benign |
0.36 |
|
R9251:Usp24
|
UTSW |
4 |
106,217,715 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9423:Usp24
|
UTSW |
4 |
106,288,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9459:Usp24
|
UTSW |
4 |
106,199,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9472:Usp24
|
UTSW |
4 |
106,261,128 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9483:Usp24
|
UTSW |
4 |
106,219,379 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9534:Usp24
|
UTSW |
4 |
106,264,312 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9653:Usp24
|
UTSW |
4 |
106,204,564 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9712:Usp24
|
UTSW |
4 |
106,204,564 (GRCm39) |
missense |
probably benign |
0.03 |
|
X0024:Usp24
|
UTSW |
4 |
106,217,643 (GRCm39) |
missense |
probably benign |
0.09 |
|
X0028:Usp24
|
UTSW |
4 |
106,225,252 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0066:Usp24
|
UTSW |
4 |
106,212,928 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGGTGGCTTAGTAAGACCACACG -3'
(R):5'- ATGCACATGTAGACGCTGGGAC -3'
Sequencing Primer
(F):5'- GCAAATGCTTTGCATGACCC -3'
(R):5'- AGCTGGTCCACATTGCAGAA -3'
|
| Posted On |
2014-05-14 |
Incidental Mutation