Incidental Mutation 'R1699:Kif21a'
| ID |
192559 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kif21a
|
| Ensembl Gene |
ENSMUSG00000022629 |
| Gene Name |
kinesin family member 21A |
| Synonyms |
N-5 kinesin |
| MMRRC Submission |
039732-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1699 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
90817479-90934151 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 90843946 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Lysine
at position 1098
(E1098K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104911
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000067205]
[ENSMUST00000088614]
[ENSMUST00000100304]
[ENSMUST00000109287]
[ENSMUST00000109288]
[ENSMUST00000229801]
|
| AlphaFold |
Q9QXL2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000067205
AA Change: E1105K
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000066911
Gene: ENSMUSG00000022629
AA Change: E1105K
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
low complexity region
|
1222 |
1234 |
N/A |
INTRINSIC |
|
low complexity region
|
1251 |
1271 |
N/A |
INTRINSIC |
|
WD40
|
1290 |
1327 |
1.21e-7 |
SMART |
|
WD40
|
1330 |
1368 |
7.28e-2 |
SMART |
|
WD40
|
1394 |
1432 |
3.33e-1 |
SMART |
|
WD40
|
1435 |
1477 |
7e-4 |
SMART |
|
WD40
|
1485 |
1523 |
2.4e-1 |
SMART |
|
WD40
|
1527 |
1566 |
1.48e-2 |
SMART |
|
WD40
|
1569 |
1606 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000088614
AA Change: E1118K
PolyPhen 2
Score 0.045 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000085985
Gene: ENSMUSG00000022629
AA Change: E1118K
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1114 |
1125 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000100304
AA Change: E1118K
PolyPhen 2
Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000097877
Gene: ENSMUSG00000022629
AA Change: E1118K
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109287
AA Change: E1105K
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000104910
Gene: ENSMUSG00000022629
AA Change: E1105K
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
WD40
|
1229 |
1266 |
1.21e-7 |
SMART |
|
WD40
|
1269 |
1307 |
7.28e-2 |
SMART |
|
WD40
|
1333 |
1371 |
3.33e-1 |
SMART |
|
WD40
|
1374 |
1416 |
7e-4 |
SMART |
|
WD40
|
1424 |
1462 |
2.4e-1 |
SMART |
|
WD40
|
1466 |
1505 |
1.48e-2 |
SMART |
|
WD40
|
1508 |
1545 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109288
AA Change: E1098K
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000104911
Gene: ENSMUSG00000022629
AA Change: E1098K
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1205 |
1216 |
N/A |
INTRINSIC |
|
WD40
|
1235 |
1272 |
1.21e-7 |
SMART |
|
WD40
|
1275 |
1313 |
7.28e-2 |
SMART |
|
WD40
|
1339 |
1377 |
3.33e-1 |
SMART |
|
WD40
|
1380 |
1422 |
7e-4 |
SMART |
|
WD40
|
1430 |
1468 |
2.4e-1 |
SMART |
|
WD40
|
1472 |
1511 |
1.48e-2 |
SMART |
|
WD40
|
1514 |
1551 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000229801
AA Change: E80K
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000229864
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 101 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca2 |
A |
G |
2: 25,337,363 (GRCm39) |
E2406G |
possibly damaging |
Het |
| Adam6b |
T |
A |
12: 113,454,205 (GRCm39) |
F341I |
probably benign |
Het |
| Adam8 |
A |
T |
7: 139,563,224 (GRCm39) |
N767K |
possibly damaging |
Het |
| Aig1 |
T |
C |
10: 13,744,366 (GRCm39) |
D46G |
possibly damaging |
Het |
| Alms1 |
A |
G |
6: 85,599,862 (GRCm39) |
I2032V |
possibly damaging |
Het |
| Ankrd16 |
A |
G |
2: 11,789,204 (GRCm39) |
I264V |
probably benign |
Het |
| Areg |
T |
G |
5: 91,291,357 (GRCm39) |
V100G |
probably damaging |
Het |
| Bcan |
A |
G |
3: 87,896,543 (GRCm39) |
Y718H |
probably damaging |
Het |
| Brsk2 |
T |
A |
7: 141,539,200 (GRCm39) |
I188N |
probably damaging |
Het |
| Cdt1 |
T |
C |
8: 123,296,722 (GRCm39) |
Y203H |
probably damaging |
Het |
| Cfap119 |
A |
T |
7: 127,186,028 (GRCm39) |
|
probably null |
Het |
| Chil3 |
A |
C |
3: 106,067,682 (GRCm39) |
|
probably null |
Het |
| Ciao2b |
A |
G |
8: 105,366,718 (GRCm39) |
V132A |
probably damaging |
Het |
| Cimip2c |
A |
G |
5: 30,641,210 (GRCm39) |
|
probably null |
Het |
| Cth |
A |
G |
3: 157,613,073 (GRCm39) |
L253P |
probably damaging |
Het |
| Cyp11b1 |
A |
G |
15: 74,712,666 (GRCm39) |
F132L |
possibly damaging |
Het |
| Dab1 |
C |
T |
4: 104,588,948 (GRCm39) |
A524V |
probably benign |
Het |
| Dnah11 |
A |
G |
12: 118,154,603 (GRCm39) |
S226P |
probably damaging |
Het |
| Egfr |
A |
T |
11: 16,809,019 (GRCm39) |
Q71L |
probably benign |
Het |
| Eml6 |
T |
A |
11: 29,696,282 (GRCm39) |
K1940* |
probably null |
Het |
| Epn2 |
T |
A |
11: 61,414,014 (GRCm39) |
K391* |
probably null |
Het |
| Erich1 |
A |
T |
8: 14,140,259 (GRCm39) |
S2T |
possibly damaging |
Het |
| Evi5 |
A |
C |
5: 107,966,786 (GRCm39) |
L245R |
probably damaging |
Het |
| Evpl |
T |
C |
11: 116,118,414 (GRCm39) |
Y731C |
probably damaging |
Het |
| Exoc3l |
G |
A |
8: 106,021,645 (GRCm39) |
H128Y |
probably benign |
Het |
| Extl1 |
G |
A |
4: 134,091,894 (GRCm39) |
Q320* |
probably null |
Het |
| Fam91a1 |
T |
A |
15: 58,304,797 (GRCm39) |
S416T |
probably benign |
Het |
| Fat3 |
A |
T |
9: 15,849,694 (GRCm39) |
S3903T |
probably damaging |
Het |
| Fer1l4 |
A |
G |
2: 155,871,605 (GRCm39) |
F1392L |
probably benign |
Het |
| Fstl4 |
T |
C |
11: 53,059,005 (GRCm39) |
I488T |
possibly damaging |
Het |
| Gak |
A |
T |
5: 108,752,243 (GRCm39) |
Y338* |
probably null |
Het |
| Garin4 |
T |
A |
1: 190,896,018 (GRCm39) |
E208D |
probably benign |
Het |
| Glp2r |
T |
C |
11: 67,648,367 (GRCm39) |
T112A |
probably benign |
Het |
| Glrb |
G |
A |
3: 80,769,081 (GRCm39) |
T180I |
probably damaging |
Het |
| Gm10118 |
C |
T |
10: 63,762,671 (GRCm39) |
|
probably benign |
Het |
| Gpr19 |
A |
T |
6: 134,847,192 (GRCm39) |
F72I |
possibly damaging |
Het |
| Grin3b |
C |
A |
10: 79,811,716 (GRCm39) |
N740K |
probably damaging |
Het |
| Gstk1 |
A |
T |
6: 42,223,535 (GRCm39) |
T42S |
probably benign |
Het |
| Hoxd1 |
G |
A |
2: 74,594,626 (GRCm39) |
A294T |
probably benign |
Het |
| Hspg2 |
T |
A |
4: 137,275,323 (GRCm39) |
|
probably null |
Het |
| Ift74 |
A |
T |
4: 94,573,940 (GRCm39) |
N472I |
probably benign |
Het |
| Il1a |
C |
T |
2: 129,144,813 (GRCm39) |
D202N |
probably damaging |
Het |
| Islr |
T |
C |
9: 58,064,778 (GRCm39) |
D243G |
probably damaging |
Het |
| Krtap16-1 |
T |
C |
11: 99,876,852 (GRCm39) |
E184G |
probably damaging |
Het |
| Lrp1b |
A |
G |
2: 41,075,974 (GRCm39) |
I1889T |
possibly damaging |
Het |
| Mcpt4 |
A |
G |
14: 56,297,416 (GRCm39) |
*247Q |
probably null |
Het |
| Megf10 |
T |
C |
18: 57,410,802 (GRCm39) |
|
probably null |
Het |
| Mettl2 |
T |
A |
11: 105,030,544 (GRCm39) |
H373Q |
probably benign |
Het |
| Mocos |
A |
G |
18: 24,816,273 (GRCm39) |
K617E |
probably damaging |
Het |
| Ms4a8a |
A |
G |
19: 11,053,761 (GRCm39) |
I115T |
probably damaging |
Het |
| Ndst1 |
T |
C |
18: 60,828,580 (GRCm39) |
Y658C |
probably damaging |
Het |
| Nin |
G |
A |
12: 70,077,712 (GRCm39) |
A1031V |
probably benign |
Het |
| Nin |
C |
A |
12: 70,092,337 (GRCm39) |
K657N |
possibly damaging |
Het |
| Noc4l |
G |
A |
5: 110,797,713 (GRCm39) |
R344* |
probably null |
Het |
| Notch2 |
T |
C |
3: 98,052,443 (GRCm39) |
S1980P |
probably damaging |
Het |
| Npat |
C |
T |
9: 53,473,960 (GRCm39) |
S584L |
probably benign |
Het |
| Nphp4 |
A |
G |
4: 152,581,121 (GRCm39) |
T102A |
probably damaging |
Het |
| Olfml2b |
A |
G |
1: 170,472,642 (GRCm39) |
N51S |
possibly damaging |
Het |
| Or2n1e |
A |
G |
17: 38,585,932 (GRCm39) |
K90R |
probably benign |
Het |
| Or2y16 |
T |
A |
11: 49,335,116 (GRCm39) |
I146N |
possibly damaging |
Het |
| Or5al1 |
T |
C |
2: 85,990,280 (GRCm39) |
I145V |
probably benign |
Het |
| Or5w22 |
A |
G |
2: 87,362,427 (GRCm39) |
T17A |
probably benign |
Het |
| Pced1b |
T |
A |
15: 97,282,758 (GRCm39) |
W266R |
probably damaging |
Het |
| Pdcd6ip |
A |
G |
9: 113,507,422 (GRCm39) |
V378A |
probably damaging |
Het |
| Pde8b |
T |
A |
13: 95,169,374 (GRCm39) |
K683N |
probably damaging |
Het |
| Pfas |
T |
G |
11: 68,888,872 (GRCm39) |
|
probably null |
Het |
| Pirb |
A |
T |
7: 3,720,637 (GRCm39) |
L287Q |
probably benign |
Het |
| Plcd4 |
T |
G |
1: 74,587,394 (GRCm39) |
S51R |
probably benign |
Het |
| Plekhh2 |
T |
A |
17: 84,884,612 (GRCm39) |
Y775* |
probably null |
Het |
| Polr3a |
G |
A |
14: 24,534,232 (GRCm39) |
P91L |
probably damaging |
Het |
| Ppp4r3b |
C |
T |
11: 29,163,765 (GRCm39) |
T47I |
possibly damaging |
Het |
| Pter |
A |
T |
2: 12,999,572 (GRCm39) |
D169V |
probably damaging |
Het |
| Ptpn12 |
A |
G |
5: 21,203,168 (GRCm39) |
S537P |
probably benign |
Het |
| Ptpru |
T |
A |
4: 131,506,361 (GRCm39) |
D1067V |
probably damaging |
Het |
| Rcn1 |
A |
T |
2: 105,229,350 (GRCm39) |
D67E |
probably damaging |
Het |
| Rfc4 |
T |
C |
16: 22,932,983 (GRCm39) |
E318G |
probably benign |
Het |
| Samd13 |
C |
A |
3: 146,368,469 (GRCm39) |
R41L |
probably benign |
Het |
| Shoc1 |
T |
C |
4: 59,113,926 (GRCm39) |
K13R |
unknown |
Het |
| Slc6a2 |
T |
C |
8: 93,699,440 (GRCm39) |
I156T |
possibly damaging |
Het |
| Spag16 |
T |
C |
1: 70,036,015 (GRCm39) |
F348L |
probably benign |
Het |
| Spag4 |
T |
C |
2: 155,907,342 (GRCm39) |
Y21H |
probably damaging |
Het |
| Stam2 |
G |
A |
2: 52,593,187 (GRCm39) |
A368V |
possibly damaging |
Het |
| Stc1 |
A |
T |
14: 69,275,776 (GRCm39) |
M190L |
probably benign |
Het |
| Stxbp1 |
A |
G |
2: 32,690,629 (GRCm39) |
L475P |
probably damaging |
Het |
| Syn3 |
A |
T |
10: 85,916,075 (GRCm39) |
Y304N |
probably damaging |
Het |
| Tbc1d15 |
G |
T |
10: 115,056,219 (GRCm39) |
T251K |
probably benign |
Het |
| Tbpl2 |
A |
T |
2: 23,985,057 (GRCm39) |
M29K |
probably benign |
Het |
| Tead3 |
T |
G |
17: 28,553,698 (GRCm39) |
Q170H |
possibly damaging |
Het |
| Tpbpb |
T |
C |
13: 61,049,977 (GRCm39) |
N51D |
probably benign |
Het |
| Tstd3 |
A |
G |
4: 21,759,400 (GRCm39) |
M124T |
probably benign |
Het |
| Ttyh1 |
T |
A |
7: 4,122,695 (GRCm39) |
H14Q |
possibly damaging |
Het |
| Tubgcp4 |
G |
A |
2: 121,020,374 (GRCm39) |
W449* |
probably null |
Het |
| Txndc11 |
A |
G |
16: 10,905,639 (GRCm39) |
|
probably null |
Het |
| Usp24 |
T |
A |
4: 106,296,024 (GRCm39) |
D2615E |
probably damaging |
Het |
| Vars1 |
A |
G |
17: 35,233,734 (GRCm39) |
E1020G |
possibly damaging |
Het |
| Vmn2r58 |
A |
G |
7: 41,509,951 (GRCm39) |
I542T |
probably benign |
Het |
| Vwf |
A |
G |
6: 125,620,032 (GRCm39) |
Y1570C |
probably damaging |
Het |
| Vwf |
A |
T |
6: 125,662,863 (GRCm39) |
Y2749F |
possibly damaging |
Het |
| Zfand1 |
A |
C |
3: 10,406,115 (GRCm39) |
V198G |
possibly damaging |
Het |
| Zfp536 |
G |
A |
7: 37,268,879 (GRCm39) |
T179I |
probably damaging |
Het |
| Zfp599 |
T |
C |
9: 22,161,700 (GRCm39) |
Y155C |
probably benign |
Het |
|
| Other mutations in Kif21a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00539:Kif21a
|
APN |
15 |
90,821,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01476:Kif21a
|
APN |
15 |
90,828,067 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL01617:Kif21a
|
APN |
15 |
90,879,840 (GRCm39) |
splice site |
probably benign |
|
|
IGL01736:Kif21a
|
APN |
15 |
90,843,948 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL01923:Kif21a
|
APN |
15 |
90,840,633 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01985:Kif21a
|
APN |
15 |
90,875,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02304:Kif21a
|
APN |
15 |
90,849,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02589:Kif21a
|
APN |
15 |
90,869,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03115:Kif21a
|
APN |
15 |
90,869,598 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03211:Kif21a
|
APN |
15 |
90,882,166 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL03372:Kif21a
|
APN |
15 |
90,840,579 (GRCm39) |
missense |
probably benign |
0.38 |
|
reflex
|
UTSW |
15 |
90,852,561 (GRCm39) |
missense |
probably null |
1.00 |
|
R0052:Kif21a
|
UTSW |
15 |
90,855,060 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0052:Kif21a
|
UTSW |
15 |
90,855,060 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0304:Kif21a
|
UTSW |
15 |
90,860,724 (GRCm39) |
splice site |
probably null |
|
|
R0378:Kif21a
|
UTSW |
15 |
90,853,977 (GRCm39) |
splice site |
probably null |
|
|
R0420:Kif21a
|
UTSW |
15 |
90,852,257 (GRCm39) |
unclassified |
probably benign |
|
|
R0536:Kif21a
|
UTSW |
15 |
90,843,886 (GRCm39) |
splice site |
probably benign |
|
|
R0826:Kif21a
|
UTSW |
15 |
90,881,744 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0971:Kif21a
|
UTSW |
15 |
90,824,784 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1052:Kif21a
|
UTSW |
15 |
90,819,853 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1168:Kif21a
|
UTSW |
15 |
90,877,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1324:Kif21a
|
UTSW |
15 |
90,832,525 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1471:Kif21a
|
UTSW |
15 |
90,840,622 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1625:Kif21a
|
UTSW |
15 |
90,826,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1636:Kif21a
|
UTSW |
15 |
90,869,008 (GRCm39) |
splice site |
probably benign |
|
|
R1647:Kif21a
|
UTSW |
15 |
90,878,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1648:Kif21a
|
UTSW |
15 |
90,878,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1703:Kif21a
|
UTSW |
15 |
90,833,250 (GRCm39) |
splice site |
probably null |
|
|
R1795:Kif21a
|
UTSW |
15 |
90,856,930 (GRCm39) |
splice site |
probably null |
|
|
R1812:Kif21a
|
UTSW |
15 |
90,855,969 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1959:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1960:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1961:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1996:Kif21a
|
UTSW |
15 |
90,878,574 (GRCm39) |
nonsense |
probably null |
|
|
R2230:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2231:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2232:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2424:Kif21a
|
UTSW |
15 |
90,855,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2429:Kif21a
|
UTSW |
15 |
90,882,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2513:Kif21a
|
UTSW |
15 |
90,878,594 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2846:Kif21a
|
UTSW |
15 |
90,818,667 (GRCm39) |
missense |
probably benign |
|
|
R3027:Kif21a
|
UTSW |
15 |
90,856,845 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3624:Kif21a
|
UTSW |
15 |
90,849,798 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3820:Kif21a
|
UTSW |
15 |
90,852,277 (GRCm39) |
missense |
probably benign |
0.17 |
|
R3923:Kif21a
|
UTSW |
15 |
90,821,497 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3962:Kif21a
|
UTSW |
15 |
90,869,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4355:Kif21a
|
UTSW |
15 |
90,855,036 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4516:Kif21a
|
UTSW |
15 |
90,855,345 (GRCm39) |
missense |
probably benign |
0.38 |
|
R4530:Kif21a
|
UTSW |
15 |
90,852,292 (GRCm39) |
splice site |
probably null |
|
|
R4612:Kif21a
|
UTSW |
15 |
90,852,426 (GRCm39) |
splice site |
probably null |
|
|
R4674:Kif21a
|
UTSW |
15 |
90,824,748 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4675:Kif21a
|
UTSW |
15 |
90,824,748 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4698:Kif21a
|
UTSW |
15 |
90,840,508 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4712:Kif21a
|
UTSW |
15 |
90,868,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4955:Kif21a
|
UTSW |
15 |
90,821,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4974:Kif21a
|
UTSW |
15 |
90,833,213 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5034:Kif21a
|
UTSW |
15 |
90,852,561 (GRCm39) |
missense |
probably null |
1.00 |
|
R5165:Kif21a
|
UTSW |
15 |
90,840,579 (GRCm39) |
missense |
probably benign |
0.38 |
|
R5464:Kif21a
|
UTSW |
15 |
90,878,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5541:Kif21a
|
UTSW |
15 |
90,852,316 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5757:Kif21a
|
UTSW |
15 |
90,835,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5936:Kif21a
|
UTSW |
15 |
90,819,850 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5976:Kif21a
|
UTSW |
15 |
90,820,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6074:Kif21a
|
UTSW |
15 |
90,865,095 (GRCm39) |
missense |
probably benign |
|
|
R6638:Kif21a
|
UTSW |
15 |
90,850,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6723:Kif21a
|
UTSW |
15 |
90,824,649 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6785:Kif21a
|
UTSW |
15 |
90,819,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6977:Kif21a
|
UTSW |
15 |
90,865,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7058:Kif21a
|
UTSW |
15 |
90,833,106 (GRCm39) |
splice site |
probably null |
|
|
R7147:Kif21a
|
UTSW |
15 |
90,865,086 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7290:Kif21a
|
UTSW |
15 |
90,851,432 (GRCm39) |
nonsense |
probably null |
|
|
R7438:Kif21a
|
UTSW |
15 |
90,877,999 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7593:Kif21a
|
UTSW |
15 |
90,828,064 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7661:Kif21a
|
UTSW |
15 |
90,865,122 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7891:Kif21a
|
UTSW |
15 |
90,840,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8137:Kif21a
|
UTSW |
15 |
90,852,645 (GRCm39) |
missense |
probably benign |
|
|
R8182:Kif21a
|
UTSW |
15 |
90,819,964 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8303:Kif21a
|
UTSW |
15 |
90,855,399 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8388:Kif21a
|
UTSW |
15 |
90,843,327 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8867:Kif21a
|
UTSW |
15 |
90,852,382 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8921:Kif21a
|
UTSW |
15 |
90,855,930 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8984:Kif21a
|
UTSW |
15 |
90,840,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9024:Kif21a
|
UTSW |
15 |
90,821,399 (GRCm39) |
nonsense |
probably null |
|
|
R9254:Kif21a
|
UTSW |
15 |
90,854,030 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9366:Kif21a
|
UTSW |
15 |
90,843,951 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9379:Kif21a
|
UTSW |
15 |
90,854,030 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9393:Kif21a
|
UTSW |
15 |
90,853,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9518:Kif21a
|
UTSW |
15 |
90,840,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9712:Kif21a
|
UTSW |
15 |
90,879,715 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9712:Kif21a
|
UTSW |
15 |
90,869,528 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9721:Kif21a
|
UTSW |
15 |
90,855,330 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGTTTCACTTCACCACAAAGCTTCATA -3'
(R):5'- GTCTCCTCATCCCAGCAATGCAA -3'
Sequencing Primer
(F):5'- gtccccttctccgaccc -3'
(R):5'- TCCCAGCAATGCAAGGGAAG -3'
|
| Posted On |
2014-05-14 |
Incidental Mutation