Incidental Mutation 'R0051:Yeats2'
ID 192641
Institutional Source Beutler Lab
Gene Symbol Yeats2
Ensembl Gene ENSMUSG00000041215
Gene Name YEATS domain containing 2
Synonyms
MMRRC Submission 038345-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.964) question?
Stock # R0051 (G1)
Quality Score 68
Status Validated
Chromosome 16
Chromosomal Location 19959813-20051323 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 20012474 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 557 (Y557*)
Ref Sequence ENSEMBL: ENSMUSP00000155891 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090052] [ENSMUST00000115560] [ENSMUST00000232019] [ENSMUST00000232338]
AlphaFold Q3TUF7
Predicted Effect probably null
Transcript: ENSMUST00000090052
AA Change: Y560*
SMART Domains Protein: ENSMUSP00000087506
Gene: ENSMUSG00000041215
AA Change: Y560*

DomainStartEndE-ValueType
Pfam:YEATS 179 262 2.6e-27 PFAM
low complexity region 299 309 N/A INTRINSIC
low complexity region 312 333 N/A INTRINSIC
low complexity region 409 429 N/A INTRINSIC
low complexity region 458 467 N/A INTRINSIC
internal_repeat_1 471 675 3.72e-6 PROSPERO
low complexity region 683 702 N/A INTRINSIC
low complexity region 738 775 N/A INTRINSIC
internal_repeat_1 785 978 3.72e-6 PROSPERO
low complexity region 1240 1249 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000115560
AA Change: Y613*
SMART Domains Protein: ENSMUSP00000111222
Gene: ENSMUSG00000041215
AA Change: Y613*

DomainStartEndE-ValueType
Pfam:YEATS 232 314 2.1e-28 PFAM
low complexity region 352 362 N/A INTRINSIC
low complexity region 365 386 N/A INTRINSIC
low complexity region 462 482 N/A INTRINSIC
low complexity region 511 520 N/A INTRINSIC
internal_repeat_1 524 728 4.68e-6 PROSPERO
low complexity region 736 755 N/A INTRINSIC
low complexity region 791 828 N/A INTRINSIC
internal_repeat_1 838 1031 4.68e-6 PROSPERO
low complexity region 1293 1302 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231671
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231795
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231861
Predicted Effect probably null
Transcript: ENSMUST00000232019
AA Change: Y575*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232172
Predicted Effect probably null
Transcript: ENSMUST00000232338
AA Change: Y557*
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.1%
  • 20x: 93.8%
Validation Efficiency 100% (64/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] YEATS2 is a scaffolding subunit of the ADA2A (TADA2A; MIM 602276)-containing (ATAC) histone acetyltransferase complex (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]
Allele List at MGI

All alleles(34) : Targeted(1) Gene trapped(33)

Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432E11Rik A G 7: 29,278,526 (GRCm39) noncoding transcript Het
Abr T A 11: 76,363,328 (GRCm39) Q163L probably benign Het
Ankrd11 C A 8: 123,616,481 (GRCm39) C2457F probably damaging Het
Anks3 G C 16: 4,765,613 (GRCm39) T163S probably benign Het
Cacna1d G A 14: 29,833,052 (GRCm39) P908S probably damaging Het
Ccdc146 C A 5: 21,521,902 (GRCm39) R374L possibly damaging Het
Cdc45 G T 16: 18,613,524 (GRCm39) A348E probably damaging Het
Cfap46 A G 7: 139,255,951 (GRCm39) C300R probably damaging Het
Cimap1a C A 7: 140,430,134 (GRCm39) probably benign Het
Coq2 T C 5: 100,811,551 (GRCm39) N146S probably benign Het
Dalrd3 T C 9: 108,449,414 (GRCm39) V120A possibly damaging Het
Dcp2 T A 18: 44,538,441 (GRCm39) probably benign Het
Ddx39a A G 8: 84,447,251 (GRCm39) K137R possibly damaging Het
Diaph3 A G 14: 87,274,890 (GRCm39) probably null Het
Dmbt1 G T 7: 130,721,225 (GRCm39) R1668L possibly damaging Het
Dnah7a T G 1: 53,560,245 (GRCm39) probably benign Het
Dpp7 A G 2: 25,246,107 (GRCm39) Y49H possibly damaging Het
Drd5 A G 5: 38,477,957 (GRCm39) S317G probably benign Het
Ecpas A G 4: 58,832,729 (GRCm39) L877S probably damaging Het
Ecsit C T 9: 21,987,584 (GRCm39) V152I probably benign Het
Eeig1 G A 2: 32,448,065 (GRCm39) R58Q possibly damaging Het
Emc1 T A 4: 139,102,474 (GRCm39) M923K possibly damaging Het
Fcrl6 A T 1: 172,426,320 (GRCm39) L159Q probably benign Het
Frrs1 T C 3: 116,678,946 (GRCm39) probably benign Het
Hspd1 A G 1: 55,121,205 (GRCm39) probably benign Het
Impg2 T A 16: 56,078,411 (GRCm39) S458T probably damaging Het
Klf17 T C 4: 117,617,589 (GRCm39) Y256C probably damaging Het
Lnx2 A G 5: 146,966,163 (GRCm39) F319L probably damaging Het
Mafg G T 11: 120,520,430 (GRCm39) R57S probably damaging Het
Med13l T A 5: 118,880,720 (GRCm39) W1271R probably damaging Het
Mrgprb1 A G 7: 48,096,962 (GRCm39) S24P probably benign Het
Mtrf1l T C 10: 5,763,384 (GRCm39) E315G probably damaging Het
Naip1 T C 13: 100,547,509 (GRCm39) E1239G probably damaging Het
Ncaph2 T C 15: 89,253,867 (GRCm39) S320P probably damaging Het
Nek11 A G 9: 105,095,738 (GRCm39) probably benign Het
Nlrp2 A T 7: 5,325,333 (GRCm39) probably benign Het
Rbm26 A C 14: 105,389,976 (GRCm39) V216G possibly damaging Het
Rnf115 A G 3: 96,692,338 (GRCm39) D178G probably damaging Het
Rtel1 C T 2: 180,992,449 (GRCm39) Q424* probably null Het
Rwdd4a A G 8: 47,990,400 (GRCm39) probably benign Het
Ryr3 T C 2: 112,699,420 (GRCm39) D890G probably damaging Het
Scarb1 C A 5: 125,358,164 (GRCm39) probably null Het
Serpina10 A G 12: 103,593,156 (GRCm39) probably benign Het
Slc12a5 T A 2: 164,828,583 (GRCm39) W508R probably damaging Het
Slc43a2 T C 11: 75,453,676 (GRCm39) C225R probably damaging Het
Slc6a9 T C 4: 117,722,056 (GRCm39) F440L probably damaging Het
Stac3 G A 10: 127,344,017 (GRCm39) R305H probably damaging Het
Stk32b A G 5: 37,616,940 (GRCm39) probably benign Het
Syna A T 5: 134,588,397 (GRCm39) L184H probably damaging Het
Tmprss7 T C 16: 45,494,302 (GRCm39) N401S probably damaging Het
Tut4 T G 4: 108,384,201 (GRCm39) S1089R probably damaging Het
Zfp352 T C 4: 90,112,522 (GRCm39) S221P probably damaging Het
Zfp575 A G 7: 24,285,512 (GRCm39) V43A probably benign Het
Zfp775 A G 6: 48,597,706 (GRCm39) T527A probably benign Het
Other mutations in Yeats2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01118:Yeats2 APN 16 20,005,054 (GRCm39) missense probably damaging 0.99
IGL01128:Yeats2 APN 16 19,980,718 (GRCm39) splice site probably benign
IGL01139:Yeats2 APN 16 20,033,143 (GRCm39) missense probably damaging 1.00
IGL01394:Yeats2 APN 16 19,980,782 (GRCm39) missense probably damaging 0.99
IGL01482:Yeats2 APN 16 20,041,671 (GRCm39) missense probably damaging 1.00
IGL01924:Yeats2 APN 16 20,024,917 (GRCm39) missense probably damaging 1.00
IGL01925:Yeats2 APN 16 19,998,430 (GRCm39) splice site probably benign
IGL02106:Yeats2 APN 16 20,011,970 (GRCm39) missense possibly damaging 0.79
IGL02370:Yeats2 APN 16 19,969,221 (GRCm39) missense probably damaging 0.99
IGL02447:Yeats2 APN 16 20,012,429 (GRCm39) missense probably benign 0.00
IGL02669:Yeats2 APN 16 20,005,033 (GRCm39) missense probably benign 0.13
IGL03155:Yeats2 APN 16 20,048,323 (GRCm39) critical splice donor site probably null
tyrion UTSW 16 20,032,151 (GRCm39) splice site probably benign
P0045:Yeats2 UTSW 16 19,975,695 (GRCm39) missense possibly damaging 0.47
R0051:Yeats2 UTSW 16 20,012,474 (GRCm39) nonsense probably null
R0118:Yeats2 UTSW 16 19,975,692 (GRCm39) nonsense probably null
R0157:Yeats2 UTSW 16 20,040,427 (GRCm39) makesense probably null
R0184:Yeats2 UTSW 16 20,022,435 (GRCm39) missense possibly damaging 0.79
R0194:Yeats2 UTSW 16 19,971,719 (GRCm39) start codon destroyed probably null 1.00
R0612:Yeats2 UTSW 16 20,005,175 (GRCm39) missense probably benign 0.00
R0655:Yeats2 UTSW 16 20,012,574 (GRCm39) nonsense probably null
R0826:Yeats2 UTSW 16 20,011,966 (GRCm39) nonsense probably null
R1526:Yeats2 UTSW 16 20,024,836 (GRCm39) missense probably damaging 1.00
R1535:Yeats2 UTSW 16 20,008,115 (GRCm39) missense probably damaging 0.99
R1749:Yeats2 UTSW 16 20,005,018 (GRCm39) nonsense probably null
R1842:Yeats2 UTSW 16 19,989,988 (GRCm39) missense probably damaging 1.00
R1843:Yeats2 UTSW 16 20,048,314 (GRCm39) missense probably benign 0.01
R1926:Yeats2 UTSW 16 20,033,176 (GRCm39) missense probably benign
R2000:Yeats2 UTSW 16 20,005,141 (GRCm39) missense probably benign 0.20
R2017:Yeats2 UTSW 16 19,977,931 (GRCm39) missense probably benign 0.01
R2076:Yeats2 UTSW 16 20,005,032 (GRCm39) missense possibly damaging 0.47
R2153:Yeats2 UTSW 16 19,972,916 (GRCm39) missense probably damaging 1.00
R2167:Yeats2 UTSW 16 20,032,151 (GRCm39) splice site probably benign
R2981:Yeats2 UTSW 16 20,005,051 (GRCm39) missense probably damaging 0.99
R3160:Yeats2 UTSW 16 20,012,395 (GRCm39) missense probably damaging 1.00
R3161:Yeats2 UTSW 16 20,012,395 (GRCm39) missense probably damaging 1.00
R3162:Yeats2 UTSW 16 20,012,395 (GRCm39) missense probably damaging 1.00
R3774:Yeats2 UTSW 16 19,969,245 (GRCm39) missense probably damaging 1.00
R4250:Yeats2 UTSW 16 19,975,685 (GRCm39) missense possibly damaging 0.90
R4305:Yeats2 UTSW 16 20,027,172 (GRCm39) missense probably damaging 1.00
R4455:Yeats2 UTSW 16 19,980,743 (GRCm39) missense possibly damaging 0.88
R4458:Yeats2 UTSW 16 20,032,071 (GRCm39) missense probably damaging 0.99
R4811:Yeats2 UTSW 16 19,971,645 (GRCm39) splice site probably null
R4902:Yeats2 UTSW 16 20,026,418 (GRCm39) missense probably benign 0.00
R5043:Yeats2 UTSW 16 20,027,215 (GRCm39) missense probably damaging 1.00
R5047:Yeats2 UTSW 16 20,027,215 (GRCm39) missense probably damaging 1.00
R5319:Yeats2 UTSW 16 20,005,175 (GRCm39) missense probably benign 0.01
R5328:Yeats2 UTSW 16 19,989,955 (GRCm39) missense probably damaging 1.00
R5360:Yeats2 UTSW 16 19,972,912 (GRCm39) missense probably damaging 0.97
R5416:Yeats2 UTSW 16 20,030,319 (GRCm39) missense probably benign 0.01
R5672:Yeats2 UTSW 16 19,980,779 (GRCm39) missense probably damaging 1.00
R5684:Yeats2 UTSW 16 20,012,553 (GRCm39) missense possibly damaging 0.94
R5932:Yeats2 UTSW 16 20,011,913 (GRCm39) missense probably benign 0.06
R5946:Yeats2 UTSW 16 20,026,513 (GRCm39) nonsense probably null
R6168:Yeats2 UTSW 16 19,998,308 (GRCm39) missense probably benign 0.01
R6169:Yeats2 UTSW 16 20,038,417 (GRCm39) missense probably damaging 1.00
R6179:Yeats2 UTSW 16 20,033,225 (GRCm39) missense probably benign 0.16
R6371:Yeats2 UTSW 16 20,040,460 (GRCm39) missense possibly damaging 0.54
R6877:Yeats2 UTSW 16 19,998,344 (GRCm39) missense probably benign 0.00
R7149:Yeats2 UTSW 16 19,972,939 (GRCm39) missense probably damaging 1.00
R7405:Yeats2 UTSW 16 20,041,663 (GRCm39) missense probably damaging 1.00
R8353:Yeats2 UTSW 16 20,041,637 (GRCm39) nonsense probably null
R8367:Yeats2 UTSW 16 20,041,575 (GRCm39) missense probably damaging 1.00
R8453:Yeats2 UTSW 16 20,041,637 (GRCm39) nonsense probably null
R8506:Yeats2 UTSW 16 19,971,684 (GRCm39) missense probably damaging 0.98
R8535:Yeats2 UTSW 16 19,977,926 (GRCm39) missense probably damaging 1.00
R8828:Yeats2 UTSW 16 19,969,260 (GRCm39) missense probably benign 0.45
R8905:Yeats2 UTSW 16 20,009,144 (GRCm39) missense probably benign 0.02
R8924:Yeats2 UTSW 16 19,969,312 (GRCm39) critical splice donor site probably null
R9087:Yeats2 UTSW 16 20,030,500 (GRCm39) critical splice donor site probably null
R9276:Yeats2 UTSW 16 19,975,786 (GRCm39) missense probably benign 0.34
R9338:Yeats2 UTSW 16 20,041,533 (GRCm39) missense probably damaging 0.99
R9338:Yeats2 UTSW 16 20,032,078 (GRCm39) missense possibly damaging 0.69
R9378:Yeats2 UTSW 16 20,033,228 (GRCm39) missense probably benign
R9569:Yeats2 UTSW 16 19,972,902 (GRCm39) missense probably damaging 1.00
R9664:Yeats2 UTSW 16 20,047,491 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACCCCGTCTCTATGACAAGTGACAG -3'
(R):5'- GTTCAGAGCAGCACTCTCTTACAGG -3'

Sequencing Primer
(F):5'- GAGCCGTTCTGTGTATCCAAAC -3'
(R):5'- CTAGAGAGAGGATACTTTGTCCC -3'
Posted On 2014-05-20