Incidental Mutation 'R1760:Plxnd1'
| ID |
192692 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Plxnd1
|
| Ensembl Gene |
ENSMUSG00000030123 |
| Gene Name |
plexin D1 |
| Synonyms |
6230425C21Rik, b2b1863Clo, b2b553Clo |
| MMRRC Submission |
039792-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1760 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
115931772-115971966 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 115944740 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 1018
(V1018E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000015511
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000015511]
|
| AlphaFold |
Q3UH93 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000015511
AA Change: V1018E
PolyPhen 2
Score 0.954 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000015511
Gene: ENSMUSG00000030123
AA Change: V1018E
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
48 |
N/A |
INTRINSIC |
|
Sema
|
61 |
531 |
6.52e-90 |
SMART |
|
PSI
|
550 |
603 |
6.06e-12 |
SMART |
|
PSI
|
703 |
755 |
1.06e-2 |
SMART |
|
Blast:PSI
|
850 |
891 |
9e-20 |
BLAST |
|
IPT
|
892 |
981 |
4.43e-20 |
SMART |
|
IPT
|
982 |
1068 |
6.61e-19 |
SMART |
|
IPT
|
1070 |
1149 |
6.13e-14 |
SMART |
|
transmembrane domain
|
1271 |
1293 |
N/A |
INTRINSIC |
|
Pfam:Plexin_cytopl
|
1345 |
1888 |
5e-238 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000131590
AA Change: V126E
|
| SMART Domains |
Protein: ENSMUSP00000115650
Gene: ENSMUSG00000030123
AA Change: V126E
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:PSI
|
2 |
34 |
1e-13 |
BLAST |
|
IPT
|
35 |
124 |
4.43e-20 |
SMART |
|
Blast:IPT
|
125 |
177 |
3e-30 |
BLAST |
|
Pfam:TIG
|
180 |
233 |
4.6e-6 |
PFAM |
|
| Meta Mutation Damage Score |
0.5410 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.3%
- 20x: 92.6%
|
| Validation Efficiency |
97% (95/98) |
| MGI Phenotype |
PHENOTYPE: Homozygous null mice display neonatal lethality, thin-walled atria, and vascular abnormalities including abnormal branchial arch artery development, cardiac outflow tract abnormalities, and reduced vascular smooth muscle around some vessels. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca2 |
T |
C |
2: 25,333,055 (GRCm39) |
S1585P |
probably benign |
Het |
| Abhd16b |
T |
C |
2: 181,135,197 (GRCm39) |
F33S |
probably damaging |
Het |
| Adgra2 |
G |
A |
8: 27,609,795 (GRCm39) |
R856Q |
probably damaging |
Het |
| Aff3 |
A |
T |
1: 38,368,945 (GRCm39) |
|
probably benign |
Het |
| Anxa2 |
A |
T |
9: 69,397,049 (GRCm39) |
Y251F |
probably benign |
Het |
| Arid1b |
A |
G |
17: 5,392,088 (GRCm39) |
T1873A |
probably damaging |
Het |
| Baz1b |
C |
A |
5: 135,271,378 (GRCm39) |
D1320E |
probably benign |
Het |
| Bbs1 |
A |
T |
19: 4,944,350 (GRCm39) |
S426R |
probably benign |
Het |
| Bid |
A |
G |
6: 120,877,209 (GRCm39) |
V44A |
possibly damaging |
Het |
| Ccdc60 |
T |
A |
5: 116,310,532 (GRCm39) |
M177L |
probably damaging |
Het |
| Cdh23 |
G |
A |
10: 60,161,855 (GRCm39) |
T1997M |
probably damaging |
Het |
| Cdh5 |
T |
A |
8: 104,854,801 (GRCm39) |
M243K |
probably benign |
Het |
| Clpb |
T |
A |
7: 101,435,905 (GRCm39) |
V578E |
possibly damaging |
Het |
| Cngb1 |
C |
A |
8: 96,026,328 (GRCm39) |
C151F |
probably benign |
Het |
| Cntnap5b |
T |
C |
1: 99,700,535 (GRCm39) |
S16P |
probably benign |
Het |
| Cr1l |
T |
A |
1: 194,797,123 (GRCm39) |
M305L |
probably benign |
Het |
| Ctnnal1 |
A |
T |
4: 56,838,988 (GRCm39) |
M235K |
probably damaging |
Het |
| Ddx55 |
A |
T |
5: 124,706,176 (GRCm39) |
R534W |
probably damaging |
Het |
| Dip2b |
T |
A |
15: 100,109,910 (GRCm39) |
L1465Q |
probably damaging |
Het |
| Dnah9 |
G |
T |
11: 65,872,048 (GRCm39) |
D2727E |
probably benign |
Het |
| Dph3b-ps |
A |
C |
13: 106,683,497 (GRCm39) |
|
noncoding transcript |
Het |
| Dst |
T |
A |
1: 34,267,684 (GRCm39) |
L2702Q |
probably damaging |
Het |
| Efnb2 |
T |
C |
8: 8,673,184 (GRCm39) |
T158A |
possibly damaging |
Het |
| Exosc10 |
A |
T |
4: 148,662,926 (GRCm39) |
K712* |
probably null |
Het |
| Fgr |
T |
C |
4: 132,725,653 (GRCm39) |
V354A |
possibly damaging |
Het |
| Fsip2 |
A |
G |
2: 82,830,185 (GRCm39) |
D6893G |
possibly damaging |
Het |
| Fsip2 |
G |
A |
2: 82,815,240 (GRCm39) |
V3658M |
probably benign |
Het |
| Fsip2 |
A |
T |
2: 82,818,055 (GRCm39) |
H4596L |
possibly damaging |
Het |
| Gm1527 |
G |
A |
3: 28,949,699 (GRCm39) |
|
probably benign |
Het |
| Gm5150 |
G |
T |
3: 16,060,468 (GRCm39) |
Q7K |
probably benign |
Het |
| Gpr155 |
C |
T |
2: 73,212,279 (GRCm39) |
V115M |
probably damaging |
Het |
| Gpr75 |
T |
C |
11: 30,841,527 (GRCm39) |
L144P |
probably damaging |
Het |
| Gsn |
T |
A |
2: 35,174,835 (GRCm39) |
Y127N |
probably damaging |
Het |
| Hk1 |
A |
G |
10: 62,117,678 (GRCm39) |
L615S |
probably damaging |
Het |
| Igsf9b |
A |
G |
9: 27,229,123 (GRCm39) |
T194A |
possibly damaging |
Het |
| Il17rd |
C |
T |
14: 26,813,763 (GRCm39) |
Q46* |
probably null |
Het |
| Jak1 |
T |
A |
4: 101,020,126 (GRCm39) |
M678L |
probably benign |
Het |
| Kif6 |
T |
C |
17: 49,922,311 (GRCm39) |
V16A |
probably benign |
Het |
| Kpna3 |
T |
C |
14: 61,607,990 (GRCm39) |
E405G |
probably benign |
Het |
| Lmtk2 |
C |
A |
5: 144,110,993 (GRCm39) |
T571K |
probably damaging |
Het |
| Mucl2 |
T |
C |
15: 103,927,838 (GRCm39) |
T40A |
possibly damaging |
Het |
| Myh11 |
G |
A |
16: 14,051,559 (GRCm39) |
|
probably benign |
Het |
| Myh7 |
C |
T |
14: 55,210,170 (GRCm39) |
R1845Q |
probably damaging |
Het |
| Myo1f |
T |
A |
17: 33,805,172 (GRCm39) |
L480Q |
probably benign |
Het |
| Nek9 |
T |
G |
12: 85,352,364 (GRCm39) |
D833A |
possibly damaging |
Het |
| Nek9 |
T |
C |
12: 85,357,184 (GRCm39) |
E660G |
probably benign |
Het |
| Or10z1 |
C |
T |
1: 174,077,926 (GRCm39) |
C189Y |
probably damaging |
Het |
| Or2a12 |
A |
G |
6: 42,904,431 (GRCm39) |
I89V |
possibly damaging |
Het |
| Or2t45 |
A |
G |
11: 58,669,195 (GRCm39) |
M81V |
possibly damaging |
Het |
| Or5h18 |
T |
C |
16: 58,847,350 (GRCm39) |
R307G |
probably benign |
Het |
| Or6c65 |
T |
A |
10: 129,603,417 (GRCm39) |
D17E |
probably benign |
Het |
| Or6f2 |
G |
A |
7: 139,756,188 (GRCm39) |
V52M |
probably damaging |
Het |
| Or7s1a-ps1 |
T |
A |
9: 18,843,791 (GRCm39) |
|
probably benign |
Het |
| Otud3 |
G |
T |
4: 138,623,092 (GRCm39) |
T383K |
possibly damaging |
Het |
| Pkp4 |
T |
C |
2: 59,142,185 (GRCm39) |
L496P |
probably damaging |
Het |
| Pla2g4e |
C |
A |
2: 120,000,527 (GRCm39) |
A737S |
possibly damaging |
Het |
| Pla2g4f |
T |
C |
2: 120,144,547 (GRCm39) |
|
probably benign |
Het |
| Ppp1r21 |
T |
G |
17: 88,869,653 (GRCm39) |
V402G |
possibly damaging |
Het |
| Prkcq |
T |
G |
2: 11,304,881 (GRCm39) |
M690R |
probably damaging |
Het |
| Ptpra |
T |
C |
2: 130,391,747 (GRCm39) |
I719T |
probably damaging |
Het |
| Rab3ip |
C |
T |
10: 116,773,415 (GRCm39) |
D133N |
probably damaging |
Het |
| Relch |
T |
G |
1: 105,647,169 (GRCm39) |
|
probably benign |
Het |
| Rsbn1 |
T |
A |
3: 103,867,347 (GRCm39) |
Y563N |
probably damaging |
Het |
| Rtf1 |
A |
C |
2: 119,558,889 (GRCm39) |
D530A |
probably benign |
Het |
| Rybp |
G |
T |
6: 100,209,224 (GRCm39) |
S199R |
probably benign |
Het |
| Sema5a |
T |
G |
15: 32,641,252 (GRCm39) |
C689G |
probably damaging |
Het |
| Senp6 |
T |
A |
9: 80,025,911 (GRCm39) |
V314E |
probably benign |
Het |
| Setd1a |
T |
A |
7: 127,385,062 (GRCm39) |
C47S |
possibly damaging |
Het |
| Slamf1 |
C |
A |
1: 171,604,734 (GRCm39) |
T168K |
probably benign |
Het |
| Slc12a5 |
T |
C |
2: 164,838,048 (GRCm39) |
S937P |
probably damaging |
Het |
| Slc38a11 |
C |
T |
2: 65,185,663 (GRCm39) |
|
probably null |
Het |
| Slc6a2 |
C |
T |
8: 93,687,846 (GRCm39) |
|
probably benign |
Het |
| Snw1 |
A |
T |
12: 87,511,459 (GRCm39) |
F64Y |
probably benign |
Het |
| Spata9 |
A |
C |
13: 76,146,643 (GRCm39) |
I172L |
probably benign |
Het |
| Sphkap |
T |
C |
1: 83,255,265 (GRCm39) |
H828R |
probably benign |
Het |
| Spmip6 |
T |
A |
4: 41,507,330 (GRCm39) |
|
probably null |
Het |
| Tmem94 |
A |
T |
11: 115,687,580 (GRCm39) |
K1146N |
probably damaging |
Het |
| Trdn |
A |
G |
10: 33,109,883 (GRCm39) |
T294A |
possibly damaging |
Het |
| Tsc22d1 |
T |
C |
14: 76,654,388 (GRCm39) |
V289A |
possibly damaging |
Het |
| Tti1 |
C |
A |
2: 157,834,955 (GRCm39) |
V1002L |
possibly damaging |
Het |
| Tubgcp4 |
T |
A |
2: 121,019,952 (GRCm39) |
|
probably null |
Het |
| Ush2a |
G |
A |
1: 188,643,180 (GRCm39) |
E4181K |
possibly damaging |
Het |
| Uvrag |
A |
G |
7: 98,537,555 (GRCm39) |
S547P |
probably benign |
Het |
| Vav3 |
T |
C |
3: 109,248,443 (GRCm39) |
V30A |
possibly damaging |
Het |
| Vegfa |
A |
G |
17: 46,336,395 (GRCm39) |
Y242H |
probably damaging |
Het |
| Vmn2r75 |
G |
T |
7: 85,798,019 (GRCm39) |
T598K |
probably damaging |
Het |
| Vps13b |
C |
T |
15: 35,884,765 (GRCm39) |
S3146L |
possibly damaging |
Het |
| Vrk3 |
A |
G |
7: 44,417,895 (GRCm39) |
Y310C |
probably damaging |
Het |
| Zfhx4 |
A |
G |
3: 5,447,676 (GRCm39) |
K1100R |
probably benign |
Het |
| Zfp748 |
T |
A |
13: 67,693,540 (GRCm39) |
|
probably null |
Het |
| Zfp760 |
A |
T |
17: 21,941,311 (GRCm39) |
D162V |
probably damaging |
Het |
| Znfx1 |
T |
A |
2: 166,881,786 (GRCm39) |
M1068L |
probably damaging |
Het |
|
| Other mutations in Plxnd1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00764:Plxnd1
|
APN |
6 |
115,944,933 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL01099:Plxnd1
|
APN |
6 |
115,946,906 (GRCm39) |
missense |
probably benign |
|
|
IGL01323:Plxnd1
|
APN |
6 |
115,943,760 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL01382:Plxnd1
|
APN |
6 |
115,937,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01786:Plxnd1
|
APN |
6 |
115,936,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02244:Plxnd1
|
APN |
6 |
115,955,218 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL02272:Plxnd1
|
APN |
6 |
115,970,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02293:Plxnd1
|
APN |
6 |
115,940,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02465:Plxnd1
|
APN |
6 |
115,932,703 (GRCm39) |
makesense |
probably null |
|
|
IGL02873:Plxnd1
|
APN |
6 |
115,936,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03209:Plxnd1
|
APN |
6 |
115,939,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Hiss
|
UTSW |
6 |
115,946,890 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
murmer
|
UTSW |
6 |
115,945,754 (GRCm39) |
missense |
probably benign |
0.00 |
|
mutter
|
UTSW |
6 |
115,945,005 (GRCm39) |
missense |
probably benign |
0.27 |
|
rattle
|
UTSW |
6 |
115,936,755 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0238:Plxnd1
|
UTSW |
6 |
115,945,754 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0238:Plxnd1
|
UTSW |
6 |
115,945,754 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0239:Plxnd1
|
UTSW |
6 |
115,945,754 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0239:Plxnd1
|
UTSW |
6 |
115,945,754 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0357:Plxnd1
|
UTSW |
6 |
115,946,421 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0646:Plxnd1
|
UTSW |
6 |
115,935,660 (GRCm39) |
splice site |
probably benign |
|
|
R0648:Plxnd1
|
UTSW |
6 |
115,970,962 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0718:Plxnd1
|
UTSW |
6 |
115,943,599 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1116:Plxnd1
|
UTSW |
6 |
115,943,966 (GRCm39) |
splice site |
probably null |
|
|
R1292:Plxnd1
|
UTSW |
6 |
115,939,644 (GRCm39) |
unclassified |
probably benign |
|
|
R1715:Plxnd1
|
UTSW |
6 |
115,945,642 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1799:Plxnd1
|
UTSW |
6 |
115,971,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1817:Plxnd1
|
UTSW |
6 |
115,957,562 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1848:Plxnd1
|
UTSW |
6 |
115,943,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1851:Plxnd1
|
UTSW |
6 |
115,940,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1864:Plxnd1
|
UTSW |
6 |
115,946,402 (GRCm39) |
splice site |
probably null |
|
|
R1865:Plxnd1
|
UTSW |
6 |
115,946,402 (GRCm39) |
splice site |
probably null |
|
|
R1875:Plxnd1
|
UTSW |
6 |
115,955,045 (GRCm39) |
splice site |
probably null |
|
|
R1899:Plxnd1
|
UTSW |
6 |
115,946,324 (GRCm39) |
missense |
probably benign |
|
|
R1913:Plxnd1
|
UTSW |
6 |
115,954,978 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1970:Plxnd1
|
UTSW |
6 |
115,939,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2007:Plxnd1
|
UTSW |
6 |
115,944,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2134:Plxnd1
|
UTSW |
6 |
115,934,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2202:Plxnd1
|
UTSW |
6 |
115,939,725 (GRCm39) |
missense |
probably benign |
0.45 |
|
R2230:Plxnd1
|
UTSW |
6 |
115,941,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2267:Plxnd1
|
UTSW |
6 |
115,939,704 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2427:Plxnd1
|
UTSW |
6 |
115,944,709 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4108:Plxnd1
|
UTSW |
6 |
115,936,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4233:Plxnd1
|
UTSW |
6 |
115,942,914 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4280:Plxnd1
|
UTSW |
6 |
115,933,056 (GRCm39) |
splice site |
probably null |
|
|
R4280:Plxnd1
|
UTSW |
6 |
115,933,055 (GRCm39) |
splice site |
probably benign |
|
|
R4346:Plxnd1
|
UTSW |
6 |
115,954,941 (GRCm39) |
missense |
probably benign |
0.16 |
|
R4439:Plxnd1
|
UTSW |
6 |
115,970,937 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4572:Plxnd1
|
UTSW |
6 |
115,932,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Plxnd1
|
UTSW |
6 |
115,945,005 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4599:Plxnd1
|
UTSW |
6 |
115,971,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4614:Plxnd1
|
UTSW |
6 |
115,949,486 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4700:Plxnd1
|
UTSW |
6 |
115,935,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4705:Plxnd1
|
UTSW |
6 |
115,935,581 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4806:Plxnd1
|
UTSW |
6 |
115,937,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4944:Plxnd1
|
UTSW |
6 |
115,932,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4977:Plxnd1
|
UTSW |
6 |
115,971,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5069:Plxnd1
|
UTSW |
6 |
115,942,862 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5155:Plxnd1
|
UTSW |
6 |
115,935,949 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5460:Plxnd1
|
UTSW |
6 |
115,934,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5729:Plxnd1
|
UTSW |
6 |
115,942,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5909:Plxnd1
|
UTSW |
6 |
115,945,649 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5992:Plxnd1
|
UTSW |
6 |
115,944,748 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6129:Plxnd1
|
UTSW |
6 |
115,955,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6254:Plxnd1
|
UTSW |
6 |
115,954,921 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6273:Plxnd1
|
UTSW |
6 |
115,955,453 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6310:Plxnd1
|
UTSW |
6 |
115,953,697 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6732:Plxnd1
|
UTSW |
6 |
115,946,890 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6857:Plxnd1
|
UTSW |
6 |
115,970,724 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7243:Plxnd1
|
UTSW |
6 |
115,949,468 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7282:Plxnd1
|
UTSW |
6 |
115,937,798 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7632:Plxnd1
|
UTSW |
6 |
115,953,600 (GRCm39) |
missense |
probably benign |
|
|
R7699:Plxnd1
|
UTSW |
6 |
115,936,755 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7915:Plxnd1
|
UTSW |
6 |
115,943,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8090:Plxnd1
|
UTSW |
6 |
115,933,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8382:Plxnd1
|
UTSW |
6 |
115,949,433 (GRCm39) |
missense |
probably benign |
|
|
R8507:Plxnd1
|
UTSW |
6 |
115,943,866 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8539:Plxnd1
|
UTSW |
6 |
115,939,768 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8548:Plxnd1
|
UTSW |
6 |
115,934,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8963:Plxnd1
|
UTSW |
6 |
115,949,506 (GRCm39) |
nonsense |
probably null |
|
|
R9119:Plxnd1
|
UTSW |
6 |
115,932,832 (GRCm39) |
splice site |
probably benign |
|
|
R9177:Plxnd1
|
UTSW |
6 |
115,943,469 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9182:Plxnd1
|
UTSW |
6 |
115,970,746 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9185:Plxnd1
|
UTSW |
6 |
115,934,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9226:Plxnd1
|
UTSW |
6 |
115,934,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9433:Plxnd1
|
UTSW |
6 |
115,945,754 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9449:Plxnd1
|
UTSW |
6 |
115,932,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9451:Plxnd1
|
UTSW |
6 |
115,940,277 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9599:Plxnd1
|
UTSW |
6 |
115,940,274 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9627:Plxnd1
|
UTSW |
6 |
115,940,274 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9644:Plxnd1
|
UTSW |
6 |
115,940,274 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9672:Plxnd1
|
UTSW |
6 |
115,940,274 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
X0024:Plxnd1
|
UTSW |
6 |
115,940,271 (GRCm39) |
missense |
probably benign |
0.02 |
|
X0026:Plxnd1
|
UTSW |
6 |
115,943,745 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
Z1088:Plxnd1
|
UTSW |
6 |
115,944,471 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCATGTACCAGAAGGTGAGGTTTCC -3'
(R):5'- TGGTAACGGTGAACGTCTCCAAAG -3'
Sequencing Primer
(F):5'- AGGTCCCTCAGCCTTGTG -3'
(R):5'- CTATGTGGTAAGTAGGCCACC -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation