Incidental Mutation 'R1764:Dennd4c'
| ID |
193258 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dennd4c
|
| Ensembl Gene |
ENSMUSG00000038024 |
| Gene Name |
DENN domain containing 4C |
| Synonyms |
1700065A05Rik |
| MMRRC Submission |
039796-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1764 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
86666792-86768840 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 86721247 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 636
(D636E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000123367
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045512]
[ENSMUST00000082026]
[ENSMUST00000142837]
|
| AlphaFold |
A6H8H2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000045512
AA Change: D636E
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000039860
Gene: ENSMUSG00000038024
AA Change: D636E
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
2.15e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
983 |
1001 |
N/A |
INTRINSIC |
|
low complexity region
|
1013 |
1025 |
N/A |
INTRINSIC |
|
low complexity region
|
1045 |
1052 |
N/A |
INTRINSIC |
|
low complexity region
|
1102 |
1113 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1186 |
N/A |
INTRINSIC |
|
low complexity region
|
1377 |
1392 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1486 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000082026
AA Change: D636E
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000080685
Gene: ENSMUSG00000038024
AA Change: D636E
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
3.19e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
983 |
1001 |
N/A |
INTRINSIC |
|
low complexity region
|
1013 |
1025 |
N/A |
INTRINSIC |
|
low complexity region
|
1045 |
1052 |
N/A |
INTRINSIC |
|
low complexity region
|
1102 |
1113 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1186 |
N/A |
INTRINSIC |
|
low complexity region
|
1377 |
1392 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1724 |
1739 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000142837
AA Change: D636E
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000123367
Gene: ENSMUSG00000038024
AA Change: D636E
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
2.68e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
934 |
952 |
N/A |
INTRINSIC |
|
low complexity region
|
964 |
976 |
N/A |
INTRINSIC |
|
low complexity region
|
996 |
1003 |
N/A |
INTRINSIC |
|
low complexity region
|
1053 |
1064 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1343 |
N/A |
INTRINSIC |
|
low complexity region
|
1423 |
1437 |
N/A |
INTRINSIC |
|
low complexity region
|
1675 |
1690 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.3478 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.1%
- 20x: 92.2%
|
| Validation Efficiency |
94% (94/100) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930522L14Rik |
A |
G |
5: 109,884,655 (GRCm39) |
V401A |
probably benign |
Het |
| Abca7 |
G |
T |
10: 79,844,784 (GRCm39) |
W1502L |
probably damaging |
Het |
| Adcy7 |
A |
G |
8: 89,035,468 (GRCm39) |
E124G |
probably benign |
Het |
| Aif1l |
G |
A |
2: 31,855,118 (GRCm39) |
E66K |
probably benign |
Het |
| Aldh8a1 |
A |
T |
10: 21,271,392 (GRCm39) |
M373L |
probably benign |
Het |
| Alg6 |
T |
C |
4: 99,629,815 (GRCm39) |
Y131H |
probably benign |
Het |
| Arhgef6 |
T |
C |
X: 56,383,922 (GRCm39) |
M5V |
probably benign |
Het |
| Arrdc4 |
A |
T |
7: 68,391,622 (GRCm39) |
I215K |
probably damaging |
Het |
| Asb4 |
A |
G |
6: 5,390,798 (GRCm39) |
|
probably null |
Het |
| Astn1 |
T |
C |
1: 158,331,821 (GRCm39) |
I305T |
probably benign |
Het |
| Atp5f1b |
T |
A |
10: 127,919,949 (GRCm39) |
|
probably benign |
Het |
| Atp8a1 |
C |
A |
5: 67,788,910 (GRCm39) |
M1044I |
probably benign |
Het |
| Atp9b |
C |
T |
18: 80,952,806 (GRCm39) |
|
probably null |
Het |
| Brd10 |
T |
A |
19: 29,696,560 (GRCm39) |
T978S |
possibly damaging |
Het |
| Btaf1 |
A |
G |
19: 36,928,518 (GRCm39) |
H113R |
probably benign |
Het |
| C87436 |
G |
T |
6: 86,430,594 (GRCm39) |
C338F |
possibly damaging |
Het |
| Casz1 |
T |
C |
4: 149,027,357 (GRCm39) |
|
probably benign |
Het |
| Cbr3 |
T |
A |
16: 93,487,370 (GRCm39) |
H184Q |
probably damaging |
Het |
| Cct8l1 |
T |
C |
5: 25,722,097 (GRCm39) |
S271P |
possibly damaging |
Het |
| Cdc34 |
A |
G |
10: 79,521,174 (GRCm39) |
K77R |
probably benign |
Het |
| Cdc34 |
G |
T |
10: 79,521,172 (GRCm39) |
|
probably null |
Het |
| Cdh20 |
A |
G |
1: 104,862,070 (GRCm39) |
|
probably benign |
Het |
| Celsr3 |
A |
G |
9: 108,706,157 (GRCm39) |
E880G |
probably damaging |
Het |
| Cers1 |
T |
G |
8: 70,774,141 (GRCm39) |
|
probably null |
Het |
| Cntn5 |
T |
C |
9: 9,673,988 (GRCm39) |
I705V |
probably benign |
Het |
| Dnah11 |
T |
C |
12: 118,154,560 (GRCm39) |
E240G |
probably benign |
Het |
| Dnah2 |
T |
C |
11: 69,314,369 (GRCm39) |
Y4100C |
probably damaging |
Het |
| Dpysl3 |
T |
C |
18: 43,496,583 (GRCm39) |
E151G |
probably damaging |
Het |
| Efcab9 |
T |
G |
11: 32,474,457 (GRCm39) |
T9P |
possibly damaging |
Het |
| Eif4g2 |
A |
T |
7: 110,673,694 (GRCm39) |
F725Y |
probably damaging |
Het |
| Epha6 |
T |
A |
16: 59,596,091 (GRCm39) |
I867F |
probably null |
Het |
| Erbin |
T |
C |
13: 103,979,959 (GRCm39) |
|
probably benign |
Het |
| Evi5l |
A |
G |
8: 4,253,560 (GRCm39) |
E468G |
probably damaging |
Het |
| Filip1l |
C |
T |
16: 57,390,401 (GRCm39) |
R330W |
probably damaging |
Het |
| Fmo3 |
C |
T |
1: 162,786,142 (GRCm39) |
V283M |
possibly damaging |
Het |
| Gabarapl1 |
A |
T |
6: 129,510,481 (GRCm39) |
K24N |
possibly damaging |
Het |
| Gigyf1 |
C |
T |
5: 137,520,770 (GRCm39) |
|
probably benign |
Het |
| Gm5581 |
T |
A |
6: 131,158,362 (GRCm39) |
|
noncoding transcript |
Het |
| Gon4l |
G |
T |
3: 88,799,906 (GRCm39) |
K850N |
probably damaging |
Het |
| Igf2bp3 |
C |
T |
6: 49,085,980 (GRCm39) |
R233H |
probably damaging |
Het |
| Iqcf4 |
G |
A |
9: 106,445,893 (GRCm39) |
R85C |
probably benign |
Het |
| Kalrn |
C |
T |
16: 34,033,243 (GRCm39) |
R473Q |
probably damaging |
Het |
| Lmod2 |
T |
A |
6: 24,603,376 (GRCm39) |
V117E |
probably damaging |
Het |
| Mapk11 |
A |
G |
15: 89,028,594 (GRCm39) |
|
probably null |
Het |
| Mcm3 |
G |
A |
1: 20,876,103 (GRCm39) |
R664C |
probably damaging |
Het |
| Mex3d |
A |
G |
10: 80,222,770 (GRCm39) |
M162T |
probably benign |
Het |
| Mrgprb3 |
A |
G |
7: 48,292,771 (GRCm39) |
I260T |
probably benign |
Het |
| Ncor2 |
G |
T |
5: 125,105,679 (GRCm39) |
A1637D |
possibly damaging |
Het |
| Nedd4 |
T |
A |
9: 72,638,189 (GRCm39) |
D441E |
probably damaging |
Het |
| Nek5 |
A |
T |
8: 22,599,928 (GRCm39) |
C194S |
probably damaging |
Het |
| Nos1ap |
T |
C |
1: 170,146,447 (GRCm39) |
D369G |
possibly damaging |
Het |
| Ntrk1 |
G |
T |
3: 87,687,391 (GRCm39) |
T681K |
probably damaging |
Het |
| Or13a24 |
T |
C |
7: 140,154,383 (GRCm39) |
W106R |
probably damaging |
Het |
| Or4f14 |
A |
G |
2: 111,742,526 (GRCm39) |
F250L |
possibly damaging |
Het |
| Otogl |
C |
T |
10: 107,735,322 (GRCm39) |
W154* |
probably null |
Het |
| Pcdh20 |
T |
C |
14: 88,706,620 (GRCm39) |
T227A |
possibly damaging |
Het |
| Pcdhb17 |
T |
C |
18: 37,620,324 (GRCm39) |
S705P |
probably damaging |
Het |
| Piezo2 |
T |
C |
18: 63,257,713 (GRCm39) |
H335R |
possibly damaging |
Het |
| Pkn2 |
T |
C |
3: 142,499,615 (GRCm39) |
Q954R |
probably damaging |
Het |
| Pramel23 |
C |
A |
4: 143,424,840 (GRCm39) |
C201F |
probably benign |
Het |
| Prkcq |
G |
A |
2: 11,237,442 (GRCm39) |
V74M |
probably damaging |
Het |
| Prkrip1 |
A |
T |
5: 136,218,489 (GRCm39) |
|
probably null |
Het |
| Pttg1ip2 |
A |
T |
5: 5,528,943 (GRCm39) |
I24N |
possibly damaging |
Het |
| Rb1cc1 |
A |
G |
1: 6,284,904 (GRCm39) |
|
probably benign |
Het |
| Rbm5 |
A |
T |
9: 107,644,763 (GRCm39) |
Y11* |
probably null |
Het |
| Rsf1 |
CG |
CGACGGCGGTG |
7: 97,229,115 (GRCm39) |
|
probably benign |
Het |
| Ryr3 |
C |
A |
2: 112,690,805 (GRCm39) |
V1082L |
probably damaging |
Het |
| Scart2 |
A |
G |
7: 139,877,178 (GRCm39) |
E831G |
probably benign |
Het |
| Sel1l3 |
C |
A |
5: 53,327,789 (GRCm39) |
E497* |
probably null |
Het |
| Serpina6 |
A |
T |
12: 103,620,182 (GRCm39) |
I189N |
probably damaging |
Het |
| Serpinb11 |
A |
T |
1: 107,304,532 (GRCm39) |
T166S |
probably benign |
Het |
| Skint7 |
T |
C |
4: 111,839,270 (GRCm39) |
L188S |
probably benign |
Het |
| Slc25a45 |
C |
T |
19: 5,934,958 (GRCm39) |
A269V |
probably damaging |
Het |
| Sltm |
A |
G |
9: 70,469,082 (GRCm39) |
T114A |
probably benign |
Het |
| Sned1 |
G |
A |
1: 93,209,376 (GRCm39) |
V830M |
possibly damaging |
Het |
| Spen |
C |
A |
4: 141,200,261 (GRCm39) |
V2766L |
probably damaging |
Het |
| Srgap2 |
T |
A |
1: 131,247,275 (GRCm39) |
I445F |
possibly damaging |
Het |
| Stox2 |
A |
T |
8: 47,647,051 (GRCm39) |
Y200* |
probably null |
Het |
| Strada |
C |
A |
11: 106,055,010 (GRCm39) |
R384L |
probably damaging |
Het |
| Tctn2 |
G |
A |
5: 124,757,094 (GRCm39) |
|
noncoding transcript |
Het |
| Tgfbr3l |
G |
T |
8: 4,299,282 (GRCm39) |
R461L |
probably benign |
Het |
| Tmem65 |
A |
G |
15: 58,661,998 (GRCm39) |
|
probably benign |
Het |
| Tpst1 |
G |
T |
5: 130,143,343 (GRCm39) |
V294F |
possibly damaging |
Het |
| Trim23 |
A |
G |
13: 104,335,126 (GRCm39) |
Y384C |
probably damaging |
Het |
| Ube3b |
C |
G |
5: 114,542,678 (GRCm39) |
L512V |
possibly damaging |
Het |
| Ubxn4 |
T |
A |
1: 128,183,916 (GRCm39) |
V92E |
probably damaging |
Het |
| Vmn2r57 |
A |
T |
7: 41,050,067 (GRCm39) |
C561S |
probably damaging |
Het |
| Vwa8 |
A |
G |
14: 79,145,635 (GRCm39) |
D104G |
probably damaging |
Het |
| Wdr25 |
T |
A |
12: 108,992,364 (GRCm39) |
L73* |
probably null |
Het |
| Wnt9a |
G |
A |
11: 59,221,728 (GRCm39) |
A209T |
probably benign |
Het |
| Zcchc17 |
A |
C |
4: 130,223,388 (GRCm39) |
C133G |
probably damaging |
Het |
| Zdhhc18 |
T |
A |
4: 133,335,987 (GRCm39) |
M375L |
probably benign |
Het |
| Zfhx3 |
T |
C |
8: 109,678,276 (GRCm39) |
F3109L |
probably benign |
Het |
| Zfp202 |
T |
A |
9: 40,121,762 (GRCm39) |
D286E |
probably benign |
Het |
| Zzef1 |
T |
C |
11: 72,784,158 (GRCm39) |
L2021P |
probably benign |
Het |
|
| Other mutations in Dennd4c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01309:Dennd4c
|
APN |
4 |
86,723,724 (GRCm39) |
splice site |
probably benign |
|
|
IGL01810:Dennd4c
|
APN |
4 |
86,717,788 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02203:Dennd4c
|
APN |
4 |
86,721,173 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02217:Dennd4c
|
APN |
4 |
86,732,036 (GRCm39) |
missense |
probably benign |
|
|
IGL02236:Dennd4c
|
APN |
4 |
86,725,672 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02256:Dennd4c
|
APN |
4 |
86,717,778 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02396:Dennd4c
|
APN |
4 |
86,743,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02523:Dennd4c
|
APN |
4 |
86,692,490 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02615:Dennd4c
|
APN |
4 |
86,739,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03069:Dennd4c
|
APN |
4 |
86,692,674 (GRCm39) |
nonsense |
probably null |
|
|
IGL03116:Dennd4c
|
APN |
4 |
86,707,057 (GRCm39) |
splice site |
probably benign |
|
|
IGL03117:Dennd4c
|
APN |
4 |
86,696,140 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03273:Dennd4c
|
APN |
4 |
86,696,033 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03329:Dennd4c
|
APN |
4 |
86,696,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03365:Dennd4c
|
APN |
4 |
86,725,663 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
PIT4486001:Dennd4c
|
UTSW |
4 |
86,717,701 (GRCm39) |
nonsense |
probably null |
|
|
R0010:Dennd4c
|
UTSW |
4 |
86,699,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0032:Dennd4c
|
UTSW |
4 |
86,746,387 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0032:Dennd4c
|
UTSW |
4 |
86,746,387 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0092:Dennd4c
|
UTSW |
4 |
86,699,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0103:Dennd4c
|
UTSW |
4 |
86,730,683 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0103:Dennd4c
|
UTSW |
4 |
86,730,683 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0511:Dennd4c
|
UTSW |
4 |
86,744,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0515:Dennd4c
|
UTSW |
4 |
86,731,703 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0578:Dennd4c
|
UTSW |
4 |
86,730,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0759:Dennd4c
|
UTSW |
4 |
86,707,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0784:Dennd4c
|
UTSW |
4 |
86,763,145 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1156:Dennd4c
|
UTSW |
4 |
86,725,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1370:Dennd4c
|
UTSW |
4 |
86,729,747 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1381:Dennd4c
|
UTSW |
4 |
86,692,769 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1569:Dennd4c
|
UTSW |
4 |
86,704,331 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R1747:Dennd4c
|
UTSW |
4 |
86,725,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Dennd4c
|
UTSW |
4 |
86,743,415 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1997:Dennd4c
|
UTSW |
4 |
86,755,634 (GRCm39) |
missense |
probably benign |
|
|
R2244:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2348:Dennd4c
|
UTSW |
4 |
86,729,764 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2968:Dennd4c
|
UTSW |
4 |
86,699,881 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3033:Dennd4c
|
UTSW |
4 |
86,743,557 (GRCm39) |
small deletion |
probably benign |
|
|
R3401:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3402:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3403:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3855:Dennd4c
|
UTSW |
4 |
86,698,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3939:Dennd4c
|
UTSW |
4 |
86,692,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4164:Dennd4c
|
UTSW |
4 |
86,725,764 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4384:Dennd4c
|
UTSW |
4 |
86,729,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4435:Dennd4c
|
UTSW |
4 |
86,716,312 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4788:Dennd4c
|
UTSW |
4 |
86,738,200 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4801:Dennd4c
|
UTSW |
4 |
86,738,121 (GRCm39) |
nonsense |
probably null |
|
|
R4802:Dennd4c
|
UTSW |
4 |
86,738,121 (GRCm39) |
nonsense |
probably null |
|
|
R4818:Dennd4c
|
UTSW |
4 |
86,743,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4923:Dennd4c
|
UTSW |
4 |
86,725,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4958:Dennd4c
|
UTSW |
4 |
86,699,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5025:Dennd4c
|
UTSW |
4 |
86,713,536 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5434:Dennd4c
|
UTSW |
4 |
86,729,693 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5662:Dennd4c
|
UTSW |
4 |
86,713,525 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5802:Dennd4c
|
UTSW |
4 |
86,729,690 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5849:Dennd4c
|
UTSW |
4 |
86,744,223 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5861:Dennd4c
|
UTSW |
4 |
86,709,589 (GRCm39) |
missense |
probably benign |
0.30 |
|
R5970:Dennd4c
|
UTSW |
4 |
86,743,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6163:Dennd4c
|
UTSW |
4 |
86,723,828 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6356:Dennd4c
|
UTSW |
4 |
86,743,686 (GRCm39) |
missense |
probably benign |
|
|
R6661:Dennd4c
|
UTSW |
4 |
86,717,626 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6855:Dennd4c
|
UTSW |
4 |
86,754,694 (GRCm39) |
missense |
probably benign |
|
|
R6983:Dennd4c
|
UTSW |
4 |
86,717,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7035:Dennd4c
|
UTSW |
4 |
86,730,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7126:Dennd4c
|
UTSW |
4 |
86,725,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7185:Dennd4c
|
UTSW |
4 |
86,729,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7212:Dennd4c
|
UTSW |
4 |
86,721,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7324:Dennd4c
|
UTSW |
4 |
86,747,975 (GRCm39) |
missense |
unknown |
|
|
R7329:Dennd4c
|
UTSW |
4 |
86,698,111 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7329:Dennd4c
|
UTSW |
4 |
86,759,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7466:Dennd4c
|
UTSW |
4 |
86,692,568 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7479:Dennd4c
|
UTSW |
4 |
86,717,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7538:Dennd4c
|
UTSW |
4 |
86,692,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7599:Dennd4c
|
UTSW |
4 |
86,729,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7688:Dennd4c
|
UTSW |
4 |
86,713,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7725:Dennd4c
|
UTSW |
4 |
86,704,330 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7751:Dennd4c
|
UTSW |
4 |
86,747,179 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7790:Dennd4c
|
UTSW |
4 |
86,717,754 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8056:Dennd4c
|
UTSW |
4 |
86,763,213 (GRCm39) |
missense |
probably null |
0.71 |
|
R8307:Dennd4c
|
UTSW |
4 |
86,744,109 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8494:Dennd4c
|
UTSW |
4 |
86,759,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8531:Dennd4c
|
UTSW |
4 |
86,744,319 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9014:Dennd4c
|
UTSW |
4 |
86,754,666 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9014:Dennd4c
|
UTSW |
4 |
86,739,702 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9017:Dennd4c
|
UTSW |
4 |
86,743,349 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9142:Dennd4c
|
UTSW |
4 |
86,755,637 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9224:Dennd4c
|
UTSW |
4 |
86,738,170 (GRCm39) |
nonsense |
probably null |
|
|
R9570:Dennd4c
|
UTSW |
4 |
86,747,208 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9644:Dennd4c
|
UTSW |
4 |
86,713,363 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9649:Dennd4c
|
UTSW |
4 |
86,743,160 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9658:Dennd4c
|
UTSW |
4 |
86,754,625 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TTTGCTCAGGACATAGGGCTGAGG -3'
(R):5'- AGATAGAAAGTCAGGCTCGCTTGC -3'
Sequencing Primer
(F):5'- GTTTCATAGTTAAGTCAGGCAGAG -3'
(R):5'- AGGCTCGCTTGCTCTCTC -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation