Incidental Mutation 'R1764:Brd10'
ID 193338
Institutional Source Beutler Lab
Gene Symbol Brd10
Ensembl Gene ENSMUSG00000046138
Gene Name bromodomain containing 10
Synonyms 9930021J03Rik, Gm9832
MMRRC Submission 039796-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.138) question?
Stock # R1764 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 29691802-29783389 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 29696560 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 978 (T978S)
Ref Sequence ENSEMBL: ENSMUSP00000135473 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000177155]
AlphaFold H3BKP8
Predicted Effect probably benign
Transcript: ENSMUST00000059484
AA Change: T1045S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000054060
Gene: ENSMUSG00000046138
AA Change: T1045S

DomainStartEndE-ValueType
low complexity region 4 66 N/A INTRINSIC
BROMO 75 198 1.22e-3 SMART
low complexity region 225 235 N/A INTRINSIC
coiled coil region 248 289 N/A INTRINSIC
low complexity region 347 365 N/A INTRINSIC
low complexity region 495 508 N/A INTRINSIC
coiled coil region 673 705 N/A INTRINSIC
low complexity region 722 756 N/A INTRINSIC
coiled coil region 764 796 N/A INTRINSIC
low complexity region 1146 1160 N/A INTRINSIC
internal_repeat_1 1164 1293 9.57e-8 PROSPERO
low complexity region 1295 1304 N/A INTRINSIC
low complexity region 1386 1415 N/A INTRINSIC
low complexity region 1468 1483 N/A INTRINSIC
low complexity region 1602 1624 N/A INTRINSIC
low complexity region 1647 1663 N/A INTRINSIC
low complexity region 1732 1745 N/A INTRINSIC
internal_repeat_1 1766 1910 9.57e-8 PROSPERO
low complexity region 1987 1993 N/A INTRINSIC
low complexity region 2013 2027 N/A INTRINSIC
low complexity region 2053 2071 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000175726
AA Change: T922S
Predicted Effect unknown
Transcript: ENSMUST00000175764
AA Change: T277S
SMART Domains Protein: ENSMUSP00000135031
Gene: ENSMUSG00000046138
AA Change: T277S

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
low complexity region 379 393 N/A INTRINSIC
internal_repeat_1 397 526 2.65e-5 PROSPERO
low complexity region 528 537 N/A INTRINSIC
low complexity region 619 648 N/A INTRINSIC
low complexity region 701 716 N/A INTRINSIC
low complexity region 835 857 N/A INTRINSIC
low complexity region 880 896 N/A INTRINSIC
low complexity region 965 978 N/A INTRINSIC
internal_repeat_1 999 1143 2.65e-5 PROSPERO
low complexity region 1220 1226 N/A INTRINSIC
low complexity region 1246 1260 N/A INTRINSIC
low complexity region 1286 1304 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000176773
Predicted Effect possibly damaging
Transcript: ENSMUST00000177155
AA Change: T978S

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000135473
Gene: ENSMUSG00000046138
AA Change: T978S

DomainStartEndE-ValueType
low complexity region 4 66 N/A INTRINSIC
BROMO 75 198 1.22e-3 SMART
low complexity region 205 219 N/A INTRINSIC
low complexity region 280 298 N/A INTRINSIC
low complexity region 428 441 N/A INTRINSIC
coiled coil region 606 638 N/A INTRINSIC
low complexity region 655 689 N/A INTRINSIC
coiled coil region 697 729 N/A INTRINSIC
low complexity region 1079 1093 N/A INTRINSIC
internal_repeat_1 1097 1226 1.32e-7 PROSPERO
low complexity region 1228 1237 N/A INTRINSIC
low complexity region 1319 1348 N/A INTRINSIC
low complexity region 1401 1416 N/A INTRINSIC
low complexity region 1535 1557 N/A INTRINSIC
low complexity region 1580 1596 N/A INTRINSIC
low complexity region 1665 1678 N/A INTRINSIC
internal_repeat_1 1699 1843 1.32e-7 PROSPERO
low complexity region 1920 1926 N/A INTRINSIC
low complexity region 1946 1960 N/A INTRINSIC
low complexity region 1986 2004 N/A INTRINSIC
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 95.1%
  • 20x: 92.2%
Validation Efficiency 94% (94/100)
Allele List at MGI
Other mutations in this stock
Total: 95 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522L14Rik A G 5: 109,884,655 (GRCm39) V401A probably benign Het
Abca7 G T 10: 79,844,784 (GRCm39) W1502L probably damaging Het
Adcy7 A G 8: 89,035,468 (GRCm39) E124G probably benign Het
Aif1l G A 2: 31,855,118 (GRCm39) E66K probably benign Het
Aldh8a1 A T 10: 21,271,392 (GRCm39) M373L probably benign Het
Alg6 T C 4: 99,629,815 (GRCm39) Y131H probably benign Het
Arhgef6 T C X: 56,383,922 (GRCm39) M5V probably benign Het
Arrdc4 A T 7: 68,391,622 (GRCm39) I215K probably damaging Het
Asb4 A G 6: 5,390,798 (GRCm39) probably null Het
Astn1 T C 1: 158,331,821 (GRCm39) I305T probably benign Het
Atp5f1b T A 10: 127,919,949 (GRCm39) probably benign Het
Atp8a1 C A 5: 67,788,910 (GRCm39) M1044I probably benign Het
Atp9b C T 18: 80,952,806 (GRCm39) probably null Het
Btaf1 A G 19: 36,928,518 (GRCm39) H113R probably benign Het
C87436 G T 6: 86,430,594 (GRCm39) C338F possibly damaging Het
Casz1 T C 4: 149,027,357 (GRCm39) probably benign Het
Cbr3 T A 16: 93,487,370 (GRCm39) H184Q probably damaging Het
Cct8l1 T C 5: 25,722,097 (GRCm39) S271P possibly damaging Het
Cdc34 A G 10: 79,521,174 (GRCm39) K77R probably benign Het
Cdc34 G T 10: 79,521,172 (GRCm39) probably null Het
Cdh20 A G 1: 104,862,070 (GRCm39) probably benign Het
Celsr3 A G 9: 108,706,157 (GRCm39) E880G probably damaging Het
Cers1 T G 8: 70,774,141 (GRCm39) probably null Het
Cntn5 T C 9: 9,673,988 (GRCm39) I705V probably benign Het
Dennd4c T A 4: 86,721,247 (GRCm39) D636E probably damaging Het
Dnah11 T C 12: 118,154,560 (GRCm39) E240G probably benign Het
Dnah2 T C 11: 69,314,369 (GRCm39) Y4100C probably damaging Het
Dpysl3 T C 18: 43,496,583 (GRCm39) E151G probably damaging Het
Efcab9 T G 11: 32,474,457 (GRCm39) T9P possibly damaging Het
Eif4g2 A T 7: 110,673,694 (GRCm39) F725Y probably damaging Het
Epha6 T A 16: 59,596,091 (GRCm39) I867F probably null Het
Erbin T C 13: 103,979,959 (GRCm39) probably benign Het
Evi5l A G 8: 4,253,560 (GRCm39) E468G probably damaging Het
Filip1l C T 16: 57,390,401 (GRCm39) R330W probably damaging Het
Fmo3 C T 1: 162,786,142 (GRCm39) V283M possibly damaging Het
Gabarapl1 A T 6: 129,510,481 (GRCm39) K24N possibly damaging Het
Gigyf1 C T 5: 137,520,770 (GRCm39) probably benign Het
Gm5581 T A 6: 131,158,362 (GRCm39) noncoding transcript Het
Gon4l G T 3: 88,799,906 (GRCm39) K850N probably damaging Het
Igf2bp3 C T 6: 49,085,980 (GRCm39) R233H probably damaging Het
Iqcf4 G A 9: 106,445,893 (GRCm39) R85C probably benign Het
Kalrn C T 16: 34,033,243 (GRCm39) R473Q probably damaging Het
Lmod2 T A 6: 24,603,376 (GRCm39) V117E probably damaging Het
Mapk11 A G 15: 89,028,594 (GRCm39) probably null Het
Mcm3 G A 1: 20,876,103 (GRCm39) R664C probably damaging Het
Mex3d A G 10: 80,222,770 (GRCm39) M162T probably benign Het
Mrgprb3 A G 7: 48,292,771 (GRCm39) I260T probably benign Het
Ncor2 G T 5: 125,105,679 (GRCm39) A1637D possibly damaging Het
Nedd4 T A 9: 72,638,189 (GRCm39) D441E probably damaging Het
Nek5 A T 8: 22,599,928 (GRCm39) C194S probably damaging Het
Nos1ap T C 1: 170,146,447 (GRCm39) D369G possibly damaging Het
Ntrk1 G T 3: 87,687,391 (GRCm39) T681K probably damaging Het
Or13a24 T C 7: 140,154,383 (GRCm39) W106R probably damaging Het
Or4f14 A G 2: 111,742,526 (GRCm39) F250L possibly damaging Het
Otogl C T 10: 107,735,322 (GRCm39) W154* probably null Het
Pcdh20 T C 14: 88,706,620 (GRCm39) T227A possibly damaging Het
Pcdhb17 T C 18: 37,620,324 (GRCm39) S705P probably damaging Het
Piezo2 T C 18: 63,257,713 (GRCm39) H335R possibly damaging Het
Pkn2 T C 3: 142,499,615 (GRCm39) Q954R probably damaging Het
Pramel23 C A 4: 143,424,840 (GRCm39) C201F probably benign Het
Prkcq G A 2: 11,237,442 (GRCm39) V74M probably damaging Het
Prkrip1 A T 5: 136,218,489 (GRCm39) probably null Het
Pttg1ip2 A T 5: 5,528,943 (GRCm39) I24N possibly damaging Het
Rb1cc1 A G 1: 6,284,904 (GRCm39) probably benign Het
Rbm5 A T 9: 107,644,763 (GRCm39) Y11* probably null Het
Rsf1 CG CGACGGCGGTG 7: 97,229,115 (GRCm39) probably benign Het
Ryr3 C A 2: 112,690,805 (GRCm39) V1082L probably damaging Het
Scart2 A G 7: 139,877,178 (GRCm39) E831G probably benign Het
Sel1l3 C A 5: 53,327,789 (GRCm39) E497* probably null Het
Serpina6 A T 12: 103,620,182 (GRCm39) I189N probably damaging Het
Serpinb11 A T 1: 107,304,532 (GRCm39) T166S probably benign Het
Skint7 T C 4: 111,839,270 (GRCm39) L188S probably benign Het
Slc25a45 C T 19: 5,934,958 (GRCm39) A269V probably damaging Het
Sltm A G 9: 70,469,082 (GRCm39) T114A probably benign Het
Sned1 G A 1: 93,209,376 (GRCm39) V830M possibly damaging Het
Spen C A 4: 141,200,261 (GRCm39) V2766L probably damaging Het
Srgap2 T A 1: 131,247,275 (GRCm39) I445F possibly damaging Het
Stox2 A T 8: 47,647,051 (GRCm39) Y200* probably null Het
Strada C A 11: 106,055,010 (GRCm39) R384L probably damaging Het
Tctn2 G A 5: 124,757,094 (GRCm39) noncoding transcript Het
Tgfbr3l G T 8: 4,299,282 (GRCm39) R461L probably benign Het
Tmem65 A G 15: 58,661,998 (GRCm39) probably benign Het
Tpst1 G T 5: 130,143,343 (GRCm39) V294F possibly damaging Het
Trim23 A G 13: 104,335,126 (GRCm39) Y384C probably damaging Het
Ube3b C G 5: 114,542,678 (GRCm39) L512V possibly damaging Het
Ubxn4 T A 1: 128,183,916 (GRCm39) V92E probably damaging Het
Vmn2r57 A T 7: 41,050,067 (GRCm39) C561S probably damaging Het
Vwa8 A G 14: 79,145,635 (GRCm39) D104G probably damaging Het
Wdr25 T A 12: 108,992,364 (GRCm39) L73* probably null Het
Wnt9a G A 11: 59,221,728 (GRCm39) A209T probably benign Het
Zcchc17 A C 4: 130,223,388 (GRCm39) C133G probably damaging Het
Zdhhc18 T A 4: 133,335,987 (GRCm39) M375L probably benign Het
Zfhx3 T C 8: 109,678,276 (GRCm39) F3109L probably benign Het
Zfp202 T A 9: 40,121,762 (GRCm39) D286E probably benign Het
Zzef1 T C 11: 72,784,158 (GRCm39) L2021P probably benign Het
Other mutations in Brd10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01311:Brd10 APN 19 29,731,420 (GRCm39) missense probably benign 0.33
IGL01535:Brd10 APN 19 29,731,212 (GRCm39) missense possibly damaging 0.53
IGL02019:Brd10 APN 19 29,694,463 (GRCm39) missense probably benign 0.28
IGL02034:Brd10 APN 19 29,694,259 (GRCm39) missense possibly damaging 0.73
IGL03114:Brd10 APN 19 29,694,532 (GRCm39) missense probably benign 0.18
IGL03382:Brd10 APN 19 29,694,676 (GRCm39) missense probably damaging 1.00
R0020:Brd10 UTSW 19 29,693,597 (GRCm39) missense probably damaging 0.98
R0020:Brd10 UTSW 19 29,693,597 (GRCm39) missense probably damaging 0.98
R0142:Brd10 UTSW 19 29,695,654 (GRCm39) missense possibly damaging 0.93
R0178:Brd10 UTSW 19 29,732,188 (GRCm39) missense probably damaging 1.00
R0453:Brd10 UTSW 19 29,731,068 (GRCm39) missense probably damaging 1.00
R0730:Brd10 UTSW 19 29,695,381 (GRCm39) missense probably benign 0.00
R0735:Brd10 UTSW 19 29,695,038 (GRCm39) missense possibly damaging 0.92
R0891:Brd10 UTSW 19 29,695,053 (GRCm39) missense probably damaging 1.00
R0894:Brd10 UTSW 19 29,697,974 (GRCm39) splice site probably benign
R1289:Brd10 UTSW 19 29,700,852 (GRCm39) missense probably benign 0.07
R1368:Brd10 UTSW 19 29,693,796 (GRCm39) missense probably damaging 0.97
R1387:Brd10 UTSW 19 29,700,853 (GRCm39) missense probably benign 0.15
R1483:Brd10 UTSW 19 29,696,745 (GRCm39) missense possibly damaging 0.93
R1526:Brd10 UTSW 19 29,712,545 (GRCm39) missense probably damaging 1.00
R1612:Brd10 UTSW 19 29,695,245 (GRCm39) missense possibly damaging 0.86
R1721:Brd10 UTSW 19 29,720,998 (GRCm39) missense probably damaging 0.99
R1822:Brd10 UTSW 19 29,693,814 (GRCm39) missense probably damaging 0.99
R1824:Brd10 UTSW 19 29,693,814 (GRCm39) missense probably damaging 0.99
R1859:Brd10 UTSW 19 29,732,323 (GRCm39) missense possibly damaging 0.53
R1868:Brd10 UTSW 19 29,720,998 (GRCm39) missense probably damaging 0.99
R1880:Brd10 UTSW 19 29,695,523 (GRCm39) missense probably benign 0.06
R1898:Brd10 UTSW 19 29,712,532 (GRCm39) missense possibly damaging 0.74
R1936:Brd10 UTSW 19 29,731,077 (GRCm39) missense possibly damaging 0.87
R1939:Brd10 UTSW 19 29,731,077 (GRCm39) missense possibly damaging 0.87
R1969:Brd10 UTSW 19 29,694,075 (GRCm39) missense possibly damaging 0.95
R2153:Brd10 UTSW 19 29,694,229 (GRCm39) missense probably benign 0.01
R2366:Brd10 UTSW 19 29,731,035 (GRCm39) missense probably damaging 0.99
R2379:Brd10 UTSW 19 29,696,275 (GRCm39) missense probably benign 0.01
R3107:Brd10 UTSW 19 29,700,847 (GRCm39) missense probably damaging 1.00
R4012:Brd10 UTSW 19 29,720,990 (GRCm39) missense probably damaging 1.00
R4222:Brd10 UTSW 19 29,696,149 (GRCm39) missense probably benign 0.18
R4328:Brd10 UTSW 19 29,720,961 (GRCm39) missense probably benign 0.00
R4329:Brd10 UTSW 19 29,720,961 (GRCm39) missense probably benign 0.00
R4387:Brd10 UTSW 19 29,782,715 (GRCm39) unclassified probably benign
R4688:Brd10 UTSW 19 29,694,501 (GRCm39) missense probably benign 0.33
R4796:Brd10 UTSW 19 29,731,018 (GRCm39) missense probably benign 0.33
R4820:Brd10 UTSW 19 29,695,809 (GRCm39) missense possibly damaging 0.53
R4832:Brd10 UTSW 19 29,694,616 (GRCm39) missense possibly damaging 0.53
R5056:Brd10 UTSW 19 29,694,759 (GRCm39) missense probably benign
R5150:Brd10 UTSW 19 29,782,950 (GRCm39) missense probably damaging 0.96
R5224:Brd10 UTSW 19 29,696,450 (GRCm39) missense possibly damaging 0.73
R5306:Brd10 UTSW 19 29,707,230 (GRCm39) intron probably benign
R5460:Brd10 UTSW 19 29,732,250 (GRCm39) missense probably damaging 0.98
R5477:Brd10 UTSW 19 29,731,518 (GRCm39) missense probably benign 0.33
R5531:Brd10 UTSW 19 29,731,072 (GRCm39) missense possibly damaging 0.73
R5559:Brd10 UTSW 19 29,694,363 (GRCm39) missense possibly damaging 0.91
R5647:Brd10 UTSW 19 29,731,210 (GRCm39) missense possibly damaging 0.73
R5886:Brd10 UTSW 19 29,696,677 (GRCm39) missense probably benign 0.03
R6029:Brd10 UTSW 19 29,732,367 (GRCm39) unclassified probably benign
R6240:Brd10 UTSW 19 29,694,640 (GRCm39) missense probably benign 0.18
R6331:Brd10 UTSW 19 29,695,147 (GRCm39) missense probably benign 0.33
R6456:Brd10 UTSW 19 29,693,914 (GRCm39) missense possibly damaging 0.93
R6584:Brd10 UTSW 19 29,696,128 (GRCm39) missense possibly damaging 0.53
R6661:Brd10 UTSW 19 29,700,864 (GRCm39) missense possibly damaging 0.53
R6991:Brd10 UTSW 19 29,696,508 (GRCm39) missense possibly damaging 0.86
R7059:Brd10 UTSW 19 29,696,945 (GRCm39) missense probably benign 0.33
R7128:Brd10 UTSW 19 29,693,881 (GRCm39) missense possibly damaging 0.53
R7211:Brd10 UTSW 19 29,763,712 (GRCm39) missense
R7471:Brd10 UTSW 19 29,707,139 (GRCm39) splice site probably null
R7686:Brd10 UTSW 19 29,694,870 (GRCm39) missense probably benign 0.34
R8012:Brd10 UTSW 19 29,695,534 (GRCm39) missense possibly damaging 0.73
R8203:Brd10 UTSW 19 29,693,443 (GRCm39) missense probably benign 0.18
R8353:Brd10 UTSW 19 29,731,242 (GRCm39) missense possibly damaging 0.53
R8672:Brd10 UTSW 19 29,731,564 (GRCm39) missense probably benign
R8755:Brd10 UTSW 19 29,693,890 (GRCm39) missense probably benign 0.03
R8918:Brd10 UTSW 19 29,696,841 (GRCm39) missense possibly damaging 0.53
R8954:Brd10 UTSW 19 29,696,126 (GRCm39) missense possibly damaging 0.72
R9038:Brd10 UTSW 19 29,731,900 (GRCm39) missense possibly damaging 0.86
R9195:Brd10 UTSW 19 29,763,703 (GRCm39) missense
R9204:Brd10 UTSW 19 29,696,938 (GRCm39) missense possibly damaging 0.73
R9518:Brd10 UTSW 19 29,731,541 (GRCm39) missense possibly damaging 0.53
R9743:Brd10 UTSW 19 29,694,261 (GRCm39) missense probably benign
R9747:Brd10 UTSW 19 29,731,911 (GRCm39) missense possibly damaging 0.73
RF011:Brd10 UTSW 19 29,721,009 (GRCm39) missense possibly damaging 0.53
X0027:Brd10 UTSW 19 29,712,599 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GGAGACAAAGGCTGTGATCTAGCAC -3'
(R):5'- TTGCCTCAAAGGCTTCAGTACCAG -3'

Sequencing Primer
(F):5'- CTAGCACTCACATTTGATGAAGG -3'
(R):5'- AAGGCTTCAGTACCAGTGTCTAC -3'
Posted On 2014-05-23