Incidental Mutation 'R1750:Inpp5d'
ID 193344
Institutional Source Beutler Lab
Gene Symbol Inpp5d
Ensembl Gene ENSMUSG00000026288
Gene Name inositol polyphosphate-5-phosphatase D
Synonyms SHIP1, Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP, SHIP, SHIP-1
MMRRC Submission 039782-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.906) question?
Stock # R1750 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 87548034-87648229 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87626803 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 540 (F540L)
Ref Sequence ENSEMBL: ENSMUSP00000127941 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042275] [ENSMUST00000072999] [ENSMUST00000167032] [ENSMUST00000168783] [ENSMUST00000169754] [ENSMUST00000170300]
AlphaFold Q9ES52
Predicted Effect probably damaging
Transcript: ENSMUST00000042275
AA Change: F539L

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000044647
Gene: ENSMUSG00000026288
AA Change: F539L

DomainStartEndE-ValueType
SH2 6 95 7.15e-29 SMART
low complexity region 107 120 N/A INTRINSIC
IPPc 404 720 4.5e-104 SMART
low complexity region 767 777 N/A INTRINSIC
low complexity region 954 979 N/A INTRINSIC
low complexity region 1045 1057 N/A INTRINSIC
low complexity region 1119 1131 N/A INTRINSIC
low complexity region 1139 1148 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000072999
AA Change: F539L

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000072763
Gene: ENSMUSG00000026288
AA Change: F539L

DomainStartEndE-ValueType
SH2 6 95 7.15e-29 SMART
low complexity region 107 120 N/A INTRINSIC
IPPc 404 720 4.5e-104 SMART
low complexity region 767 777 N/A INTRINSIC
low complexity region 932 953 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000167032
AA Change: F277L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000126569
Gene: ENSMUSG00000026288
AA Change: F277L

DomainStartEndE-ValueType
IPPc 142 458 4.5e-104 SMART
low complexity region 505 515 N/A INTRINSIC
low complexity region 692 717 N/A INTRINSIC
low complexity region 783 795 N/A INTRINSIC
low complexity region 857 869 N/A INTRINSIC
low complexity region 877 886 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000168783
AA Change: F540L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000131244
Gene: ENSMUSG00000026288
AA Change: F540L

DomainStartEndE-ValueType
SH2 6 95 7.15e-29 SMART
low complexity region 107 118 N/A INTRINSIC
IPPc 405 721 4.5e-104 SMART
low complexity region 768 778 N/A INTRINSIC
low complexity region 985 997 N/A INTRINSIC
low complexity region 1059 1071 N/A INTRINSIC
low complexity region 1079 1088 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000169754
AA Change: F540L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000127941
Gene: ENSMUSG00000026288
AA Change: F540L

DomainStartEndE-ValueType
SH2 6 95 4.6e-31 SMART
low complexity region 107 118 N/A INTRINSIC
IPPc 405 721 2.2e-106 SMART
low complexity region 768 778 N/A INTRINSIC
low complexity region 955 980 N/A INTRINSIC
low complexity region 1046 1058 N/A INTRINSIC
low complexity region 1120 1132 N/A INTRINSIC
low complexity region 1140 1149 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000170300
AA Change: F277L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000132384
Gene: ENSMUSG00000026288
AA Change: F277L

DomainStartEndE-ValueType
IPPc 142 458 4.5e-104 SMART
low complexity region 505 515 N/A INTRINSIC
low complexity region 722 734 N/A INTRINSIC
low complexity region 796 808 N/A INTRINSIC
low complexity region 816 825 N/A INTRINSIC
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.9%
  • 10x: 95.2%
  • 20x: 91.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
PHENOTYPE: Homozygous null mice fail to reject fully mismatched allogeneic marrow grafts, do not develop graft versus host disease, and show enhanced survival after such transplants. Homozygous splice site mutants exhibit wasting, granulocytic lung infiltration anddefective cytolysis by NK cells and CTLs. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 113 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402N03Rik G T 7: 130,747,859 (GRCm39) N44K probably benign Het
Acd C A 8: 106,425,524 (GRCm39) A270S possibly damaging Het
Acnat1 G A 4: 49,451,042 (GRCm39) T23I probably benign Het
Adam26a T G 8: 44,023,226 (GRCm39) E88A possibly damaging Het
Adgrb1 G A 15: 74,413,676 (GRCm39) V589M probably benign Het
Agbl2 T A 2: 90,646,720 (GRCm39) probably benign Het
Aif1 G A 17: 35,391,127 (GRCm39) P44L probably benign Het
Amh AGCGCCTTGG AG 10: 80,641,419 (GRCm39) probably null Het
Asap2 T C 12: 21,253,999 (GRCm39) L170P probably damaging Het
Btg2 T C 1: 134,006,769 (GRCm39) D8G probably benign Het
Cacna1g A T 11: 94,334,118 (GRCm39) V841E probably damaging Het
Cacna2d1 C T 5: 16,469,286 (GRCm39) P230L probably benign Het
Cacna2d2 A T 9: 107,401,843 (GRCm39) D766V probably damaging Het
Carns1 A G 19: 4,223,156 (GRCm39) W23R possibly damaging Het
Cdk11b T A 4: 155,713,137 (GRCm39) probably null Het
Chrna3 T C 9: 54,923,341 (GRCm39) S156G probably damaging Het
Cmya5 A T 13: 93,232,171 (GRCm39) N972K probably benign Het
Cpne7 C A 8: 123,861,263 (GRCm39) P541T probably damaging Het
Cracd A G 5: 77,005,522 (GRCm39) I628V unknown Het
Csmd1 A T 8: 15,967,303 (GRCm39) L3187I probably damaging Het
Dbt A G 3: 116,339,943 (GRCm39) I404V probably benign Het
Dgki A T 6: 36,893,369 (GRCm39) I819K probably damaging Het
Dip2b T A 15: 100,076,347 (GRCm39) S782T probably benign Het
Dlc1 A T 8: 37,325,244 (GRCm39) probably null Het
Dnajc13 A T 9: 104,098,676 (GRCm39) V459E probably damaging Het
Enam A G 5: 88,651,086 (GRCm39) E790G probably damaging Het
Epb41l4a G C 18: 33,961,261 (GRCm39) Y424* probably null Het
Extl1 A G 4: 134,089,999 (GRCm39) S370P probably benign Het
Fan1 T C 7: 64,022,761 (GRCm39) Y164C probably benign Het
Fbxw15 G A 9: 109,387,314 (GRCm39) S227F probably damaging Het
Fbxw25 A T 9: 109,479,141 (GRCm39) I370N probably benign Het
Fcgbp T A 7: 27,792,868 (GRCm39) Y957* probably null Het
Gkap1 C A 13: 58,384,857 (GRCm39) E77* probably null Het
Gkn1 A T 6: 87,326,105 (GRCm39) N28K unknown Het
Gls2 A G 10: 128,037,194 (GRCm39) E245G probably damaging Het
Glyat G A 19: 12,623,679 (GRCm39) V32I probably benign Het
Gm2431 A T 7: 141,811,762 (GRCm39) C47* probably null Het
Gm5431 T C 11: 48,785,658 (GRCm39) D239G probably benign Het
Ift70a1 C T 2: 75,810,599 (GRCm39) V495I probably benign Het
Kcna1 A C 6: 126,619,771 (GRCm39) I183S probably benign Het
Kpna2 G T 11: 106,882,271 (GRCm39) L212I probably damaging Het
Krt36 C G 11: 99,994,884 (GRCm39) R229S probably benign Het
Krt78 G A 15: 101,854,812 (GRCm39) H1000Y probably benign Het
Krt90 A G 15: 101,461,800 (GRCm39) probably benign Het
Ldlrad4 C A 18: 68,239,758 (GRCm39) F59L probably benign Het
Lrrc3b T C 14: 15,358,601 (GRCm38) N2D probably benign Het
Madd T C 2: 90,998,236 (GRCm39) D239G probably damaging Het
Mapk8ip3 C T 17: 25,133,433 (GRCm39) G332S probably null Het
Mastl A T 2: 23,036,093 (GRCm39) L141* probably null Het
Mdh1b T C 1: 63,758,681 (GRCm39) N304D probably benign Het
Mfsd4b3-ps G T 10: 39,823,929 (GRCm39) N110K probably benign Het
Mtus2 T C 5: 148,214,443 (GRCm39) S1035P probably damaging Het
Muc21 T A 17: 35,931,940 (GRCm39) probably benign Het
Myh11 T A 16: 14,018,622 (GRCm39) D1908V probably damaging Het
Myh11 T C 16: 14,033,654 (GRCm39) E1080G probably damaging Het
Mypn A C 10: 62,971,976 (GRCm39) M688R probably benign Het
Nat8l G T 5: 34,158,130 (GRCm39) C180F probably damaging Het
Nip7 T A 8: 107,784,018 (GRCm39) L86Q probably damaging Het
Nisch C T 14: 30,896,839 (GRCm39) probably benign Het
Nop2 A G 6: 125,114,601 (GRCm39) I283V probably benign Het
Oas1h T A 5: 121,009,840 (GRCm39) probably null Het
Or10ag56 T C 2: 87,139,196 (GRCm39) V41A probably benign Het
Or2g25 A C 17: 37,970,564 (GRCm39) I220S probably damaging Het
Or4c101 C A 2: 88,390,402 (GRCm39) D185E possibly damaging Het
Or4c104 T C 2: 88,586,117 (GRCm39) R301G probably benign Het
Or56b1b A T 7: 108,164,564 (GRCm39) L146* probably null Het
Or5w17 T A 2: 87,583,530 (GRCm39) D269V probably damaging Het
Or8b42 T A 9: 38,341,986 (GRCm39) M136K probably damaging Het
P4hb A G 11: 120,453,546 (GRCm39) V373A probably damaging Het
Pappa2 C A 1: 158,590,720 (GRCm39) E1645* probably null Het
Pcdh10 G T 3: 45,336,316 (GRCm39) E877* probably null Het
Pcdhb17 C T 18: 37,618,764 (GRCm39) R185C probably damaging Het
Pcdhb17 A G 18: 37,620,070 (GRCm39) H620R possibly damaging Het
Pdcl3 T A 1: 39,034,946 (GRCm39) F168I probably damaging Het
Pde4a T A 9: 21,114,528 (GRCm39) I365N probably damaging Het
Pdzd2 A G 15: 12,385,950 (GRCm39) V940A probably damaging Het
Picalm T A 7: 89,840,390 (GRCm39) S399T possibly damaging Het
Pigk A T 3: 152,450,101 (GRCm39) I249F probably damaging Het
Plxnb1 C A 9: 108,940,836 (GRCm39) H1570Q probably benign Het
Plxnc1 A G 10: 94,635,359 (GRCm39) Y1321H probably damaging Het
Ppm1g G A 5: 31,363,560 (GRCm39) S114F probably damaging Het
Rassf4 A G 6: 116,617,228 (GRCm39) M259T probably damaging Het
Rbm47 T C 5: 66,176,653 (GRCm39) K557E possibly damaging Het
Rhobtb1 A G 10: 69,115,236 (GRCm39) K21R probably damaging Het
Selenoi T C 5: 30,462,771 (GRCm39) F212S probably benign Het
Shc3 T G 13: 51,603,328 (GRCm39) Y259S probably damaging Het
Skic3 T A 13: 76,288,720 (GRCm39) L951Q possibly damaging Het
Slc11a2 T C 15: 100,299,168 (GRCm39) N134S probably damaging Het
Slc9a7 A T X: 20,028,717 (GRCm39) M368K probably damaging Het
Slx4ip T A 2: 136,888,669 (GRCm39) C117S probably damaging Het
Spata31d1d T A 13: 59,876,509 (GRCm39) Q342L probably benign Het
Spink13 T A 18: 62,740,820 (GRCm39) Y93F probably damaging Het
St6galnac5 A T 3: 152,551,958 (GRCm39) I203N possibly damaging Het
Syne2 T A 12: 76,099,579 (GRCm39) C5335S probably damaging Het
Tagap T A 17: 8,148,742 (GRCm39) D173E probably benign Het
Tekt3 A C 11: 62,960,867 (GRCm39) Y12S probably damaging Het
Tmem81 T A 1: 132,435,321 (GRCm39) N42K probably damaging Het
Tnc A G 4: 63,890,972 (GRCm39) W1728R probably damaging Het
Ttc33 C T 15: 5,241,579 (GRCm39) R135* probably null Het
Unc5c A G 3: 141,533,278 (GRCm39) D842G possibly damaging Het
Usp43 A T 11: 67,770,779 (GRCm39) H618Q probably damaging Het
Vmn2r50 T G 7: 9,786,915 (GRCm39) N64T possibly damaging Het
Vmn2r53 T C 7: 12,315,632 (GRCm39) Y729C probably damaging Het
Vmn2r59 T A 7: 41,695,251 (GRCm39) H387L possibly damaging Het
Vstm2a G T 11: 16,213,166 (GRCm39) V184F possibly damaging Het
Wdr53 T G 16: 32,070,935 (GRCm39) N93K probably damaging Het
Wdr95 A G 5: 149,505,351 (GRCm39) probably null Het
Xpot A T 10: 121,438,932 (GRCm39) probably null Het
Xrcc5 C T 1: 72,364,246 (GRCm39) Q233* probably null Het
Zbtb18 T A 1: 177,275,077 (GRCm39) C137S possibly damaging Het
Zfp58 C A 13: 67,639,598 (GRCm39) G298* probably null Het
Zfp963 A G 8: 70,196,100 (GRCm39) S118P possibly damaging Het
Zmynd15 A T 11: 70,353,393 (GRCm39) Q336L probably benign Het
Other mutations in Inpp5d
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00323:Inpp5d APN 1 87,611,537 (GRCm39) missense probably benign 0.00
IGL00329:Inpp5d APN 1 87,595,725 (GRCm39) missense probably benign 0.00
IGL00897:Inpp5d APN 1 87,639,836 (GRCm39) missense probably benign 0.14
IGL01314:Inpp5d APN 1 87,611,472 (GRCm39) nonsense probably null
IGL02145:Inpp5d APN 1 87,642,777 (GRCm39) missense probably damaging 1.00
IGL02422:Inpp5d APN 1 87,635,854 (GRCm39) missense probably damaging 1.00
IGL02538:Inpp5d APN 1 87,623,088 (GRCm39) missense probably null 0.92
IGL02680:Inpp5d APN 1 87,629,205 (GRCm39) missense possibly damaging 0.87
IGL03083:Inpp5d APN 1 87,638,863 (GRCm39) missense probably damaging 1.00
IGL03308:Inpp5d APN 1 87,630,919 (GRCm39) missense probably damaging 1.00
americas UTSW 1 87,642,864 (GRCm39) missense probably damaging 1.00
Apfelsine UTSW 1 87,611,567 (GRCm39) nonsense probably null
Auburn UTSW 1 87,609,402 (GRCm39) splice site probably null
Autumnal UTSW 1 87,619,433 (GRCm39) missense probably damaging 0.97
Gourd UTSW 1 87,625,337 (GRCm39) intron probably benign
lyda UTSW 1 87,611,484 (GRCm39) missense probably damaging 1.00
Mandarin UTSW 1 87,637,348 (GRCm39) missense probably damaging 0.99
naranjo UTSW 1 87,635,933 (GRCm39) critical splice donor site probably null
New_black UTSW 1 87,637,397 (GRCm39) missense probably damaging 1.00
Orange UTSW 1 87,625,268 (GRCm39) critical splice donor site probably null
pantone UTSW 1 87,627,397 (GRCm39) missense probably damaging 1.00
sailing UTSW 1 87,633,686 (GRCm39) missense probably damaging 1.00
Salamander UTSW 1 87,623,102 (GRCm39) missense probably damaging 0.99
Sandstone UTSW 1 87,623,122 (GRCm39) missense probably damaging 1.00
styx UTSW 1 87,597,506 (GRCm39) critical splice donor site probably benign
tangerine UTSW 1 87,633,671 (GRCm39) missense probably damaging 1.00
ulster UTSW 1 87,629,198 (GRCm39) nonsense probably null
R0010:Inpp5d UTSW 1 87,625,268 (GRCm39) critical splice donor site probably null
R0037:Inpp5d UTSW 1 87,635,851 (GRCm39) missense probably damaging 0.99
R0087:Inpp5d UTSW 1 87,642,860 (GRCm39) missense probably damaging 1.00
R0492:Inpp5d UTSW 1 87,625,872 (GRCm39) missense possibly damaging 0.94
R0520:Inpp5d UTSW 1 87,633,642 (GRCm39) splice site probably benign
R0733:Inpp5d UTSW 1 87,595,799 (GRCm39) splice site probably benign
R1464:Inpp5d UTSW 1 87,625,827 (GRCm39) splice site probably benign
R1576:Inpp5d UTSW 1 87,609,280 (GRCm39) missense probably damaging 0.96
R1576:Inpp5d UTSW 1 87,597,407 (GRCm39) missense probably benign 0.16
R1592:Inpp5d UTSW 1 87,593,254 (GRCm39) missense possibly damaging 0.90
R1774:Inpp5d UTSW 1 87,595,611 (GRCm39) missense probably benign 0.30
R1972:Inpp5d UTSW 1 87,604,036 (GRCm39) missense probably benign 0.00
R2024:Inpp5d UTSW 1 87,623,072 (GRCm39) nonsense probably null
R2405:Inpp5d UTSW 1 87,627,451 (GRCm39) missense possibly damaging 0.94
R3412:Inpp5d UTSW 1 87,595,779 (GRCm39) missense possibly damaging 0.93
R3414:Inpp5d UTSW 1 87,595,779 (GRCm39) missense possibly damaging 0.93
R3756:Inpp5d UTSW 1 87,629,130 (GRCm39) splice site probably benign
R4652:Inpp5d UTSW 1 87,593,173 (GRCm39) missense probably benign 0.03
R4676:Inpp5d UTSW 1 87,642,864 (GRCm39) missense probably damaging 1.00
R4834:Inpp5d UTSW 1 87,625,245 (GRCm39) missense possibly damaging 0.52
R5086:Inpp5d UTSW 1 87,633,686 (GRCm39) missense probably damaging 1.00
R5159:Inpp5d UTSW 1 87,604,064 (GRCm39) missense probably damaging 1.00
R5250:Inpp5d UTSW 1 87,637,397 (GRCm39) missense probably damaging 1.00
R5442:Inpp5d UTSW 1 87,645,788 (GRCm39) missense probably benign 0.02
R5875:Inpp5d UTSW 1 87,645,696 (GRCm39) missense possibly damaging 0.47
R6135:Inpp5d UTSW 1 87,548,119 (GRCm39) splice site probably null
R6371:Inpp5d UTSW 1 87,627,397 (GRCm39) missense probably damaging 1.00
R6385:Inpp5d UTSW 1 87,627,397 (GRCm39) missense probably damaging 1.00
R6386:Inpp5d UTSW 1 87,627,397 (GRCm39) missense probably damaging 1.00
R6526:Inpp5d UTSW 1 87,603,972 (GRCm39) start gained probably benign
R6572:Inpp5d UTSW 1 87,623,118 (GRCm39) missense probably damaging 0.99
R6831:Inpp5d UTSW 1 87,629,198 (GRCm39) nonsense probably null
R6853:Inpp5d UTSW 1 87,609,402 (GRCm39) splice site probably null
R6883:Inpp5d UTSW 1 87,627,412 (GRCm39) missense probably damaging 0.98
R7082:Inpp5d UTSW 1 87,623,102 (GRCm39) missense probably damaging 0.99
R7215:Inpp5d UTSW 1 87,628,940 (GRCm39) missense probably benign 0.30
R7418:Inpp5d UTSW 1 87,635,933 (GRCm39) critical splice donor site probably null
R7471:Inpp5d UTSW 1 87,623,122 (GRCm39) missense probably damaging 1.00
R7593:Inpp5d UTSW 1 87,645,500 (GRCm39) missense possibly damaging 0.82
R7716:Inpp5d UTSW 1 87,593,121 (GRCm39) missense probably damaging 0.97
R7781:Inpp5d UTSW 1 87,627,394 (GRCm39) missense probably damaging 1.00
R7808:Inpp5d UTSW 1 87,611,567 (GRCm39) nonsense probably null
R7920:Inpp5d UTSW 1 87,633,671 (GRCm39) missense probably damaging 1.00
R8788:Inpp5d UTSW 1 87,611,484 (GRCm39) missense probably damaging 1.00
R8839:Inpp5d UTSW 1 87,619,433 (GRCm39) missense probably damaging 0.97
R8905:Inpp5d UTSW 1 87,637,348 (GRCm39) missense probably damaging 0.99
R8906:Inpp5d UTSW 1 87,625,337 (GRCm39) intron probably benign
R9517:Inpp5d UTSW 1 87,638,853 (GRCm39) missense probably benign 0.01
R9667:Inpp5d UTSW 1 87,623,128 (GRCm39) missense probably damaging 1.00
R9716:Inpp5d UTSW 1 87,625,191 (GRCm39) missense possibly damaging 0.90
Z1176:Inpp5d UTSW 1 87,630,853 (GRCm39) missense probably damaging 1.00
Z1176:Inpp5d UTSW 1 87,597,431 (GRCm39) missense probably benign 0.16
Z1191:Inpp5d UTSW 1 87,611,492 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGTAGAAAATCACAAGGCTGCTACCAC -3'
(R):5'- TCTGGGAAACCCAACTGGGAACAC -3'

Sequencing Primer
(F):5'- GCTACCACCTGCCAGTC -3'
(R):5'- ATGCAGGAATCTACCCATTAGG -3'
Posted On 2014-05-23