Incidental Mutation 'R1750:Pdzd2'
| ID |
193454 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pdzd2
|
| Ensembl Gene |
ENSMUSG00000022197 |
| Gene Name |
PDZ domain containing 2 |
| Synonyms |
Gm21706, A930022H17Rik, Pdzk3, 4930537L06Rik, LOC223364 |
| MMRRC Submission |
039782-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.117)
|
| Stock # |
R1750 (G1)
|
| Quality Score |
204 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
12359797-12740010 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 12385950 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 940
(V940A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000074788
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075317]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000075317
AA Change: V940A
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000074788
Gene: ENSMUSG00000022197
AA Change: V940A
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
81 |
179 |
1.27e-2 |
SMART |
|
PDZ
|
342 |
419 |
1.51e-18 |
SMART |
|
PDZ
|
597 |
675 |
5.25e-18 |
SMART |
|
low complexity region
|
690 |
718 |
N/A |
INTRINSIC |
|
PDZ
|
738 |
817 |
1.64e-10 |
SMART |
|
low complexity region
|
861 |
869 |
N/A |
INTRINSIC |
|
low complexity region
|
969 |
984 |
N/A |
INTRINSIC |
|
low complexity region
|
986 |
1000 |
N/A |
INTRINSIC |
|
low complexity region
|
1436 |
1459 |
N/A |
INTRINSIC |
|
low complexity region
|
1525 |
1537 |
N/A |
INTRINSIC |
|
low complexity region
|
1538 |
1553 |
N/A |
INTRINSIC |
|
low complexity region
|
1567 |
1586 |
N/A |
INTRINSIC |
|
low complexity region
|
2111 |
2129 |
N/A |
INTRINSIC |
|
low complexity region
|
2190 |
2198 |
N/A |
INTRINSIC |
|
low complexity region
|
2335 |
2354 |
N/A |
INTRINSIC |
|
low complexity region
|
2469 |
2479 |
N/A |
INTRINSIC |
|
PDZ
|
2589 |
2666 |
1.3e-13 |
SMART |
|
PDZ
|
2716 |
2794 |
9.42e-20 |
SMART |
|
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.9%
- 10x: 95.2%
- 20x: 91.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit normal response to acute and chronic pain. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 113 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933402N03Rik |
G |
T |
7: 130,747,859 (GRCm39) |
N44K |
probably benign |
Het |
| Acd |
C |
A |
8: 106,425,524 (GRCm39) |
A270S |
possibly damaging |
Het |
| Acnat1 |
G |
A |
4: 49,451,042 (GRCm39) |
T23I |
probably benign |
Het |
| Adam26a |
T |
G |
8: 44,023,226 (GRCm39) |
E88A |
possibly damaging |
Het |
| Adgrb1 |
G |
A |
15: 74,413,676 (GRCm39) |
V589M |
probably benign |
Het |
| Agbl2 |
T |
A |
2: 90,646,720 (GRCm39) |
|
probably benign |
Het |
| Aif1 |
G |
A |
17: 35,391,127 (GRCm39) |
P44L |
probably benign |
Het |
| Amh |
AGCGCCTTGG |
AG |
10: 80,641,419 (GRCm39) |
|
probably null |
Het |
| Asap2 |
T |
C |
12: 21,253,999 (GRCm39) |
L170P |
probably damaging |
Het |
| Btg2 |
T |
C |
1: 134,006,769 (GRCm39) |
D8G |
probably benign |
Het |
| Cacna1g |
A |
T |
11: 94,334,118 (GRCm39) |
V841E |
probably damaging |
Het |
| Cacna2d1 |
C |
T |
5: 16,469,286 (GRCm39) |
P230L |
probably benign |
Het |
| Cacna2d2 |
A |
T |
9: 107,401,843 (GRCm39) |
D766V |
probably damaging |
Het |
| Carns1 |
A |
G |
19: 4,223,156 (GRCm39) |
W23R |
possibly damaging |
Het |
| Cdk11b |
T |
A |
4: 155,713,137 (GRCm39) |
|
probably null |
Het |
| Chrna3 |
T |
C |
9: 54,923,341 (GRCm39) |
S156G |
probably damaging |
Het |
| Cmya5 |
A |
T |
13: 93,232,171 (GRCm39) |
N972K |
probably benign |
Het |
| Cpne7 |
C |
A |
8: 123,861,263 (GRCm39) |
P541T |
probably damaging |
Het |
| Cracd |
A |
G |
5: 77,005,522 (GRCm39) |
I628V |
unknown |
Het |
| Csmd1 |
A |
T |
8: 15,967,303 (GRCm39) |
L3187I |
probably damaging |
Het |
| Dbt |
A |
G |
3: 116,339,943 (GRCm39) |
I404V |
probably benign |
Het |
| Dgki |
A |
T |
6: 36,893,369 (GRCm39) |
I819K |
probably damaging |
Het |
| Dip2b |
T |
A |
15: 100,076,347 (GRCm39) |
S782T |
probably benign |
Het |
| Dlc1 |
A |
T |
8: 37,325,244 (GRCm39) |
|
probably null |
Het |
| Dnajc13 |
A |
T |
9: 104,098,676 (GRCm39) |
V459E |
probably damaging |
Het |
| Enam |
A |
G |
5: 88,651,086 (GRCm39) |
E790G |
probably damaging |
Het |
| Epb41l4a |
G |
C |
18: 33,961,261 (GRCm39) |
Y424* |
probably null |
Het |
| Extl1 |
A |
G |
4: 134,089,999 (GRCm39) |
S370P |
probably benign |
Het |
| Fan1 |
T |
C |
7: 64,022,761 (GRCm39) |
Y164C |
probably benign |
Het |
| Fbxw15 |
G |
A |
9: 109,387,314 (GRCm39) |
S227F |
probably damaging |
Het |
| Fbxw25 |
A |
T |
9: 109,479,141 (GRCm39) |
I370N |
probably benign |
Het |
| Fcgbp |
T |
A |
7: 27,792,868 (GRCm39) |
Y957* |
probably null |
Het |
| Gkap1 |
C |
A |
13: 58,384,857 (GRCm39) |
E77* |
probably null |
Het |
| Gkn1 |
A |
T |
6: 87,326,105 (GRCm39) |
N28K |
unknown |
Het |
| Gls2 |
A |
G |
10: 128,037,194 (GRCm39) |
E245G |
probably damaging |
Het |
| Glyat |
G |
A |
19: 12,623,679 (GRCm39) |
V32I |
probably benign |
Het |
| Gm2431 |
A |
T |
7: 141,811,762 (GRCm39) |
C47* |
probably null |
Het |
| Gm5431 |
T |
C |
11: 48,785,658 (GRCm39) |
D239G |
probably benign |
Het |
| Ift70a1 |
C |
T |
2: 75,810,599 (GRCm39) |
V495I |
probably benign |
Het |
| Inpp5d |
T |
C |
1: 87,626,803 (GRCm39) |
F540L |
probably damaging |
Het |
| Kcna1 |
A |
C |
6: 126,619,771 (GRCm39) |
I183S |
probably benign |
Het |
| Kpna2 |
G |
T |
11: 106,882,271 (GRCm39) |
L212I |
probably damaging |
Het |
| Krt36 |
C |
G |
11: 99,994,884 (GRCm39) |
R229S |
probably benign |
Het |
| Krt78 |
G |
A |
15: 101,854,812 (GRCm39) |
H1000Y |
probably benign |
Het |
| Krt90 |
A |
G |
15: 101,461,800 (GRCm39) |
|
probably benign |
Het |
| Ldlrad4 |
C |
A |
18: 68,239,758 (GRCm39) |
F59L |
probably benign |
Het |
| Lrrc3b |
T |
C |
14: 15,358,601 (GRCm38) |
N2D |
probably benign |
Het |
| Madd |
T |
C |
2: 90,998,236 (GRCm39) |
D239G |
probably damaging |
Het |
| Mapk8ip3 |
C |
T |
17: 25,133,433 (GRCm39) |
G332S |
probably null |
Het |
| Mastl |
A |
T |
2: 23,036,093 (GRCm39) |
L141* |
probably null |
Het |
| Mdh1b |
T |
C |
1: 63,758,681 (GRCm39) |
N304D |
probably benign |
Het |
| Mfsd4b3-ps |
G |
T |
10: 39,823,929 (GRCm39) |
N110K |
probably benign |
Het |
| Mtus2 |
T |
C |
5: 148,214,443 (GRCm39) |
S1035P |
probably damaging |
Het |
| Muc21 |
T |
A |
17: 35,931,940 (GRCm39) |
|
probably benign |
Het |
| Myh11 |
T |
C |
16: 14,033,654 (GRCm39) |
E1080G |
probably damaging |
Het |
| Myh11 |
T |
A |
16: 14,018,622 (GRCm39) |
D1908V |
probably damaging |
Het |
| Mypn |
A |
C |
10: 62,971,976 (GRCm39) |
M688R |
probably benign |
Het |
| Nat8l |
G |
T |
5: 34,158,130 (GRCm39) |
C180F |
probably damaging |
Het |
| Nip7 |
T |
A |
8: 107,784,018 (GRCm39) |
L86Q |
probably damaging |
Het |
| Nisch |
C |
T |
14: 30,896,839 (GRCm39) |
|
probably benign |
Het |
| Nop2 |
A |
G |
6: 125,114,601 (GRCm39) |
I283V |
probably benign |
Het |
| Oas1h |
T |
A |
5: 121,009,840 (GRCm39) |
|
probably null |
Het |
| Or10ag56 |
T |
C |
2: 87,139,196 (GRCm39) |
V41A |
probably benign |
Het |
| Or2g25 |
A |
C |
17: 37,970,564 (GRCm39) |
I220S |
probably damaging |
Het |
| Or4c101 |
C |
A |
2: 88,390,402 (GRCm39) |
D185E |
possibly damaging |
Het |
| Or4c104 |
T |
C |
2: 88,586,117 (GRCm39) |
R301G |
probably benign |
Het |
| Or56b1b |
A |
T |
7: 108,164,564 (GRCm39) |
L146* |
probably null |
Het |
| Or5w17 |
T |
A |
2: 87,583,530 (GRCm39) |
D269V |
probably damaging |
Het |
| Or8b42 |
T |
A |
9: 38,341,986 (GRCm39) |
M136K |
probably damaging |
Het |
| P4hb |
A |
G |
11: 120,453,546 (GRCm39) |
V373A |
probably damaging |
Het |
| Pappa2 |
C |
A |
1: 158,590,720 (GRCm39) |
E1645* |
probably null |
Het |
| Pcdh10 |
G |
T |
3: 45,336,316 (GRCm39) |
E877* |
probably null |
Het |
| Pcdhb17 |
C |
T |
18: 37,618,764 (GRCm39) |
R185C |
probably damaging |
Het |
| Pcdhb17 |
A |
G |
18: 37,620,070 (GRCm39) |
H620R |
possibly damaging |
Het |
| Pdcl3 |
T |
A |
1: 39,034,946 (GRCm39) |
F168I |
probably damaging |
Het |
| Pde4a |
T |
A |
9: 21,114,528 (GRCm39) |
I365N |
probably damaging |
Het |
| Picalm |
T |
A |
7: 89,840,390 (GRCm39) |
S399T |
possibly damaging |
Het |
| Pigk |
A |
T |
3: 152,450,101 (GRCm39) |
I249F |
probably damaging |
Het |
| Plxnb1 |
C |
A |
9: 108,940,836 (GRCm39) |
H1570Q |
probably benign |
Het |
| Plxnc1 |
A |
G |
10: 94,635,359 (GRCm39) |
Y1321H |
probably damaging |
Het |
| Ppm1g |
G |
A |
5: 31,363,560 (GRCm39) |
S114F |
probably damaging |
Het |
| Rassf4 |
A |
G |
6: 116,617,228 (GRCm39) |
M259T |
probably damaging |
Het |
| Rbm47 |
T |
C |
5: 66,176,653 (GRCm39) |
K557E |
possibly damaging |
Het |
| Rhobtb1 |
A |
G |
10: 69,115,236 (GRCm39) |
K21R |
probably damaging |
Het |
| Selenoi |
T |
C |
5: 30,462,771 (GRCm39) |
F212S |
probably benign |
Het |
| Shc3 |
T |
G |
13: 51,603,328 (GRCm39) |
Y259S |
probably damaging |
Het |
| Skic3 |
T |
A |
13: 76,288,720 (GRCm39) |
L951Q |
possibly damaging |
Het |
| Slc11a2 |
T |
C |
15: 100,299,168 (GRCm39) |
N134S |
probably damaging |
Het |
| Slc9a7 |
A |
T |
X: 20,028,717 (GRCm39) |
M368K |
probably damaging |
Het |
| Slx4ip |
T |
A |
2: 136,888,669 (GRCm39) |
C117S |
probably damaging |
Het |
| Spata31d1d |
T |
A |
13: 59,876,509 (GRCm39) |
Q342L |
probably benign |
Het |
| Spink13 |
T |
A |
18: 62,740,820 (GRCm39) |
Y93F |
probably damaging |
Het |
| St6galnac5 |
A |
T |
3: 152,551,958 (GRCm39) |
I203N |
possibly damaging |
Het |
| Syne2 |
T |
A |
12: 76,099,579 (GRCm39) |
C5335S |
probably damaging |
Het |
| Tagap |
T |
A |
17: 8,148,742 (GRCm39) |
D173E |
probably benign |
Het |
| Tekt3 |
A |
C |
11: 62,960,867 (GRCm39) |
Y12S |
probably damaging |
Het |
| Tmem81 |
T |
A |
1: 132,435,321 (GRCm39) |
N42K |
probably damaging |
Het |
| Tnc |
A |
G |
4: 63,890,972 (GRCm39) |
W1728R |
probably damaging |
Het |
| Ttc33 |
C |
T |
15: 5,241,579 (GRCm39) |
R135* |
probably null |
Het |
| Unc5c |
A |
G |
3: 141,533,278 (GRCm39) |
D842G |
possibly damaging |
Het |
| Usp43 |
A |
T |
11: 67,770,779 (GRCm39) |
H618Q |
probably damaging |
Het |
| Vmn2r50 |
T |
G |
7: 9,786,915 (GRCm39) |
N64T |
possibly damaging |
Het |
| Vmn2r53 |
T |
C |
7: 12,315,632 (GRCm39) |
Y729C |
probably damaging |
Het |
| Vmn2r59 |
T |
A |
7: 41,695,251 (GRCm39) |
H387L |
possibly damaging |
Het |
| Vstm2a |
G |
T |
11: 16,213,166 (GRCm39) |
V184F |
possibly damaging |
Het |
| Wdr53 |
T |
G |
16: 32,070,935 (GRCm39) |
N93K |
probably damaging |
Het |
| Wdr95 |
A |
G |
5: 149,505,351 (GRCm39) |
|
probably null |
Het |
| Xpot |
A |
T |
10: 121,438,932 (GRCm39) |
|
probably null |
Het |
| Xrcc5 |
C |
T |
1: 72,364,246 (GRCm39) |
Q233* |
probably null |
Het |
| Zbtb18 |
T |
A |
1: 177,275,077 (GRCm39) |
C137S |
possibly damaging |
Het |
| Zfp58 |
C |
A |
13: 67,639,598 (GRCm39) |
G298* |
probably null |
Het |
| Zfp963 |
A |
G |
8: 70,196,100 (GRCm39) |
S118P |
possibly damaging |
Het |
| Zmynd15 |
A |
T |
11: 70,353,393 (GRCm39) |
Q336L |
probably benign |
Het |
|
| Other mutations in Pdzd2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00159:Pdzd2
|
APN |
15 |
12,458,069 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL00586:Pdzd2
|
APN |
15 |
12,365,853 (GRCm39) |
splice site |
probably null |
|
|
IGL00697:Pdzd2
|
APN |
15 |
12,373,733 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL00721:Pdzd2
|
APN |
15 |
12,374,498 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00971:Pdzd2
|
APN |
15 |
12,374,804 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01066:Pdzd2
|
APN |
15 |
12,402,718 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01389:Pdzd2
|
APN |
15 |
12,374,712 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL01505:Pdzd2
|
APN |
15 |
12,458,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01527:Pdzd2
|
APN |
15 |
12,445,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01584:Pdzd2
|
APN |
15 |
12,592,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01763:Pdzd2
|
APN |
15 |
12,372,632 (GRCm39) |
missense |
probably benign |
|
|
IGL01915:Pdzd2
|
APN |
15 |
12,371,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01947:Pdzd2
|
APN |
15 |
12,592,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02058:Pdzd2
|
APN |
15 |
12,376,382 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02274:Pdzd2
|
APN |
15 |
12,445,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Pdzd2
|
APN |
15 |
12,375,851 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02600:Pdzd2
|
APN |
15 |
12,411,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02637:Pdzd2
|
APN |
15 |
12,385,720 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02639:Pdzd2
|
APN |
15 |
12,592,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02712:Pdzd2
|
APN |
15 |
12,376,113 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02967:Pdzd2
|
APN |
15 |
12,374,427 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02992:Pdzd2
|
APN |
15 |
12,382,708 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL03005:Pdzd2
|
APN |
15 |
12,385,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03067:Pdzd2
|
APN |
15 |
12,388,628 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03335:Pdzd2
|
APN |
15 |
12,373,850 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4280001:Pdzd2
|
UTSW |
15 |
12,399,374 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0022:Pdzd2
|
UTSW |
15 |
12,371,691 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0241:Pdzd2
|
UTSW |
15 |
12,368,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0241:Pdzd2
|
UTSW |
15 |
12,368,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0446:Pdzd2
|
UTSW |
15 |
12,375,110 (GRCm39) |
missense |
probably benign |
0.43 |
|
R0462:Pdzd2
|
UTSW |
15 |
12,592,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0562:Pdzd2
|
UTSW |
15 |
12,592,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0589:Pdzd2
|
UTSW |
15 |
12,376,385 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0639:Pdzd2
|
UTSW |
15 |
12,458,144 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0925:Pdzd2
|
UTSW |
15 |
12,399,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1015:Pdzd2
|
UTSW |
15 |
12,374,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1054:Pdzd2
|
UTSW |
15 |
12,371,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1070:Pdzd2
|
UTSW |
15 |
12,390,052 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1099:Pdzd2
|
UTSW |
15 |
12,373,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1122:Pdzd2
|
UTSW |
15 |
12,457,981 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1126:Pdzd2
|
UTSW |
15 |
12,458,306 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1381:Pdzd2
|
UTSW |
15 |
12,385,525 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1385:Pdzd2
|
UTSW |
15 |
12,411,108 (GRCm39) |
missense |
probably benign |
0.38 |
|
R1513:Pdzd2
|
UTSW |
15 |
12,373,915 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1538:Pdzd2
|
UTSW |
15 |
12,373,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1775:Pdzd2
|
UTSW |
15 |
12,592,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1801:Pdzd2
|
UTSW |
15 |
12,387,740 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R1832:Pdzd2
|
UTSW |
15 |
12,390,134 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1856:Pdzd2
|
UTSW |
15 |
12,373,941 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1870:Pdzd2
|
UTSW |
15 |
12,457,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1879:Pdzd2
|
UTSW |
15 |
12,373,986 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R2072:Pdzd2
|
UTSW |
15 |
12,385,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2073:Pdzd2
|
UTSW |
15 |
12,385,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2075:Pdzd2
|
UTSW |
15 |
12,385,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2125:Pdzd2
|
UTSW |
15 |
12,373,676 (GRCm39) |
missense |
probably benign |
0.37 |
|
R2142:Pdzd2
|
UTSW |
15 |
12,406,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2155:Pdzd2
|
UTSW |
15 |
12,375,879 (GRCm39) |
missense |
probably benign |
0.43 |
|
R2282:Pdzd2
|
UTSW |
15 |
12,373,934 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2407:Pdzd2
|
UTSW |
15 |
12,373,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3545:Pdzd2
|
UTSW |
15 |
12,375,557 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3878:Pdzd2
|
UTSW |
15 |
12,376,262 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3879:Pdzd2
|
UTSW |
15 |
12,375,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4396:Pdzd2
|
UTSW |
15 |
12,387,732 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4398:Pdzd2
|
UTSW |
15 |
12,376,061 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4491:Pdzd2
|
UTSW |
15 |
12,385,723 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4492:Pdzd2
|
UTSW |
15 |
12,385,723 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4492:Pdzd2
|
UTSW |
15 |
12,419,567 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R4656:Pdzd2
|
UTSW |
15 |
12,385,797 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4715:Pdzd2
|
UTSW |
15 |
12,419,602 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4803:Pdzd2
|
UTSW |
15 |
12,374,681 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4893:Pdzd2
|
UTSW |
15 |
12,385,429 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4959:Pdzd2
|
UTSW |
15 |
12,375,734 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4973:Pdzd2
|
UTSW |
15 |
12,375,734 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5030:Pdzd2
|
UTSW |
15 |
12,592,494 (GRCm39) |
nonsense |
probably null |
|
|
R5174:Pdzd2
|
UTSW |
15 |
12,372,600 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5230:Pdzd2
|
UTSW |
15 |
12,390,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5256:Pdzd2
|
UTSW |
15 |
12,373,028 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5268:Pdzd2
|
UTSW |
15 |
12,592,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5488:Pdzd2
|
UTSW |
15 |
12,382,762 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5489:Pdzd2
|
UTSW |
15 |
12,382,762 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5588:Pdzd2
|
UTSW |
15 |
12,374,367 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5605:Pdzd2
|
UTSW |
15 |
12,592,436 (GRCm39) |
nonsense |
probably null |
|
|
R5704:Pdzd2
|
UTSW |
15 |
12,385,761 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5858:Pdzd2
|
UTSW |
15 |
12,442,675 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6048:Pdzd2
|
UTSW |
15 |
12,592,656 (GRCm39) |
splice site |
probably null |
|
|
R6222:Pdzd2
|
UTSW |
15 |
12,374,652 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6311:Pdzd2
|
UTSW |
15 |
12,458,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6734:Pdzd2
|
UTSW |
15 |
12,592,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6897:Pdzd2
|
UTSW |
15 |
12,385,951 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6900:Pdzd2
|
UTSW |
15 |
12,374,123 (GRCm39) |
missense |
probably benign |
|
|
R6955:Pdzd2
|
UTSW |
15 |
12,401,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6959:Pdzd2
|
UTSW |
15 |
12,375,993 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6992:Pdzd2
|
UTSW |
15 |
12,457,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7014:Pdzd2
|
UTSW |
15 |
12,373,061 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7014:Pdzd2
|
UTSW |
15 |
12,372,647 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7110:Pdzd2
|
UTSW |
15 |
12,368,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7180:Pdzd2
|
UTSW |
15 |
12,376,209 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7228:Pdzd2
|
UTSW |
15 |
12,458,231 (GRCm39) |
nonsense |
probably null |
|
|
R7228:Pdzd2
|
UTSW |
15 |
12,373,059 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7317:Pdzd2
|
UTSW |
15 |
12,592,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7322:Pdzd2
|
UTSW |
15 |
12,437,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7349:Pdzd2
|
UTSW |
15 |
12,399,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7600:Pdzd2
|
UTSW |
15 |
12,372,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7663:Pdzd2
|
UTSW |
15 |
12,373,289 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7712:Pdzd2
|
UTSW |
15 |
12,407,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7716:Pdzd2
|
UTSW |
15 |
12,373,460 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R7740:Pdzd2
|
UTSW |
15 |
12,374,102 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7748:Pdzd2
|
UTSW |
15 |
12,385,872 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8017:Pdzd2
|
UTSW |
15 |
12,373,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8019:Pdzd2
|
UTSW |
15 |
12,373,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8108:Pdzd2
|
UTSW |
15 |
12,373,592 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8109:Pdzd2
|
UTSW |
15 |
12,373,592 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8110:Pdzd2
|
UTSW |
15 |
12,373,592 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8111:Pdzd2
|
UTSW |
15 |
12,373,592 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8145:Pdzd2
|
UTSW |
15 |
12,407,458 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8220:Pdzd2
|
UTSW |
15 |
12,592,249 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8278:Pdzd2
|
UTSW |
15 |
12,375,995 (GRCm39) |
missense |
probably benign |
|
|
R8768:Pdzd2
|
UTSW |
15 |
12,437,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8879:Pdzd2
|
UTSW |
15 |
12,402,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9019:Pdzd2
|
UTSW |
15 |
12,375,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9030:Pdzd2
|
UTSW |
15 |
12,374,385 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9061:Pdzd2
|
UTSW |
15 |
12,374,753 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9302:Pdzd2
|
UTSW |
15 |
12,374,342 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9321:Pdzd2
|
UTSW |
15 |
12,386,023 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9421:Pdzd2
|
UTSW |
15 |
12,375,114 (GRCm39) |
missense |
|
|
|
R9515:Pdzd2
|
UTSW |
15 |
12,374,621 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9592:Pdzd2
|
UTSW |
15 |
12,458,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9614:Pdzd2
|
UTSW |
15 |
12,375,486 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9630:Pdzd2
|
UTSW |
15 |
12,374,443 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9776:Pdzd2
|
UTSW |
15 |
12,457,909 (GRCm39) |
missense |
probably benign |
0.03 |
|
X0057:Pdzd2
|
UTSW |
15 |
12,411,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0063:Pdzd2
|
UTSW |
15 |
12,368,805 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
X0066:Pdzd2
|
UTSW |
15 |
12,372,942 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCAAACCTAGTGTCATCCTGTACC -3'
(R):5'- TGGCTGGACAAGGCAGACTTTACC -3'
Sequencing Primer
(F):5'- CTAGTGTCATCCTGTACCAGAGG -3'
(R):5'- AAGAGCAGTCGCTGGTATTTAC -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation