Incidental Mutation 'R0017:Or7c19'
ID 19352
Institutional Source Beutler Lab
Gene Symbol Or7c19
Ensembl Gene ENSMUSG00000051952
Gene Name olfactory receptor family 7 subfamily C member 19
Synonyms MOR141-3, Olfr371, GA_x6K02T2NUPS-13298842-13299780
MMRRC Submission 038312-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R0017 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 8
Chromosomal Location 85957126-85958064 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 85957706 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 194 (I194N)
Ref Sequence ENSEMBL: ENSMUSP00000151714 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070849] [ENSMUST00000218663]
AlphaFold Q8VGB8
Predicted Effect probably benign
Transcript: ENSMUST00000070849
AA Change: I194N

PolyPhen 2 Score 0.250 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000077921
Gene: ENSMUSG00000051952
AA Change: I194N

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 9.1e-55 PFAM
Pfam:7TM_GPCR_Srx 32 305 2.2e-6 PFAM
Pfam:7TM_GPCR_Srsx 35 305 3.2e-8 PFAM
Pfam:7tm_1 41 290 9.2e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000218663
AA Change: I194N

PolyPhen 2 Score 0.250 (Sensitivity: 0.91; Specificity: 0.88)
Meta Mutation Damage Score 0.4863 question?
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.7%
  • 10x: 95.0%
  • 20x: 89.2%
Validation Efficiency 96% (76/79)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010I14Rik G T 17: 9,226,938 (GRCm39) probably benign Het
Abca13 T A 11: 9,242,775 (GRCm39) I1546N probably damaging Het
Actrt3 A T 3: 30,652,422 (GRCm39) M224K probably benign Het
Adgrv1 T C 13: 81,727,065 (GRCm39) N429S probably benign Het
Appbp2 A C 11: 85,105,129 (GRCm39) C146G possibly damaging Het
Cabp2 A C 19: 4,136,242 (GRCm39) D83A possibly damaging Het
Ccl1 A G 11: 82,068,843 (GRCm39) probably null Het
Cdca8 T C 4: 124,814,168 (GRCm39) T208A probably benign Het
Dach1 C T 14: 98,406,184 (GRCm39) G188R probably damaging Het
Dcdc5 G A 2: 106,187,541 (GRCm39) noncoding transcript Het
Efr3b C A 12: 4,043,003 (GRCm39) C89F probably damaging Het
Enpp3 C T 10: 24,675,051 (GRCm39) probably null Het
Ep400 A T 5: 110,821,395 (GRCm39) V2467E probably damaging Het
Ermap T C 4: 119,037,145 (GRCm39) probably benign Het
Fig4 A G 10: 41,149,003 (GRCm39) Y150H possibly damaging Het
Fsip2 G A 2: 82,822,416 (GRCm39) V6050M probably damaging Het
Gnb1l T C 16: 18,359,810 (GRCm39) W72R probably damaging Het
Gpld1 A G 13: 25,174,101 (GRCm39) D842G probably damaging Het
Hmgcr A G 13: 96,788,597 (GRCm39) probably benign Het
Hrc A G 7: 44,985,794 (GRCm39) H315R possibly damaging Het
Ifit2 A T 19: 34,550,973 (GRCm39) N171I probably damaging Het
Ipo11 T A 13: 107,023,238 (GRCm39) I416L probably benign Het
Kcnab1 G A 3: 65,264,527 (GRCm39) V259M probably damaging Het
Kcng4 T C 8: 120,360,259 (GRCm39) Y39C probably damaging Het
Kif5c A G 2: 49,622,725 (GRCm39) T526A probably benign Het
Kntc1 A G 5: 123,919,044 (GRCm39) Y805C probably damaging Het
Mal A G 2: 127,482,227 (GRCm39) S59P probably damaging Het
Myh15 A G 16: 48,983,423 (GRCm39) N1513D probably damaging Het
Ncoa2 A G 1: 13,244,976 (GRCm39) L574P probably damaging Het
Nmd3 A G 3: 69,643,425 (GRCm39) probably null Het
Nucb2 A G 7: 116,132,386 (GRCm39) D331G probably benign Het
Nwd1 T C 8: 73,436,053 (GRCm39) probably benign Het
Nynrin T C 14: 56,109,852 (GRCm39) F1653S probably damaging Het
Or4a80 A C 2: 89,582,365 (GRCm39) I269S possibly damaging Het
Or8b12b T G 9: 37,684,274 (GRCm39) F106L probably benign Het
Pfdn6 T C 17: 34,158,538 (GRCm39) R79G probably damaging Het
Pkd1 G T 17: 24,797,513 (GRCm39) probably null Het
Pramel4 T G 4: 143,794,914 (GRCm39) C434G probably benign Het
Ptpn13 T C 5: 103,634,638 (GRCm39) probably null Het
Ptpro T C 6: 137,393,825 (GRCm39) V831A probably benign Het
Rabl6 A T 2: 25,492,579 (GRCm39) probably benign Het
Reg3b T A 6: 78,349,844 (GRCm39) M128K possibly damaging Het
Rif1 A G 2: 52,006,686 (GRCm39) T2207A probably benign Het
Rpa1 A C 11: 75,205,687 (GRCm39) N223K probably null Het
Rras2 T C 7: 113,647,490 (GRCm39) probably benign Het
Ryr1 T A 7: 28,746,967 (GRCm39) E3760V probably damaging Het
Scyl3 T A 1: 163,767,538 (GRCm39) I204N possibly damaging Het
Serpinb9h A C 13: 33,588,494 (GRCm39) I360L probably damaging Het
Slc16a12 A G 19: 34,650,098 (GRCm39) probably benign Het
Slc22a1 A G 17: 12,878,646 (GRCm39) F356L probably damaging Het
Slc22a29 A G 19: 8,195,630 (GRCm39) probably benign Het
Slc45a1 C A 4: 150,714,023 (GRCm39) D741Y possibly damaging Het
Slco1a5 A T 6: 142,182,061 (GRCm39) probably benign Het
Smg5 G T 3: 88,258,412 (GRCm39) R461L probably damaging Het
Snrk T C 9: 121,995,306 (GRCm39) S362P probably damaging Het
Spata31d1b A G 13: 59,863,883 (GRCm39) S344G probably benign Het
Sync G A 4: 129,187,537 (GRCm39) V190M probably damaging Het
Taf5l T C 8: 124,730,383 (GRCm39) Y67C probably damaging Het
Tbkbp1 A G 11: 97,037,115 (GRCm39) probably benign Het
Tshr A T 12: 91,504,660 (GRCm39) I533F possibly damaging Het
Tsn T C 1: 118,228,589 (GRCm39) D211G probably damaging Het
Ttn G A 2: 76,621,988 (GRCm39) T15518I probably benign Het
Unc13c T C 9: 73,600,583 (GRCm39) D1387G probably benign Het
Vapb A G 2: 173,613,397 (GRCm39) T99A probably benign Het
Vmn2r127 A G 17: 19,373,879 (GRCm39) noncoding transcript Het
Zfp280d A T 9: 72,246,292 (GRCm39) probably null Het
Other mutations in Or7c19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01104:Or7c19 APN 8 85,957,813 (GRCm39) missense probably benign 0.14
IGL01380:Or7c19 APN 8 85,957,775 (GRCm39) missense probably damaging 0.99
IGL01380:Or7c19 APN 8 85,957,958 (GRCm39) missense possibly damaging 0.95
IGL01680:Or7c19 APN 8 85,957,308 (GRCm39) missense probably benign
IGL01880:Or7c19 APN 8 85,957,712 (GRCm39) missense probably benign 0.00
IGL02194:Or7c19 APN 8 85,957,262 (GRCm39) missense possibly damaging 0.82
IGL02416:Or7c19 APN 8 85,957,662 (GRCm39) nonsense probably null
IGL02494:Or7c19 APN 8 85,957,312 (GRCm39) missense possibly damaging 0.95
IGL03072:Or7c19 APN 8 85,957,139 (GRCm39) missense probably benign 0.08
IGL03130:Or7c19 APN 8 85,957,258 (GRCm39) missense possibly damaging 0.93
R1157:Or7c19 UTSW 8 85,957,889 (GRCm39) missense probably damaging 0.98
R1165:Or7c19 UTSW 8 85,957,400 (GRCm39) missense probably damaging 0.98
R1730:Or7c19 UTSW 8 85,957,477 (GRCm39) missense probably benign 0.16
R2017:Or7c19 UTSW 8 85,957,373 (GRCm39) missense possibly damaging 0.91
R2426:Or7c19 UTSW 8 85,957,693 (GRCm39) missense probably damaging 0.97
R4447:Or7c19 UTSW 8 85,957,995 (GRCm39) nonsense probably null
R4703:Or7c19 UTSW 8 85,957,237 (GRCm39) missense possibly damaging 0.95
R4797:Or7c19 UTSW 8 85,957,567 (GRCm39) missense probably benign
R5029:Or7c19 UTSW 8 85,957,835 (GRCm39) missense probably benign 0.00
R5173:Or7c19 UTSW 8 85,957,205 (GRCm39) missense probably damaging 0.99
R6349:Or7c19 UTSW 8 85,957,787 (GRCm39) missense possibly damaging 0.93
R7754:Or7c19 UTSW 8 85,957,427 (GRCm39) missense possibly damaging 0.71
R8955:Or7c19 UTSW 8 85,957,913 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGGGCATCCAGACTCAGAGTAAGC -3'
(R):5'- GGCAGGTTCCATAGAACAGAGACAC -3'

Sequencing Primer
(F):5'- ACTGTGATGGCATATGACCGC -3'
(R):5'- GTTCCATAGAACAGAGACACAACTG -3'
Posted On 2013-04-11