Incidental Mutation 'R0017:Nynrin'
| ID |
19372 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nynrin
|
| Ensembl Gene |
ENSMUSG00000075592 |
| Gene Name |
NYN domain and retroviral integrase containing |
| Synonyms |
|
| MMRRC Submission |
038312-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0017 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
(trace)
|
| Chromosome |
14 |
| Chromosomal Location |
56091572-56112193 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 56109852 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Serine
at position 1653
(F1653S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129557
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000100529]
[ENSMUST00000168479]
|
| AlphaFold |
Q5DTZ0 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000100529
AA Change: F1653S
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000098098
Gene: ENSMUSG00000075592
AA Change: F1653S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
581 |
606 |
N/A |
INTRINSIC |
|
Pfam:RNase_Zc3h12a
|
739 |
890 |
1.6e-54 |
PFAM |
|
low complexity region
|
938 |
952 |
N/A |
INTRINSIC |
|
low complexity region
|
1212 |
1228 |
N/A |
INTRINSIC |
|
low complexity region
|
1390 |
1397 |
N/A |
INTRINSIC |
|
PDB:3S3O|B
|
1478 |
1706 |
6e-8 |
PDB |
|
SCOP:d1cxqa_
|
1552 |
1646 |
2e-12 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000168479
AA Change: F1653S
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000129557
Gene: ENSMUSG00000075592
AA Change: F1653S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
581 |
606 |
N/A |
INTRINSIC |
|
Pfam:RNase_Zc3h12a
|
739 |
890 |
5.5e-54 |
PFAM |
|
low complexity region
|
938 |
952 |
N/A |
INTRINSIC |
|
low complexity region
|
1212 |
1228 |
N/A |
INTRINSIC |
|
low complexity region
|
1390 |
1397 |
N/A |
INTRINSIC |
|
PDB:3S3O|B
|
1478 |
1706 |
6e-8 |
PDB |
|
SCOP:d1cxqa_
|
1552 |
1646 |
2e-12 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000181218
|
| Meta Mutation Damage Score |
0.1630 |
| Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.7%
- 10x: 95.0%
- 20x: 89.2%
|
| Validation Efficiency |
96% (76/79) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700010I14Rik |
G |
T |
17: 9,226,938 (GRCm39) |
|
probably benign |
Het |
| Abca13 |
T |
A |
11: 9,242,775 (GRCm39) |
I1546N |
probably damaging |
Het |
| Actrt3 |
A |
T |
3: 30,652,422 (GRCm39) |
M224K |
probably benign |
Het |
| Adgrv1 |
T |
C |
13: 81,727,065 (GRCm39) |
N429S |
probably benign |
Het |
| Appbp2 |
A |
C |
11: 85,105,129 (GRCm39) |
C146G |
possibly damaging |
Het |
| Cabp2 |
A |
C |
19: 4,136,242 (GRCm39) |
D83A |
possibly damaging |
Het |
| Ccl1 |
A |
G |
11: 82,068,843 (GRCm39) |
|
probably null |
Het |
| Cdca8 |
T |
C |
4: 124,814,168 (GRCm39) |
T208A |
probably benign |
Het |
| Dach1 |
C |
T |
14: 98,406,184 (GRCm39) |
G188R |
probably damaging |
Het |
| Dcdc5 |
G |
A |
2: 106,187,541 (GRCm39) |
|
noncoding transcript |
Het |
| Efr3b |
C |
A |
12: 4,043,003 (GRCm39) |
C89F |
probably damaging |
Het |
| Enpp3 |
C |
T |
10: 24,675,051 (GRCm39) |
|
probably null |
Het |
| Ep400 |
A |
T |
5: 110,821,395 (GRCm39) |
V2467E |
probably damaging |
Het |
| Ermap |
T |
C |
4: 119,037,145 (GRCm39) |
|
probably benign |
Het |
| Fig4 |
A |
G |
10: 41,149,003 (GRCm39) |
Y150H |
possibly damaging |
Het |
| Fsip2 |
G |
A |
2: 82,822,416 (GRCm39) |
V6050M |
probably damaging |
Het |
| Gnb1l |
T |
C |
16: 18,359,810 (GRCm39) |
W72R |
probably damaging |
Het |
| Gpld1 |
A |
G |
13: 25,174,101 (GRCm39) |
D842G |
probably damaging |
Het |
| Hmgcr |
A |
G |
13: 96,788,597 (GRCm39) |
|
probably benign |
Het |
| Hrc |
A |
G |
7: 44,985,794 (GRCm39) |
H315R |
possibly damaging |
Het |
| Ifit2 |
A |
T |
19: 34,550,973 (GRCm39) |
N171I |
probably damaging |
Het |
| Ipo11 |
T |
A |
13: 107,023,238 (GRCm39) |
I416L |
probably benign |
Het |
| Kcnab1 |
G |
A |
3: 65,264,527 (GRCm39) |
V259M |
probably damaging |
Het |
| Kcng4 |
T |
C |
8: 120,360,259 (GRCm39) |
Y39C |
probably damaging |
Het |
| Kif5c |
A |
G |
2: 49,622,725 (GRCm39) |
T526A |
probably benign |
Het |
| Kntc1 |
A |
G |
5: 123,919,044 (GRCm39) |
Y805C |
probably damaging |
Het |
| Mal |
A |
G |
2: 127,482,227 (GRCm39) |
S59P |
probably damaging |
Het |
| Myh15 |
A |
G |
16: 48,983,423 (GRCm39) |
N1513D |
probably damaging |
Het |
| Ncoa2 |
A |
G |
1: 13,244,976 (GRCm39) |
L574P |
probably damaging |
Het |
| Nmd3 |
A |
G |
3: 69,643,425 (GRCm39) |
|
probably null |
Het |
| Nucb2 |
A |
G |
7: 116,132,386 (GRCm39) |
D331G |
probably benign |
Het |
| Nwd1 |
T |
C |
8: 73,436,053 (GRCm39) |
|
probably benign |
Het |
| Or4a80 |
A |
C |
2: 89,582,365 (GRCm39) |
I269S |
possibly damaging |
Het |
| Or7c19 |
T |
A |
8: 85,957,706 (GRCm39) |
I194N |
probably benign |
Het |
| Or8b12b |
T |
G |
9: 37,684,274 (GRCm39) |
F106L |
probably benign |
Het |
| Pfdn6 |
T |
C |
17: 34,158,538 (GRCm39) |
R79G |
probably damaging |
Het |
| Pkd1 |
G |
T |
17: 24,797,513 (GRCm39) |
|
probably null |
Het |
| Pramel4 |
T |
G |
4: 143,794,914 (GRCm39) |
C434G |
probably benign |
Het |
| Ptpn13 |
T |
C |
5: 103,634,638 (GRCm39) |
|
probably null |
Het |
| Ptpro |
T |
C |
6: 137,393,825 (GRCm39) |
V831A |
probably benign |
Het |
| Rabl6 |
A |
T |
2: 25,492,579 (GRCm39) |
|
probably benign |
Het |
| Reg3b |
T |
A |
6: 78,349,844 (GRCm39) |
M128K |
possibly damaging |
Het |
| Rif1 |
A |
G |
2: 52,006,686 (GRCm39) |
T2207A |
probably benign |
Het |
| Rpa1 |
A |
C |
11: 75,205,687 (GRCm39) |
N223K |
probably null |
Het |
| Rras2 |
T |
C |
7: 113,647,490 (GRCm39) |
|
probably benign |
Het |
| Ryr1 |
T |
A |
7: 28,746,967 (GRCm39) |
E3760V |
probably damaging |
Het |
| Scyl3 |
T |
A |
1: 163,767,538 (GRCm39) |
I204N |
possibly damaging |
Het |
| Serpinb9h |
A |
C |
13: 33,588,494 (GRCm39) |
I360L |
probably damaging |
Het |
| Slc16a12 |
A |
G |
19: 34,650,098 (GRCm39) |
|
probably benign |
Het |
| Slc22a1 |
A |
G |
17: 12,878,646 (GRCm39) |
F356L |
probably damaging |
Het |
| Slc22a29 |
A |
G |
19: 8,195,630 (GRCm39) |
|
probably benign |
Het |
| Slc45a1 |
C |
A |
4: 150,714,023 (GRCm39) |
D741Y |
possibly damaging |
Het |
| Slco1a5 |
A |
T |
6: 142,182,061 (GRCm39) |
|
probably benign |
Het |
| Smg5 |
G |
T |
3: 88,258,412 (GRCm39) |
R461L |
probably damaging |
Het |
| Snrk |
T |
C |
9: 121,995,306 (GRCm39) |
S362P |
probably damaging |
Het |
| Spata31d1b |
A |
G |
13: 59,863,883 (GRCm39) |
S344G |
probably benign |
Het |
| Sync |
G |
A |
4: 129,187,537 (GRCm39) |
V190M |
probably damaging |
Het |
| Taf5l |
T |
C |
8: 124,730,383 (GRCm39) |
Y67C |
probably damaging |
Het |
| Tbkbp1 |
A |
G |
11: 97,037,115 (GRCm39) |
|
probably benign |
Het |
| Tshr |
A |
T |
12: 91,504,660 (GRCm39) |
I533F |
possibly damaging |
Het |
| Tsn |
T |
C |
1: 118,228,589 (GRCm39) |
D211G |
probably damaging |
Het |
| Ttn |
G |
A |
2: 76,621,988 (GRCm39) |
T15518I |
probably benign |
Het |
| Unc13c |
T |
C |
9: 73,600,583 (GRCm39) |
D1387G |
probably benign |
Het |
| Vapb |
A |
G |
2: 173,613,397 (GRCm39) |
T99A |
probably benign |
Het |
| Vmn2r127 |
A |
G |
17: 19,373,879 (GRCm39) |
|
noncoding transcript |
Het |
| Zfp280d |
A |
T |
9: 72,246,292 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Nynrin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01020:Nynrin
|
APN |
14 |
56,105,905 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL01131:Nynrin
|
APN |
14 |
56,110,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01357:Nynrin
|
APN |
14 |
56,107,874 (GRCm39) |
missense |
probably benign |
|
|
IGL01537:Nynrin
|
APN |
14 |
56,109,502 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01583:Nynrin
|
APN |
14 |
56,107,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01726:Nynrin
|
APN |
14 |
56,101,611 (GRCm39) |
missense |
probably benign |
|
|
IGL02161:Nynrin
|
APN |
14 |
56,101,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02167:Nynrin
|
APN |
14 |
56,100,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02247:Nynrin
|
APN |
14 |
56,109,167 (GRCm39) |
nonsense |
probably null |
|
|
IGL02302:Nynrin
|
APN |
14 |
56,105,962 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL02524:Nynrin
|
APN |
14 |
56,108,931 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL02600:Nynrin
|
APN |
14 |
56,101,449 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02639:Nynrin
|
APN |
14 |
56,108,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02654:Nynrin
|
APN |
14 |
56,100,716 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02659:Nynrin
|
APN |
14 |
56,103,554 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02736:Nynrin
|
APN |
14 |
56,108,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02949:Nynrin
|
APN |
14 |
56,109,837 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4458001:Nynrin
|
UTSW |
14 |
56,101,425 (GRCm39) |
missense |
probably benign |
0.39 |
|
R0078:Nynrin
|
UTSW |
14 |
56,100,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0211:Nynrin
|
UTSW |
14 |
56,109,255 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0211:Nynrin
|
UTSW |
14 |
56,109,255 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0413:Nynrin
|
UTSW |
14 |
56,109,648 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0609:Nynrin
|
UTSW |
14 |
56,110,218 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0626:Nynrin
|
UTSW |
14 |
56,105,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1205:Nynrin
|
UTSW |
14 |
56,091,646 (GRCm39) |
intron |
probably benign |
|
|
R1222:Nynrin
|
UTSW |
14 |
56,100,998 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1385:Nynrin
|
UTSW |
14 |
56,102,356 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1820:Nynrin
|
UTSW |
14 |
56,107,835 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1829:Nynrin
|
UTSW |
14 |
56,110,404 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1874:Nynrin
|
UTSW |
14 |
56,100,950 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1927:Nynrin
|
UTSW |
14 |
56,101,049 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2233:Nynrin
|
UTSW |
14 |
56,109,524 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R3018:Nynrin
|
UTSW |
14 |
56,100,867 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3154:Nynrin
|
UTSW |
14 |
56,101,044 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3853:Nynrin
|
UTSW |
14 |
56,101,562 (GRCm39) |
missense |
probably benign |
0.24 |
|
R4648:Nynrin
|
UTSW |
14 |
56,110,351 (GRCm39) |
nonsense |
probably null |
|
|
R4722:Nynrin
|
UTSW |
14 |
56,091,852 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4735:Nynrin
|
UTSW |
14 |
56,107,625 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4736:Nynrin
|
UTSW |
14 |
56,101,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4780:Nynrin
|
UTSW |
14 |
56,100,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4804:Nynrin
|
UTSW |
14 |
56,102,326 (GRCm39) |
missense |
probably benign |
|
|
R4816:Nynrin
|
UTSW |
14 |
56,109,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5307:Nynrin
|
UTSW |
14 |
56,101,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5372:Nynrin
|
UTSW |
14 |
56,105,948 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5432:Nynrin
|
UTSW |
14 |
56,101,923 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5800:Nynrin
|
UTSW |
14 |
56,108,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5825:Nynrin
|
UTSW |
14 |
56,101,683 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6149:Nynrin
|
UTSW |
14 |
56,091,780 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6244:Nynrin
|
UTSW |
14 |
56,105,485 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6350:Nynrin
|
UTSW |
14 |
56,105,533 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6379:Nynrin
|
UTSW |
14 |
56,107,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6437:Nynrin
|
UTSW |
14 |
56,109,227 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6501:Nynrin
|
UTSW |
14 |
56,100,989 (GRCm39) |
missense |
probably benign |
|
|
R6702:Nynrin
|
UTSW |
14 |
56,101,935 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6703:Nynrin
|
UTSW |
14 |
56,101,935 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6907:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6908:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6928:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6934:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6935:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7197:Nynrin
|
UTSW |
14 |
56,109,380 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7204:Nynrin
|
UTSW |
14 |
56,110,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7272:Nynrin
|
UTSW |
14 |
56,107,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7335:Nynrin
|
UTSW |
14 |
56,101,371 (GRCm39) |
missense |
probably benign |
|
|
R7361:Nynrin
|
UTSW |
14 |
56,107,857 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7368:Nynrin
|
UTSW |
14 |
56,107,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7443:Nynrin
|
UTSW |
14 |
56,108,873 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7584:Nynrin
|
UTSW |
14 |
56,109,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7677:Nynrin
|
UTSW |
14 |
56,107,693 (GRCm39) |
missense |
probably benign |
|
|
R7723:Nynrin
|
UTSW |
14 |
56,109,502 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7776:Nynrin
|
UTSW |
14 |
56,103,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7787:Nynrin
|
UTSW |
14 |
56,107,980 (GRCm39) |
missense |
probably benign |
|
|
R7842:Nynrin
|
UTSW |
14 |
56,102,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7852:Nynrin
|
UTSW |
14 |
56,108,886 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8040:Nynrin
|
UTSW |
14 |
56,108,982 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8159:Nynrin
|
UTSW |
14 |
56,102,517 (GRCm39) |
missense |
probably benign |
|
|
R8159:Nynrin
|
UTSW |
14 |
56,100,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8258:Nynrin
|
UTSW |
14 |
56,100,815 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8259:Nynrin
|
UTSW |
14 |
56,100,815 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8343:Nynrin
|
UTSW |
14 |
56,101,248 (GRCm39) |
missense |
probably benign |
|
|
R8504:Nynrin
|
UTSW |
14 |
56,107,703 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8671:Nynrin
|
UTSW |
14 |
56,107,899 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8691:Nynrin
|
UTSW |
14 |
56,110,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8777:Nynrin
|
UTSW |
14 |
56,109,120 (GRCm39) |
missense |
probably benign |
|
|
R8777-TAIL:Nynrin
|
UTSW |
14 |
56,109,120 (GRCm39) |
missense |
probably benign |
|
|
R9041:Nynrin
|
UTSW |
14 |
56,108,753 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9346:Nynrin
|
UTSW |
14 |
56,100,495 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9366:Nynrin
|
UTSW |
14 |
56,100,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9690:Nynrin
|
UTSW |
14 |
56,108,204 (GRCm39) |
missense |
probably benign |
0.00 |
|
RF007:Nynrin
|
UTSW |
14 |
56,103,658 (GRCm39) |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGGCATTCCCTCTGAAGCCCTATAC -3'
(R):5'- AAGAAAGCGTCCATCTTGAGCCC -3'
Sequencing Primer
(F):5'- TCTGAAGCCCTATACGCACG -3'
(R):5'- ACGGGCTCCATCAGCTTC -3'
|
| Posted On |
2013-04-11 |
Incidental Mutation