Incidental Mutation 'R1749:Klra6'
ID 194195
Institutional Source Beutler Lab
Gene Symbol Klra6
Ensembl Gene ENSMUSG00000061769
Gene Name killer cell lectin-like receptor, subfamily A, member 6
Synonyms Ly49F, Ly49f
MMRRC Submission 039781-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # R1749 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 129989996-130003917 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 129995915 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 148 (F148I)
Ref Sequence ENSEMBL: ENSMUSP00000073700 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074056]
AlphaFold Q60653
Predicted Effect probably damaging
Transcript: ENSMUST00000074056
AA Change: F148I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073700
Gene: ENSMUSG00000061769
AA Change: F148I

DomainStartEndE-ValueType
Blast:CLECT 73 123 3e-9 BLAST
CLECT 143 258 8.42e-18 SMART
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.9%
  • 10x: 95.4%
  • 20x: 93.0%
Validation Efficiency
MGI Phenotype FUNCTION: This gene belongs to the highly polymorphic family of C-type lectin-like Ly49 genes that are expressed in natural killer (NK) cells. The encoded protein is a homodimeric type II transmembrane receptor located at the cell surface and inhibits NK cell activation upon ligand binding. This gene is located in a cluster of several Klra paralogs on chromosome 6. Different strains of mice show variation in the number of paralogs, including strain specific duplications, deletions and pseudogene sequences. [provided by RefSeq, Apr 2015]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ak5 A T 3: 152,178,557 (GRCm39) M486K probably damaging Het
Arhgef6 T C X: 56,383,922 (GRCm39) M5V probably benign Het
Aspn A T 13: 49,705,261 (GRCm39) D41V probably benign Het
Atp8a2 C A 14: 60,097,623 (GRCm39) E802* probably null Het
Barhl2 T C 5: 106,605,572 (GRCm39) S46G unknown Het
Cacna1e A G 1: 154,319,746 (GRCm39) V1318A probably damaging Het
Ccdc69 T C 11: 54,941,979 (GRCm39) R176G probably null Het
Cdan1 T C 2: 120,560,280 (GRCm39) N321S probably damaging Het
Cep85l T C 10: 53,154,250 (GRCm39) D681G probably damaging Het
Cntrob A T 11: 69,213,700 (GRCm39) V30E probably damaging Het
Csmd3 C T 15: 47,449,056 (GRCm39) G3646E probably damaging Het
Cx3cl1 A G 8: 95,506,789 (GRCm39) probably null Het
Dab1 A T 4: 104,185,495 (GRCm39) probably benign Het
Dennd2c T C 3: 103,039,352 (GRCm39) S167P possibly damaging Het
Dock2 A G 11: 34,182,767 (GRCm39) probably null Het
Dok3 GCC GC 13: 55,672,168 (GRCm39) probably null Het
Ebf1 A T 11: 44,798,835 (GRCm39) I287L possibly damaging Het
Eci1 G A 17: 24,645,721 (GRCm39) probably null Het
Emb T A 13: 117,386,242 (GRCm39) I133N possibly damaging Het
Fam91a1 A G 15: 58,298,443 (GRCm39) I184V probably benign Het
Fbn2 T C 18: 58,183,348 (GRCm39) D1779G probably benign Het
Fgfr4 T A 13: 55,315,605 (GRCm39) probably null Het
Flt1 G A 5: 147,591,929 (GRCm39) T511M probably benign Het
Gys1 T C 7: 45,089,456 (GRCm39) L205P probably damaging Het
Hepacam2 A G 6: 3,483,379 (GRCm39) V134A probably damaging Het
Htr3a A G 9: 48,812,233 (GRCm39) V291A probably damaging Het
Ip6k3 T A 17: 27,364,053 (GRCm39) T332S probably benign Het
Kntc1 T C 5: 123,927,162 (GRCm39) S1206P probably benign Het
Mbnl2 T A 14: 120,626,462 (GRCm39) C231S probably damaging Het
Mdn1 A T 4: 32,773,952 (GRCm39) D5521V probably damaging Het
Mylip G A 13: 45,557,946 (GRCm39) V52M possibly damaging Het
Naip6 A G 13: 100,444,763 (GRCm39) S232P probably benign Het
Ndc80 T C 17: 71,808,550 (GRCm39) K504R probably benign Het
Nf2 T C 11: 4,753,694 (GRCm39) N220S possibly damaging Het
Nfasc T A 1: 132,539,370 (GRCm39) I393F probably damaging Het
Or12d2 T C 17: 37,624,952 (GRCm39) T108A probably benign Het
Pabpc1 T C 15: 36,608,584 (GRCm39) Y56C probably damaging Het
Pcca A G 14: 122,938,542 (GRCm39) K498R probably damaging Het
Phldb1 A G 9: 44,627,045 (GRCm39) S467P probably damaging Het
Ptprn2 T C 12: 116,544,048 (GRCm39) S47P probably benign Het
Rtca A T 3: 116,291,293 (GRCm39) I229N possibly damaging Het
Sh3rf2 T A 18: 42,286,359 (GRCm39) S617R probably damaging Het
Slc14a2 T G 18: 78,190,295 (GRCm39) T885P possibly damaging Het
Sp100 A C 1: 85,627,357 (GRCm39) T417P possibly damaging Het
Tat A T 8: 110,722,846 (GRCm39) N303Y probably damaging Het
Tet2 A G 3: 133,185,892 (GRCm39) probably null Het
Tln2 C T 9: 67,193,796 (GRCm39) A1773T probably benign Het
Tnks1bp1 A G 2: 84,893,411 (GRCm39) S1113G probably benign Het
Tspear G A 10: 77,705,507 (GRCm39) E302K probably benign Het
Tulp3 A G 6: 128,314,722 (GRCm39) L23P probably damaging Het
Vti1b T C 12: 79,211,807 (GRCm39) E42G probably damaging Het
Yeats2 G T 16: 20,005,018 (GRCm39) E333* probably null Het
Zfp455 T G 13: 67,355,073 (GRCm39) C114G probably damaging Het
Zfp532 G A 18: 65,756,555 (GRCm39) V163M possibly damaging Het
Zfp940 A T 7: 29,544,952 (GRCm39) C318* probably null Het
Other mutations in Klra6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00861:Klra6 APN 6 130,000,663 (GRCm39) missense possibly damaging 0.77
IGL02037:Klra6 APN 6 129,990,439 (GRCm39) missense probably benign 0.02
IGL02319:Klra6 APN 6 130,002,177 (GRCm39) missense probably damaging 0.98
IGL02427:Klra6 APN 6 129,993,680 (GRCm39) missense possibly damaging 0.54
IGL02730:Klra6 APN 6 129,999,660 (GRCm39) missense probably benign
IGL02822:Klra6 APN 6 129,993,673 (GRCm39) nonsense probably null
R0485:Klra6 UTSW 6 130,000,601 (GRCm39) missense probably benign 0.12
R0697:Klra6 UTSW 6 129,993,687 (GRCm39) missense probably benign 0.18
R0731:Klra6 UTSW 6 129,999,668 (GRCm39) missense probably damaging 1.00
R1081:Klra6 UTSW 6 129,999,588 (GRCm39) missense probably damaging 0.96
R1708:Klra6 UTSW 6 129,999,677 (GRCm39) nonsense probably null
R1842:Klra6 UTSW 6 129,999,573 (GRCm39) missense probably benign 0.14
R1944:Klra6 UTSW 6 129,995,908 (GRCm39) missense possibly damaging 0.92
R4214:Klra6 UTSW 6 129,995,885 (GRCm39) missense probably benign 0.10
R5210:Klra6 UTSW 6 129,995,855 (GRCm39) nonsense probably null
R5286:Klra6 UTSW 6 129,995,932 (GRCm39) missense probably benign 0.02
R5418:Klra6 UTSW 6 129,990,393 (GRCm39) missense probably damaging 0.96
R5764:Klra6 UTSW 6 129,999,692 (GRCm39) missense possibly damaging 0.92
R6193:Klra6 UTSW 6 129,995,881 (GRCm39) missense probably benign 0.12
R6536:Klra6 UTSW 6 130,000,682 (GRCm39) missense probably benign 0.07
R6696:Klra6 UTSW 6 129,993,696 (GRCm39) missense probably benign
R7021:Klra6 UTSW 6 129,995,821 (GRCm39) missense possibly damaging 0.93
R7718:Klra6 UTSW 6 129,990,315 (GRCm39) frame shift probably null
R8500:Klra6 UTSW 6 129,999,660 (GRCm39) missense probably benign
R8910:Klra6 UTSW 6 129,993,647 (GRCm39) missense probably benign
R8983:Klra6 UTSW 6 129,999,573 (GRCm39) missense probably benign 0.14
R9164:Klra6 UTSW 6 129,993,687 (GRCm39) missense possibly damaging 0.95
R9775:Klra6 UTSW 6 129,999,639 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCTTGTACACTCCTGAGAAAGGGAGG -3'
(R):5'- TGTTTAGCCAAGGAAGGACTCAAACTG -3'

Sequencing Primer
(F):5'- acaaaacaaaacaaaacaaaacaaGC -3'
(R):5'- GGCATAAATCATCCTGTCAAGCTG -3'
Posted On 2014-05-23