Mutagenetix > Incidental Mutation

Incidental Mutation 'R1768:Aox1'

194534

Institutional Source

Beutler Lab

Gene Symbol

Aox1

Ensembl Gene

ENSMUSG00000063558

Gene Name

aldehyde oxidase 1

Synonyms

Aox-1, retinal oxidase, Aox-2, Aox2

MMRRC Submission

039799-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1768 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

58069090-58145572 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 58393354 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 1199 (C1199S)

Ref Sequence

ENSEMBL: ENSMUSP00000110006 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000114366]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000114366
AA Change: C1199S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000110006
Gene: ENSMUSG00000079554
AA Change: C1199S

Domain	Start	End	E-Value	Type
Pfam:Fer2	13	83	3.4e-9	PFAM
Pfam:Fer2_2	92	166	4.2e-30	PFAM
Pfam:FAD_binding_5	241	421	5.1e-46	PFAM
CO_deh_flav_C	428	532	1.4e-23	SMART
Ald_Xan_dh_C	604	707	4.64e-47	SMART
Pfam:Ald_Xan_dh_C2	717	1251	1.3e-178	PFAM
low complexity region	1257	1271	N/A	INTRINSIC
low complexity region	1285	1303	N/A	INTRINSIC

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 97.4%
3x: 96.9%
10x: 95.3%
20x: 92.4%

Validation Efficiency

91% (107/117)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 112 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921524L21Rik	G	C	18: 6,623,470 (GRCm39)	R60P	possibly damaging	Het
Arhgap18	G	A	10: 26,763,857 (GRCm39)	M482I	probably damaging	Het
Arhgap18	G	T	10: 26,763,858 (GRCm39)	A483S	probably damaging	Het
Arid4a	G	A	12: 71,122,112 (GRCm39)	S509N	probably benign	Het
BC051019	T	C	7: 109,322,381 (GRCm39)	T38A	probably benign	Het
Bcam	T	C	7: 19,499,543 (GRCm39)	N192S	probably null	Het
Bend5	A	T	4: 111,311,438 (GRCm39)	K351*	probably null	Het
Bicdl2	T	A	17: 23,884,923 (GRCm39)	M208K	probably damaging	Het
Ccp110	A	T	7: 118,325,247 (GRCm39)		probably null	Het
Cdc6	A	T	11: 98,803,043 (GRCm39)	T328S	probably damaging	Het
Cdk5rap2	G	T	4: 70,225,470 (GRCm39)	N558K	probably benign	Het
Cdkn1c	C	T	7: 143,012,858 (GRCm39)	R146K	probably benign	Het
Ceacam18	G	A	7: 43,297,918 (GRCm39)	C371Y	probably benign	Het
Cep95	T	A	11: 106,697,177 (GRCm39)	C233*	probably null	Het
Chrnd	A	G	1: 87,122,650 (GRCm39)	I144V	probably benign	Het
Col6a4	T	A	9: 105,957,299 (GRCm39)	Q175L	probably benign	Het
Cym	A	T	3: 107,120,816 (GRCm39)	V263E	probably damaging	Het
Cyp2a4	G	T	7: 26,012,197 (GRCm39)	V327F	possibly damaging	Het
Dhx29	T	A	13: 113,084,774 (GRCm39)	M664K	probably damaging	Het
Dlec1	T	G	9: 118,975,075 (GRCm39)		probably null	Het
Dna2	T	C	10: 62,792,863 (GRCm39)	Y293H	probably benign	Het
Dnase1l3	T	A	14: 7,974,104 (GRCm38)	N196Y	probably damaging	Het
Eea1	T	A	10: 95,832,822 (GRCm39)	D222E	probably damaging	Het
Efcab14	A	T	4: 115,610,116 (GRCm39)		probably null	Het
Entpd5	C	T	12: 84,432,985 (GRCm39)	R189H	probably benign	Het
Exoc4	A	T	6: 33,734,985 (GRCm39)	K534M	probably damaging	Het
Extl1	T	A	4: 134,098,449 (GRCm39)	Y194F	probably benign	Het
Eya1	A	G	1: 14,323,299 (GRCm39)	L161S	possibly damaging	Het
Fam163b	T	C	2: 27,002,874 (GRCm39)	E41G	possibly damaging	Het
Fam180a	A	C	6: 35,292,287 (GRCm39)	S40A	probably benign	Het
Fbxl4	T	C	4: 22,385,950 (GRCm39)	S186P	probably benign	Het
Fbxw19	A	T	9: 109,323,840 (GRCm39)	L45*	probably null	Het
Fgf14	G	T	14: 124,913,924 (GRCm39)	T69N	probably benign	Het
Flt1	A	G	5: 147,609,519 (GRCm39)	Y432H	probably damaging	Het
Frmd4b	A	T	6: 97,283,725 (GRCm39)	L374Q	possibly damaging	Het
G6pc2	T	A	2: 69,053,321 (GRCm39)	V125D	probably damaging	Het
Gm10033	T	C	8: 69,826,210 (GRCm39)	I119M	unknown	Het
Gna15	A	T	10: 81,347,954 (GRCm39)	L164Q	probably damaging	Het
Gnaz	C	A	10: 74,827,702 (GRCm39)	D151E	possibly damaging	Het
Has1	T	C	17: 18,070,562 (GRCm39)	T120A	probably benign	Het
Hectd4	T	A	5: 121,496,366 (GRCm39)	D3919E	possibly damaging	Het
Hs3st5	A	G	10: 36,709,165 (GRCm39)	I233M	probably benign	Het
Ilf3	T	C	9: 21,314,438 (GRCm39)		probably benign	Het
Inpp5b	T	A	4: 124,687,069 (GRCm39)	L765*	probably null	Het
Insr	A	T	8: 3,209,561 (GRCm39)	I1174N	probably damaging	Het
Kash5	T	A	7: 44,838,227 (GRCm39)		probably null	Het
Kcnq3	A	G	15: 65,877,755 (GRCm39)	L445P	probably damaging	Het
Kctd20	A	T	17: 29,181,824 (GRCm39)	N159Y	probably damaging	Het
Kctd20	A	T	17: 29,185,755 (GRCm39)	D366V	probably damaging	Het
Klk15	T	C	7: 43,587,757 (GRCm39)		probably benign	Het
Lama4	T	G	10: 38,979,497 (GRCm39)	N1658K	possibly damaging	Het
Lonrf2	G	A	1: 38,852,357 (GRCm39)	P165S	probably benign	Het
Mas1	T	C	17: 13,060,586 (GRCm39)	Y279C	probably damaging	Het
Mast2	G	T	4: 116,164,156 (GRCm39)	D1747E	probably damaging	Het
Mest	G	A	6: 30,745,138 (GRCm39)	M235I	probably benign	Het
Mfsd6	A	G	1: 52,699,964 (GRCm39)		probably null	Het
Mllt10	T	A	2: 18,167,657 (GRCm39)	S449R	probably damaging	Het
Mon2	T	A	10: 122,849,668 (GRCm39)	T1211S	probably benign	Het
Mrnip	G	A	11: 50,067,688 (GRCm39)	C27Y	probably damaging	Het
Myh15	A	T	16: 48,983,498 (GRCm39)	T1538S	probably benign	Het
Nfatc2ip	A	G	7: 125,989,634 (GRCm39)	V250A	probably benign	Het
Npy1r	A	G	8: 67,157,177 (GRCm39)	D199G	possibly damaging	Het
Numbl	A	G	7: 26,980,379 (GRCm39)	T454A	probably benign	Het
Nutm2	T	G	13: 50,627,152 (GRCm39)	F436V	probably damaging	Het
Opa1	T	C	16: 29,439,628 (GRCm39)	S773P	probably benign	Het
Or12e1	T	A	2: 87,022,042 (GRCm39)	S4T	probably benign	Het
Or2d3	A	T	7: 106,491,184 (GRCm39)		probably null	Het
Or2d3	G	T	7: 106,491,185 (GRCm39)	L44M	probably damaging	Het
Or2r11	A	G	6: 42,437,611 (GRCm39)	L114S	probably damaging	Het
Or2t48	A	G	11: 58,420,602 (GRCm39)	L70P	probably damaging	Het
Or51b17	A	G	7: 103,542,484 (GRCm39)	S153P	probably benign	Het
Or51m1	C	T	7: 103,578,932 (GRCm39)	R301*	probably null	Het
Or52e7	A	G	7: 104,685,157 (GRCm39)	S251G	probably benign	Het
Or52i2	A	G	7: 102,319,508 (GRCm39)	Y127C	probably damaging	Het
Or8b12c	T	A	9: 37,715,599 (GRCm39)	Y131N	probably damaging	Het
Pde8a	G	C	7: 80,950,471 (GRCm39)		probably null	Het
Pgam1	T	C	19: 41,906,144 (GRCm39)	F232S	probably damaging	Het
Pgk1	T	A	X: 105,243,914 (GRCm39)	V303E	possibly damaging	Het
Pirb	A	T	7: 3,720,189 (GRCm39)	C395S	probably damaging	Het
Plxnc1	C	T	10: 94,680,184 (GRCm39)	V824I	probably benign	Het
Ppp6r1	A	G	7: 4,636,691 (GRCm39)		probably null	Het
Rapgef4	C	A	2: 72,056,131 (GRCm39)		probably benign	Het
Rars1	T	A	11: 35,700,465 (GRCm39)	T539S	probably damaging	Het
Rbm44	G	T	1: 91,081,679 (GRCm39)		probably null	Het
Samd4b	A	G	7: 28,113,317 (GRCm39)	I216T	probably benign	Het
Serpine2	A	C	1: 79,794,532 (GRCm39)	F134V	probably damaging	Het
Shmt1	A	G	11: 60,683,790 (GRCm39)	Y341H	probably damaging	Het
Slc23a2	C	A	2: 131,917,561 (GRCm39)	V226F	probably benign	Het
Slc23a4	A	G	6: 34,933,896 (GRCm39)	I69T	probably damaging	Het
Slc37a1	C	A	17: 31,552,652 (GRCm39)	T319K	possibly damaging	Het
Slc6a4	A	T	11: 76,904,078 (GRCm39)	T178S	probably damaging	Het
Smarca4	G	A	9: 21,612,479 (GRCm39)	A1588T	possibly damaging	Het
Spag17	A	T	3: 99,934,668 (GRCm39)	Y650F	possibly damaging	Het
Stab2	C	T	10: 86,838,872 (GRCm39)	G65S	probably damaging	Het
Stambpl1	C	G	19: 34,204,121 (GRCm39)	N70K	probably damaging	Het
Stip1	C	A	19: 6,999,165 (GRCm39)	C471F	probably damaging	Het
Taf1	T	C	X: 100,584,500 (GRCm39)	S223P	probably benign	Het
Tchh	C	A	3: 93,350,882 (GRCm39)	N107K	possibly damaging	Het
Tenm3	A	C	8: 48,685,139 (GRCm39)	H2432Q	probably damaging	Het
Tmem243	A	G	5: 9,168,548 (GRCm39)	N110S	probably damaging	Het
Toe1	A	T	4: 116,662,076 (GRCm39)	I306F	probably benign	Het
Trank1	G	A	9: 111,221,995 (GRCm39)	V2911M	probably damaging	Het
Trpm4	A	G	7: 44,958,036 (GRCm39)	I811T	probably damaging	Het
Tspear	T	A	10: 77,710,950 (GRCm39)		probably null	Het
Ttc28	A	T	5: 111,425,034 (GRCm39)	I1589F	possibly damaging	Het
Tubgcp3	A	G	8: 12,699,686 (GRCm39)		probably benign	Het
U2af2	C	A	7: 5,070,544 (GRCm39)	R78S	probably benign	Het
Wdr17	A	T	8: 55,126,689 (GRCm39)	D388E	possibly damaging	Het
Wdr3	A	T	3: 100,061,186 (GRCm39)	S261T	probably benign	Het
Zfp667	A	G	7: 6,308,066 (GRCm39)	N245D	possibly damaging	Het
Zfp692	A	G	11: 58,201,002 (GRCm39)		probably benign	Het
Zfp729a	T	C	13: 67,767,370 (GRCm39)	H953R	probably benign	Het

Other mutations in Aox1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00336:Aox1	APN	1	58,098,203 (GRCm39)	missense	probably damaging	1.00
IGL01014:Aox1	APN	1	58,361,960 (GRCm39)	missense	possibly damaging	0.73
IGL01077:Aox1	APN	1	58,096,569 (GRCm39)	splice site	probably benign
IGL01288:Aox1	APN	1	58,333,566 (GRCm39)	missense	probably damaging	0.99
IGL01335:Aox1	APN	1	58,121,312 (GRCm39)	nonsense	probably null
IGL01383:Aox1	APN	1	58,333,464 (GRCm39)	missense	probably benign	0.09
IGL01410:Aox1	APN	1	58,145,184 (GRCm39)	splice site	probably null
IGL01684:Aox1	APN	1	58,116,740 (GRCm39)	splice site	probably null
IGL01727:Aox1	APN	1	58,112,387 (GRCm39)	nonsense	probably null
IGL01734:Aox1	APN	1	58,393,469 (GRCm39)	missense	possibly damaging	0.95
IGL01793:Aox1	APN	1	58,375,783 (GRCm39)	missense	possibly damaging	0.79
IGL01805:Aox1	APN	1	58,120,672 (GRCm39)	missense	possibly damaging	0.94
IGL01834:Aox1	APN	1	58,348,183 (GRCm39)	missense	possibly damaging	0.90
IGL01924:Aox1	APN	1	58,326,902 (GRCm39)	missense	possibly damaging	0.90
IGL01996:Aox1	APN	1	58,121,225 (GRCm39)	missense	probably benign	0.11
IGL02060:Aox1	APN	1	58,137,114 (GRCm39)	missense	possibly damaging	0.95
IGL02206:Aox1	APN	1	58,104,499 (GRCm39)	missense	probably benign	0.00
IGL02591:Aox1	APN	1	58,398,158 (GRCm39)	nonsense	probably null
IGL02645:Aox1	APN	1	58,373,883 (GRCm39)	missense	probably damaging	1.00
IGL02710:Aox1	APN	1	58,373,928 (GRCm39)	critical splice donor site	probably null
IGL02801:Aox1	APN	1	58,393,336 (GRCm39)	missense	probably damaging	1.00
IGL02839:Aox1	APN	1	58,107,943 (GRCm39)	missense	probably benign	0.05
IGL02975:Aox1	APN	1	58,107,550 (GRCm39)	missense	probably damaging	1.00
IGL02988:Aox1	APN	1	58,376,509 (GRCm39)	missense	probably benign
IGL03062:Aox1	APN	1	58,117,624 (GRCm39)	missense	probably benign	0.01
IGL03104:Aox1	APN	1	58,321,918 (GRCm39)	missense	probably benign
IGL03121:Aox1	APN	1	58,398,113 (GRCm39)	missense	probably damaging	1.00
IGL03191:Aox1	APN	1	58,398,228 (GRCm39)	missense	probably null	0.98
IGL03236:Aox1	APN	1	58,349,156 (GRCm39)	nonsense	probably null
IGL03286:Aox1	APN	1	58,088,543 (GRCm39)	missense	probably benign	0.19
IGL03335:Aox1	APN	1	58,115,319 (GRCm39)	missense	probably damaging	0.98
IGL03395:Aox1	APN	1	58,107,884 (GRCm39)	splice site	probably benign
IGL03409:Aox1	APN	1	58,393,588 (GRCm39)	missense	possibly damaging	0.91
PIT4362001:Aox1	UTSW	1	58,321,839 (GRCm39)	missense	probably damaging	1.00
R0035:Aox1	UTSW	1	58,393,581 (GRCm39)	missense	probably benign	0.00
R0035:Aox1	UTSW	1	58,393,581 (GRCm39)	missense	probably benign	0.00
R0048:Aox1	UTSW	1	58,112,371 (GRCm39)	missense	probably damaging	0.98
R0144:Aox1	UTSW	1	58,109,233 (GRCm39)	missense	probably benign	0.00
R0207:Aox1	UTSW	1	58,144,173 (GRCm39)	missense	possibly damaging	0.82
R0267:Aox1	UTSW	1	58,378,605 (GRCm39)	splice site	probably benign
R0357:Aox1	UTSW	1	58,131,675 (GRCm39)	missense	probably damaging	1.00
R0383:Aox1	UTSW	1	58,100,400 (GRCm39)	missense	probably benign	0.00
R0388:Aox1	UTSW	1	58,393,565 (GRCm39)	missense	probably damaging	1.00
R0399:Aox1	UTSW	1	58,108,008 (GRCm39)	splice site	probably null
R0409:Aox1	UTSW	1	58,375,783 (GRCm39)	missense	possibly damaging	0.90
R0465:Aox1	UTSW	1	58,101,366 (GRCm39)	missense	probably damaging	1.00
R0480:Aox1	UTSW	1	58,082,810 (GRCm39)	splice site	probably benign
R0547:Aox1	UTSW	1	58,349,201 (GRCm39)	missense	probably damaging	0.96
R0630:Aox1	UTSW	1	58,376,480 (GRCm39)	splice site	probably benign
R0726:Aox1	UTSW	1	58,373,941 (GRCm39)	splice site	probably benign
R0734:Aox1	UTSW	1	58,344,500 (GRCm39)	missense	probably benign	0.22
R0831:Aox1	UTSW	1	58,378,842 (GRCm39)	missense	probably benign	0.28
R0961:Aox1	UTSW	1	58,349,230 (GRCm39)	missense	probably benign	0.00
R1005:Aox1	UTSW	1	58,104,511 (GRCm39)	missense	probably benign	0.00
R1404:Aox1	UTSW	1	58,385,371 (GRCm39)	splice site	probably benign
R1507:Aox1	UTSW	1	58,143,610 (GRCm39)	missense	probably benign	0.01
R1512:Aox1	UTSW	1	58,346,510 (GRCm39)	missense	probably benign	0.00
R1573:Aox1	UTSW	1	58,348,186 (GRCm39)	missense	probably benign	0.00
R1592:Aox1	UTSW	1	58,339,853 (GRCm39)	missense	probably benign	0.00
R1597:Aox1	UTSW	1	58,086,326 (GRCm39)	missense	probably damaging	1.00
R1693:Aox1	UTSW	1	58,124,701 (GRCm39)	missense	probably damaging	1.00
R1709:Aox1	UTSW	1	58,116,633 (GRCm39)	missense	probably benign
R1747:Aox1	UTSW	1	58,378,751 (GRCm39)	missense	probably benign	0.01
R1809:Aox1	UTSW	1	58,333,484 (GRCm39)	missense	probably benign
R1823:Aox1	UTSW	1	58,351,518 (GRCm39)	missense	probably benign	0.02
R1834:Aox1	UTSW	1	58,348,150 (GRCm39)	missense	probably benign	0.08
R1835:Aox1	UTSW	1	58,348,150 (GRCm39)	missense	probably benign	0.08
R1836:Aox1	UTSW	1	58,348,150 (GRCm39)	missense	probably benign	0.08
R1869:Aox1	UTSW	1	58,115,262 (GRCm39)	missense	probably damaging	1.00
R1870:Aox1	UTSW	1	58,115,262 (GRCm39)	missense	probably damaging	1.00
R1898:Aox1	UTSW	1	58,117,601 (GRCm39)	missense	probably damaging	1.00
R1908:Aox1	UTSW	1	58,141,783 (GRCm39)	missense	probably damaging	1.00
R2002:Aox1	UTSW	1	58,086,300 (GRCm39)	missense	possibly damaging	0.69
R2062:Aox1	UTSW	1	58,098,351 (GRCm39)	splice site	probably null
R2065:Aox1	UTSW	1	58,098,351 (GRCm39)	splice site	probably null
R2219:Aox1	UTSW	1	58,388,289 (GRCm39)	splice site	probably null
R2220:Aox1	UTSW	1	58,388,289 (GRCm39)	splice site	probably null
R2265:Aox1	UTSW	1	58,120,679 (GRCm39)	missense	probably damaging	0.99
R2508:Aox1	UTSW	1	58,382,832 (GRCm39)	missense	probably benign	0.38
R2942:Aox1	UTSW	1	58,376,540 (GRCm39)	missense	probably benign	0.03
R2967:Aox1	UTSW	1	58,361,993 (GRCm39)	missense	probably damaging	0.96
R3082:Aox1	UTSW	1	58,322,759 (GRCm39)	splice site	probably benign
R3161:Aox1	UTSW	1	58,343,597 (GRCm39)	missense	possibly damaging	0.91
R3408:Aox1	UTSW	1	58,382,827 (GRCm39)	missense	probably benign	0.32
R3713:Aox1	UTSW	1	58,095,374 (GRCm39)	missense	probably benign	0.01
R3778:Aox1	UTSW	1	58,092,862 (GRCm39)	missense	possibly damaging	0.89
R3803:Aox1	UTSW	1	58,329,058 (GRCm39)	splice site	probably null
R3894:Aox1	UTSW	1	58,373,837 (GRCm39)	critical splice acceptor site	probably null
R4198:Aox1	UTSW	1	58,124,766 (GRCm39)	missense	probably benign
R4214:Aox1	UTSW	1	58,346,603 (GRCm39)	critical splice donor site	probably null
R4249:Aox1	UTSW	1	58,338,978 (GRCm39)	missense	probably benign	0.01
R4296:Aox1	UTSW	1	58,096,559 (GRCm39)	splice site	probably null
R4562:Aox1	UTSW	1	58,098,215 (GRCm39)	missense	probably damaging	0.99
R4666:Aox1	UTSW	1	58,343,756 (GRCm39)	nonsense	probably null
R4668:Aox1	UTSW	1	58,373,853 (GRCm39)	missense	possibly damaging	0.63
R4703:Aox1	UTSW	1	58,398,116 (GRCm39)	missense	possibly damaging	0.78
R4758:Aox1	UTSW	1	58,371,741 (GRCm39)	missense	probably benign	0.00
R4858:Aox1	UTSW	1	58,143,640 (GRCm39)	missense	probably benign
R4862:Aox1	UTSW	1	58,134,316 (GRCm39)	missense	probably damaging	0.98
R4890:Aox1	UTSW	1	58,373,862 (GRCm39)	missense	probably benign	0.11
R4900:Aox1	UTSW	1	58,344,544 (GRCm39)	missense	probably benign
R4924:Aox1	UTSW	1	58,344,503 (GRCm39)	missense	probably damaging	1.00
R4970:Aox1	UTSW	1	58,349,254 (GRCm39)	splice site	probably null
R5048:Aox1	UTSW	1	58,098,641 (GRCm39)	splice site	probably benign
R5112:Aox1	UTSW	1	58,349,254 (GRCm39)	splice site	probably null
R5127:Aox1	UTSW	1	58,069,185 (GRCm39)	missense	probably benign	0.00
R5139:Aox1	UTSW	1	58,100,456 (GRCm39)	missense	probably benign	0.03
R5157:Aox1	UTSW	1	58,109,222 (GRCm39)	missense	probably damaging	1.00
R5168:Aox1	UTSW	1	58,088,561 (GRCm39)	missense	probably damaging	1.00
R5186:Aox1	UTSW	1	58,107,529 (GRCm39)	missense	probably damaging	1.00
R5235:Aox1	UTSW	1	58,096,714 (GRCm39)	missense	possibly damaging	0.77
R5289:Aox1	UTSW	1	58,131,717 (GRCm39)	missense	probably damaging	0.99
R5466:Aox1	UTSW	1	58,080,619 (GRCm39)	missense	probably damaging	1.00
R5540:Aox1	UTSW	1	58,143,569 (GRCm39)	missense	probably benign	0.03
R5615:Aox1	UTSW	1	58,136,125 (GRCm39)	missense	probably benign
R5652:Aox1	UTSW	1	58,134,356 (GRCm39)	missense	probably damaging	1.00
R5920:Aox1	UTSW	1	58,088,631 (GRCm39)	missense	probably damaging	1.00
R5987:Aox1	UTSW	1	58,346,518 (GRCm39)	missense	probably benign	0.00
R6008:Aox1	UTSW	1	58,116,672 (GRCm39)	missense	probably damaging	1.00
R6073:Aox1	UTSW	1	58,143,668 (GRCm39)	critical splice donor site	probably null
R6215:Aox1	UTSW	1	58,124,620 (GRCm39)	missense	probably benign
R6239:Aox1	UTSW	1	58,344,550 (GRCm39)	critical splice donor site	probably null
R6273:Aox1	UTSW	1	58,378,831 (GRCm39)	missense	probably benign	0.00
R6291:Aox1	UTSW	1	58,369,965 (GRCm39)	missense	probably damaging	0.98
R6334:Aox1	UTSW	1	58,346,566 (GRCm39)	nonsense	probably null
R6403:Aox1	UTSW	1	58,107,594 (GRCm39)	missense	probably damaging	1.00
R6440:Aox1	UTSW	1	58,133,631 (GRCm39)	missense	probably damaging	1.00
R6601:Aox1	UTSW	1	58,102,665 (GRCm39)	missense	probably damaging	1.00
R6608:Aox1	UTSW	1	58,096,705 (GRCm39)	missense	probably benign	0.40
R6752:Aox1	UTSW	1	58,086,398 (GRCm39)	missense	probably benign	0.00
R6764:Aox1	UTSW	1	58,389,441 (GRCm39)	missense	probably damaging	0.97
R6766:Aox1	UTSW	1	58,388,227 (GRCm39)	missense	possibly damaging	0.95
R6789:Aox1	UTSW	1	58,343,644 (GRCm39)	missense	probably benign	0.01
R6804:Aox1	UTSW	1	58,343,757 (GRCm39)	missense	probably benign	0.04
R6989:Aox1	UTSW	1	58,124,611 (GRCm39)	missense	probably damaging	1.00
R7007:Aox1	UTSW	1	58,370,051 (GRCm39)	missense	probably damaging	1.00
R7015:Aox1	UTSW	1	58,321,917 (GRCm39)	missense	probably benign	0.00
R7042:Aox1	UTSW	1	58,141,759 (GRCm39)	missense	probably damaging	0.99
R7055:Aox1	UTSW	1	58,338,927 (GRCm39)	missense	probably benign	0.08
R7089:Aox1	UTSW	1	58,375,808 (GRCm39)	missense	probably benign	0.01
R7157:Aox1	UTSW	1	58,322,651 (GRCm39)	missense	probably benign	0.00
R7303:Aox1	UTSW	1	58,373,924 (GRCm39)	nonsense	probably null
R7426:Aox1	UTSW	1	58,329,142 (GRCm39)	nonsense	probably null
R7442:Aox1	UTSW	1	58,121,172 (GRCm39)	missense	probably damaging	1.00
R7506:Aox1	UTSW	1	58,088,562 (GRCm39)	missense	probably damaging	1.00
R7563:Aox1	UTSW	1	58,086,304 (GRCm39)	missense	probably benign	0.32
R7589:Aox1	UTSW	1	58,080,643 (GRCm39)	missense	probably damaging	1.00
R7735:Aox1	UTSW	1	58,107,451 (GRCm39)	missense	probably benign	0.01
R7762:Aox1	UTSW	1	58,388,263 (GRCm39)	missense	probably damaging	1.00
R7814:Aox1	UTSW	1	58,124,626 (GRCm39)	missense	probably benign
R7876:Aox1	UTSW	1	58,101,330 (GRCm39)	nonsense	probably null
R7899:Aox1	UTSW	1	58,320,396 (GRCm39)	splice site	probably null
R7905:Aox1	UTSW	1	58,143,557 (GRCm39)	missense	possibly damaging	0.72
R7908:Aox1	UTSW	1	58,145,227 (GRCm39)	missense	possibly damaging	0.68
R7942:Aox1	UTSW	1	58,376,590 (GRCm39)	missense	probably damaging	1.00
R7975:Aox1	UTSW	1	58,348,187 (GRCm39)	missense	probably benign	0.02
R8029:Aox1	UTSW	1	58,382,827 (GRCm39)	missense	probably benign	0.32
R8032:Aox1	UTSW	1	58,389,442 (GRCm39)	missense	probably benign	0.01
R8116:Aox1	UTSW	1	58,115,283 (GRCm39)	missense	probably damaging	1.00
R8147:Aox1	UTSW	1	58,339,821 (GRCm39)	missense	probably benign	0.02
R8165:Aox1	UTSW	1	58,348,088 (GRCm39)	missense	probably benign	0.08
R8179:Aox1	UTSW	1	58,137,117 (GRCm39)	missense	probably damaging	1.00
R8264:Aox1	UTSW	1	58,092,873 (GRCm39)	missense	possibly damaging	0.92
R8284:Aox1	UTSW	1	58,115,250 (GRCm39)	missense	probably damaging	1.00
R8326:Aox1	UTSW	1	58,335,046 (GRCm39)	missense	probably benign
R8415:Aox1	UTSW	1	58,080,638 (GRCm39)	missense	probably damaging	1.00
R8770:Aox1	UTSW	1	58,378,763 (GRCm39)	missense	probably benign	0.10
R8946:Aox1	UTSW	1	58,145,227 (GRCm39)	missense	possibly damaging	0.68
R8973:Aox1	UTSW	1	58,329,113 (GRCm39)	missense	probably benign	0.34
R8988:Aox1	UTSW	1	58,088,625 (GRCm39)	missense	possibly damaging	0.48
R9015:Aox1	UTSW	1	58,382,851 (GRCm39)	missense	probably damaging	1.00
R9097:Aox1	UTSW	1	58,326,887 (GRCm39)	missense	possibly damaging	0.82
R9101:Aox1	UTSW	1	58,371,796 (GRCm39)	missense	probably benign	0.03
R9108:Aox1	UTSW	1	58,321,851 (GRCm39)	missense	probably damaging	1.00
R9180:Aox1	UTSW	1	58,378,777 (GRCm39)	nonsense	probably null
R9258:Aox1	UTSW	1	58,351,515 (GRCm39)	missense	probably damaging	1.00
R9293:Aox1	UTSW	1	58,361,953 (GRCm39)	missense	possibly damaging	0.86
R9296:Aox1	UTSW	1	58,124,612 (GRCm39)	missense	probably damaging	1.00
R9382:Aox1	UTSW	1	58,104,501 (GRCm39)	missense	possibly damaging	0.48
R9461:Aox1	UTSW	1	58,116,736 (GRCm39)	critical splice donor site	probably null
R9519:Aox1	UTSW	1	58,373,926 (GRCm39)	missense	probably damaging	0.98
R9581:Aox1	UTSW	1	58,370,055 (GRCm39)	critical splice donor site	probably null
Z1088:Aox1	UTSW	1	58,120,701 (GRCm39)	missense	probably benign	0.01
Z1177:Aox1	UTSW	1	58,393,556 (GRCm39)	missense	possibly damaging	0.69

Predicted Primers

PCR Primer
(F):5'- AACTCAAGGTCACTGTGGCAGC -3'
(R):5'- CCTCGGTGGTATAAAGGCCCATTC -3'

Sequencing Primer
(F):5'- caattgcctttgttctgagctaAC -3'
(R):5'- GGCCCATTCCTTGAATAAATGC -3'

Posted On

2014-05-23