Incidental Mutation 'R1755:Vmn2r96'
ID |
194810 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r96
|
Ensembl Gene |
ENSMUSG00000091679 |
Gene Name |
vomeronasal 2, receptor 96 |
Synonyms |
EG433070 |
MMRRC Submission |
039787-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.157)
|
Stock # |
R1755 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
17 |
Chromosomal Location |
18793282-18818419 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 18802915 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glycine to Aspartic acid
at position 83
(G83D)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000131564
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165692]
[ENSMUST00000177244]
[ENSMUST00000231261]
[ENSMUST00000231286]
|
AlphaFold |
E9PZU5 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000165692
AA Change: G83D
PolyPhen 2
Score 0.499 (Sensitivity: 0.88; Specificity: 0.90)
|
SMART Domains |
Protein: ENSMUSP00000131564 Gene: ENSMUSG00000091679 AA Change: G83D
Domain | Start | End | E-Value | Type |
Pfam:ANF_receptor
|
1 |
257 |
8.6e-20 |
PFAM |
Pfam:NCD3G
|
317 |
370 |
3.7e-22 |
PFAM |
Pfam:7tm_3
|
402 |
638 |
3.9e-53 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000177244
AA Change: G275D
PolyPhen 2
Score 0.239 (Sensitivity: 0.91; Specificity: 0.88)
|
SMART Domains |
Protein: ENSMUSP00000135095 Gene: ENSMUSG00000091679 AA Change: G275D
Domain | Start | End | E-Value | Type |
Pfam:ANF_receptor
|
1 |
245 |
4.2e-19 |
PFAM |
Pfam:NCD3G
|
317 |
370 |
6.9e-21 |
PFAM |
Pfam:7tm_3
|
400 |
639 |
3.4e-75 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000231261
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000231286
AA Change: G275D
PolyPhen 2
Score 0.239 (Sensitivity: 0.91; Specificity: 0.88)
|
Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.2%
- 20x: 92.0%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 67 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4933402J07Rik |
G |
A |
8: 88,315,585 (GRCm39) |
R225H |
possibly damaging |
Het |
9330159F19Rik |
A |
T |
10: 29,098,290 (GRCm39) |
H199L |
possibly damaging |
Het |
Acaca |
AC |
A |
11: 84,167,390 (GRCm39) |
|
probably null |
Het |
Adam23 |
G |
A |
1: 63,582,329 (GRCm39) |
V326M |
probably damaging |
Het |
Aldh1a2 |
T |
A |
9: 71,169,023 (GRCm39) |
Y168* |
probably null |
Het |
Ano6 |
A |
G |
15: 95,870,451 (GRCm39) |
K869E |
possibly damaging |
Het |
Aplp2 |
G |
A |
9: 31,088,400 (GRCm39) |
A106V |
probably damaging |
Het |
Arhgdib |
T |
A |
6: 136,906,612 (GRCm39) |
K30* |
probably null |
Het |
Arl11 |
A |
G |
14: 61,548,393 (GRCm39) |
T68A |
probably benign |
Het |
Atg7 |
A |
G |
6: 114,650,638 (GRCm39) |
T83A |
possibly damaging |
Het |
Card9 |
T |
C |
2: 26,249,546 (GRCm39) |
E5G |
probably damaging |
Het |
Cars1 |
A |
G |
7: 143,123,194 (GRCm39) |
V474A |
probably damaging |
Het |
Cd300ld2 |
A |
G |
11: 114,904,601 (GRCm39) |
F89L |
probably benign |
Het |
Celf2 |
T |
A |
2: 6,889,769 (GRCm39) |
M1L |
probably benign |
Het |
Cnot1 |
T |
C |
8: 96,451,205 (GRCm39) |
D2174G |
probably damaging |
Het |
Col1a2 |
G |
A |
6: 4,518,822 (GRCm39) |
|
probably benign |
Het |
Cox6b2 |
A |
G |
7: 4,754,937 (GRCm39) |
F74S |
probably damaging |
Het |
Cyp11b1 |
T |
A |
15: 74,710,383 (GRCm39) |
Q306L |
probably benign |
Het |
Ddx3y |
A |
G |
Y: 1,279,543 (GRCm39) |
I107T |
probably benign |
Het |
Dnah5 |
A |
T |
15: 28,326,782 (GRCm39) |
Y1997F |
probably damaging |
Het |
Dync2i1 |
A |
G |
12: 116,189,649 (GRCm39) |
L620P |
probably damaging |
Het |
Epha4 |
A |
T |
1: 77,364,460 (GRCm39) |
I683N |
probably damaging |
Het |
Fam120a |
G |
T |
13: 49,039,219 (GRCm39) |
A979E |
possibly damaging |
Het |
Gmip |
A |
G |
8: 70,266,774 (GRCm39) |
I296M |
probably damaging |
Het |
Gpr37l1 |
A |
G |
1: 135,094,639 (GRCm39) |
S202P |
probably damaging |
Het |
Ifi208 |
C |
A |
1: 173,505,476 (GRCm39) |
D75E |
possibly damaging |
Het |
Il24 |
T |
C |
1: 130,811,680 (GRCm39) |
N132S |
possibly damaging |
Het |
Katnal2 |
A |
G |
18: 77,099,763 (GRCm39) |
C124R |
probably benign |
Het |
Kcnq3 |
A |
T |
15: 65,867,270 (GRCm39) |
L791Q |
probably damaging |
Het |
Kcns3 |
T |
A |
12: 11,141,445 (GRCm39) |
D418V |
probably benign |
Het |
Kif13a |
A |
G |
13: 46,906,089 (GRCm39) |
V618A |
possibly damaging |
Het |
Kif13a |
A |
T |
13: 46,927,154 (GRCm39) |
V1179E |
possibly damaging |
Het |
Lpp |
A |
G |
16: 24,663,874 (GRCm39) |
I259V |
probably benign |
Het |
Mapkapk2 |
A |
G |
1: 130,986,087 (GRCm39) |
|
probably null |
Het |
Marchf7 |
T |
C |
2: 60,065,265 (GRCm39) |
S514P |
probably benign |
Het |
Nr4a2 |
T |
A |
2: 56,999,104 (GRCm39) |
L381F |
probably damaging |
Het |
Nt5dc3 |
A |
G |
10: 86,660,115 (GRCm39) |
D328G |
probably damaging |
Het |
Obox6 |
T |
C |
7: 15,568,445 (GRCm39) |
K144E |
probably damaging |
Het |
Oga |
A |
T |
19: 45,746,845 (GRCm39) |
M735K |
possibly damaging |
Het |
Olfml2b |
G |
A |
1: 170,509,346 (GRCm39) |
V565M |
probably damaging |
Het |
Or1d2 |
T |
C |
11: 74,255,819 (GRCm39) |
V108A |
probably damaging |
Het |
Orc3 |
G |
A |
4: 34,575,114 (GRCm39) |
A590V |
possibly damaging |
Het |
Picalm |
T |
C |
7: 89,809,757 (GRCm39) |
S78P |
possibly damaging |
Het |
Por |
T |
A |
5: 135,758,339 (GRCm39) |
Y105* |
probably null |
Het |
Ppara |
A |
G |
15: 85,682,180 (GRCm39) |
K292R |
probably benign |
Het |
Pramel27 |
T |
C |
4: 143,577,380 (GRCm39) |
F3S |
probably damaging |
Het |
Prss59 |
T |
G |
6: 40,903,096 (GRCm39) |
Y92S |
probably damaging |
Het |
Ralgds |
T |
A |
2: 28,440,558 (GRCm39) |
I844N |
probably damaging |
Het |
Rttn |
T |
C |
18: 89,027,441 (GRCm39) |
Y519H |
probably damaging |
Het |
Scn9a |
A |
G |
2: 66,332,060 (GRCm39) |
V1261A |
probably benign |
Het |
Slc2a2 |
T |
A |
3: 28,767,811 (GRCm39) |
|
probably null |
Het |
Slc5a7 |
T |
C |
17: 54,600,006 (GRCm39) |
M136V |
probably benign |
Het |
Smc4 |
C |
A |
3: 68,941,441 (GRCm39) |
A1232E |
probably damaging |
Het |
Smg1 |
A |
T |
7: 117,802,287 (GRCm39) |
C270* |
probably null |
Het |
Sparcl1 |
C |
T |
5: 104,240,690 (GRCm39) |
E245K |
probably benign |
Het |
Taf2 |
T |
C |
15: 54,879,850 (GRCm39) |
H1162R |
probably damaging |
Het |
Tlr3 |
T |
C |
8: 45,851,010 (GRCm39) |
D105G |
probably benign |
Het |
Tmem62 |
T |
C |
2: 120,814,958 (GRCm39) |
|
probably null |
Het |
Triobp |
G |
A |
15: 78,850,679 (GRCm39) |
A278T |
probably benign |
Het |
Ufd1 |
T |
G |
16: 18,642,003 (GRCm39) |
C151W |
probably damaging |
Het |
Upk1b |
T |
G |
16: 38,600,402 (GRCm39) |
M193L |
probably benign |
Het |
Usp15 |
A |
G |
10: 122,968,949 (GRCm39) |
M334T |
probably damaging |
Het |
Utp20 |
A |
G |
10: 88,645,631 (GRCm39) |
S541P |
probably benign |
Het |
Vmn1r61 |
A |
T |
7: 5,614,302 (GRCm39) |
L4* |
probably null |
Het |
Zbtb8a |
T |
C |
4: 129,248,110 (GRCm39) |
D387G |
possibly damaging |
Het |
Zfp106 |
A |
T |
2: 120,365,656 (GRCm39) |
N250K |
probably damaging |
Het |
Zfp292 |
A |
G |
4: 34,811,043 (GRCm39) |
V667A |
probably benign |
Het |
|
Other mutations in Vmn2r96 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00562:Vmn2r96
|
APN |
17 |
18,804,077 (GRCm39) |
missense |
probably benign |
0.00 |
IGL00563:Vmn2r96
|
APN |
17 |
18,804,077 (GRCm39) |
missense |
probably benign |
0.00 |
IGL00769:Vmn2r96
|
APN |
17 |
18,804,081 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01314:Vmn2r96
|
APN |
17 |
18,803,226 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01983:Vmn2r96
|
APN |
17 |
18,817,527 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02314:Vmn2r96
|
APN |
17 |
18,804,221 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02600:Vmn2r96
|
APN |
17 |
18,817,829 (GRCm39) |
missense |
probably benign |
|
IGL02672:Vmn2r96
|
APN |
17 |
18,818,376 (GRCm39) |
missense |
probably benign |
0.02 |
IGL02750:Vmn2r96
|
APN |
17 |
18,802,851 (GRCm39) |
missense |
probably benign |
0.01 |
IGL03068:Vmn2r96
|
APN |
17 |
18,803,137 (GRCm39) |
missense |
probably benign |
0.00 |
IGL03411:Vmn2r96
|
APN |
17 |
18,806,634 (GRCm39) |
missense |
possibly damaging |
0.88 |
R0316:Vmn2r96
|
UTSW |
17 |
18,802,827 (GRCm39) |
missense |
probably damaging |
1.00 |
R0502:Vmn2r96
|
UTSW |
17 |
18,804,262 (GRCm39) |
missense |
probably benign |
|
R0580:Vmn2r96
|
UTSW |
17 |
18,802,900 (GRCm39) |
missense |
probably damaging |
1.00 |
R0652:Vmn2r96
|
UTSW |
17 |
18,817,830 (GRCm39) |
missense |
probably benign |
0.05 |
R0789:Vmn2r96
|
UTSW |
17 |
18,802,738 (GRCm39) |
missense |
possibly damaging |
0.81 |
R1462:Vmn2r96
|
UTSW |
17 |
18,817,660 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1462:Vmn2r96
|
UTSW |
17 |
18,817,660 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1660:Vmn2r96
|
UTSW |
17 |
18,817,988 (GRCm39) |
missense |
probably benign |
0.00 |
R1843:Vmn2r96
|
UTSW |
17 |
18,818,183 (GRCm39) |
missense |
probably benign |
0.14 |
R1943:Vmn2r96
|
UTSW |
17 |
18,806,664 (GRCm39) |
missense |
probably benign |
0.09 |
R1993:Vmn2r96
|
UTSW |
17 |
18,804,138 (GRCm39) |
missense |
probably damaging |
1.00 |
R2018:Vmn2r96
|
UTSW |
17 |
18,804,263 (GRCm39) |
missense |
probably benign |
|
R2405:Vmn2r96
|
UTSW |
17 |
18,818,102 (GRCm39) |
missense |
probably damaging |
0.96 |
R3977:Vmn2r96
|
UTSW |
17 |
18,817,941 (GRCm39) |
missense |
probably damaging |
1.00 |
R3979:Vmn2r96
|
UTSW |
17 |
18,817,941 (GRCm39) |
missense |
probably damaging |
1.00 |
R4059:Vmn2r96
|
UTSW |
17 |
18,818,339 (GRCm39) |
missense |
probably benign |
0.20 |
R4693:Vmn2r96
|
UTSW |
17 |
18,803,270 (GRCm39) |
missense |
probably benign |
0.03 |
R4709:Vmn2r96
|
UTSW |
17 |
18,803,088 (GRCm39) |
missense |
probably benign |
0.36 |
R4776:Vmn2r96
|
UTSW |
17 |
18,817,770 (GRCm39) |
missense |
probably damaging |
1.00 |
R4882:Vmn2r96
|
UTSW |
17 |
18,817,866 (GRCm39) |
missense |
probably damaging |
1.00 |
R4920:Vmn2r96
|
UTSW |
17 |
18,802,918 (GRCm39) |
missense |
probably benign |
0.07 |
R5143:Vmn2r96
|
UTSW |
17 |
18,804,120 (GRCm39) |
missense |
possibly damaging |
0.65 |
R5301:Vmn2r96
|
UTSW |
17 |
18,817,950 (GRCm39) |
missense |
probably damaging |
0.98 |
R5507:Vmn2r96
|
UTSW |
17 |
18,818,091 (GRCm39) |
missense |
probably damaging |
1.00 |
R6151:Vmn2r96
|
UTSW |
17 |
18,804,221 (GRCm39) |
missense |
probably benign |
0.01 |
R6181:Vmn2r96
|
UTSW |
17 |
18,804,126 (GRCm39) |
missense |
probably benign |
|
R6339:Vmn2r96
|
UTSW |
17 |
18,804,124 (GRCm39) |
missense |
possibly damaging |
0.84 |
R6404:Vmn2r96
|
UTSW |
17 |
18,817,793 (GRCm39) |
missense |
probably damaging |
1.00 |
R6452:Vmn2r96
|
UTSW |
17 |
18,804,117 (GRCm39) |
missense |
probably benign |
0.07 |
R6749:Vmn2r96
|
UTSW |
17 |
18,818,352 (GRCm39) |
missense |
probably damaging |
0.99 |
R6813:Vmn2r96
|
UTSW |
17 |
18,802,116 (GRCm39) |
missense |
probably benign |
0.04 |
R6851:Vmn2r96
|
UTSW |
17 |
18,802,800 (GRCm39) |
missense |
possibly damaging |
0.95 |
R6944:Vmn2r96
|
UTSW |
17 |
18,817,891 (GRCm39) |
missense |
probably benign |
0.16 |
R6949:Vmn2r96
|
UTSW |
17 |
18,818,100 (GRCm39) |
missense |
probably damaging |
1.00 |
R6962:Vmn2r96
|
UTSW |
17 |
18,818,283 (GRCm39) |
missense |
probably damaging |
0.99 |
R6990:Vmn2r96
|
UTSW |
17 |
18,804,082 (GRCm39) |
missense |
probably benign |
|
R7149:Vmn2r96
|
UTSW |
17 |
18,817,989 (GRCm39) |
missense |
possibly damaging |
0.89 |
R7346:Vmn2r96
|
UTSW |
17 |
18,803,029 (GRCm39) |
missense |
probably benign |
0.15 |
R7385:Vmn2r96
|
UTSW |
17 |
18,803,302 (GRCm39) |
missense |
probably damaging |
1.00 |
R7442:Vmn2r96
|
UTSW |
17 |
18,793,662 (GRCm39) |
missense |
probably benign |
0.02 |
R7509:Vmn2r96
|
UTSW |
17 |
18,802,995 (GRCm39) |
missense |
probably benign |
0.02 |
R7652:Vmn2r96
|
UTSW |
17 |
18,793,832 (GRCm39) |
missense |
probably benign |
|
R7659:Vmn2r96
|
UTSW |
17 |
18,793,749 (GRCm39) |
missense |
probably benign |
0.00 |
R7753:Vmn2r96
|
UTSW |
17 |
18,806,663 (GRCm39) |
missense |
possibly damaging |
0.46 |
R7855:Vmn2r96
|
UTSW |
17 |
18,818,130 (GRCm39) |
missense |
possibly damaging |
0.59 |
R8166:Vmn2r96
|
UTSW |
17 |
18,802,744 (GRCm39) |
missense |
probably damaging |
1.00 |
R8260:Vmn2r96
|
UTSW |
17 |
18,804,243 (GRCm39) |
missense |
probably benign |
0.04 |
R8323:Vmn2r96
|
UTSW |
17 |
18,803,023 (GRCm39) |
missense |
probably damaging |
0.99 |
R8787:Vmn2r96
|
UTSW |
17 |
18,818,250 (GRCm39) |
missense |
probably damaging |
1.00 |
R8837:Vmn2r96
|
UTSW |
17 |
18,802,888 (GRCm39) |
missense |
probably benign |
|
R8933:Vmn2r96
|
UTSW |
17 |
18,804,241 (GRCm39) |
missense |
probably benign |
0.11 |
R9306:Vmn2r96
|
UTSW |
17 |
18,803,226 (GRCm39) |
missense |
probably benign |
0.00 |
R9481:Vmn2r96
|
UTSW |
17 |
18,793,621 (GRCm39) |
start gained |
probably benign |
|
R9626:Vmn2r96
|
UTSW |
17 |
18,793,758 (GRCm39) |
missense |
probably benign |
0.14 |
R9629:Vmn2r96
|
UTSW |
17 |
18,803,257 (GRCm39) |
missense |
probably benign |
0.15 |
Z1088:Vmn2r96
|
UTSW |
17 |
18,817,628 (GRCm39) |
missense |
possibly damaging |
0.86 |
Z1177:Vmn2r96
|
UTSW |
17 |
18,818,376 (GRCm39) |
missense |
probably benign |
0.02 |
|
Predicted Primers |
PCR Primer
(F):5'- GGTTGGTCTCATCCTTCCCAATGAC -3'
(R):5'- TGGAGGCTGTAAGCCACAGCATAC -3'
Sequencing Primer
(F):5'- TCCTTCCCAATGACCACAAAG -3'
(R):5'- ATCCAAGGTAGCATTGGTTTGAC -3'
|
Posted On |
2014-05-23 |