Incidental Mutation 'R1758:Arap3'
| ID |
195137 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arap3
|
| Ensembl Gene |
ENSMUSG00000024451 |
| Gene Name |
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 |
| Synonyms |
Centd3, E030006K04Rik, DRAG1 |
| MMRRC Submission |
039790-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.814)
|
| Stock # |
R1758 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
18 |
| Chromosomal Location |
38105681-38132022 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 38122965 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 512
(V512I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000035662
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042944]
|
| AlphaFold |
Q8R5G7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000042944
AA Change: V512I
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000035662
Gene: ENSMUSG00000024451
AA Change: V512I
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
1 |
68 |
1.5e-7 |
SMART |
|
low complexity region
|
81 |
98 |
N/A |
INTRINSIC |
|
low complexity region
|
134 |
142 |
N/A |
INTRINSIC |
|
PH
|
283 |
376 |
3.4e-16 |
SMART |
|
PH
|
390 |
480 |
1.61e-8 |
SMART |
|
ArfGap
|
484 |
606 |
1.44e-25 |
SMART |
|
low complexity region
|
642 |
661 |
N/A |
INTRINSIC |
|
PH
|
671 |
785 |
2.86e1 |
SMART |
|
PH
|
795 |
901 |
6.87e-3 |
SMART |
|
RhoGAP
|
913 |
1089 |
2.11e-47 |
SMART |
|
Pfam:RA
|
1113 |
1206 |
6.2e-16 |
PFAM |
|
PH
|
1220 |
1323 |
3.46e-8 |
SMART |
|
low complexity region
|
1388 |
1407 |
N/A |
INTRINSIC |
|
low complexity region
|
1457 |
1469 |
N/A |
INTRINSIC |
|
low complexity region
|
1475 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1494 |
1529 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000185063
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.6%
- 20x: 93.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
PHENOTYPE: Mice homozygous for a knock-out allele die around E11 exhibiting pallor, embryonic growth arrest, yolk sac and placental abnormalities, and an endothelial cell-autonomous defect in sprouting angiogenesis. Knock-in mice homozygous for a point mutation display similar angiogenesis defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(5) : Targeted(5)
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700029H14Rik |
T |
C |
8: 13,612,237 (GRCm39) |
R38G |
possibly damaging |
Het |
| 4930590J08Rik |
T |
C |
6: 91,892,203 (GRCm39) |
V155A |
possibly damaging |
Het |
| Adgb |
A |
G |
10: 10,302,349 (GRCm39) |
S406P |
probably damaging |
Het |
| Adgrb2 |
C |
A |
4: 129,905,668 (GRCm39) |
T893N |
probably damaging |
Het |
| Adgrf5 |
T |
C |
17: 43,735,484 (GRCm39) |
|
probably null |
Het |
| Alms1 |
T |
A |
6: 85,605,487 (GRCm39) |
I2379N |
probably damaging |
Het |
| Atf4 |
C |
T |
15: 80,141,414 (GRCm39) |
T268I |
probably benign |
Het |
| Cblif |
G |
A |
19: 11,735,179 (GRCm39) |
M266I |
probably damaging |
Het |
| Ccdc154 |
T |
C |
17: 25,382,156 (GRCm39) |
L25P |
probably damaging |
Het |
| Ccdc9 |
G |
A |
7: 16,010,161 (GRCm39) |
S381F |
probably damaging |
Het |
| Cdk17 |
C |
T |
10: 93,044,112 (GRCm39) |
T17M |
probably damaging |
Het |
| Cep128 |
T |
C |
12: 91,314,352 (GRCm39) |
N142S |
probably benign |
Het |
| Cep78 |
A |
G |
19: 15,936,900 (GRCm39) |
I602T |
probably damaging |
Het |
| Clasp1 |
C |
T |
1: 118,475,755 (GRCm39) |
T935I |
probably damaging |
Het |
| Cnr1 |
T |
C |
4: 33,945,000 (GRCm39) |
S463P |
probably damaging |
Het |
| Cntnap1 |
T |
A |
11: 101,075,449 (GRCm39) |
W876R |
probably damaging |
Het |
| Cntnap5c |
A |
G |
17: 58,349,545 (GRCm39) |
D286G |
probably damaging |
Het |
| Copa |
C |
T |
1: 171,931,711 (GRCm39) |
R321C |
probably damaging |
Het |
| Cspg4b |
A |
G |
13: 113,505,266 (GRCm39) |
T2132A |
possibly damaging |
Het |
| Ctla2a |
T |
G |
13: 61,083,256 (GRCm39) |
E98A |
probably damaging |
Het |
| Cux1 |
A |
T |
5: 136,421,176 (GRCm39) |
D183E |
probably damaging |
Het |
| Cxcl15 |
A |
C |
5: 90,949,323 (GRCm39) |
T163P |
unknown |
Het |
| Ddias |
T |
C |
7: 92,508,571 (GRCm39) |
N448S |
probably benign |
Het |
| Dhx8 |
T |
C |
11: 101,657,564 (GRCm39) |
F1152S |
probably damaging |
Het |
| Dnah12 |
C |
A |
14: 26,488,071 (GRCm39) |
Q992K |
probably benign |
Het |
| Eno3 |
G |
T |
11: 70,552,251 (GRCm39) |
W301L |
possibly damaging |
Het |
| Faap100 |
A |
T |
11: 120,268,059 (GRCm39) |
V238E |
probably damaging |
Het |
| Fgf4 |
A |
G |
7: 144,416,049 (GRCm39) |
S137G |
probably benign |
Het |
| Fhod3 |
A |
C |
18: 25,253,367 (GRCm39) |
D1439A |
possibly damaging |
Het |
| Frem2 |
A |
G |
3: 53,560,778 (GRCm39) |
L1243P |
probably damaging |
Het |
| Gkn3 |
T |
G |
6: 87,365,817 (GRCm39) |
M1L |
probably benign |
Het |
| Gm10250 |
T |
C |
15: 5,150,509 (GRCm39) |
|
probably benign |
Het |
| Gm12185 |
T |
C |
11: 48,798,859 (GRCm39) |
T545A |
possibly damaging |
Het |
| Gm14226 |
T |
A |
2: 154,867,378 (GRCm39) |
L445H |
probably damaging |
Het |
| Gm3404 |
A |
T |
5: 146,463,036 (GRCm39) |
M73L |
probably benign |
Het |
| Gm973 |
G |
T |
1: 59,673,169 (GRCm39) |
R976S |
unknown |
Het |
| Gpr146 |
A |
T |
5: 139,379,137 (GRCm39) |
H313L |
probably benign |
Het |
| Gys2 |
T |
A |
6: 142,418,432 (GRCm39) |
E32D |
probably damaging |
Het |
| Igsf10 |
G |
A |
3: 59,236,617 (GRCm39) |
T1188I |
probably benign |
Het |
| Igsf9b |
A |
T |
9: 27,245,548 (GRCm39) |
T1172S |
possibly damaging |
Het |
| Itga8 |
T |
A |
2: 12,270,144 (GRCm39) |
N114I |
possibly damaging |
Het |
| Itsn2 |
T |
A |
12: 4,708,160 (GRCm39) |
V795E |
possibly damaging |
Het |
| Kdm1b |
T |
A |
13: 47,214,244 (GRCm39) |
S197T |
probably benign |
Het |
| Kif5c |
G |
A |
2: 49,613,145 (GRCm39) |
R161Q |
probably benign |
Het |
| Krt33b |
T |
C |
11: 99,916,361 (GRCm39) |
Y232C |
probably damaging |
Het |
| Lonrf2 |
G |
A |
1: 38,852,357 (GRCm39) |
P165S |
probably benign |
Het |
| Lrp1 |
A |
T |
10: 127,424,453 (GRCm39) |
N744K |
possibly damaging |
Het |
| Mcm10 |
C |
A |
2: 5,008,861 (GRCm39) |
L369F |
probably damaging |
Het |
| Muc5ac |
T |
A |
7: 141,355,268 (GRCm39) |
I1018N |
possibly damaging |
Het |
| Myom2 |
T |
C |
8: 15,115,795 (GRCm39) |
L70P |
probably benign |
Het |
| Myt1l |
T |
A |
12: 29,877,241 (GRCm39) |
N297K |
unknown |
Het |
| Ncr1 |
C |
T |
7: 4,343,807 (GRCm39) |
T98I |
probably benign |
Het |
| Nek3 |
T |
C |
8: 22,650,278 (GRCm39) |
E78G |
probably damaging |
Het |
| Nfatc3 |
T |
A |
8: 106,825,768 (GRCm39) |
N606K |
probably damaging |
Het |
| Nup107 |
T |
G |
10: 117,597,248 (GRCm39) |
D669A |
probably damaging |
Het |
| Or10ag52 |
A |
T |
2: 87,043,758 (GRCm39) |
Q174L |
probably benign |
Het |
| Or10c1 |
A |
T |
17: 37,522,204 (GRCm39) |
I180N |
possibly damaging |
Het |
| Or4c3 |
T |
C |
2: 89,851,673 (GRCm39) |
T246A |
probably benign |
Het |
| Or8b55 |
A |
T |
9: 38,726,871 (GRCm39) |
H24L |
probably benign |
Het |
| Pcnx1 |
T |
C |
12: 82,030,258 (GRCm39) |
V1711A |
probably benign |
Het |
| Pik3c3 |
A |
G |
18: 30,410,063 (GRCm39) |
D99G |
probably damaging |
Het |
| Pinx1 |
C |
A |
14: 64,157,024 (GRCm39) |
T317K |
probably benign |
Het |
| Ppargc1b |
G |
T |
18: 61,431,857 (GRCm39) |
|
probably null |
Het |
| Pradc1 |
T |
A |
6: 85,424,203 (GRCm39) |
I119F |
possibly damaging |
Het |
| Psat1 |
G |
T |
19: 15,892,243 (GRCm39) |
T242K |
probably damaging |
Het |
| Psma6 |
G |
A |
12: 55,454,317 (GRCm39) |
C28Y |
probably damaging |
Het |
| Pyurf |
A |
T |
6: 57,668,817 (GRCm39) |
C58* |
probably null |
Het |
| Rab3gap2 |
C |
A |
1: 185,016,081 (GRCm39) |
A1331E |
probably benign |
Het |
| Rnase4 |
T |
C |
14: 51,342,722 (GRCm39) |
*149Q |
probably null |
Het |
| Ruvbl2 |
T |
C |
7: 45,074,586 (GRCm39) |
K184R |
probably benign |
Het |
| Scn7a |
T |
G |
2: 66,510,527 (GRCm39) |
M1292L |
probably benign |
Het |
| Scn7a |
A |
T |
2: 66,531,231 (GRCm39) |
Y549N |
probably damaging |
Het |
| Selp |
A |
G |
1: 163,959,854 (GRCm39) |
D370G |
possibly damaging |
Het |
| Slc22a15 |
G |
A |
3: 101,767,769 (GRCm39) |
Q386* |
probably null |
Het |
| Slc22a29 |
A |
G |
19: 8,195,126 (GRCm39) |
|
probably null |
Het |
| Slc26a7 |
A |
C |
4: 14,548,491 (GRCm39) |
I266S |
possibly damaging |
Het |
| Smpd4 |
T |
C |
16: 17,443,872 (GRCm39) |
S112P |
probably damaging |
Het |
| Smpd4 |
T |
A |
16: 17,458,744 (GRCm39) |
L165Q |
probably damaging |
Het |
| Snx33 |
A |
G |
9: 56,833,982 (GRCm39) |
I29T |
probably benign |
Het |
| Spen |
G |
A |
4: 141,203,686 (GRCm39) |
P1647L |
unknown |
Het |
| Strip2 |
T |
C |
6: 29,941,940 (GRCm39) |
|
probably null |
Het |
| Swsap1 |
C |
T |
9: 21,867,280 (GRCm39) |
R75* |
probably null |
Het |
| Tesl1 |
A |
G |
X: 23,772,990 (GRCm39) |
I164V |
probably benign |
Het |
| Tmem210 |
C |
T |
2: 25,178,435 (GRCm39) |
T32I |
probably damaging |
Het |
| Tnn |
C |
T |
1: 159,975,154 (GRCm39) |
R91H |
possibly damaging |
Het |
| Tnni1 |
G |
A |
1: 135,736,420 (GRCm39) |
R94H |
probably damaging |
Het |
| Tnrc6c |
T |
A |
11: 117,651,556 (GRCm39) |
V1693D |
probably benign |
Het |
| Trip4 |
G |
A |
9: 65,782,259 (GRCm39) |
Q158* |
probably null |
Het |
| Ttc39b |
T |
C |
4: 83,155,586 (GRCm39) |
E474G |
probably damaging |
Het |
| Usp50 |
C |
A |
2: 126,617,782 (GRCm39) |
C221F |
probably damaging |
Het |
| Vmn1r171 |
T |
C |
7: 23,331,781 (GRCm39) |
I2T |
probably benign |
Het |
| Wdr62 |
T |
A |
7: 29,967,328 (GRCm39) |
I309F |
probably damaging |
Het |
| Xdh |
A |
T |
17: 74,217,204 (GRCm39) |
V688E |
probably damaging |
Het |
| Zfyve26 |
A |
G |
12: 79,285,718 (GRCm39) |
L2353P |
probably damaging |
Het |
| Zgpat |
C |
A |
2: 181,020,633 (GRCm39) |
R269S |
probably damaging |
Het |
|
| Other mutations in Arap3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00515:Arap3
|
APN |
18 |
38,108,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01145:Arap3
|
APN |
18 |
38,122,232 (GRCm39) |
missense |
probably benign |
|
|
IGL01154:Arap3
|
APN |
18 |
38,129,787 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL01305:Arap3
|
APN |
18 |
38,124,380 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01542:Arap3
|
APN |
18 |
38,123,889 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01543:Arap3
|
APN |
18 |
38,123,889 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01544:Arap3
|
APN |
18 |
38,123,889 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01545:Arap3
|
APN |
18 |
38,123,889 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01677:Arap3
|
APN |
18 |
38,129,700 (GRCm39) |
missense |
probably benign |
|
|
IGL01925:Arap3
|
APN |
18 |
38,117,299 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL01933:Arap3
|
APN |
18 |
38,111,506 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02048:Arap3
|
APN |
18 |
38,130,032 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL02064:Arap3
|
APN |
18 |
38,124,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02207:Arap3
|
APN |
18 |
38,120,906 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02376:Arap3
|
APN |
18 |
38,111,506 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02531:Arap3
|
APN |
18 |
38,122,804 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02568:Arap3
|
APN |
18 |
38,129,711 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL02640:Arap3
|
APN |
18 |
38,120,855 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02658:Arap3
|
APN |
18 |
38,124,047 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03090:Arap3
|
APN |
18 |
38,122,165 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03352:Arap3
|
APN |
18 |
38,114,355 (GRCm39) |
splice site |
probably benign |
|
|
ANU22:Arap3
|
UTSW |
18 |
38,124,380 (GRCm39) |
critical splice donor site |
probably null |
|
|
P0016:Arap3
|
UTSW |
18 |
38,117,401 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4260001:Arap3
|
UTSW |
18 |
38,129,948 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0066:Arap3
|
UTSW |
18 |
38,129,760 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0324:Arap3
|
UTSW |
18 |
38,106,278 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0562:Arap3
|
UTSW |
18 |
38,108,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1289:Arap3
|
UTSW |
18 |
38,115,026 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1346:Arap3
|
UTSW |
18 |
38,108,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1419:Arap3
|
UTSW |
18 |
38,111,485 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1470:Arap3
|
UTSW |
18 |
38,122,249 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1470:Arap3
|
UTSW |
18 |
38,122,249 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1537:Arap3
|
UTSW |
18 |
38,122,737 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1644:Arap3
|
UTSW |
18 |
38,117,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1731:Arap3
|
UTSW |
18 |
38,122,965 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1843:Arap3
|
UTSW |
18 |
38,108,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1907:Arap3
|
UTSW |
18 |
38,129,724 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1954:Arap3
|
UTSW |
18 |
38,115,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2124:Arap3
|
UTSW |
18 |
38,106,403 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2135:Arap3
|
UTSW |
18 |
38,107,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2172:Arap3
|
UTSW |
18 |
38,123,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2418:Arap3
|
UTSW |
18 |
38,122,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2419:Arap3
|
UTSW |
18 |
38,122,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2907:Arap3
|
UTSW |
18 |
38,123,580 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4425:Arap3
|
UTSW |
18 |
38,111,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4669:Arap3
|
UTSW |
18 |
38,129,307 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4734:Arap3
|
UTSW |
18 |
38,129,328 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4815:Arap3
|
UTSW |
18 |
38,106,296 (GRCm39) |
missense |
probably benign |
|
|
R5328:Arap3
|
UTSW |
18 |
38,124,740 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5350:Arap3
|
UTSW |
18 |
38,115,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5466:Arap3
|
UTSW |
18 |
38,129,789 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5482:Arap3
|
UTSW |
18 |
38,107,727 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5572:Arap3
|
UTSW |
18 |
38,124,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5779:Arap3
|
UTSW |
18 |
38,117,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6053:Arap3
|
UTSW |
18 |
38,123,824 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6144:Arap3
|
UTSW |
18 |
38,118,486 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6166:Arap3
|
UTSW |
18 |
38,107,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6248:Arap3
|
UTSW |
18 |
38,124,407 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6266:Arap3
|
UTSW |
18 |
38,123,844 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6385:Arap3
|
UTSW |
18 |
38,130,084 (GRCm39) |
nonsense |
probably null |
|
|
R6694:Arap3
|
UTSW |
18 |
38,124,590 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6856:Arap3
|
UTSW |
18 |
38,112,916 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7073:Arap3
|
UTSW |
18 |
38,107,495 (GRCm39) |
nonsense |
probably null |
|
|
R7297:Arap3
|
UTSW |
18 |
38,106,616 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7352:Arap3
|
UTSW |
18 |
38,106,331 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7652:Arap3
|
UTSW |
18 |
38,111,505 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7726:Arap3
|
UTSW |
18 |
38,122,520 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7747:Arap3
|
UTSW |
18 |
38,121,941 (GRCm39) |
splice site |
probably null |
|
|
R7944:Arap3
|
UTSW |
18 |
38,122,232 (GRCm39) |
missense |
probably benign |
|
|
R8152:Arap3
|
UTSW |
18 |
38,124,410 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R8338:Arap3
|
UTSW |
18 |
38,106,683 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8549:Arap3
|
UTSW |
18 |
38,106,365 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8793:Arap3
|
UTSW |
18 |
38,107,492 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8876:Arap3
|
UTSW |
18 |
38,130,077 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9142:Arap3
|
UTSW |
18 |
38,112,934 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9237:Arap3
|
UTSW |
18 |
38,112,934 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9583:Arap3
|
UTSW |
18 |
38,109,096 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9696:Arap3
|
UTSW |
18 |
38,112,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0011:Arap3
|
UTSW |
18 |
38,107,154 (GRCm39) |
critical splice donor site |
probably null |
|
|
X0026:Arap3
|
UTSW |
18 |
38,118,364 (GRCm39) |
critical splice donor site |
probably null |
|
|
X0027:Arap3
|
UTSW |
18 |
38,106,538 (GRCm39) |
splice site |
probably null |
|
|
X0066:Arap3
|
UTSW |
18 |
38,124,699 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CCCTGTGCTGACCTGTTAGAACAC -3'
(R):5'- ACGCCTCCTCAAACGGATATCAATG -3'
Sequencing Primer
(F):5'- TGTTAGAACACAAAAACCAAGTGGC -3'
(R):5'- cctgagatagatgaaaccctgataac -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation