Incidental Mutation 'R1771:Tacc2'
| ID |
196595 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tacc2
|
| Ensembl Gene |
ENSMUSG00000030852 |
| Gene Name |
transforming, acidic coiled-coil containing protein 2 |
| Synonyms |
|
| MMRRC Submission |
039802-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1771 (G1)
|
| Quality Score |
215 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
130179168-130366515 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 130343970 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Arginine
at position 700
(K700R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000147134
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000033141]
[ENSMUST00000059145]
[ENSMUST00000084513]
[ENSMUST00000124096]
[ENSMUST00000207282]
[ENSMUST00000207376]
[ENSMUST00000207395]
[ENSMUST00000208722]
[ENSMUST00000207549]
[ENSMUST00000209108]
[ENSMUST00000208743]
[ENSMUST00000207789]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000033141
AA Change: K700R
PolyPhen 2
Score 0.882 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000033141
Gene: ENSMUSG00000030852
AA Change: K700R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
37 |
63 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
71 |
181 |
1.04e-5 |
PROSPERO |
|
low complexity region
|
235 |
246 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
258 |
345 |
6.53e-5 |
PROSPERO |
|
internal_repeat_1
|
373 |
456 |
1.04e-5 |
PROSPERO |
|
low complexity region
|
461 |
476 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
504 |
N/A |
INTRINSIC |
|
low complexity region
|
538 |
552 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
629 |
716 |
6.53e-5 |
PROSPERO |
|
coiled coil region
|
763 |
790 |
N/A |
INTRINSIC |
|
Pfam:TACC
|
829 |
1035 |
3.4e-85 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000059145
AA Change: K810R
PolyPhen 2
Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000061242
Gene: ENSMUSG00000030852
AA Change: K810R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
87 |
102 |
N/A |
INTRINSIC |
|
low complexity region
|
147 |
173 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
291 |
2.03e-5 |
PROSPERO |
|
low complexity region
|
345 |
356 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
483 |
566 |
2.03e-5 |
PROSPERO |
|
low complexity region
|
571 |
586 |
N/A |
INTRINSIC |
|
low complexity region
|
603 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
648 |
662 |
N/A |
INTRINSIC |
|
coiled coil region
|
873 |
900 |
N/A |
INTRINSIC |
|
Pfam:TACC
|
939 |
1145 |
4e-85 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000084513
AA Change: K2543R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000081561
Gene: ENSMUSG00000030852
AA Change: K2543R
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
19 |
346 |
3.83e-6 |
PROSPERO |
|
low complexity region
|
398 |
410 |
N/A |
INTRINSIC |
|
low complexity region
|
413 |
431 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
778 |
1068 |
3.83e-6 |
PROSPERO |
|
low complexity region
|
1397 |
1415 |
N/A |
INTRINSIC |
|
low complexity region
|
1723 |
1739 |
N/A |
INTRINSIC |
|
low complexity region
|
1794 |
1809 |
N/A |
INTRINSIC |
|
low complexity region
|
1854 |
1880 |
N/A |
INTRINSIC |
|
low complexity region
|
2052 |
2063 |
N/A |
INTRINSIC |
|
low complexity region
|
2278 |
2293 |
N/A |
INTRINSIC |
|
low complexity region
|
2310 |
2321 |
N/A |
INTRINSIC |
|
low complexity region
|
2355 |
2369 |
N/A |
INTRINSIC |
|
coiled coil region
|
2606 |
2633 |
N/A |
INTRINSIC |
|
Pfam:TACC
|
2673 |
2873 |
6.1e-87 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124096
|
| SMART Domains |
Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
1 |
118 |
4.8e-19 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1 |
118 |
1.7e-50 |
PFAM |
|
low complexity region
|
146 |
160 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000207282
AA Change: K688R
PolyPhen 2
Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000207376
AA Change: K360R
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000207395
AA Change: K570R
PolyPhen 2
Score 0.882 (Sensitivity: 0.82; Specificity: 0.94)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000208722
AA Change: K810R
PolyPhen 2
Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000207549
AA Change: K309R
PolyPhen 2
Score 0.114 (Sensitivity: 0.93; Specificity: 0.86)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000209108
AA Change: K313R
PolyPhen 2
Score 0.216 (Sensitivity: 0.91; Specificity: 0.88)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000208743
AA Change: K700R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000207789
|
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.9%
- 10x: 95.2%
- 20x: 92.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice are healthy and fertile and do not display any increase in tumorigenesis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 102 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acss3 |
A |
G |
10: 106,773,061 (GRCm39) |
S642P |
probably damaging |
Het |
| Adam30 |
T |
C |
3: 98,068,835 (GRCm39) |
S95P |
possibly damaging |
Het |
| Ahnak |
G |
A |
19: 8,991,117 (GRCm39) |
V4134I |
probably benign |
Het |
| Ankrd13a |
T |
C |
5: 114,941,649 (GRCm39) |
V512A |
probably benign |
Het |
| Asph |
A |
T |
4: 9,598,773 (GRCm39) |
S149R |
probably damaging |
Het |
| Atp2b4 |
C |
A |
1: 133,660,131 (GRCm39) |
V384L |
probably damaging |
Het |
| Atp8a1 |
A |
G |
5: 67,805,074 (GRCm39) |
W1014R |
probably damaging |
Het |
| Cand1 |
A |
C |
10: 119,044,211 (GRCm39) |
N1054K |
probably benign |
Het |
| Car15 |
A |
T |
16: 17,654,730 (GRCm39) |
V96E |
probably damaging |
Het |
| Cd1d1 |
T |
C |
3: 86,905,972 (GRCm39) |
E101G |
possibly damaging |
Het |
| Cd84 |
A |
G |
1: 171,700,317 (GRCm39) |
T145A |
possibly damaging |
Het |
| Ceacam1 |
T |
A |
7: 25,171,469 (GRCm39) |
T332S |
probably benign |
Het |
| Clca3a2 |
A |
T |
3: 144,787,171 (GRCm39) |
V500E |
probably benign |
Het |
| Cul9 |
A |
T |
17: 46,848,738 (GRCm39) |
M666K |
probably benign |
Het |
| Dennd3 |
A |
G |
15: 73,426,950 (GRCm39) |
T776A |
possibly damaging |
Het |
| Dennd5a |
T |
C |
7: 109,517,893 (GRCm39) |
D581G |
probably damaging |
Het |
| Dgkh |
A |
G |
14: 78,846,967 (GRCm39) |
V371A |
probably damaging |
Het |
| Dhcr24 |
A |
G |
4: 106,435,450 (GRCm39) |
T314A |
probably benign |
Het |
| Diaph1 |
G |
T |
18: 38,024,071 (GRCm39) |
P589Q |
unknown |
Het |
| Disp2 |
C |
T |
2: 118,621,778 (GRCm39) |
Q837* |
probably null |
Het |
| Dusp3 |
A |
T |
11: 101,875,561 (GRCm39) |
M1K |
probably null |
Het |
| Ecpas |
A |
G |
4: 58,879,100 (GRCm39) |
I63T |
probably damaging |
Het |
| Eddm13 |
G |
T |
7: 6,280,541 (GRCm39) |
|
probably null |
Het |
| Erich3 |
A |
C |
3: 154,454,109 (GRCm39) |
D625A |
possibly damaging |
Het |
| Fat2 |
G |
A |
11: 55,201,691 (GRCm39) |
S461L |
probably benign |
Het |
| Fmn2 |
A |
G |
1: 174,436,342 (GRCm39) |
|
probably benign |
Het |
| Foxi1 |
A |
G |
11: 34,157,594 (GRCm39) |
Y144H |
probably damaging |
Het |
| Ftcd |
G |
A |
10: 76,423,202 (GRCm39) |
V458M |
probably damaging |
Het |
| Gm3604 |
C |
A |
13: 62,517,888 (GRCm39) |
G157* |
probably null |
Het |
| Gnpda1 |
C |
T |
18: 38,466,380 (GRCm39) |
R79Q |
probably benign |
Het |
| Gpr65 |
T |
A |
12: 98,242,259 (GRCm39) |
I304K |
probably damaging |
Het |
| Grem1 |
T |
C |
2: 113,580,021 (GRCm39) |
E160G |
probably benign |
Het |
| Gria2 |
T |
A |
3: 80,599,608 (GRCm39) |
K759* |
probably null |
Het |
| Gsg1l |
A |
G |
7: 125,557,745 (GRCm39) |
S128P |
probably damaging |
Het |
| Hdac1 |
A |
T |
4: 129,415,221 (GRCm39) |
I240N |
probably damaging |
Het |
| Hic2 |
C |
T |
16: 17,076,578 (GRCm39) |
T469M |
probably benign |
Het |
| Hoxc10 |
A |
C |
15: 102,875,522 (GRCm39) |
D77A |
probably damaging |
Het |
| Itprid1 |
T |
C |
6: 55,875,132 (GRCm39) |
S361P |
probably benign |
Het |
| Klhl14 |
T |
A |
18: 21,784,677 (GRCm39) |
H250L |
probably damaging |
Het |
| Klk1b24 |
A |
G |
7: 43,837,653 (GRCm39) |
|
probably null |
Het |
| Letm1 |
T |
A |
5: 33,926,811 (GRCm39) |
H162L |
probably damaging |
Het |
| Loxl3 |
A |
T |
6: 83,026,890 (GRCm39) |
Y573F |
probably damaging |
Het |
| Macf1 |
A |
T |
4: 123,405,901 (GRCm39) |
I330N |
probably damaging |
Het |
| Mchr1 |
T |
A |
15: 81,121,436 (GRCm39) |
I62N |
probably damaging |
Het |
| Mcm8 |
C |
T |
2: 132,685,476 (GRCm39) |
Q803* |
probably null |
Het |
| Msh3 |
T |
G |
13: 92,349,004 (GRCm39) |
D1075A |
probably benign |
Het |
| Msh6 |
T |
A |
17: 88,291,950 (GRCm39) |
V235D |
probably benign |
Het |
| Mthfd2l |
A |
T |
5: 91,122,254 (GRCm39) |
D253V |
probably damaging |
Het |
| Mtor |
T |
C |
4: 148,555,081 (GRCm39) |
V901A |
possibly damaging |
Het |
| Muc20 |
A |
T |
16: 32,614,222 (GRCm39) |
I385N |
probably damaging |
Het |
| Myo6 |
G |
T |
9: 80,193,082 (GRCm39) |
C829F |
probably damaging |
Het |
| Nbea |
T |
C |
3: 55,841,940 (GRCm39) |
I1914V |
probably benign |
Het |
| Ncor1 |
T |
C |
11: 62,217,938 (GRCm39) |
E1462G |
probably damaging |
Het |
| Necab1 |
A |
G |
4: 15,111,267 (GRCm39) |
Y54H |
probably damaging |
Het |
| Nlrp4b |
A |
G |
7: 10,452,520 (GRCm39) |
K15R |
probably damaging |
Het |
| Ntrk1 |
A |
G |
3: 87,696,937 (GRCm39) |
S139P |
probably benign |
Het |
| Oas1d |
T |
C |
5: 121,053,900 (GRCm39) |
F120S |
probably damaging |
Het |
| Ofd1 |
A |
G |
X: 165,189,002 (GRCm39) |
Y755H |
probably benign |
Het |
| Or10al2 |
A |
G |
17: 37,983,554 (GRCm39) |
I213M |
probably damaging |
Het |
| Or13a25 |
A |
G |
7: 140,248,048 (GRCm39) |
T276A |
probably benign |
Het |
| Or4f47 |
T |
G |
2: 111,973,065 (GRCm39) |
Y258* |
probably null |
Het |
| Or5c1 |
T |
A |
2: 37,222,430 (GRCm39) |
F224I |
probably benign |
Het |
| Or5p58 |
A |
C |
7: 107,694,816 (GRCm39) |
|
probably null |
Het |
| Or9s27 |
A |
G |
1: 92,516,837 (GRCm39) |
I262V |
probably benign |
Het |
| Plekha6 |
T |
C |
1: 133,201,651 (GRCm39) |
S355P |
probably benign |
Het |
| Prdm14 |
T |
C |
1: 13,189,082 (GRCm39) |
K421E |
probably damaging |
Het |
| Prss36 |
A |
G |
7: 127,532,625 (GRCm39) |
L731P |
probably damaging |
Het |
| Rad51d |
A |
G |
11: 82,774,764 (GRCm39) |
L97P |
probably damaging |
Het |
| Rbl1 |
C |
A |
2: 157,005,454 (GRCm39) |
|
probably null |
Het |
| Rnh1 |
G |
T |
7: 140,744,519 (GRCm39) |
A52D |
possibly damaging |
Het |
| Rps24 |
A |
G |
14: 24,541,830 (GRCm39) |
T6A |
probably damaging |
Het |
| Ryr2 |
A |
C |
13: 11,760,062 (GRCm39) |
|
probably null |
Het |
| Samd4 |
A |
T |
14: 47,326,532 (GRCm39) |
N454I |
probably damaging |
Het |
| Sap130 |
T |
C |
18: 31,769,135 (GRCm39) |
I32T |
probably benign |
Het |
| Sap30l |
A |
T |
11: 57,696,925 (GRCm39) |
N85I |
probably damaging |
Het |
| Sbf2 |
G |
A |
7: 110,060,353 (GRCm39) |
Q204* |
probably null |
Het |
| Slc45a3 |
T |
C |
1: 131,904,694 (GRCm39) |
W6R |
possibly damaging |
Het |
| Snx16 |
A |
G |
3: 10,484,221 (GRCm39) |
V334A |
probably damaging |
Het |
| Soat1 |
C |
T |
1: 156,269,991 (GRCm39) |
V143I |
probably benign |
Het |
| Sp8 |
T |
A |
12: 118,813,302 (GRCm39) |
F386I |
probably damaging |
Het |
| Spag6 |
C |
T |
2: 18,738,928 (GRCm39) |
S286L |
probably benign |
Het |
| Srpra |
A |
T |
9: 35,124,147 (GRCm39) |
N31I |
possibly damaging |
Het |
| Ssbp4 |
A |
G |
8: 71,051,502 (GRCm39) |
|
probably null |
Het |
| Stxbp2 |
G |
T |
8: 3,684,064 (GRCm39) |
A124S |
probably benign |
Het |
| Tatdn2 |
A |
T |
6: 113,679,060 (GRCm39) |
|
probably null |
Het |
| Tecrl |
G |
A |
5: 83,439,134 (GRCm39) |
T226I |
probably damaging |
Het |
| Timeless |
T |
G |
10: 128,083,477 (GRCm39) |
V702G |
probably benign |
Het |
| Tjp1 |
A |
T |
7: 64,962,753 (GRCm39) |
S1061R |
probably benign |
Het |
| Tmem39b |
A |
T |
4: 129,587,011 (GRCm39) |
C67S |
probably damaging |
Het |
| Tstd3 |
T |
C |
4: 21,759,475 (GRCm39) |
Y99C |
probably damaging |
Het |
| Ttc39c |
T |
A |
18: 12,817,881 (GRCm39) |
|
probably null |
Het |
| Ttll7 |
C |
T |
3: 146,600,160 (GRCm39) |
P23S |
probably benign |
Het |
| Uba5 |
A |
G |
9: 103,927,107 (GRCm39) |
F290S |
probably damaging |
Het |
| Ubap2l |
T |
C |
3: 89,926,538 (GRCm39) |
Y623C |
probably damaging |
Het |
| Ube3a |
A |
G |
7: 58,925,714 (GRCm39) |
E164G |
probably damaging |
Het |
| Ugcg |
A |
G |
4: 59,207,775 (GRCm39) |
N38S |
probably benign |
Het |
| Ugp2 |
G |
A |
11: 21,279,915 (GRCm39) |
T283I |
probably damaging |
Het |
| Vmn1r55 |
A |
T |
7: 5,149,919 (GRCm39) |
I168N |
probably benign |
Het |
| Wdr27 |
A |
C |
17: 15,112,703 (GRCm39) |
S668A |
probably damaging |
Het |
| Wnt2 |
T |
A |
6: 18,008,696 (GRCm39) |
N247I |
probably damaging |
Het |
| Zfp850 |
A |
T |
7: 27,684,700 (GRCm39) |
C15* |
probably null |
Het |
| Zfp959 |
A |
G |
17: 56,204,677 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Tacc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00836:Tacc2
|
APN |
7 |
130,360,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01396:Tacc2
|
APN |
7 |
130,360,919 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01621:Tacc2
|
APN |
7 |
130,331,498 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02000:Tacc2
|
APN |
7 |
130,330,898 (GRCm39) |
splice site |
probably null |
|
|
IGL02075:Tacc2
|
APN |
7 |
130,330,582 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02201:Tacc2
|
APN |
7 |
130,227,942 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02205:Tacc2
|
APN |
7 |
130,228,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02399:Tacc2
|
APN |
7 |
130,225,129 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02456:Tacc2
|
APN |
7 |
130,227,991 (GRCm39) |
missense |
probably benign |
0.35 |
|
IGL02559:Tacc2
|
APN |
7 |
130,360,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02734:Tacc2
|
APN |
7 |
130,227,829 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02800:Tacc2
|
APN |
7 |
130,225,809 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL02938:Tacc2
|
APN |
7 |
130,330,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03031:Tacc2
|
APN |
7 |
130,225,585 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03278:Tacc2
|
APN |
7 |
130,335,298 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03283:Tacc2
|
APN |
7 |
130,343,996 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL03371:Tacc2
|
APN |
7 |
130,227,791 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
aces
|
UTSW |
7 |
130,335,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Jacks
|
UTSW |
7 |
130,227,494 (GRCm39) |
missense |
probably damaging |
0.98 |
|
kings
|
UTSW |
7 |
130,225,213 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0002:Tacc2
|
UTSW |
7 |
130,223,515 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0119:Tacc2
|
UTSW |
7 |
130,223,605 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0244:Tacc2
|
UTSW |
7 |
130,353,555 (GRCm39) |
splice site |
probably benign |
|
|
R0619:Tacc2
|
UTSW |
7 |
130,318,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0624:Tacc2
|
UTSW |
7 |
130,179,239 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0632:Tacc2
|
UTSW |
7 |
130,227,325 (GRCm39) |
nonsense |
probably null |
|
|
R1015:Tacc2
|
UTSW |
7 |
130,225,795 (GRCm39) |
missense |
probably benign |
|
|
R1081:Tacc2
|
UTSW |
7 |
130,330,304 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1086:Tacc2
|
UTSW |
7 |
130,228,227 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1351:Tacc2
|
UTSW |
7 |
130,264,733 (GRCm39) |
intron |
probably benign |
|
|
R1538:Tacc2
|
UTSW |
7 |
130,227,149 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1743:Tacc2
|
UTSW |
7 |
130,228,328 (GRCm39) |
nonsense |
probably null |
|
|
R1876:Tacc2
|
UTSW |
7 |
130,225,475 (GRCm39) |
missense |
probably benign |
0.38 |
|
R1893:Tacc2
|
UTSW |
7 |
130,227,055 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1899:Tacc2
|
UTSW |
7 |
130,225,932 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2005:Tacc2
|
UTSW |
7 |
130,333,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Tacc2
|
UTSW |
7 |
130,223,587 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2338:Tacc2
|
UTSW |
7 |
130,335,299 (GRCm39) |
splice site |
probably null |
|
|
R2407:Tacc2
|
UTSW |
7 |
130,223,770 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R3051:Tacc2
|
UTSW |
7 |
130,227,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3052:Tacc2
|
UTSW |
7 |
130,227,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3053:Tacc2
|
UTSW |
7 |
130,227,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3116:Tacc2
|
UTSW |
7 |
130,360,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3412:Tacc2
|
UTSW |
7 |
130,336,724 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3683:Tacc2
|
UTSW |
7 |
130,226,800 (GRCm39) |
missense |
probably benign |
0.40 |
|
R3685:Tacc2
|
UTSW |
7 |
130,226,800 (GRCm39) |
missense |
probably benign |
0.40 |
|
R3872:Tacc2
|
UTSW |
7 |
130,224,152 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4063:Tacc2
|
UTSW |
7 |
130,330,852 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4410:Tacc2
|
UTSW |
7 |
130,343,941 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4434:Tacc2
|
UTSW |
7 |
130,225,271 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4438:Tacc2
|
UTSW |
7 |
130,225,271 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4618:Tacc2
|
UTSW |
7 |
130,227,946 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4674:Tacc2
|
UTSW |
7 |
130,226,591 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4742:Tacc2
|
UTSW |
7 |
130,227,697 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4934:Tacc2
|
UTSW |
7 |
130,330,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4947:Tacc2
|
UTSW |
7 |
130,227,629 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4964:Tacc2
|
UTSW |
7 |
130,330,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4966:Tacc2
|
UTSW |
7 |
130,330,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4967:Tacc2
|
UTSW |
7 |
130,225,678 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5052:Tacc2
|
UTSW |
7 |
130,336,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5276:Tacc2
|
UTSW |
7 |
130,331,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Tacc2
|
UTSW |
7 |
130,335,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5331:Tacc2
|
UTSW |
7 |
130,335,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5372:Tacc2
|
UTSW |
7 |
130,224,990 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5556:Tacc2
|
UTSW |
7 |
130,276,336 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5645:Tacc2
|
UTSW |
7 |
130,225,781 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5886:Tacc2
|
UTSW |
7 |
130,330,850 (GRCm39) |
missense |
probably benign |
0.18 |
|
R5996:Tacc2
|
UTSW |
7 |
130,225,213 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6074:Tacc2
|
UTSW |
7 |
130,227,165 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6127:Tacc2
|
UTSW |
7 |
130,227,845 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6156:Tacc2
|
UTSW |
7 |
130,227,494 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6298:Tacc2
|
UTSW |
7 |
130,228,255 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6444:Tacc2
|
UTSW |
7 |
130,225,142 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6533:Tacc2
|
UTSW |
7 |
130,224,567 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6724:Tacc2
|
UTSW |
7 |
130,330,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7111:Tacc2
|
UTSW |
7 |
130,330,618 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7150:Tacc2
|
UTSW |
7 |
130,330,807 (GRCm39) |
missense |
probably benign |
|
|
R7290:Tacc2
|
UTSW |
7 |
130,331,103 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7404:Tacc2
|
UTSW |
7 |
130,225,066 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7460:Tacc2
|
UTSW |
7 |
130,226,363 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7651:Tacc2
|
UTSW |
7 |
130,224,884 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7666:Tacc2
|
UTSW |
7 |
130,318,544 (GRCm39) |
start gained |
probably benign |
|
|
R7695:Tacc2
|
UTSW |
7 |
130,330,633 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7766:Tacc2
|
UTSW |
7 |
130,345,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7793:Tacc2
|
UTSW |
7 |
130,224,843 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7861:Tacc2
|
UTSW |
7 |
130,227,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8204:Tacc2
|
UTSW |
7 |
130,226,159 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8244:Tacc2
|
UTSW |
7 |
130,330,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8245:Tacc2
|
UTSW |
7 |
130,331,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8283:Tacc2
|
UTSW |
7 |
130,227,034 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8348:Tacc2
|
UTSW |
7 |
130,225,019 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8369:Tacc2
|
UTSW |
7 |
130,223,888 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8381:Tacc2
|
UTSW |
7 |
130,225,972 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8804:Tacc2
|
UTSW |
7 |
130,294,693 (GRCm39) |
missense |
probably benign |
|
|
R8809:Tacc2
|
UTSW |
7 |
130,276,421 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8835:Tacc2
|
UTSW |
7 |
130,228,258 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8880:Tacc2
|
UTSW |
7 |
130,318,564 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8918:Tacc2
|
UTSW |
7 |
130,227,823 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8936:Tacc2
|
UTSW |
7 |
130,228,367 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8953:Tacc2
|
UTSW |
7 |
130,227,487 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9026:Tacc2
|
UTSW |
7 |
130,225,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9193:Tacc2
|
UTSW |
7 |
130,228,304 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9221:Tacc2
|
UTSW |
7 |
130,226,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9221:Tacc2
|
UTSW |
7 |
130,226,058 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9222:Tacc2
|
UTSW |
7 |
130,227,985 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9264:Tacc2
|
UTSW |
7 |
130,228,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9312:Tacc2
|
UTSW |
7 |
130,223,978 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9380:Tacc2
|
UTSW |
7 |
130,226,771 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9515:Tacc2
|
UTSW |
7 |
130,366,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9705:Tacc2
|
UTSW |
7 |
130,361,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0010:Tacc2
|
UTSW |
7 |
130,336,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tacc2
|
UTSW |
7 |
130,346,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tacc2
|
UTSW |
7 |
130,226,000 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
Z1176:Tacc2
|
UTSW |
7 |
130,225,100 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Tacc2
|
UTSW |
7 |
130,336,679 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
Z1177:Tacc2
|
UTSW |
7 |
130,227,504 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Tacc2
|
UTSW |
7 |
130,226,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACATGGCTTTTGTCTCTCGGACAC -3'
(R):5'- AGGGGATTACCCATCATCAGTCCAG -3'
Sequencing Primer
(F):5'- TTAGCCAGGGCTTCCTAATAGAC -3'
(R):5'- CATCATCAGTCCAGTTTCAAGG -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation