Incidental Mutation 'R1468:Or4c107'
ID 197686
Institutional Source Beutler Lab
Gene Symbol Or4c107
Ensembl Gene ENSMUSG00000048226
Gene Name olfactory receptor family 4 subfamily C member 107
Synonyms Olfr1212, MOR233-17, GA_x6K02T2Q125-50437014-50437949, MOR233-20
MMRRC Submission 039521-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R1468 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 88788812-88789747 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to G at 88789387 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 192 (Y192*)
Ref Sequence ENSEMBL: ENSMUSP00000149781 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055895] [ENSMUST00000215781]
AlphaFold Q7TR08
Predicted Effect probably null
Transcript: ENSMUST00000055895
AA Change: Y192*
SMART Domains Protein: ENSMUSP00000052837
Gene: ENSMUSG00000048226
AA Change: Y192*

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 1.9e-46 PFAM
Pfam:7tm_1 39 286 7.1e-15 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000215781
AA Change: Y192*
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.7%
  • 10x: 94.6%
  • 20x: 90.1%
Validation Efficiency 98% (106/108)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 112 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900092C05Rik T G 7: 12,246,507 (GRCm39) M1R probably null Het
4933440N22Rik C A 6: 117,884,540 (GRCm39) probably benign Het
5031439G07Rik G T 15: 84,837,345 (GRCm39) P280T probably damaging Het
Abca2 C T 2: 25,331,308 (GRCm39) S1267L probably damaging Het
Acsl3 A T 1: 78,684,126 (GRCm39) R719S probably benign Het
Adam1a A T 5: 121,657,839 (GRCm39) probably null Het
Adamts7 T C 9: 90,070,851 (GRCm39) probably benign Het
Adgrf3 G A 5: 30,407,227 (GRCm39) probably benign Het
Aldh6a1 T C 12: 84,488,544 (GRCm39) E89G possibly damaging Het
Ankrd36 A G 11: 5,525,752 (GRCm39) Y238C probably damaging Het
Ankrd65 G A 4: 155,877,362 (GRCm39) R291Q probably benign Het
Ano2 C T 6: 125,773,227 (GRCm39) R287W probably damaging Het
Ap1ar A G 3: 127,606,215 (GRCm39) I125T probably benign Het
Arid1b A G 17: 5,293,197 (GRCm39) D705G probably damaging Het
Asb18 T A 1: 89,924,005 (GRCm39) N86I probably damaging Het
Bicral A T 17: 47,135,519 (GRCm39) S564T probably benign Het
Bpifa6 A G 2: 153,831,192 (GRCm39) M253V probably benign Het
Braf T C 6: 39,642,017 (GRCm39) D194G probably damaging Het
Brinp3 C A 1: 146,777,700 (GRCm39) P716T probably benign Het
C7 T A 15: 5,041,631 (GRCm39) Y425F probably damaging Het
Ccdc102a T C 8: 95,632,714 (GRCm39) K421R probably benign Het
Cep89 G A 7: 35,120,388 (GRCm39) probably null Het
Chgb A T 2: 132,634,720 (GRCm39) M221L probably benign Het
Chst14 A G 2: 118,758,145 (GRCm39) Y313C probably damaging Het
Ciita G A 16: 10,331,152 (GRCm39) probably null Het
Clec12b A T 6: 129,357,603 (GRCm39) I85N probably damaging Het
Clec2e G T 6: 129,070,459 (GRCm39) Y187* probably null Het
Crbn T C 6: 106,767,804 (GRCm39) K229E probably benign Het
Ctdspl2 A T 2: 121,811,762 (GRCm39) Q201L probably benign Het
Ctrb1 G T 8: 112,416,041 (GRCm39) probably benign Het
Cyp2c55 T A 19: 38,999,525 (GRCm39) V77E probably damaging Het
Cyp2c69 A C 19: 39,837,839 (GRCm39) D414E probably damaging Het
Ddx47 T C 6: 134,988,703 (GRCm39) probably benign Het
Dlg1 A G 16: 31,661,640 (GRCm39) probably null Het
Dnah5 C A 15: 28,230,609 (GRCm39) S169* probably null Het
Dock4 C A 12: 40,805,809 (GRCm39) T927K probably benign Het
Esrp2 T G 8: 106,860,453 (GRCm39) D259A probably damaging Het
Fam169a A G 13: 97,255,038 (GRCm39) K418R probably benign Het
Fancm A T 12: 65,146,067 (GRCm39) I597F probably damaging Het
Fastkd2 G T 1: 63,771,385 (GRCm39) probably benign Het
Fat1 G A 8: 45,463,582 (GRCm39) V1375M probably damaging Het
Fbxw10 A T 11: 62,753,464 (GRCm39) D486V probably damaging Het
Fech C T 18: 64,603,744 (GRCm39) probably benign Het
Fermt1 C T 2: 132,766,942 (GRCm39) E342K probably benign Het
Foxp1 T A 6: 98,955,181 (GRCm39) H195L possibly damaging Het
Gfra1 T A 19: 58,440,407 (GRCm39) I138L probably benign Het
Gm12185 T C 11: 48,806,501 (GRCm39) D230G possibly damaging Het
Gm14403 T A 2: 177,199,024 (GRCm39) probably benign Het
Gpd2 A C 2: 57,245,786 (GRCm39) T439P probably damaging Het
Gpm6a A T 8: 55,490,385 (GRCm39) K20N probably damaging Het
Hc A T 2: 34,873,819 (GRCm39) Y158* probably null Het
Hectd4 A T 5: 121,487,235 (GRCm39) D3410V possibly damaging Het
Il17b G A 18: 61,823,483 (GRCm39) probably null Het
Irx4 G T 13: 73,413,695 (GRCm39) R55L possibly damaging Het
Itgav A T 2: 83,596,245 (GRCm39) probably benign Het
Lama3 T C 18: 12,574,164 (GRCm39) V582A probably benign Het
Ldhd G T 8: 112,353,925 (GRCm39) A425E possibly damaging Het
Lrp1b C T 2: 40,817,841 (GRCm39) probably null Het
Lrp5 T C 19: 3,670,191 (GRCm39) T638A possibly damaging Het
Lrrk1 A C 7: 65,909,722 (GRCm39) F1996C probably damaging Het
Ly6h G A 15: 75,437,986 (GRCm39) S21L probably benign Het
Mctp1 T C 13: 76,973,392 (GRCm39) V431A probably benign Het
Metap2 C T 10: 93,707,345 (GRCm39) probably null Het
Mfsd2b T A 12: 4,920,536 (GRCm39) K94* probably null Het
Micall2 A G 5: 139,705,097 (GRCm39) L79P probably damaging Het
Mucl2 T C 15: 103,927,673 (GRCm39) T95A possibly damaging Het
Myo15a A T 11: 60,396,832 (GRCm39) T2634S probably damaging Het
Myo5b G T 18: 74,873,574 (GRCm39) V1467L probably damaging Het
Nfic G T 10: 81,256,414 (GRCm39) D105E probably damaging Het
Nrdc T A 4: 108,873,865 (GRCm39) F227Y probably benign Het
Nrp2 A T 1: 62,777,458 (GRCm39) I88F probably damaging Het
Nup160 A T 2: 90,530,887 (GRCm39) H515L probably benign Het
Nup205 G A 6: 35,202,917 (GRCm39) probably null Het
Oas1g G A 5: 121,020,069 (GRCm39) T179I probably benign Het
Ogfr A T 2: 180,236,543 (GRCm39) E376V probably damaging Het
Or2l13 T G 16: 19,306,378 (GRCm39) S263R probably benign Het
Or4a69 A T 2: 89,312,855 (GRCm39) V208D possibly damaging Het
Or52d1 G T 7: 103,755,896 (GRCm39) V137F possibly damaging Het
Or5p6 C T 7: 107,631,595 (GRCm39) probably null Het
Pard3b T C 1: 62,384,188 (GRCm39) V851A probably benign Het
Pcdhb16 A T 18: 37,611,142 (GRCm39) Y34F probably damaging Het
Pikfyve T C 1: 65,290,825 (GRCm39) Y1215H probably damaging Het
Pkhd1 A T 1: 20,593,565 (GRCm39) V1516E probably damaging Het
Pla2g4a A T 1: 149,763,344 (GRCm39) probably benign Het
Ptprg A T 14: 12,190,767 (GRCm38) I818F probably benign Het
Ralgapb A G 2: 158,304,173 (GRCm39) E644G possibly damaging Het
Rbm45 A G 2: 76,202,459 (GRCm39) I127M probably damaging Het
Rtp2 T C 16: 23,746,220 (GRCm39) Y157C probably damaging Het
Sema3f A T 9: 107,564,771 (GRCm39) probably benign Het
Sf3b3 A T 8: 111,564,006 (GRCm39) Y329N probably damaging Het
Sfxn1 A G 13: 54,239,646 (GRCm39) probably null Het
Shkbp1 A T 7: 27,044,751 (GRCm39) C447S probably damaging Het
Sipa1l3 A G 7: 29,021,685 (GRCm39) S689P possibly damaging Het
Slc7a8 A G 14: 54,970,656 (GRCm39) S332P probably damaging Het
Slit1 C A 19: 41,596,823 (GRCm39) C1092F probably damaging Het
Slx9 A G 10: 77,333,360 (GRCm39) probably benign Het
Stard9 A G 2: 120,533,678 (GRCm39) I619V possibly damaging Het
Sycp3 T C 10: 88,305,454 (GRCm39) V185A possibly damaging Het
Taar9 A T 10: 23,985,382 (GRCm39) N17K possibly damaging Het
Tbkbp1 T C 11: 97,039,814 (GRCm39) E102G probably damaging Het
Tex44 A G 1: 86,354,834 (GRCm39) N248D probably benign Het
Tmem63b C G 17: 45,989,904 (GRCm39) R88P possibly damaging Het
Tnpo1 C T 13: 98,986,665 (GRCm39) V781I probably benign Het
Tonsl C T 15: 76,520,761 (GRCm39) probably null Het
Ttc6 A G 12: 57,721,463 (GRCm39) K984R possibly damaging Het
Usp34 A G 11: 23,391,171 (GRCm39) E2263G probably damaging Het
Usp8 A G 2: 126,596,847 (GRCm39) K875E probably damaging Het
Vapb C T 2: 173,603,905 (GRCm39) probably benign Het
Vmn1r223 A G 13: 23,434,038 (GRCm39) I211V possibly damaging Het
Vmn2r81 G A 10: 79,129,496 (GRCm39) V796I probably damaging Het
Wdr90 A T 17: 26,073,027 (GRCm39) V856D probably damaging Het
Wnk2 T A 13: 49,235,571 (GRCm39) T615S probably damaging Het
Other mutations in Or4c107
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Or4c107 APN 2 88,789,110 (GRCm39) missense probably damaging 0.98
IGL01398:Or4c107 APN 2 88,789,193 (GRCm39) missense probably damaging 1.00
IGL01537:Or4c107 APN 2 88,788,885 (GRCm39) missense probably benign 0.00
IGL02197:Or4c107 APN 2 88,789,028 (GRCm39) missense probably benign 0.05
IGL02557:Or4c107 APN 2 88,789,025 (GRCm39) missense probably benign 0.00
R0276:Or4c107 UTSW 2 88,789,099 (GRCm39) nonsense probably null
R0568:Or4c107 UTSW 2 88,789,387 (GRCm39) nonsense probably null
R0699:Or4c107 UTSW 2 88,788,960 (GRCm39) missense probably benign 0.31
R1101:Or4c107 UTSW 2 88,789,328 (GRCm39) missense possibly damaging 0.60
R1205:Or4c107 UTSW 2 88,788,932 (GRCm39) missense probably benign 0.00
R1468:Or4c107 UTSW 2 88,789,387 (GRCm39) nonsense probably null
R1845:Or4c107 UTSW 2 88,789,211 (GRCm39) missense probably damaging 0.99
R2031:Or4c107 UTSW 2 88,789,643 (GRCm39) missense probably benign 0.19
R2418:Or4c107 UTSW 2 88,789,380 (GRCm39) missense probably benign 0.01
R2419:Or4c107 UTSW 2 88,789,380 (GRCm39) missense probably benign 0.01
R3781:Or4c107 UTSW 2 88,789,091 (GRCm39) nonsense probably null
R4049:Or4c107 UTSW 2 88,789,617 (GRCm39) missense probably benign 0.09
R4440:Or4c107 UTSW 2 88,789,685 (GRCm39) missense probably benign 0.22
R4583:Or4c107 UTSW 2 88,789,556 (GRCm39) missense probably damaging 0.99
R4646:Or4c107 UTSW 2 88,789,556 (GRCm39) missense probably damaging 0.99
R4648:Or4c107 UTSW 2 88,789,556 (GRCm39) missense probably damaging 0.99
R4674:Or4c107 UTSW 2 88,789,216 (GRCm39) missense probably damaging 0.98
R4851:Or4c107 UTSW 2 88,788,930 (GRCm39) missense probably damaging 1.00
R4971:Or4c107 UTSW 2 88,788,863 (GRCm39) missense probably damaging 1.00
R5610:Or4c107 UTSW 2 88,789,170 (GRCm39) missense probably damaging 1.00
R5805:Or4c107 UTSW 2 88,788,985 (GRCm39) missense possibly damaging 0.50
R5887:Or4c107 UTSW 2 88,789,098 (GRCm39) missense possibly damaging 0.60
R6023:Or4c107 UTSW 2 88,789,059 (GRCm39) missense possibly damaging 0.76
R6118:Or4c107 UTSW 2 88,789,462 (GRCm39) nonsense probably null
R7490:Or4c107 UTSW 2 88,789,392 (GRCm39) missense probably benign 0.00
R7542:Or4c107 UTSW 2 88,789,119 (GRCm39) missense probably benign 0.01
R7612:Or4c107 UTSW 2 88,788,849 (GRCm39) missense probably damaging 1.00
R7972:Or4c107 UTSW 2 88,789,177 (GRCm39) nonsense probably null
R8422:Or4c107 UTSW 2 88,789,341 (GRCm39) missense probably benign 0.05
R9111:Or4c107 UTSW 2 88,789,055 (GRCm39) missense probably benign 0.00
Z1177:Or4c107 UTSW 2 88,789,721 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CTACATGGCAACAATTGGAGGCAAC -3'
(R):5'- TGAAACCACAACAGCAATGTGGGAT -3'

Sequencing Primer
(F):5'- CTCTTCCATAATGAACTGGAGGC -3'
(R):5'- TTTCCATCGCCCTTCAGAACTG -3'
Posted On 2014-05-23