Incidental Mutation 'R1468:Lrrk1'
| ID |
197721 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrrk1
|
| Ensembl Gene |
ENSMUSG00000015133 |
| Gene Name |
leucine-rich repeat kinase 1 |
| Synonyms |
D130026O16Rik, C230002E15Rik |
| MMRRC Submission |
039521-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1468 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
65908493-66038089 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 65909722 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Cysteine
at position 1996
(F1996C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000015277
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000015277]
[ENSMUST00000145954]
|
| AlphaFold |
Q3UHC2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000015277
AA Change: F1996C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000015277
Gene: ENSMUSG00000015133
AA Change: F1996C
| Domain | Start | End | E-Value | Type |
|---|
|
ANK
|
86 |
116 |
9.33e2 |
SMART |
|
ANK
|
119 |
148 |
1.14e2 |
SMART |
|
ANK
|
152 |
182 |
8.36e1 |
SMART |
|
ANK
|
193 |
223 |
2.6e1 |
SMART |
|
LRR
|
278 |
300 |
2.84e2 |
SMART |
|
LRR
|
301 |
325 |
7.79e0 |
SMART |
|
LRR
|
328 |
351 |
3.27e1 |
SMART |
|
LRR_TYP
|
379 |
401 |
2.53e-2 |
SMART |
|
LRR
|
403 |
427 |
5.89e1 |
SMART |
|
LRR
|
472 |
493 |
5.27e1 |
SMART |
|
LRR
|
548 |
569 |
2.92e2 |
SMART |
|
LRR
|
570 |
594 |
5.88e0 |
SMART |
|
Pfam:Arf
|
625 |
786 |
2e-8 |
PFAM |
|
Pfam:Roc
|
640 |
761 |
3.1e-24 |
PFAM |
|
Pfam:Ras
|
640 |
782 |
2.2e-7 |
PFAM |
|
Pfam:COR
|
844 |
1046 |
4.7e-26 |
PFAM |
|
low complexity region
|
1109 |
1119 |
N/A |
INTRINSIC |
|
low complexity region
|
1209 |
1222 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
1243 |
1521 |
7.8e-40 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1244 |
1520 |
9.4e-39 |
PFAM |
|
low complexity region
|
1642 |
1654 |
N/A |
INTRINSIC |
|
low complexity region
|
1839 |
1846 |
N/A |
INTRINSIC |
|
low complexity region
|
1852 |
1871 |
N/A |
INTRINSIC |
|
low complexity region
|
1957 |
1970 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137181
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145954
|
| SMART Domains |
Protein: ENSMUSP00000114938
Gene: ENSMUSG00000015133
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
124 |
137 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
158 |
435 |
6.6e-46 |
PFAM |
|
Pfam:Pkinase_Tyr
|
159 |
435 |
5.8e-40 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000167705
|
| Meta Mutation Damage Score |
0.4315 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.7%
- 10x: 94.6%
- 20x: 90.1%
|
| Validation Efficiency |
98% (106/108) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice homozygous for another knock-out allele exhibit severe osteopetrosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 112 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2900092C05Rik |
T |
G |
7: 12,246,507 (GRCm39) |
M1R |
probably null |
Het |
| 4933440N22Rik |
C |
A |
6: 117,884,540 (GRCm39) |
|
probably benign |
Het |
| 5031439G07Rik |
G |
T |
15: 84,837,345 (GRCm39) |
P280T |
probably damaging |
Het |
| Abca2 |
C |
T |
2: 25,331,308 (GRCm39) |
S1267L |
probably damaging |
Het |
| Acsl3 |
A |
T |
1: 78,684,126 (GRCm39) |
R719S |
probably benign |
Het |
| Adam1a |
A |
T |
5: 121,657,839 (GRCm39) |
|
probably null |
Het |
| Adamts7 |
T |
C |
9: 90,070,851 (GRCm39) |
|
probably benign |
Het |
| Adgrf3 |
G |
A |
5: 30,407,227 (GRCm39) |
|
probably benign |
Het |
| Aldh6a1 |
T |
C |
12: 84,488,544 (GRCm39) |
E89G |
possibly damaging |
Het |
| Ankrd36 |
A |
G |
11: 5,525,752 (GRCm39) |
Y238C |
probably damaging |
Het |
| Ankrd65 |
G |
A |
4: 155,877,362 (GRCm39) |
R291Q |
probably benign |
Het |
| Ano2 |
C |
T |
6: 125,773,227 (GRCm39) |
R287W |
probably damaging |
Het |
| Ap1ar |
A |
G |
3: 127,606,215 (GRCm39) |
I125T |
probably benign |
Het |
| Arid1b |
A |
G |
17: 5,293,197 (GRCm39) |
D705G |
probably damaging |
Het |
| Asb18 |
T |
A |
1: 89,924,005 (GRCm39) |
N86I |
probably damaging |
Het |
| Bicral |
A |
T |
17: 47,135,519 (GRCm39) |
S564T |
probably benign |
Het |
| Bpifa6 |
A |
G |
2: 153,831,192 (GRCm39) |
M253V |
probably benign |
Het |
| Braf |
T |
C |
6: 39,642,017 (GRCm39) |
D194G |
probably damaging |
Het |
| Brinp3 |
C |
A |
1: 146,777,700 (GRCm39) |
P716T |
probably benign |
Het |
| C7 |
T |
A |
15: 5,041,631 (GRCm39) |
Y425F |
probably damaging |
Het |
| Ccdc102a |
T |
C |
8: 95,632,714 (GRCm39) |
K421R |
probably benign |
Het |
| Cep89 |
G |
A |
7: 35,120,388 (GRCm39) |
|
probably null |
Het |
| Chgb |
A |
T |
2: 132,634,720 (GRCm39) |
M221L |
probably benign |
Het |
| Chst14 |
A |
G |
2: 118,758,145 (GRCm39) |
Y313C |
probably damaging |
Het |
| Ciita |
G |
A |
16: 10,331,152 (GRCm39) |
|
probably null |
Het |
| Clec12b |
A |
T |
6: 129,357,603 (GRCm39) |
I85N |
probably damaging |
Het |
| Clec2e |
G |
T |
6: 129,070,459 (GRCm39) |
Y187* |
probably null |
Het |
| Crbn |
T |
C |
6: 106,767,804 (GRCm39) |
K229E |
probably benign |
Het |
| Ctdspl2 |
A |
T |
2: 121,811,762 (GRCm39) |
Q201L |
probably benign |
Het |
| Ctrb1 |
G |
T |
8: 112,416,041 (GRCm39) |
|
probably benign |
Het |
| Cyp2c55 |
T |
A |
19: 38,999,525 (GRCm39) |
V77E |
probably damaging |
Het |
| Cyp2c69 |
A |
C |
19: 39,837,839 (GRCm39) |
D414E |
probably damaging |
Het |
| Ddx47 |
T |
C |
6: 134,988,703 (GRCm39) |
|
probably benign |
Het |
| Dlg1 |
A |
G |
16: 31,661,640 (GRCm39) |
|
probably null |
Het |
| Dnah5 |
C |
A |
15: 28,230,609 (GRCm39) |
S169* |
probably null |
Het |
| Dock4 |
C |
A |
12: 40,805,809 (GRCm39) |
T927K |
probably benign |
Het |
| Esrp2 |
T |
G |
8: 106,860,453 (GRCm39) |
D259A |
probably damaging |
Het |
| Fam169a |
A |
G |
13: 97,255,038 (GRCm39) |
K418R |
probably benign |
Het |
| Fancm |
A |
T |
12: 65,146,067 (GRCm39) |
I597F |
probably damaging |
Het |
| Fastkd2 |
G |
T |
1: 63,771,385 (GRCm39) |
|
probably benign |
Het |
| Fat1 |
G |
A |
8: 45,463,582 (GRCm39) |
V1375M |
probably damaging |
Het |
| Fbxw10 |
A |
T |
11: 62,753,464 (GRCm39) |
D486V |
probably damaging |
Het |
| Fech |
C |
T |
18: 64,603,744 (GRCm39) |
|
probably benign |
Het |
| Fermt1 |
C |
T |
2: 132,766,942 (GRCm39) |
E342K |
probably benign |
Het |
| Foxp1 |
T |
A |
6: 98,955,181 (GRCm39) |
H195L |
possibly damaging |
Het |
| Gfra1 |
T |
A |
19: 58,440,407 (GRCm39) |
I138L |
probably benign |
Het |
| Gm12185 |
T |
C |
11: 48,806,501 (GRCm39) |
D230G |
possibly damaging |
Het |
| Gm14403 |
T |
A |
2: 177,199,024 (GRCm39) |
|
probably benign |
Het |
| Gpd2 |
A |
C |
2: 57,245,786 (GRCm39) |
T439P |
probably damaging |
Het |
| Gpm6a |
A |
T |
8: 55,490,385 (GRCm39) |
K20N |
probably damaging |
Het |
| Hc |
A |
T |
2: 34,873,819 (GRCm39) |
Y158* |
probably null |
Het |
| Hectd4 |
A |
T |
5: 121,487,235 (GRCm39) |
D3410V |
possibly damaging |
Het |
| Il17b |
G |
A |
18: 61,823,483 (GRCm39) |
|
probably null |
Het |
| Irx4 |
G |
T |
13: 73,413,695 (GRCm39) |
R55L |
possibly damaging |
Het |
| Itgav |
A |
T |
2: 83,596,245 (GRCm39) |
|
probably benign |
Het |
| Lama3 |
T |
C |
18: 12,574,164 (GRCm39) |
V582A |
probably benign |
Het |
| Ldhd |
G |
T |
8: 112,353,925 (GRCm39) |
A425E |
possibly damaging |
Het |
| Lrp1b |
C |
T |
2: 40,817,841 (GRCm39) |
|
probably null |
Het |
| Lrp5 |
T |
C |
19: 3,670,191 (GRCm39) |
T638A |
possibly damaging |
Het |
| Ly6h |
G |
A |
15: 75,437,986 (GRCm39) |
S21L |
probably benign |
Het |
| Mctp1 |
T |
C |
13: 76,973,392 (GRCm39) |
V431A |
probably benign |
Het |
| Metap2 |
C |
T |
10: 93,707,345 (GRCm39) |
|
probably null |
Het |
| Mfsd2b |
T |
A |
12: 4,920,536 (GRCm39) |
K94* |
probably null |
Het |
| Micall2 |
A |
G |
5: 139,705,097 (GRCm39) |
L79P |
probably damaging |
Het |
| Mucl2 |
T |
C |
15: 103,927,673 (GRCm39) |
T95A |
possibly damaging |
Het |
| Myo15a |
A |
T |
11: 60,396,832 (GRCm39) |
T2634S |
probably damaging |
Het |
| Myo5b |
G |
T |
18: 74,873,574 (GRCm39) |
V1467L |
probably damaging |
Het |
| Nfic |
G |
T |
10: 81,256,414 (GRCm39) |
D105E |
probably damaging |
Het |
| Nrdc |
T |
A |
4: 108,873,865 (GRCm39) |
F227Y |
probably benign |
Het |
| Nrp2 |
A |
T |
1: 62,777,458 (GRCm39) |
I88F |
probably damaging |
Het |
| Nup160 |
A |
T |
2: 90,530,887 (GRCm39) |
H515L |
probably benign |
Het |
| Nup205 |
G |
A |
6: 35,202,917 (GRCm39) |
|
probably null |
Het |
| Oas1g |
G |
A |
5: 121,020,069 (GRCm39) |
T179I |
probably benign |
Het |
| Ogfr |
A |
T |
2: 180,236,543 (GRCm39) |
E376V |
probably damaging |
Het |
| Or2l13 |
T |
G |
16: 19,306,378 (GRCm39) |
S263R |
probably benign |
Het |
| Or4a69 |
A |
T |
2: 89,312,855 (GRCm39) |
V208D |
possibly damaging |
Het |
| Or4c107 |
T |
G |
2: 88,789,387 (GRCm39) |
Y192* |
probably null |
Het |
| Or52d1 |
G |
T |
7: 103,755,896 (GRCm39) |
V137F |
possibly damaging |
Het |
| Or5p6 |
C |
T |
7: 107,631,595 (GRCm39) |
|
probably null |
Het |
| Pard3b |
T |
C |
1: 62,384,188 (GRCm39) |
V851A |
probably benign |
Het |
| Pcdhb16 |
A |
T |
18: 37,611,142 (GRCm39) |
Y34F |
probably damaging |
Het |
| Pikfyve |
T |
C |
1: 65,290,825 (GRCm39) |
Y1215H |
probably damaging |
Het |
| Pkhd1 |
A |
T |
1: 20,593,565 (GRCm39) |
V1516E |
probably damaging |
Het |
| Pla2g4a |
A |
T |
1: 149,763,344 (GRCm39) |
|
probably benign |
Het |
| Ptprg |
A |
T |
14: 12,190,767 (GRCm38) |
I818F |
probably benign |
Het |
| Ralgapb |
A |
G |
2: 158,304,173 (GRCm39) |
E644G |
possibly damaging |
Het |
| Rbm45 |
A |
G |
2: 76,202,459 (GRCm39) |
I127M |
probably damaging |
Het |
| Rtp2 |
T |
C |
16: 23,746,220 (GRCm39) |
Y157C |
probably damaging |
Het |
| Sema3f |
A |
T |
9: 107,564,771 (GRCm39) |
|
probably benign |
Het |
| Sf3b3 |
A |
T |
8: 111,564,006 (GRCm39) |
Y329N |
probably damaging |
Het |
| Sfxn1 |
A |
G |
13: 54,239,646 (GRCm39) |
|
probably null |
Het |
| Shkbp1 |
A |
T |
7: 27,044,751 (GRCm39) |
C447S |
probably damaging |
Het |
| Sipa1l3 |
A |
G |
7: 29,021,685 (GRCm39) |
S689P |
possibly damaging |
Het |
| Slc7a8 |
A |
G |
14: 54,970,656 (GRCm39) |
S332P |
probably damaging |
Het |
| Slit1 |
C |
A |
19: 41,596,823 (GRCm39) |
C1092F |
probably damaging |
Het |
| Slx9 |
A |
G |
10: 77,333,360 (GRCm39) |
|
probably benign |
Het |
| Stard9 |
A |
G |
2: 120,533,678 (GRCm39) |
I619V |
possibly damaging |
Het |
| Sycp3 |
T |
C |
10: 88,305,454 (GRCm39) |
V185A |
possibly damaging |
Het |
| Taar9 |
A |
T |
10: 23,985,382 (GRCm39) |
N17K |
possibly damaging |
Het |
| Tbkbp1 |
T |
C |
11: 97,039,814 (GRCm39) |
E102G |
probably damaging |
Het |
| Tex44 |
A |
G |
1: 86,354,834 (GRCm39) |
N248D |
probably benign |
Het |
| Tmem63b |
C |
G |
17: 45,989,904 (GRCm39) |
R88P |
possibly damaging |
Het |
| Tnpo1 |
C |
T |
13: 98,986,665 (GRCm39) |
V781I |
probably benign |
Het |
| Tonsl |
C |
T |
15: 76,520,761 (GRCm39) |
|
probably null |
Het |
| Ttc6 |
A |
G |
12: 57,721,463 (GRCm39) |
K984R |
possibly damaging |
Het |
| Usp34 |
A |
G |
11: 23,391,171 (GRCm39) |
E2263G |
probably damaging |
Het |
| Usp8 |
A |
G |
2: 126,596,847 (GRCm39) |
K875E |
probably damaging |
Het |
| Vapb |
C |
T |
2: 173,603,905 (GRCm39) |
|
probably benign |
Het |
| Vmn1r223 |
A |
G |
13: 23,434,038 (GRCm39) |
I211V |
possibly damaging |
Het |
| Vmn2r81 |
G |
A |
10: 79,129,496 (GRCm39) |
V796I |
probably damaging |
Het |
| Wdr90 |
A |
T |
17: 26,073,027 (GRCm39) |
V856D |
probably damaging |
Het |
| Wnk2 |
T |
A |
13: 49,235,571 (GRCm39) |
T615S |
probably damaging |
Het |
|
| Other mutations in Lrrk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01365:Lrrk1
|
APN |
7 |
65,937,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01511:Lrrk1
|
APN |
7 |
65,915,198 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02337:Lrrk1
|
APN |
7 |
65,929,164 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02636:Lrrk1
|
APN |
7 |
65,958,407 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02679:Lrrk1
|
APN |
7 |
65,924,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02711:Lrrk1
|
APN |
7 |
65,980,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02742:Lrrk1
|
APN |
7 |
65,958,439 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02878:Lrrk1
|
APN |
7 |
65,912,311 (GRCm39) |
missense |
probably benign |
|
|
IGL03135:Lrrk1
|
APN |
7 |
65,912,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03191:Lrrk1
|
APN |
7 |
65,909,707 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03198:Lrrk1
|
APN |
7 |
65,956,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
combustion
|
UTSW |
7 |
65,912,413 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
fluorine
|
UTSW |
7 |
65,952,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
halide
|
UTSW |
7 |
65,915,222 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
Heiland
|
UTSW |
7 |
65,912,481 (GRCm39) |
missense |
probably damaging |
0.96 |
|
liebster
|
UTSW |
7 |
65,944,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
magi
|
UTSW |
7 |
65,931,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
oxidation
|
UTSW |
7 |
65,929,120 (GRCm39) |
missense |
probably benign |
0.00 |
|
phlogiston
|
UTSW |
7 |
65,928,268 (GRCm39) |
splice site |
probably benign |
|
|
Savior
|
UTSW |
7 |
65,912,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
wenig
|
UTSW |
7 |
65,922,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
65,942,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
65,942,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0276:Lrrk1
|
UTSW |
7 |
65,946,011 (GRCm39) |
splice site |
probably benign |
|
|
R0505:Lrrk1
|
UTSW |
7 |
65,940,656 (GRCm39) |
splice site |
probably null |
|
|
R0609:Lrrk1
|
UTSW |
7 |
65,916,363 (GRCm39) |
splice site |
probably null |
|
|
R0650:Lrrk1
|
UTSW |
7 |
65,942,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0676:Lrrk1
|
UTSW |
7 |
65,944,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1157:Lrrk1
|
UTSW |
7 |
65,912,031 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1435:Lrrk1
|
UTSW |
7 |
65,922,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
65,909,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1498:Lrrk1
|
UTSW |
7 |
65,952,419 (GRCm39) |
nonsense |
probably null |
|
|
R1620:Lrrk1
|
UTSW |
7 |
66,031,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1884:Lrrk1
|
UTSW |
7 |
65,912,185 (GRCm39) |
missense |
probably benign |
|
|
R1891:Lrrk1
|
UTSW |
7 |
65,929,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1989:Lrrk1
|
UTSW |
7 |
65,931,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2107:Lrrk1
|
UTSW |
7 |
65,929,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2140:Lrrk1
|
UTSW |
7 |
65,980,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2144:Lrrk1
|
UTSW |
7 |
65,945,911 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2147:Lrrk1
|
UTSW |
7 |
65,935,159 (GRCm39) |
splice site |
probably null |
|
|
R3176:Lrrk1
|
UTSW |
7 |
65,955,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R3276:Lrrk1
|
UTSW |
7 |
65,955,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R3886:Lrrk1
|
UTSW |
7 |
65,942,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3893:Lrrk1
|
UTSW |
7 |
65,928,268 (GRCm39) |
splice site |
probably benign |
|
|
R3906:Lrrk1
|
UTSW |
7 |
65,944,651 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R4259:Lrrk1
|
UTSW |
7 |
65,980,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4649:Lrrk1
|
UTSW |
7 |
65,922,801 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4653:Lrrk1
|
UTSW |
7 |
65,922,801 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4672:Lrrk1
|
UTSW |
7 |
65,929,120 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4693:Lrrk1
|
UTSW |
7 |
65,912,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4729:Lrrk1
|
UTSW |
7 |
65,912,041 (GRCm39) |
missense |
probably benign |
|
|
R4737:Lrrk1
|
UTSW |
7 |
65,956,621 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4795:Lrrk1
|
UTSW |
7 |
65,912,413 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4911:Lrrk1
|
UTSW |
7 |
65,945,202 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5002:Lrrk1
|
UTSW |
7 |
65,982,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5254:Lrrk1
|
UTSW |
7 |
65,956,855 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5407:Lrrk1
|
UTSW |
7 |
65,920,545 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5482:Lrrk1
|
UTSW |
7 |
65,980,418 (GRCm39) |
missense |
probably benign |
|
|
R5600:Lrrk1
|
UTSW |
7 |
65,956,963 (GRCm39) |
missense |
probably benign |
0.31 |
|
R5615:Lrrk1
|
UTSW |
7 |
65,937,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6041:Lrrk1
|
UTSW |
7 |
65,911,881 (GRCm39) |
missense |
probably benign |
|
|
R6211:Lrrk1
|
UTSW |
7 |
65,952,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6271:Lrrk1
|
UTSW |
7 |
65,956,851 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6276:Lrrk1
|
UTSW |
7 |
65,956,587 (GRCm39) |
splice site |
probably null |
|
|
R6447:Lrrk1
|
UTSW |
7 |
65,952,476 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6478:Lrrk1
|
UTSW |
7 |
65,912,481 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6615:Lrrk1
|
UTSW |
7 |
65,931,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6745:Lrrk1
|
UTSW |
7 |
65,922,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6836:Lrrk1
|
UTSW |
7 |
65,992,527 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6995:Lrrk1
|
UTSW |
7 |
65,942,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7107:Lrrk1
|
UTSW |
7 |
65,937,191 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7137:Lrrk1
|
UTSW |
7 |
65,935,027 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7203:Lrrk1
|
UTSW |
7 |
65,920,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7224:Lrrk1
|
UTSW |
7 |
65,982,134 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7239:Lrrk1
|
UTSW |
7 |
65,911,903 (GRCm39) |
missense |
probably benign |
|
|
R7440:Lrrk1
|
UTSW |
7 |
65,940,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7515:Lrrk1
|
UTSW |
7 |
65,912,310 (GRCm39) |
missense |
probably benign |
|
|
R7593:Lrrk1
|
UTSW |
7 |
65,958,439 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7728:Lrrk1
|
UTSW |
7 |
65,912,463 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7984:Lrrk1
|
UTSW |
7 |
65,950,477 (GRCm39) |
splice site |
probably null |
|
|
R7993:Lrrk1
|
UTSW |
7 |
65,912,202 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8009:Lrrk1
|
UTSW |
7 |
65,915,222 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8037:Lrrk1
|
UTSW |
7 |
65,935,089 (GRCm39) |
missense |
probably benign |
|
|
R8101:Lrrk1
|
UTSW |
7 |
65,992,530 (GRCm39) |
missense |
probably benign |
|
|
R8116:Lrrk1
|
UTSW |
7 |
65,912,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8126:Lrrk1
|
UTSW |
7 |
65,942,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8278:Lrrk1
|
UTSW |
7 |
65,928,432 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8559:Lrrk1
|
UTSW |
7 |
65,932,075 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R8669:Lrrk1
|
UTSW |
7 |
65,912,344 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8690:Lrrk1
|
UTSW |
7 |
65,952,477 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8955:Lrrk1
|
UTSW |
7 |
65,919,573 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9135:Lrrk1
|
UTSW |
7 |
65,928,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9380:Lrrk1
|
UTSW |
7 |
65,928,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9625:Lrrk1
|
UTSW |
7 |
65,909,666 (GRCm39) |
makesense |
probably null |
|
|
R9721:Lrrk1
|
UTSW |
7 |
65,924,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF018:Lrrk1
|
UTSW |
7 |
66,031,250 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGAACCCACTTGTCTTCTGTGCC -3'
(R):5'- CCAGACTGAGCTGTTTATGACACCC -3'
Sequencing Primer
(F):5'- CTTCTCTTGCGAGTACAAGC -3'
(R):5'- GAGCTGTTTATGACACCCTCTTAG -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation