Incidental Mutation 'R1468:Dock4'
| ID |
197745 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dock4
|
| Ensembl Gene |
ENSMUSG00000035954 |
| Gene Name |
dedicator of cytokinesis 4 |
| Synonyms |
6330411N01Rik, EST N28122 |
| MMRRC Submission |
039521-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.181)
|
| Stock # |
R1468 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
40495956-40896873 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 40805809 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Lysine
at position 927
(T927K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000047387
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000037488]
[ENSMUST00000220912]
|
| AlphaFold |
P59764 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000037488
AA Change: T927K
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000047387
Gene: ENSMUSG00000035954
AA Change: T927K
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
9 |
66 |
7.29e-10 |
SMART |
|
Pfam:DOCK_N
|
69 |
392 |
8.2e-110 |
PFAM |
|
Pfam:DOCK-C2
|
397 |
583 |
1.9e-55 |
PFAM |
|
low complexity region
|
829 |
842 |
N/A |
INTRINSIC |
|
Pfam:DHR-2
|
1092 |
1596 |
5e-108 |
PFAM |
|
low complexity region
|
1651 |
1664 |
N/A |
INTRINSIC |
|
low complexity region
|
1681 |
1696 |
N/A |
INTRINSIC |
|
low complexity region
|
1700 |
1713 |
N/A |
INTRINSIC |
|
low complexity region
|
1842 |
1872 |
N/A |
INTRINSIC |
|
low complexity region
|
1883 |
1896 |
N/A |
INTRINSIC |
|
low complexity region
|
1940 |
1950 |
N/A |
INTRINSIC |
|
low complexity region
|
1958 |
1973 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000220912
AA Change: T927K
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000222287
|
| Meta Mutation Damage Score |
0.0591 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.7%
- 10x: 94.6%
- 20x: 90.1%
|
| Validation Efficiency |
98% (106/108) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous disruption of this gene leads to complete embryonic lethality. Heterozygotes display altered blood vessel lumen formation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 112 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2900092C05Rik |
T |
G |
7: 12,246,507 (GRCm39) |
M1R |
probably null |
Het |
| 4933440N22Rik |
C |
A |
6: 117,884,540 (GRCm39) |
|
probably benign |
Het |
| 5031439G07Rik |
G |
T |
15: 84,837,345 (GRCm39) |
P280T |
probably damaging |
Het |
| Abca2 |
C |
T |
2: 25,331,308 (GRCm39) |
S1267L |
probably damaging |
Het |
| Acsl3 |
A |
T |
1: 78,684,126 (GRCm39) |
R719S |
probably benign |
Het |
| Adam1a |
A |
T |
5: 121,657,839 (GRCm39) |
|
probably null |
Het |
| Adamts7 |
T |
C |
9: 90,070,851 (GRCm39) |
|
probably benign |
Het |
| Adgrf3 |
G |
A |
5: 30,407,227 (GRCm39) |
|
probably benign |
Het |
| Aldh6a1 |
T |
C |
12: 84,488,544 (GRCm39) |
E89G |
possibly damaging |
Het |
| Ankrd36 |
A |
G |
11: 5,525,752 (GRCm39) |
Y238C |
probably damaging |
Het |
| Ankrd65 |
G |
A |
4: 155,877,362 (GRCm39) |
R291Q |
probably benign |
Het |
| Ano2 |
C |
T |
6: 125,773,227 (GRCm39) |
R287W |
probably damaging |
Het |
| Ap1ar |
A |
G |
3: 127,606,215 (GRCm39) |
I125T |
probably benign |
Het |
| Arid1b |
A |
G |
17: 5,293,197 (GRCm39) |
D705G |
probably damaging |
Het |
| Asb18 |
T |
A |
1: 89,924,005 (GRCm39) |
N86I |
probably damaging |
Het |
| Bicral |
A |
T |
17: 47,135,519 (GRCm39) |
S564T |
probably benign |
Het |
| Bpifa6 |
A |
G |
2: 153,831,192 (GRCm39) |
M253V |
probably benign |
Het |
| Braf |
T |
C |
6: 39,642,017 (GRCm39) |
D194G |
probably damaging |
Het |
| Brinp3 |
C |
A |
1: 146,777,700 (GRCm39) |
P716T |
probably benign |
Het |
| C7 |
T |
A |
15: 5,041,631 (GRCm39) |
Y425F |
probably damaging |
Het |
| Ccdc102a |
T |
C |
8: 95,632,714 (GRCm39) |
K421R |
probably benign |
Het |
| Cep89 |
G |
A |
7: 35,120,388 (GRCm39) |
|
probably null |
Het |
| Chgb |
A |
T |
2: 132,634,720 (GRCm39) |
M221L |
probably benign |
Het |
| Chst14 |
A |
G |
2: 118,758,145 (GRCm39) |
Y313C |
probably damaging |
Het |
| Ciita |
G |
A |
16: 10,331,152 (GRCm39) |
|
probably null |
Het |
| Clec12b |
A |
T |
6: 129,357,603 (GRCm39) |
I85N |
probably damaging |
Het |
| Clec2e |
G |
T |
6: 129,070,459 (GRCm39) |
Y187* |
probably null |
Het |
| Crbn |
T |
C |
6: 106,767,804 (GRCm39) |
K229E |
probably benign |
Het |
| Ctdspl2 |
A |
T |
2: 121,811,762 (GRCm39) |
Q201L |
probably benign |
Het |
| Ctrb1 |
G |
T |
8: 112,416,041 (GRCm39) |
|
probably benign |
Het |
| Cyp2c55 |
T |
A |
19: 38,999,525 (GRCm39) |
V77E |
probably damaging |
Het |
| Cyp2c69 |
A |
C |
19: 39,837,839 (GRCm39) |
D414E |
probably damaging |
Het |
| Ddx47 |
T |
C |
6: 134,988,703 (GRCm39) |
|
probably benign |
Het |
| Dlg1 |
A |
G |
16: 31,661,640 (GRCm39) |
|
probably null |
Het |
| Dnah5 |
C |
A |
15: 28,230,609 (GRCm39) |
S169* |
probably null |
Het |
| Esrp2 |
T |
G |
8: 106,860,453 (GRCm39) |
D259A |
probably damaging |
Het |
| Fam169a |
A |
G |
13: 97,255,038 (GRCm39) |
K418R |
probably benign |
Het |
| Fancm |
A |
T |
12: 65,146,067 (GRCm39) |
I597F |
probably damaging |
Het |
| Fastkd2 |
G |
T |
1: 63,771,385 (GRCm39) |
|
probably benign |
Het |
| Fat1 |
G |
A |
8: 45,463,582 (GRCm39) |
V1375M |
probably damaging |
Het |
| Fbxw10 |
A |
T |
11: 62,753,464 (GRCm39) |
D486V |
probably damaging |
Het |
| Fech |
C |
T |
18: 64,603,744 (GRCm39) |
|
probably benign |
Het |
| Fermt1 |
C |
T |
2: 132,766,942 (GRCm39) |
E342K |
probably benign |
Het |
| Foxp1 |
T |
A |
6: 98,955,181 (GRCm39) |
H195L |
possibly damaging |
Het |
| Gfra1 |
T |
A |
19: 58,440,407 (GRCm39) |
I138L |
probably benign |
Het |
| Gm12185 |
T |
C |
11: 48,806,501 (GRCm39) |
D230G |
possibly damaging |
Het |
| Gm14403 |
T |
A |
2: 177,199,024 (GRCm39) |
|
probably benign |
Het |
| Gpd2 |
A |
C |
2: 57,245,786 (GRCm39) |
T439P |
probably damaging |
Het |
| Gpm6a |
A |
T |
8: 55,490,385 (GRCm39) |
K20N |
probably damaging |
Het |
| Hc |
A |
T |
2: 34,873,819 (GRCm39) |
Y158* |
probably null |
Het |
| Hectd4 |
A |
T |
5: 121,487,235 (GRCm39) |
D3410V |
possibly damaging |
Het |
| Il17b |
G |
A |
18: 61,823,483 (GRCm39) |
|
probably null |
Het |
| Irx4 |
G |
T |
13: 73,413,695 (GRCm39) |
R55L |
possibly damaging |
Het |
| Itgav |
A |
T |
2: 83,596,245 (GRCm39) |
|
probably benign |
Het |
| Lama3 |
T |
C |
18: 12,574,164 (GRCm39) |
V582A |
probably benign |
Het |
| Ldhd |
G |
T |
8: 112,353,925 (GRCm39) |
A425E |
possibly damaging |
Het |
| Lrp1b |
C |
T |
2: 40,817,841 (GRCm39) |
|
probably null |
Het |
| Lrp5 |
T |
C |
19: 3,670,191 (GRCm39) |
T638A |
possibly damaging |
Het |
| Lrrk1 |
A |
C |
7: 65,909,722 (GRCm39) |
F1996C |
probably damaging |
Het |
| Ly6h |
G |
A |
15: 75,437,986 (GRCm39) |
S21L |
probably benign |
Het |
| Mctp1 |
T |
C |
13: 76,973,392 (GRCm39) |
V431A |
probably benign |
Het |
| Metap2 |
C |
T |
10: 93,707,345 (GRCm39) |
|
probably null |
Het |
| Mfsd2b |
T |
A |
12: 4,920,536 (GRCm39) |
K94* |
probably null |
Het |
| Micall2 |
A |
G |
5: 139,705,097 (GRCm39) |
L79P |
probably damaging |
Het |
| Mucl2 |
T |
C |
15: 103,927,673 (GRCm39) |
T95A |
possibly damaging |
Het |
| Myo15a |
A |
T |
11: 60,396,832 (GRCm39) |
T2634S |
probably damaging |
Het |
| Myo5b |
G |
T |
18: 74,873,574 (GRCm39) |
V1467L |
probably damaging |
Het |
| Nfic |
G |
T |
10: 81,256,414 (GRCm39) |
D105E |
probably damaging |
Het |
| Nrdc |
T |
A |
4: 108,873,865 (GRCm39) |
F227Y |
probably benign |
Het |
| Nrp2 |
A |
T |
1: 62,777,458 (GRCm39) |
I88F |
probably damaging |
Het |
| Nup160 |
A |
T |
2: 90,530,887 (GRCm39) |
H515L |
probably benign |
Het |
| Nup205 |
G |
A |
6: 35,202,917 (GRCm39) |
|
probably null |
Het |
| Oas1g |
G |
A |
5: 121,020,069 (GRCm39) |
T179I |
probably benign |
Het |
| Ogfr |
A |
T |
2: 180,236,543 (GRCm39) |
E376V |
probably damaging |
Het |
| Or2l13 |
T |
G |
16: 19,306,378 (GRCm39) |
S263R |
probably benign |
Het |
| Or4a69 |
A |
T |
2: 89,312,855 (GRCm39) |
V208D |
possibly damaging |
Het |
| Or4c107 |
T |
G |
2: 88,789,387 (GRCm39) |
Y192* |
probably null |
Het |
| Or52d1 |
G |
T |
7: 103,755,896 (GRCm39) |
V137F |
possibly damaging |
Het |
| Or5p6 |
C |
T |
7: 107,631,595 (GRCm39) |
|
probably null |
Het |
| Pard3b |
T |
C |
1: 62,384,188 (GRCm39) |
V851A |
probably benign |
Het |
| Pcdhb16 |
A |
T |
18: 37,611,142 (GRCm39) |
Y34F |
probably damaging |
Het |
| Pikfyve |
T |
C |
1: 65,290,825 (GRCm39) |
Y1215H |
probably damaging |
Het |
| Pkhd1 |
A |
T |
1: 20,593,565 (GRCm39) |
V1516E |
probably damaging |
Het |
| Pla2g4a |
A |
T |
1: 149,763,344 (GRCm39) |
|
probably benign |
Het |
| Ptprg |
A |
T |
14: 12,190,767 (GRCm38) |
I818F |
probably benign |
Het |
| Ralgapb |
A |
G |
2: 158,304,173 (GRCm39) |
E644G |
possibly damaging |
Het |
| Rbm45 |
A |
G |
2: 76,202,459 (GRCm39) |
I127M |
probably damaging |
Het |
| Rtp2 |
T |
C |
16: 23,746,220 (GRCm39) |
Y157C |
probably damaging |
Het |
| Sema3f |
A |
T |
9: 107,564,771 (GRCm39) |
|
probably benign |
Het |
| Sf3b3 |
A |
T |
8: 111,564,006 (GRCm39) |
Y329N |
probably damaging |
Het |
| Sfxn1 |
A |
G |
13: 54,239,646 (GRCm39) |
|
probably null |
Het |
| Shkbp1 |
A |
T |
7: 27,044,751 (GRCm39) |
C447S |
probably damaging |
Het |
| Sipa1l3 |
A |
G |
7: 29,021,685 (GRCm39) |
S689P |
possibly damaging |
Het |
| Slc7a8 |
A |
G |
14: 54,970,656 (GRCm39) |
S332P |
probably damaging |
Het |
| Slit1 |
C |
A |
19: 41,596,823 (GRCm39) |
C1092F |
probably damaging |
Het |
| Slx9 |
A |
G |
10: 77,333,360 (GRCm39) |
|
probably benign |
Het |
| Stard9 |
A |
G |
2: 120,533,678 (GRCm39) |
I619V |
possibly damaging |
Het |
| Sycp3 |
T |
C |
10: 88,305,454 (GRCm39) |
V185A |
possibly damaging |
Het |
| Taar9 |
A |
T |
10: 23,985,382 (GRCm39) |
N17K |
possibly damaging |
Het |
| Tbkbp1 |
T |
C |
11: 97,039,814 (GRCm39) |
E102G |
probably damaging |
Het |
| Tex44 |
A |
G |
1: 86,354,834 (GRCm39) |
N248D |
probably benign |
Het |
| Tmem63b |
C |
G |
17: 45,989,904 (GRCm39) |
R88P |
possibly damaging |
Het |
| Tnpo1 |
C |
T |
13: 98,986,665 (GRCm39) |
V781I |
probably benign |
Het |
| Tonsl |
C |
T |
15: 76,520,761 (GRCm39) |
|
probably null |
Het |
| Ttc6 |
A |
G |
12: 57,721,463 (GRCm39) |
K984R |
possibly damaging |
Het |
| Usp34 |
A |
G |
11: 23,391,171 (GRCm39) |
E2263G |
probably damaging |
Het |
| Usp8 |
A |
G |
2: 126,596,847 (GRCm39) |
K875E |
probably damaging |
Het |
| Vapb |
C |
T |
2: 173,603,905 (GRCm39) |
|
probably benign |
Het |
| Vmn1r223 |
A |
G |
13: 23,434,038 (GRCm39) |
I211V |
possibly damaging |
Het |
| Vmn2r81 |
G |
A |
10: 79,129,496 (GRCm39) |
V796I |
probably damaging |
Het |
| Wdr90 |
A |
T |
17: 26,073,027 (GRCm39) |
V856D |
probably damaging |
Het |
| Wnk2 |
T |
A |
13: 49,235,571 (GRCm39) |
T615S |
probably damaging |
Het |
|
| Other mutations in Dock4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00427:Dock4
|
APN |
12 |
40,882,305 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL00726:Dock4
|
APN |
12 |
40,840,067 (GRCm39) |
splice site |
probably benign |
|
|
IGL00790:Dock4
|
APN |
12 |
40,884,390 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01061:Dock4
|
APN |
12 |
40,752,968 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01083:Dock4
|
APN |
12 |
40,838,380 (GRCm39) |
splice site |
probably benign |
|
|
IGL01412:Dock4
|
APN |
12 |
40,780,040 (GRCm39) |
splice site |
probably benign |
|
|
IGL01583:Dock4
|
APN |
12 |
40,860,466 (GRCm39) |
nonsense |
probably null |
|
|
IGL01603:Dock4
|
APN |
12 |
40,743,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01766:Dock4
|
APN |
12 |
40,496,378 (GRCm39) |
nonsense |
probably null |
|
|
IGL02067:Dock4
|
APN |
12 |
40,884,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02302:Dock4
|
APN |
12 |
40,775,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02406:Dock4
|
APN |
12 |
40,827,206 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02547:Dock4
|
APN |
12 |
40,787,478 (GRCm39) |
missense |
probably benign |
|
|
IGL02613:Dock4
|
APN |
12 |
40,860,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02643:Dock4
|
APN |
12 |
40,718,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02952:Dock4
|
APN |
12 |
40,760,902 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02994:Dock4
|
APN |
12 |
40,829,159 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03096:Dock4
|
APN |
12 |
40,798,000 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03144:Dock4
|
APN |
12 |
40,742,906 (GRCm39) |
splice site |
probably benign |
|
|
IGL03223:Dock4
|
APN |
12 |
40,867,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03296:Dock4
|
APN |
12 |
40,783,256 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL03349:Dock4
|
APN |
12 |
40,783,309 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL03353:Dock4
|
APN |
12 |
40,867,757 (GRCm39) |
splice site |
probably null |
|
|
BB005:Dock4
|
UTSW |
12 |
40,838,302 (GRCm39) |
missense |
probably damaging |
0.98 |
|
BB015:Dock4
|
UTSW |
12 |
40,838,302 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0046:Dock4
|
UTSW |
12 |
40,787,359 (GRCm39) |
splice site |
probably benign |
|
|
R0046:Dock4
|
UTSW |
12 |
40,787,359 (GRCm39) |
splice site |
probably benign |
|
|
R0110:Dock4
|
UTSW |
12 |
40,671,311 (GRCm39) |
splice site |
probably benign |
|
|
R0238:Dock4
|
UTSW |
12 |
40,787,539 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0238:Dock4
|
UTSW |
12 |
40,787,539 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0239:Dock4
|
UTSW |
12 |
40,787,539 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0239:Dock4
|
UTSW |
12 |
40,787,539 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0472:Dock4
|
UTSW |
12 |
40,888,437 (GRCm39) |
intron |
probably benign |
|
|
R0616:Dock4
|
UTSW |
12 |
40,754,414 (GRCm39) |
missense |
probably benign |
0.31 |
|
R0647:Dock4
|
UTSW |
12 |
40,760,883 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0706:Dock4
|
UTSW |
12 |
40,752,922 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0791:Dock4
|
UTSW |
12 |
40,754,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0940:Dock4
|
UTSW |
12 |
40,681,626 (GRCm39) |
splice site |
probably benign |
|
|
R1087:Dock4
|
UTSW |
12 |
40,779,937 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1180:Dock4
|
UTSW |
12 |
40,690,413 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1194:Dock4
|
UTSW |
12 |
40,879,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1463:Dock4
|
UTSW |
12 |
40,866,324 (GRCm39) |
frame shift |
probably null |
|
|
R1468:Dock4
|
UTSW |
12 |
40,805,809 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1523:Dock4
|
UTSW |
12 |
40,743,024 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1616:Dock4
|
UTSW |
12 |
40,719,044 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1682:Dock4
|
UTSW |
12 |
40,775,779 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1691:Dock4
|
UTSW |
12 |
40,775,754 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1693:Dock4
|
UTSW |
12 |
40,884,721 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1737:Dock4
|
UTSW |
12 |
40,857,000 (GRCm39) |
splice site |
probably null |
|
|
R1802:Dock4
|
UTSW |
12 |
40,844,597 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1813:Dock4
|
UTSW |
12 |
40,686,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1846:Dock4
|
UTSW |
12 |
40,783,267 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1959:Dock4
|
UTSW |
12 |
40,760,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1975:Dock4
|
UTSW |
12 |
40,829,641 (GRCm39) |
splice site |
probably benign |
|
|
R1986:Dock4
|
UTSW |
12 |
40,780,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2105:Dock4
|
UTSW |
12 |
40,742,988 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2134:Dock4
|
UTSW |
12 |
40,795,667 (GRCm39) |
missense |
probably benign |
|
|
R2135:Dock4
|
UTSW |
12 |
40,795,667 (GRCm39) |
missense |
probably benign |
|
|
R2154:Dock4
|
UTSW |
12 |
40,894,547 (GRCm39) |
small insertion |
probably benign |
|
|
R2154:Dock4
|
UTSW |
12 |
40,870,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2864:Dock4
|
UTSW |
12 |
40,780,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2890:Dock4
|
UTSW |
12 |
40,673,800 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3086:Dock4
|
UTSW |
12 |
40,781,862 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3808:Dock4
|
UTSW |
12 |
40,722,809 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3811:Dock4
|
UTSW |
12 |
40,829,123 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3836:Dock4
|
UTSW |
12 |
40,844,623 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3838:Dock4
|
UTSW |
12 |
40,844,623 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4091:Dock4
|
UTSW |
12 |
40,894,266 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4735:Dock4
|
UTSW |
12 |
40,681,525 (GRCm39) |
missense |
probably benign |
0.31 |
|
R4752:Dock4
|
UTSW |
12 |
40,496,364 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4828:Dock4
|
UTSW |
12 |
40,718,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5039:Dock4
|
UTSW |
12 |
40,867,745 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5092:Dock4
|
UTSW |
12 |
40,894,440 (GRCm39) |
missense |
probably benign |
|
|
R5146:Dock4
|
UTSW |
12 |
40,699,491 (GRCm39) |
splice site |
probably null |
|
|
R5213:Dock4
|
UTSW |
12 |
40,726,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5214:Dock4
|
UTSW |
12 |
40,754,465 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5270:Dock4
|
UTSW |
12 |
40,783,270 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5426:Dock4
|
UTSW |
12 |
40,795,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5474:Dock4
|
UTSW |
12 |
40,795,730 (GRCm39) |
missense |
probably benign |
|
|
R5544:Dock4
|
UTSW |
12 |
40,884,701 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5615:Dock4
|
UTSW |
12 |
40,699,479 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5649:Dock4
|
UTSW |
12 |
40,894,539 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5702:Dock4
|
UTSW |
12 |
40,787,490 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5846:Dock4
|
UTSW |
12 |
40,867,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5847:Dock4
|
UTSW |
12 |
40,671,250 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5895:Dock4
|
UTSW |
12 |
40,805,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5997:Dock4
|
UTSW |
12 |
40,805,833 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6011:Dock4
|
UTSW |
12 |
40,867,756 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6022:Dock4
|
UTSW |
12 |
40,798,109 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6038:Dock4
|
UTSW |
12 |
40,783,350 (GRCm39) |
splice site |
probably null |
|
|
R6038:Dock4
|
UTSW |
12 |
40,783,350 (GRCm39) |
splice site |
probably null |
|
|
R6179:Dock4
|
UTSW |
12 |
40,781,868 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6479:Dock4
|
UTSW |
12 |
40,878,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6516:Dock4
|
UTSW |
12 |
40,781,898 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6748:Dock4
|
UTSW |
12 |
40,754,465 (GRCm39) |
missense |
probably benign |
0.44 |
|
R6752:Dock4
|
UTSW |
12 |
40,870,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6814:Dock4
|
UTSW |
12 |
40,862,325 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6864:Dock4
|
UTSW |
12 |
40,795,745 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6872:Dock4
|
UTSW |
12 |
40,862,325 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6891:Dock4
|
UTSW |
12 |
40,829,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6937:Dock4
|
UTSW |
12 |
40,884,634 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6950:Dock4
|
UTSW |
12 |
40,783,313 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7081:Dock4
|
UTSW |
12 |
40,671,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7129:Dock4
|
UTSW |
12 |
40,878,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7140:Dock4
|
UTSW |
12 |
40,686,158 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7241:Dock4
|
UTSW |
12 |
40,844,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7378:Dock4
|
UTSW |
12 |
40,838,243 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7714:Dock4
|
UTSW |
12 |
40,775,648 (GRCm39) |
nonsense |
probably null |
|
|
R7720:Dock4
|
UTSW |
12 |
40,856,974 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7756:Dock4
|
UTSW |
12 |
40,760,878 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7758:Dock4
|
UTSW |
12 |
40,760,878 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7759:Dock4
|
UTSW |
12 |
40,867,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7787:Dock4
|
UTSW |
12 |
40,775,676 (GRCm39) |
missense |
probably benign |
|
|
R7879:Dock4
|
UTSW |
12 |
40,780,083 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R7928:Dock4
|
UTSW |
12 |
40,838,302 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8000:Dock4
|
UTSW |
12 |
40,883,118 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8042:Dock4
|
UTSW |
12 |
40,795,759 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8231:Dock4
|
UTSW |
12 |
40,752,950 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8234:Dock4
|
UTSW |
12 |
40,884,837 (GRCm39) |
splice site |
probably null |
|
|
R8758:Dock4
|
UTSW |
12 |
40,838,231 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8871:Dock4
|
UTSW |
12 |
40,795,730 (GRCm39) |
missense |
probably benign |
|
|
R8873:Dock4
|
UTSW |
12 |
40,726,767 (GRCm39) |
nonsense |
probably null |
|
|
R8884:Dock4
|
UTSW |
12 |
40,856,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9164:Dock4
|
UTSW |
12 |
40,754,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9225:Dock4
|
UTSW |
12 |
40,879,669 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9276:Dock4
|
UTSW |
12 |
40,699,404 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9307:Dock4
|
UTSW |
12 |
40,686,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9675:Dock4
|
UTSW |
12 |
40,894,393 (GRCm39) |
small insertion |
probably benign |
|
|
R9675:Dock4
|
UTSW |
12 |
40,894,379 (GRCm39) |
small insertion |
probably benign |
|
|
R9676:Dock4
|
UTSW |
12 |
40,894,397 (GRCm39) |
small insertion |
probably benign |
|
|
R9676:Dock4
|
UTSW |
12 |
40,894,387 (GRCm39) |
small insertion |
probably benign |
|
|
R9676:Dock4
|
UTSW |
12 |
40,894,379 (GRCm39) |
small insertion |
probably benign |
|
|
R9676:Dock4
|
UTSW |
12 |
40,894,401 (GRCm39) |
small insertion |
probably benign |
|
|
R9678:Dock4
|
UTSW |
12 |
40,894,396 (GRCm39) |
small insertion |
probably benign |
|
|
R9678:Dock4
|
UTSW |
12 |
40,894,387 (GRCm39) |
small insertion |
probably benign |
|
|
R9678:Dock4
|
UTSW |
12 |
40,894,379 (GRCm39) |
small insertion |
probably benign |
|
|
R9691:Dock4
|
UTSW |
12 |
40,686,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF018:Dock4
|
UTSW |
12 |
40,894,398 (GRCm39) |
frame shift |
probably null |
|
|
RF025:Dock4
|
UTSW |
12 |
40,894,392 (GRCm39) |
frame shift |
probably null |
|
|
RF063:Dock4
|
UTSW |
12 |
40,894,398 (GRCm39) |
frame shift |
probably null |
|
|
X0028:Dock4
|
UTSW |
12 |
40,719,046 (GRCm39) |
missense |
probably benign |
0.25 |
|
Z1176:Dock4
|
UTSW |
12 |
40,681,615 (GRCm39) |
missense |
probably benign |
0.16 |
|
Z1176:Dock4
|
UTSW |
12 |
40,681,613 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Dock4
|
UTSW |
12 |
40,867,640 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCTGCTGAGTCAAAAGACCAGTGTG -3'
(R):5'- GTGCTGGAAGAATGAACCTAGTCCC -3'
Sequencing Primer
(F):5'- ACCAGTGTGCGGATGAGC -3'
(R):5'- GGAAGAATGAACCTAGTCCCATTTG -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation