Incidental Mutation 'R1469:Dock3'
| ID |
197839 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dock3
|
| Ensembl Gene |
ENSMUSG00000039716 |
| Gene Name |
dedicator of cyto-kinesis 3 |
| Synonyms |
Moca, PBP |
| MMRRC Submission |
039522-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.616)
|
| Stock # |
R1469 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
106770024-107109108 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 106832908 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 1034
(N1034K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000047652
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044532]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000044532
AA Change: N1034K
PolyPhen 2
Score 0.374 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000047652
Gene: ENSMUSG00000039716
AA Change: N1034K
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
9 |
66 |
3.85e-9 |
SMART |
|
Pfam:DOCK_N
|
69 |
412 |
1.4e-120 |
PFAM |
|
Pfam:DOCK-C2
|
417 |
608 |
7.7e-56 |
PFAM |
|
low complexity region
|
854 |
867 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
916 |
N/A |
INTRINSIC |
|
Pfam:DHR-2
|
1121 |
1628 |
9e-133 |
PFAM |
|
low complexity region
|
1679 |
1690 |
N/A |
INTRINSIC |
|
low complexity region
|
1693 |
1704 |
N/A |
INTRINSIC |
|
low complexity region
|
1730 |
1754 |
N/A |
INTRINSIC |
|
low complexity region
|
1880 |
1902 |
N/A |
INTRINSIC |
|
low complexity region
|
1963 |
1977 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000165075
AA Change: N120K
|
| SMART Domains |
Protein: ENSMUSP00000130873
Gene: ENSMUSG00000039716
AA Change: N120K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168759
|
| SMART Domains |
Protein: ENSMUSP00000131410
Gene: ENSMUSG00000039716
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DHR-2
|
1 |
241 |
4e-48 |
PFAM |
|
| Meta Mutation Damage Score |
0.1353 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.7%
- 10x: 94.8%
- 20x: 90.6%
|
| Validation Efficiency |
98% (95/97) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit abnormal behaviors and muscular weakness associated with axonal dystrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 103 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aasdh |
A |
T |
5: 77,039,526 (GRCm39) |
V261E |
probably damaging |
Het |
| Abca15 |
A |
G |
7: 119,981,720 (GRCm39) |
E1058G |
probably benign |
Het |
| Abcb5 |
T |
G |
12: 118,831,681 (GRCm39) |
I1224L |
possibly damaging |
Het |
| Actn4 |
G |
A |
7: 28,597,691 (GRCm39) |
|
probably benign |
Het |
| Actn4 |
A |
G |
7: 28,604,753 (GRCm39) |
V348A |
probably benign |
Het |
| Agtr1b |
A |
T |
3: 20,369,664 (GRCm39) |
L314H |
probably damaging |
Het |
| Ankrd55 |
T |
C |
13: 112,504,460 (GRCm39) |
M402T |
probably benign |
Het |
| Antxrl |
T |
C |
14: 33,789,388 (GRCm39) |
|
probably benign |
Het |
| Asap2 |
A |
G |
12: 21,263,180 (GRCm39) |
Q265R |
probably benign |
Het |
| Atp2b4 |
G |
A |
1: 133,634,677 (GRCm39) |
R1124C |
probably damaging |
Het |
| Atp2c1 |
A |
T |
9: 105,312,351 (GRCm39) |
C353* |
probably null |
Het |
| Atp8b5 |
T |
A |
4: 43,291,733 (GRCm39) |
|
probably null |
Het |
| Baz1b |
T |
A |
5: 135,246,833 (GRCm39) |
Y761N |
probably damaging |
Het |
| Bend6 |
A |
G |
1: 33,903,824 (GRCm39) |
V38A |
probably benign |
Het |
| Camk1g |
T |
C |
1: 193,044,399 (GRCm39) |
E5G |
possibly damaging |
Het |
| Ccdc14 |
T |
A |
16: 34,527,152 (GRCm39) |
H352Q |
probably damaging |
Het |
| Cdh2 |
A |
G |
18: 16,757,324 (GRCm39) |
V641A |
possibly damaging |
Het |
| Celsr2 |
C |
A |
3: 108,321,424 (GRCm39) |
D463Y |
probably damaging |
Het |
| Cldn16 |
C |
A |
16: 26,292,930 (GRCm39) |
|
probably benign |
Het |
| Clec7a |
A |
C |
6: 129,449,535 (GRCm39) |
|
probably benign |
Het |
| Cnih2 |
T |
C |
19: 5,143,730 (GRCm39) |
Y142C |
probably damaging |
Het |
| Coa5 |
T |
A |
1: 37,459,681 (GRCm39) |
R71* |
probably null |
Het |
| Csmd3 |
A |
T |
15: 47,532,598 (GRCm39) |
Y2532* |
probably null |
Het |
| Cytl1 |
A |
T |
5: 37,892,991 (GRCm39) |
M34L |
probably benign |
Het |
| Dctn1 |
T |
A |
6: 83,169,871 (GRCm39) |
I590N |
probably damaging |
Het |
| Dhx57 |
T |
C |
17: 80,561,847 (GRCm39) |
H889R |
probably damaging |
Het |
| Dock10 |
A |
G |
1: 80,490,275 (GRCm39) |
I1948T |
probably benign |
Het |
| Dzip1l |
G |
A |
9: 99,541,829 (GRCm39) |
|
probably null |
Het |
| Eif4g1 |
T |
A |
16: 20,498,758 (GRCm39) |
V439E |
possibly damaging |
Het |
| Eml5 |
T |
C |
12: 98,825,082 (GRCm39) |
I712V |
probably benign |
Het |
| Entrep1 |
G |
A |
19: 23,950,970 (GRCm39) |
T537I |
probably benign |
Het |
| Epha3 |
C |
T |
16: 63,473,857 (GRCm39) |
G300D |
probably damaging |
Het |
| Erbb4 |
A |
C |
1: 68,599,841 (GRCm39) |
S79A |
probably damaging |
Het |
| Gclc |
T |
C |
9: 77,688,419 (GRCm39) |
V205A |
probably benign |
Het |
| Gdpd4 |
A |
G |
7: 97,623,673 (GRCm39) |
|
probably null |
Het |
| Gm11564 |
C |
T |
11: 99,706,058 (GRCm39) |
C124Y |
unknown |
Het |
| Gm16494 |
T |
C |
17: 47,327,770 (GRCm39) |
E38G |
probably damaging |
Het |
| Gtf2h1 |
T |
C |
7: 46,454,549 (GRCm39) |
|
probably null |
Het |
| Gtsf2 |
G |
T |
15: 103,349,644 (GRCm39) |
R68S |
probably benign |
Het |
| Heatr5b |
T |
C |
17: 79,115,813 (GRCm39) |
Q881R |
probably damaging |
Het |
| Hmox1 |
C |
A |
8: 75,825,463 (GRCm39) |
L236I |
probably benign |
Het |
| Ighv8-12 |
T |
C |
12: 115,611,963 (GRCm39) |
I7V |
probably benign |
Het |
| Itprip |
A |
G |
19: 47,885,314 (GRCm39) |
Y434H |
probably damaging |
Het |
| Izumo1 |
T |
C |
7: 45,272,437 (GRCm39) |
S73P |
probably damaging |
Het |
| Kifbp |
A |
T |
10: 62,395,229 (GRCm39) |
F471Y |
probably damaging |
Het |
| Knl1 |
A |
G |
2: 118,901,827 (GRCm39) |
N1176S |
possibly damaging |
Het |
| Limch1 |
T |
C |
5: 67,039,323 (GRCm39) |
|
probably benign |
Het |
| Mecom |
A |
T |
3: 30,034,197 (GRCm39) |
L493Q |
probably damaging |
Het |
| Mprip |
T |
C |
11: 59,650,016 (GRCm39) |
V1240A |
probably damaging |
Het |
| Mrpl3 |
T |
C |
9: 104,954,201 (GRCm39) |
S302P |
probably damaging |
Het |
| Muc19 |
T |
C |
15: 91,758,498 (GRCm39) |
|
noncoding transcript |
Het |
| Mycbp2 |
T |
C |
14: 103,425,956 (GRCm39) |
T2390A |
probably damaging |
Het |
| Myo1c |
T |
C |
11: 75,560,787 (GRCm39) |
S766P |
probably damaging |
Het |
| Myo9b |
A |
G |
8: 71,743,680 (GRCm39) |
Q247R |
probably damaging |
Het |
| Nav3 |
G |
A |
10: 109,596,369 (GRCm39) |
T1423I |
probably damaging |
Het |
| Nefh |
A |
T |
11: 4,890,066 (GRCm39) |
I851N |
probably benign |
Het |
| Nup98 |
T |
C |
7: 101,788,008 (GRCm39) |
T1004A |
probably benign |
Het |
| Or1e17 |
T |
C |
11: 73,831,383 (GRCm39) |
F104L |
probably benign |
Het |
| Or1e22 |
G |
A |
11: 73,377,149 (GRCm39) |
S167L |
possibly damaging |
Het |
| Or5k8 |
G |
A |
16: 58,644,973 (GRCm39) |
T33I |
probably benign |
Het |
| Or5p76 |
T |
C |
7: 108,122,411 (GRCm39) |
T249A |
probably benign |
Het |
| Osgin1 |
G |
T |
8: 120,172,124 (GRCm39) |
R306L |
possibly damaging |
Het |
| Otof |
A |
G |
5: 30,537,571 (GRCm39) |
L1246P |
probably benign |
Het |
| Pde8a |
T |
A |
7: 80,952,019 (GRCm39) |
N273K |
probably damaging |
Het |
| Phf14 |
T |
A |
6: 11,933,726 (GRCm39) |
M196K |
possibly damaging |
Het |
| Pkd1l3 |
T |
C |
8: 110,373,585 (GRCm39) |
S1374P |
possibly damaging |
Het |
| Pkhd1l1 |
T |
C |
15: 44,400,282 (GRCm39) |
V2142A |
probably benign |
Het |
| Plb1 |
A |
G |
5: 32,512,170 (GRCm39) |
E1318G |
possibly damaging |
Het |
| Plekhh2 |
A |
G |
17: 84,883,199 (GRCm39) |
I756V |
probably benign |
Het |
| Prag1 |
A |
T |
8: 36,613,452 (GRCm39) |
|
probably benign |
Het |
| Primpol |
A |
G |
8: 47,046,672 (GRCm39) |
V208A |
probably benign |
Het |
| Ptch2 |
C |
A |
4: 116,965,662 (GRCm39) |
A389E |
probably benign |
Het |
| Pzp |
A |
G |
6: 128,489,319 (GRCm39) |
Y431H |
probably benign |
Het |
| Rnf43 |
G |
A |
11: 87,622,233 (GRCm39) |
G445R |
probably damaging |
Het |
| Scn5a |
A |
T |
9: 119,362,727 (GRCm39) |
|
probably null |
Het |
| Sf3a1 |
A |
T |
11: 4,125,380 (GRCm39) |
|
probably benign |
Het |
| Shisa9 |
T |
A |
16: 11,802,935 (GRCm39) |
M164K |
probably damaging |
Het |
| Skint1 |
A |
G |
4: 111,882,708 (GRCm39) |
I251V |
probably benign |
Het |
| Slc16a14 |
C |
T |
1: 84,907,182 (GRCm39) |
D31N |
probably damaging |
Het |
| Slc22a13 |
T |
C |
9: 119,022,361 (GRCm39) |
S548G |
possibly damaging |
Het |
| Slc4a9 |
T |
C |
18: 36,664,154 (GRCm39) |
F316L |
probably benign |
Het |
| Smchd1 |
C |
T |
17: 71,656,725 (GRCm39) |
R1914H |
probably damaging |
Het |
| Snx16 |
C |
T |
3: 10,499,431 (GRCm39) |
D200N |
probably damaging |
Het |
| Spock3 |
A |
G |
8: 63,404,934 (GRCm39) |
D34G |
probably damaging |
Het |
| Sspo |
T |
C |
6: 48,467,916 (GRCm39) |
C4154R |
probably damaging |
Het |
| Sytl3 |
C |
T |
17: 6,954,723 (GRCm39) |
A131V |
probably benign |
Het |
| Tacc1 |
T |
A |
8: 25,672,271 (GRCm39) |
D319V |
probably benign |
Het |
| Tead1 |
A |
T |
7: 112,475,391 (GRCm39) |
K234I |
probably damaging |
Het |
| Tgfbrap1 |
C |
T |
1: 43,114,618 (GRCm39) |
V161I |
probably benign |
Het |
| Tmem94 |
T |
C |
11: 115,685,917 (GRCm39) |
|
probably benign |
Het |
| Tnfaip3 |
A |
G |
10: 18,884,017 (GRCm39) |
V121A |
probably damaging |
Het |
| Tnnt2 |
A |
G |
1: 135,779,793 (GRCm39) |
T297A |
possibly damaging |
Het |
| Trappc11 |
G |
A |
8: 47,957,000 (GRCm39) |
L809F |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,601,869 (GRCm39) |
I18598V |
probably benign |
Het |
| Ube2o |
A |
G |
11: 116,436,650 (GRCm39) |
|
probably benign |
Het |
| Unc5a |
A |
G |
13: 55,144,232 (GRCm39) |
N186D |
probably damaging |
Het |
| Uqcrfs1 |
C |
A |
13: 30,724,784 (GRCm39) |
G252V |
probably damaging |
Het |
| Vmn2r115 |
T |
C |
17: 23,564,992 (GRCm39) |
I293T |
probably damaging |
Het |
| Vmn2r9 |
T |
C |
5: 108,991,694 (GRCm39) |
T556A |
probably benign |
Het |
| Wnk1 |
G |
A |
6: 119,927,645 (GRCm39) |
|
probably benign |
Het |
| Ythdc2 |
T |
A |
18: 44,997,529 (GRCm39) |
Y1029N |
probably benign |
Het |
| Zfp451 |
T |
A |
1: 33,808,894 (GRCm39) |
K989M |
possibly damaging |
Het |
| Zfpm1 |
C |
T |
8: 123,062,585 (GRCm39) |
T548M |
probably damaging |
Het |
|
| Other mutations in Dock3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00940:Dock3
|
APN |
9 |
106,788,576 (GRCm39) |
splice site |
probably benign |
|
|
IGL01067:Dock3
|
APN |
9 |
106,959,572 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01160:Dock3
|
APN |
9 |
106,783,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01290:Dock3
|
APN |
9 |
106,835,599 (GRCm39) |
splice site |
probably benign |
|
|
IGL01291:Dock3
|
APN |
9 |
106,835,599 (GRCm39) |
splice site |
probably benign |
|
|
IGL01391:Dock3
|
APN |
9 |
106,784,433 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL01399:Dock3
|
APN |
9 |
106,870,670 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01660:Dock3
|
APN |
9 |
106,909,563 (GRCm39) |
splice site |
probably benign |
|
|
IGL01752:Dock3
|
APN |
9 |
106,902,512 (GRCm39) |
splice site |
probably benign |
|
|
IGL01820:Dock3
|
APN |
9 |
106,773,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01908:Dock3
|
APN |
9 |
106,783,861 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02191:Dock3
|
APN |
9 |
106,815,340 (GRCm39) |
missense |
probably benign |
|
|
IGL02227:Dock3
|
APN |
9 |
106,939,254 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02309:Dock3
|
APN |
9 |
106,790,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Dock3
|
APN |
9 |
106,790,298 (GRCm39) |
splice site |
probably benign |
|
|
IGL02469:Dock3
|
APN |
9 |
106,863,215 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02545:Dock3
|
APN |
9 |
106,939,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02894:Dock3
|
APN |
9 |
106,807,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02934:Dock3
|
APN |
9 |
106,900,944 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03027:Dock3
|
APN |
9 |
106,870,677 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03068:Dock3
|
APN |
9 |
106,841,958 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL03128:Dock3
|
APN |
9 |
106,909,491 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03161:Dock3
|
APN |
9 |
106,900,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03263:Dock3
|
APN |
9 |
106,807,330 (GRCm39) |
splice site |
probably benign |
|
|
IGL03279:Dock3
|
APN |
9 |
106,788,447 (GRCm39) |
splice site |
probably benign |
|
|
IGL03366:Dock3
|
APN |
9 |
106,882,632 (GRCm39) |
missense |
probably benign |
0.01 |
|
Implosion
|
UTSW |
9 |
106,815,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
Squeeze
|
UTSW |
9 |
106,807,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Tight
|
UTSW |
9 |
106,872,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
ANU05:Dock3
|
UTSW |
9 |
106,772,862 (GRCm39) |
missense |
probably benign |
|
|
R0025:Dock3
|
UTSW |
9 |
106,790,467 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0025:Dock3
|
UTSW |
9 |
106,790,467 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0030:Dock3
|
UTSW |
9 |
106,789,512 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0076:Dock3
|
UTSW |
9 |
106,788,685 (GRCm39) |
splice site |
probably benign |
|
|
R0076:Dock3
|
UTSW |
9 |
106,788,685 (GRCm39) |
splice site |
probably benign |
|
|
R0206:Dock3
|
UTSW |
9 |
106,874,195 (GRCm39) |
nonsense |
probably null |
|
|
R0208:Dock3
|
UTSW |
9 |
106,874,195 (GRCm39) |
nonsense |
probably null |
|
|
R0384:Dock3
|
UTSW |
9 |
106,779,094 (GRCm39) |
splice site |
probably benign |
|
|
R0610:Dock3
|
UTSW |
9 |
106,900,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0731:Dock3
|
UTSW |
9 |
106,847,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1184:Dock3
|
UTSW |
9 |
106,846,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1350:Dock3
|
UTSW |
9 |
106,791,831 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1393:Dock3
|
UTSW |
9 |
106,788,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1424:Dock3
|
UTSW |
9 |
106,790,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Dock3
|
UTSW |
9 |
106,832,908 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1539:Dock3
|
UTSW |
9 |
106,874,112 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1539:Dock3
|
UTSW |
9 |
106,829,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1571:Dock3
|
UTSW |
9 |
106,815,158 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1682:Dock3
|
UTSW |
9 |
106,851,040 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1795:Dock3
|
UTSW |
9 |
106,902,534 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1987:Dock3
|
UTSW |
9 |
106,985,620 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2000:Dock3
|
UTSW |
9 |
106,870,160 (GRCm39) |
splice site |
probably benign |
|
|
R2074:Dock3
|
UTSW |
9 |
106,870,662 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R2114:Dock3
|
UTSW |
9 |
106,870,743 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2265:Dock3
|
UTSW |
9 |
106,818,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Dock3
|
UTSW |
9 |
106,818,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2370:Dock3
|
UTSW |
9 |
106,829,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2377:Dock3
|
UTSW |
9 |
106,773,090 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2385:Dock3
|
UTSW |
9 |
106,868,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Dock3
|
UTSW |
9 |
106,791,740 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R3076:Dock3
|
UTSW |
9 |
106,818,725 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3122:Dock3
|
UTSW |
9 |
106,788,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4052:Dock3
|
UTSW |
9 |
106,850,995 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4294:Dock3
|
UTSW |
9 |
106,807,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4623:Dock3
|
UTSW |
9 |
106,939,244 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4664:Dock3
|
UTSW |
9 |
106,870,743 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4705:Dock3
|
UTSW |
9 |
106,902,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Dock3
|
UTSW |
9 |
106,829,557 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4898:Dock3
|
UTSW |
9 |
106,870,171 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4898:Dock3
|
UTSW |
9 |
106,807,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4948:Dock3
|
UTSW |
9 |
106,868,354 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4961:Dock3
|
UTSW |
9 |
106,818,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4986:Dock3
|
UTSW |
9 |
106,809,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5054:Dock3
|
UTSW |
9 |
106,815,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5065:Dock3
|
UTSW |
9 |
106,832,883 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5081:Dock3
|
UTSW |
9 |
106,868,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5101:Dock3
|
UTSW |
9 |
106,846,980 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5135:Dock3
|
UTSW |
9 |
106,810,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5227:Dock3
|
UTSW |
9 |
106,863,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5257:Dock3
|
UTSW |
9 |
106,874,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5258:Dock3
|
UTSW |
9 |
106,874,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5273:Dock3
|
UTSW |
9 |
106,777,904 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5322:Dock3
|
UTSW |
9 |
106,779,028 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5482:Dock3
|
UTSW |
9 |
106,855,937 (GRCm39) |
nonsense |
probably null |
|
|
R5553:Dock3
|
UTSW |
9 |
106,868,309 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5631:Dock3
|
UTSW |
9 |
106,832,898 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5739:Dock3
|
UTSW |
9 |
106,850,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5838:Dock3
|
UTSW |
9 |
106,772,687 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R5888:Dock3
|
UTSW |
9 |
106,901,002 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5960:Dock3
|
UTSW |
9 |
106,788,554 (GRCm39) |
nonsense |
probably null |
|
|
R5974:Dock3
|
UTSW |
9 |
106,871,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6116:Dock3
|
UTSW |
9 |
106,809,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6162:Dock3
|
UTSW |
9 |
106,841,998 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6176:Dock3
|
UTSW |
9 |
106,790,147 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6219:Dock3
|
UTSW |
9 |
106,872,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6238:Dock3
|
UTSW |
9 |
106,790,147 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6266:Dock3
|
UTSW |
9 |
106,841,952 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6291:Dock3
|
UTSW |
9 |
106,785,631 (GRCm39) |
missense |
probably benign |
|
|
R6531:Dock3
|
UTSW |
9 |
106,844,415 (GRCm39) |
missense |
probably benign |
|
|
R6567:Dock3
|
UTSW |
9 |
106,773,946 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6572:Dock3
|
UTSW |
9 |
106,866,674 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6620:Dock3
|
UTSW |
9 |
106,815,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6726:Dock3
|
UTSW |
9 |
107,036,651 (GRCm39) |
nonsense |
probably null |
|
|
R7085:Dock3
|
UTSW |
9 |
106,779,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7151:Dock3
|
UTSW |
9 |
106,841,916 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7320:Dock3
|
UTSW |
9 |
106,772,723 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7357:Dock3
|
UTSW |
9 |
106,882,568 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7423:Dock3
|
UTSW |
9 |
106,844,370 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7426:Dock3
|
UTSW |
9 |
106,772,782 (GRCm39) |
missense |
probably benign |
|
|
R7439:Dock3
|
UTSW |
9 |
106,900,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7452:Dock3
|
UTSW |
9 |
106,866,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7470:Dock3
|
UTSW |
9 |
106,882,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7879:Dock3
|
UTSW |
9 |
106,785,700 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8047:Dock3
|
UTSW |
9 |
106,870,208 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8308:Dock3
|
UTSW |
9 |
106,790,371 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8837:Dock3
|
UTSW |
9 |
106,774,539 (GRCm39) |
missense |
probably benign |
|
|
R8862:Dock3
|
UTSW |
9 |
106,855,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8952:Dock3
|
UTSW |
9 |
106,850,958 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9230:Dock3
|
UTSW |
9 |
106,807,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9269:Dock3
|
UTSW |
9 |
106,818,522 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9272:Dock3
|
UTSW |
9 |
106,774,569 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9344:Dock3
|
UTSW |
9 |
106,870,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9757:Dock3
|
UTSW |
9 |
106,901,035 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9764:Dock3
|
UTSW |
9 |
106,959,713 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9766:Dock3
|
UTSW |
9 |
106,788,483 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0023:Dock3
|
UTSW |
9 |
106,863,197 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCCATCATCACACGCATGTCC -3'
(R):5'- GTTGGGAGCCAGGCATCTATGAAG -3'
Sequencing Primer
(F):5'- CCTTGGAAAACCAGCTTTGTG -3'
(R):5'- CTGTTGGCTTCAGAAGGAATC -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation