Incidental Mutation 'R1725:Krt6a'
ID 198108
Institutional Source Beutler Lab
Gene Symbol Krt6a
Ensembl Gene ENSMUSG00000058354
Gene Name keratin 6A
Synonyms Krt2-6a, MK6a, Krt2-6c, mK6[a]
MMRRC Submission 039757-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.197) question?
Stock # R1725 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 101598363-101602740 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 101600992 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 268 (M268K)
Ref Sequence ENSEMBL: ENSMUSP00000023788 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023788]
AlphaFold P50446
Predicted Effect probably damaging
Transcript: ENSMUST00000023788
AA Change: M268K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000023788
Gene: ENSMUSG00000058354
AA Change: M268K

DomainStartEndE-ValueType
Pfam:Keratin_2_head 15 148 4.1e-36 PFAM
Filament 151 464 7.2e-178 SMART
low complexity region 483 551 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196874
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229164
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230205
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 96.9%
  • 10x: 95.3%
  • 20x: 92.5%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted null mutation exhibit delayed wound healing. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310079G19Rik A T 16: 88,424,163 (GRCm39) F109L probably benign Het
Aacs T C 5: 125,559,999 (GRCm39) probably null Het
Abcc6 C A 7: 45,641,781 (GRCm39) D866Y possibly damaging Het
Acox3 T C 5: 35,749,516 (GRCm39) Y214H probably benign Het
Acss2 A G 2: 155,398,764 (GRCm39) T404A possibly damaging Het
Adgrb3 T A 1: 25,865,381 (GRCm39) E154V probably damaging Het
Akap12 G A 10: 4,303,942 (GRCm39) V251M probably damaging Het
Ambp A T 4: 63,062,513 (GRCm39) M242K possibly damaging Het
Angptl7 T G 4: 148,584,469 (GRCm39) Y93S probably damaging Het
Apof A G 10: 128,105,680 (GRCm39) probably benign Het
Arv1 T C 8: 125,455,191 (GRCm39) F135L probably damaging Het
Auh G A 13: 52,989,532 (GRCm39) P308L probably benign Het
Cacna1s C T 1: 136,026,361 (GRCm39) T1116I probably damaging Het
Ccdc91 A G 6: 147,493,541 (GRCm39) E311G unknown Het
Cenpf T C 1: 189,412,676 (GRCm39) T196A probably damaging Het
Chd8 A T 14: 52,470,030 (GRCm39) S527T probably benign Het
Csmd3 A C 15: 47,460,203 (GRCm39) N3529K probably damaging Het
Csnk2a1 T C 2: 152,099,892 (GRCm39) V116A probably damaging Het
Dhx36 T G 3: 62,414,360 (GRCm39) M1L probably benign Het
Diaph3 A G 14: 87,203,759 (GRCm39) probably null Het
Ephb2 G A 4: 136,387,089 (GRCm39) Q714* probably null Het
Eprs1 T A 1: 185,139,189 (GRCm39) L858Q probably damaging Het
Espl1 G T 15: 102,221,656 (GRCm39) V982L probably benign Het
Eya2 A G 2: 165,566,605 (GRCm39) T219A probably benign Het
Fam83f T G 15: 80,576,468 (GRCm39) V373G possibly damaging Het
Fbxl18 C T 5: 142,872,458 (GRCm39) R259H probably damaging Het
Gcc2 G A 10: 58,139,937 (GRCm39) R1629H possibly damaging Het
Gje1 G A 10: 14,592,168 (GRCm39) R205* probably null Het
Gm10277 TC T 11: 77,676,828 (GRCm39) probably null Het
Kmt2d T C 15: 98,743,115 (GRCm39) probably benign Het
Loxhd1 T A 18: 77,380,937 (GRCm39) S85T probably benign Het
Loxl3 G A 6: 83,012,574 (GRCm39) V38I probably benign Het
Mill2 A G 7: 18,573,993 (GRCm39) D26G probably benign Het
Muc15 T C 2: 110,561,591 (GRCm39) L9S probably damaging Het
Nat8f4 G A 6: 85,878,080 (GRCm39) R148* probably null Het
Nav3 A T 10: 109,659,451 (GRCm39) V722E probably damaging Het
Nfkb1 C A 3: 135,373,519 (GRCm39) G10W probably damaging Het
Or10j5 C T 1: 172,784,908 (GRCm39) P182L possibly damaging Het
Or2ag1 A T 7: 106,313,265 (GRCm39) F208I probably benign Het
Or2t1 T G 14: 14,328,977 (GRCm38) Y289D probably damaging Het
Or5b120 T C 19: 13,479,883 (GRCm39) Y59H probably damaging Het
Pcdhb22 T A 18: 37,653,241 (GRCm39) C313S probably benign Het
Plin4 A G 17: 56,413,473 (GRCm39) L384P probably damaging Het
Pm20d1 T C 1: 131,743,796 (GRCm39) I487T probably damaging Het
Prex1 A T 2: 166,443,656 (GRCm39) D334E probably damaging Het
Psg28 A T 7: 18,161,936 (GRCm39) I189N possibly damaging Het
Ptk2 A G 15: 73,114,255 (GRCm39) V701A possibly damaging Het
Rae1 A G 2: 172,848,754 (GRCm39) I123M possibly damaging Het
Sh3glb2 C A 2: 30,240,679 (GRCm39) E129* probably null Het
Simc1 T C 13: 54,674,219 (GRCm39) S856P probably damaging Het
Slc19a1 T A 10: 76,877,672 (GRCm39) M69K probably benign Het
Slc30a8 A T 15: 52,197,000 (GRCm39) I304F possibly damaging Het
Snx1 A G 9: 66,005,611 (GRCm39) probably null Het
Spmip5 T G 19: 58,781,194 (GRCm39) K10T probably benign Het
Stx18 G A 5: 38,292,599 (GRCm39) V234M probably damaging Het
Sulf2 T C 2: 165,923,281 (GRCm39) T615A probably damaging Het
Sult3a2 T A 10: 33,655,705 (GRCm39) K91N probably benign Het
Tet1 A G 10: 62,650,256 (GRCm39) S22P probably damaging Het
Tmc3 T C 7: 83,253,940 (GRCm39) V362A probably damaging Het
Trim16 A C 11: 62,711,331 (GRCm39) M1L possibly damaging Het
Trp53bp1 C T 2: 121,082,481 (GRCm39) V10I possibly damaging Het
Ttc12 T G 9: 49,369,415 (GRCm39) D235A probably benign Het
Ttn T C 2: 76,692,727 (GRCm39) R452G possibly damaging Het
Ugt2b38 A T 5: 87,559,730 (GRCm39) H387Q probably damaging Het
Usp48 T A 4: 137,360,733 (GRCm39) L20* probably null Het
Utrn T C 10: 12,539,263 (GRCm39) D1918G probably damaging Het
Vmn1r158 A G 7: 22,490,072 (GRCm39) S46P probably benign Het
Vmn2r97 T A 17: 19,149,397 (GRCm39) W262R probably benign Het
Vps13d A T 4: 144,869,830 (GRCm39) S1917T possibly damaging Het
Vsx1 T C 2: 150,528,120 (GRCm39) N158D probably benign Het
Vwf G A 6: 125,623,245 (GRCm39) V1781I probably benign Het
Wrap73 T C 4: 154,233,209 (GRCm39) Y128H possibly damaging Het
Zfp472 A G 17: 33,196,311 (GRCm39) K129E possibly damaging Het
Zscan18 A T 7: 12,504,784 (GRCm39) L611Q probably damaging Het
Other mutations in Krt6a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00493:Krt6a APN 15 101,601,229 (GRCm39) missense probably damaging 1.00
IGL00596:Krt6a APN 15 101,602,665 (GRCm39) missense possibly damaging 0.53
PIT4468001:Krt6a UTSW 15 101,602,352 (GRCm39) missense probably damaging 0.98
R0024:Krt6a UTSW 15 101,599,150 (GRCm39) splice site probably benign
R0024:Krt6a UTSW 15 101,599,150 (GRCm39) splice site probably benign
R0811:Krt6a UTSW 15 101,601,183 (GRCm39) missense probably damaging 1.00
R0812:Krt6a UTSW 15 101,601,183 (GRCm39) missense probably damaging 1.00
R0828:Krt6a UTSW 15 101,602,271 (GRCm39) missense probably damaging 0.99
R0924:Krt6a UTSW 15 101,599,235 (GRCm39) splice site probably benign
R1525:Krt6a UTSW 15 101,602,637 (GRCm39) missense probably benign
R1591:Krt6a UTSW 15 101,600,792 (GRCm39) splice site probably null
R1962:Krt6a UTSW 15 101,599,900 (GRCm39) missense probably damaging 1.00
R2201:Krt6a UTSW 15 101,601,606 (GRCm39) missense probably benign 0.41
R3024:Krt6a UTSW 15 101,599,724 (GRCm39) missense probably benign 0.02
R3158:Krt6a UTSW 15 101,599,801 (GRCm39) missense probably damaging 1.00
R5369:Krt6a UTSW 15 101,600,993 (GRCm39) missense probably benign 0.06
R5637:Krt6a UTSW 15 101,600,714 (GRCm39) missense probably benign 0.25
R6164:Krt6a UTSW 15 101,601,008 (GRCm39) missense probably damaging 0.99
R6320:Krt6a UTSW 15 101,600,744 (GRCm39) missense probably damaging 0.99
R6562:Krt6a UTSW 15 101,600,094 (GRCm39) missense probably benign 0.36
R7267:Krt6a UTSW 15 101,602,289 (GRCm39) missense probably benign 0.03
R7560:Krt6a UTSW 15 101,598,994 (GRCm39) missense unknown
R7621:Krt6a UTSW 15 101,600,187 (GRCm39) missense possibly damaging 0.92
R7671:Krt6a UTSW 15 101,598,978 (GRCm39) missense unknown
R8017:Krt6a UTSW 15 101,602,304 (GRCm39) missense probably damaging 1.00
R8019:Krt6a UTSW 15 101,602,304 (GRCm39) missense probably damaging 1.00
R8318:Krt6a UTSW 15 101,602,682 (GRCm39) start codon destroyed probably null 0.02
R8508:Krt6a UTSW 15 101,601,170 (GRCm39) missense probably damaging 1.00
R9183:Krt6a UTSW 15 101,601,446 (GRCm39) missense probably benign 0.03
R9652:Krt6a UTSW 15 101,599,120 (GRCm39) missense probably benign 0.35
X0067:Krt6a UTSW 15 101,602,212 (GRCm39) missense possibly damaging 0.83
Predicted Primers PCR Primer
(F):5'- AGAGGTCAAACACTTTGCCCAGG -3'
(R):5'- GAGGCTGCCATTGATACCATCCAC -3'

Sequencing Primer
(F):5'- TTTGCCCAGGGGGAAAAAAATAAAG -3'
(R):5'- CCCGTGGCTCCAATATAGTG -3'
Posted On 2014-05-23