Incidental Mutation 'R1726:Or10j5'
ID 198122
Institutional Source Beutler Lab
Gene Symbol Or10j5
Ensembl Gene ENSMUSG00000037924
Gene Name olfactory receptor family 10 subfamily J member 5
Synonyms Olfr16, MOR267-13, GA_x6K02T2R7CC-893157-892228, MOR23
MMRRC Submission 039758-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # R1726 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 172784335-172785384 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 172784658 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 99 (T99A)
Ref Sequence ENSEMBL: ENSMUSP00000149249 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038432] [ENSMUST00000215254]
AlphaFold Q62007
Predicted Effect probably benign
Transcript: ENSMUST00000038432
AA Change: T99A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000041524
Gene: ENSMUSG00000037924
AA Change: T99A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 7.5e-51 PFAM
Pfam:7tm_1 41 289 3.4e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215254
AA Change: T99A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Meta Mutation Damage Score 0.2085 question?
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 96.9%
  • 10x: 95.4%
  • 20x: 92.6%
Validation Efficiency 97% (63/65)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 G C 12: 118,838,536 (GRCm39) probably null Het
Abcb5 A T 12: 118,871,267 (GRCm39) S711T possibly damaging Het
Acoxl G A 2: 127,722,366 (GRCm39) G216R probably damaging Het
Arhgef18 A T 8: 3,504,228 (GRCm39) N949I possibly damaging Het
Bltp3a C A 17: 28,105,225 (GRCm39) probably null Het
Brip1 A T 11: 85,955,740 (GRCm39) S924R probably benign Het
Btf3 C T 13: 98,452,804 (GRCm39) M1I probably null Het
Ccdc141 A G 2: 76,938,700 (GRCm39) probably benign Het
Ccdc80 A T 16: 44,916,368 (GRCm39) T375S probably benign Het
Ccl11 A G 11: 81,952,546 (GRCm39) K40E possibly damaging Het
Chrnb2 A T 3: 89,668,509 (GRCm39) C269S probably damaging Het
Dgat2 A G 7: 98,831,623 (GRCm39) S33P possibly damaging Het
Dip2c A G 13: 9,625,464 (GRCm39) D608G probably damaging Het
Dnah2 A T 11: 69,388,715 (GRCm39) D889E probably damaging Het
Dvl2 A T 11: 69,900,287 (GRCm39) T694S probably benign Het
Elapor1 A G 3: 108,375,184 (GRCm39) I561T possibly damaging Het
Fbf1 A G 11: 116,036,280 (GRCm39) V1100A probably benign Het
Galt G A 4: 41,756,001 (GRCm39) W22* probably null Het
Garem1 C A 18: 21,281,319 (GRCm39) V346L probably damaging Het
Gm10277 TC T 11: 77,676,828 (GRCm39) probably null Het
Gm10762 A T 2: 128,809,135 (GRCm39) probably benign Het
Gm21900 A G Y: 10,616,358 (GRCm39) probably null Het
Gm2663 T C 6: 40,974,960 (GRCm39) Y37C probably damaging Het
Gm42791 C A 5: 148,896,311 (GRCm39) probably benign Het
Gm5134 C A 10: 75,828,361 (GRCm39) P314T possibly damaging Het
Gtf3c2 T C 5: 31,326,467 (GRCm39) E348G possibly damaging Het
H2-T24 T A 17: 36,326,513 (GRCm39) M129L probably benign Het
Ikzf2 C A 1: 69,587,847 (GRCm39) R214L probably damaging Het
Insyn2a T C 7: 134,500,867 (GRCm39) probably benign Het
Itpr3 T A 17: 27,330,664 (GRCm39) L1691Q probably damaging Het
Kmt2c C T 5: 25,520,003 (GRCm39) G2036R probably damaging Het
Lrp10 T C 14: 54,707,113 (GRCm39) L650P probably damaging Het
Mcm9 G A 10: 53,413,977 (GRCm39) P368S possibly damaging Het
Mob3b A G 4: 34,954,028 (GRCm39) M214T probably benign Het
Mrpl1 T C 5: 96,371,686 (GRCm39) V71A probably benign Het
Mrpl57 A G 14: 58,064,092 (GRCm39) E40G probably damaging Het
Mtmr9 A G 14: 63,774,547 (GRCm39) V162A possibly damaging Het
Nalcn A T 14: 123,545,816 (GRCm39) V1065E probably damaging Het
Nemp2 A G 1: 52,676,554 (GRCm39) D42G probably damaging Het
Npepps A G 11: 97,115,495 (GRCm39) L623P probably damaging Het
Olig3 A G 10: 19,232,482 (GRCm39) S36G probably benign Het
Or11g26 T A 14: 50,753,636 (GRCm39) probably null Het
Or5e1 T C 7: 108,354,215 (GRCm39) S51P probably benign Het
Pcdhb14 T A 18: 37,582,647 (GRCm39) Y584* probably null Het
Pcyox1l T C 18: 61,830,849 (GRCm39) Y341C probably benign Het
Pdxdc1 A C 16: 13,656,164 (GRCm39) probably null Het
Pias4 A C 10: 80,991,689 (GRCm39) V313G probably damaging Het
Pkd1 C T 17: 24,783,150 (GRCm39) T81M probably damaging Het
Ptprm T C 17: 67,349,322 (GRCm39) I40M probably damaging Het
Reep6 T C 10: 80,170,954 (GRCm39) S277P probably benign Het
Shank3 A G 15: 89,442,189 (GRCm39) E1694G probably damaging Het
Shq1 T C 6: 100,613,996 (GRCm39) Y274C probably benign Het
Slc12a6 T A 2: 112,177,771 (GRCm39) I630N probably damaging Het
Slc14a1 T A 18: 78,159,681 (GRCm39) N15Y probably benign Het
Slc17a4 A T 13: 24,089,574 (GRCm39) Y114* probably null Het
Slc26a1 C T 5: 108,821,541 (GRCm39) G116D probably damaging Het
Smg8 G T 11: 86,971,439 (GRCm39) Y777* probably null Het
Tlr11 A T 14: 50,598,998 (GRCm39) H328L probably benign Het
Ube2c G T 2: 164,613,237 (GRCm39) A52S probably damaging Het
Unc5c A G 3: 141,523,864 (GRCm39) S806G probably damaging Het
Zfp874b A T 13: 67,622,839 (GRCm39) I153K probably damaging Het
Zkscan2 T A 7: 123,089,046 (GRCm39) E408D probably damaging Het
Other mutations in Or10j5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00334:Or10j5 APN 1 172,785,158 (GRCm39) missense possibly damaging 0.66
IGL00336:Or10j5 APN 1 172,785,045 (GRCm39) missense probably benign 0.30
IGL01155:Or10j5 APN 1 172,784,491 (GRCm39) missense probably benign 0.43
IGL01549:Or10j5 APN 1 172,784,541 (GRCm39) missense probably damaging 1.00
IGL02679:Or10j5 APN 1 172,784,743 (GRCm39) missense probably damaging 1.00
IGL03071:Or10j5 APN 1 172,784,502 (GRCm39) missense probably benign 0.01
IGL03352:Or10j5 APN 1 172,784,850 (GRCm39) missense probably benign 0.00
R0449:Or10j5 UTSW 1 172,784,965 (GRCm39) missense probably damaging 1.00
R1725:Or10j5 UTSW 1 172,784,908 (GRCm39) missense possibly damaging 0.90
R1735:Or10j5 UTSW 1 172,784,374 (GRCm39) missense probably benign
R1928:Or10j5 UTSW 1 172,784,881 (GRCm39) missense probably damaging 0.98
R4258:Or10j5 UTSW 1 172,785,205 (GRCm39) missense possibly damaging 0.88
R4359:Or10j5 UTSW 1 172,784,647 (GRCm39) missense probably benign
R4434:Or10j5 UTSW 1 172,785,111 (GRCm39) missense probably damaging 1.00
R4666:Or10j5 UTSW 1 172,785,157 (GRCm39) missense probably benign
R4874:Or10j5 UTSW 1 172,785,166 (GRCm39) missense probably benign 0.00
R5063:Or10j5 UTSW 1 172,785,009 (GRCm39) missense possibly damaging 0.48
R5988:Or10j5 UTSW 1 172,784,723 (GRCm39) nonsense probably null
R6074:Or10j5 UTSW 1 172,784,945 (GRCm39) missense probably benign 0.10
R7021:Or10j5 UTSW 1 172,784,494 (GRCm39) missense probably benign 0.01
R7234:Or10j5 UTSW 1 172,784,673 (GRCm39) missense probably damaging 0.96
R7527:Or10j5 UTSW 1 172,784,511 (GRCm39) missense probably benign 0.00
R8271:Or10j5 UTSW 1 172,784,744 (GRCm39) nonsense probably null
R8890:Or10j5 UTSW 1 172,785,045 (GRCm39) missense probably benign 0.30
R8906:Or10j5 UTSW 1 172,784,186 (GRCm39) start gained probably benign
R9048:Or10j5 UTSW 1 172,784,929 (GRCm39) missense probably benign
R9583:Or10j5 UTSW 1 172,784,893 (GRCm39) missense probably damaging 1.00
Z1088:Or10j5 UTSW 1 172,784,891 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACAAAGGAGGGGCGTTTTATTCACC -3'
(R):5'- ACATGGCTGGCACATGAAGAACTG -3'

Sequencing Primer
(F):5'- TCCAGCTTTGGAAAGCATCAG -3'
(R):5'- TGCCATAACCAGGCCAGTG -3'
Posted On 2014-05-23