Incidental Mutation 'R1727:Tet2'
| ID |
198211 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tet2
|
| Ensembl Gene |
ENSMUSG00000040943 |
| Gene Name |
tet methylcytosine dioxygenase 2 |
| Synonyms |
E130014J05Rik, Ayu17-449 |
| MMRRC Submission |
039759-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1727 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
133169438-133250882 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 133193051 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Valine
at position 461
(D461V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000143029
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000098603]
[ENSMUST00000196398]
[ENSMUST00000197118]
|
| AlphaFold |
Q4JK59 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000098603
AA Change: D461V
PolyPhen 2
Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000096203
Gene: ENSMUSG00000040943
AA Change: D461V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
690 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
862 |
N/A |
INTRINSIC |
|
low complexity region
|
884 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
899 |
921 |
N/A |
INTRINSIC |
|
Tet_JBP
|
1203 |
1819 |
7e-301 |
SMART |
|
low complexity region
|
1832 |
1844 |
N/A |
INTRINSIC |
|
low complexity region
|
1885 |
1897 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000196398
AA Change: D461V
PolyPhen 2
Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000143029
Gene: ENSMUSG00000040943
AA Change: D461V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
690 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
862 |
N/A |
INTRINSIC |
|
low complexity region
|
884 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
899 |
921 |
N/A |
INTRINSIC |
|
Tet_JBP
|
1211 |
1827 |
3.4e-305 |
SMART |
|
low complexity region
|
1840 |
1852 |
N/A |
INTRINSIC |
|
low complexity region
|
1893 |
1905 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197118
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.3%
- 20x: 92.3%
|
| Validation Efficiency |
96% (98/102) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele die shortly after birth and exhibit a loss of acidic granules in the proximal convoluted tubules of the kidneys. Mice homozygous for a conditional allele activated in hematopoeitic compartment exhibit self-renewal and myeloid transforamtion. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(1246) : Targeted(6) Gene trapped(1240)
|
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts6 |
T |
C |
13: 104,565,472 (GRCm39) |
|
probably benign |
Het |
| Ak2 |
C |
T |
4: 128,901,556 (GRCm39) |
P159L |
probably damaging |
Het |
| Akap8l |
C |
T |
17: 32,551,457 (GRCm39) |
R511H |
probably damaging |
Het |
| Akr1a1 |
A |
G |
4: 116,498,248 (GRCm39) |
L99P |
probably damaging |
Het |
| Anxa8 |
T |
A |
14: 33,811,547 (GRCm39) |
M34K |
probably damaging |
Het |
| Axl |
T |
G |
7: 25,460,191 (GRCm39) |
D767A |
possibly damaging |
Het |
| B430305J03Rik |
A |
G |
3: 61,271,299 (GRCm39) |
|
probably benign |
Het |
| Cdh24 |
A |
T |
14: 54,876,095 (GRCm39) |
Y182* |
probably null |
Het |
| Cdk5rap2 |
T |
C |
4: 70,190,916 (GRCm39) |
D1043G |
probably benign |
Het |
| Cdk5rap2 |
A |
T |
4: 70,208,209 (GRCm39) |
S746T |
possibly damaging |
Het |
| Cep120 |
T |
C |
18: 53,860,801 (GRCm39) |
M210V |
probably benign |
Het |
| Chga |
C |
T |
12: 102,527,696 (GRCm39) |
H117Y |
possibly damaging |
Het |
| Cnga4 |
T |
C |
7: 105,054,961 (GRCm39) |
W79R |
probably damaging |
Het |
| Cntnap5b |
C |
T |
1: 100,141,469 (GRCm39) |
T575I |
possibly damaging |
Het |
| Col6a3 |
T |
A |
1: 90,724,296 (GRCm39) |
|
probably null |
Het |
| Copz2 |
T |
C |
11: 96,744,301 (GRCm39) |
V71A |
probably benign |
Het |
| Dennd3 |
G |
T |
15: 73,436,977 (GRCm39) |
R1068L |
possibly damaging |
Het |
| Dhrs7 |
T |
C |
12: 72,706,238 (GRCm39) |
T56A |
probably damaging |
Het |
| Dnah17 |
G |
A |
11: 117,961,315 (GRCm39) |
T2557I |
probably damaging |
Het |
| Dnah17 |
A |
T |
11: 117,987,362 (GRCm39) |
L1320* |
probably null |
Het |
| Dynlt2b |
T |
A |
16: 32,241,751 (GRCm39) |
M78K |
probably benign |
Het |
| Eif3b |
T |
C |
5: 140,411,077 (GRCm39) |
I176T |
probably damaging |
Het |
| Eif4b |
T |
A |
15: 101,998,497 (GRCm39) |
D392E |
possibly damaging |
Het |
| Eif4h |
T |
C |
5: 134,668,134 (GRCm39) |
Y7C |
probably damaging |
Het |
| Enam |
A |
T |
5: 88,651,853 (GRCm39) |
S1046C |
probably damaging |
Het |
| Epg5 |
T |
A |
18: 78,059,030 (GRCm39) |
V1928E |
possibly damaging |
Het |
| Erbin |
T |
A |
13: 103,964,476 (GRCm39) |
E1222V |
probably benign |
Het |
| Fhdc1 |
T |
A |
3: 84,353,483 (GRCm39) |
I581F |
possibly damaging |
Het |
| Fhip2b |
C |
A |
14: 70,831,438 (GRCm39) |
G32V |
probably damaging |
Het |
| Fstl4 |
A |
C |
11: 52,959,478 (GRCm39) |
Q173P |
probably damaging |
Het |
| Gm266 |
A |
G |
12: 111,451,913 (GRCm39) |
F98L |
possibly damaging |
Het |
| Gsdmc2 |
T |
C |
15: 63,721,628 (GRCm39) |
|
probably benign |
Het |
| Gtf2h3 |
A |
G |
5: 124,728,419 (GRCm39) |
Q156R |
probably benign |
Het |
| H2-T23 |
T |
C |
17: 36,342,545 (GRCm39) |
T198A |
possibly damaging |
Het |
| Il1r1 |
C |
A |
1: 40,332,424 (GRCm39) |
A68E |
probably benign |
Het |
| Kcna7 |
A |
T |
7: 45,058,930 (GRCm39) |
I406F |
possibly damaging |
Het |
| Lbr |
A |
G |
1: 181,647,481 (GRCm39) |
I432T |
probably benign |
Het |
| Lnx1 |
A |
T |
5: 74,768,577 (GRCm39) |
|
probably null |
Het |
| Lrrcc1 |
T |
A |
3: 14,602,423 (GRCm39) |
I50N |
probably damaging |
Het |
| Lss |
T |
C |
10: 76,375,678 (GRCm39) |
V237A |
possibly damaging |
Het |
| Mcm10 |
A |
G |
2: 5,011,336 (GRCm39) |
F212L |
probably benign |
Het |
| Methig1 |
A |
C |
15: 100,251,130 (GRCm39) |
I14L |
probably benign |
Het |
| Mrpl41 |
A |
T |
2: 24,864,636 (GRCm39) |
V55E |
probably damaging |
Het |
| Mtfp1 |
C |
A |
11: 4,043,982 (GRCm39) |
D83Y |
probably damaging |
Het |
| Myh1 |
T |
A |
11: 67,101,292 (GRCm39) |
|
probably benign |
Het |
| Myo1e |
T |
C |
9: 70,283,806 (GRCm39) |
F834S |
possibly damaging |
Het |
| Ndufs7 |
A |
T |
10: 80,091,853 (GRCm39) |
|
probably benign |
Het |
| Nlrp4e |
T |
A |
7: 23,020,420 (GRCm39) |
N302K |
probably benign |
Het |
| Nt5e |
T |
A |
9: 88,210,082 (GRCm39) |
M115K |
possibly damaging |
Het |
| Nup153 |
A |
T |
13: 46,847,261 (GRCm39) |
C723S |
probably damaging |
Het |
| Obox6 |
G |
A |
7: 15,568,502 (GRCm39) |
P125S |
probably benign |
Het |
| Or1n2 |
G |
A |
2: 36,797,405 (GRCm39) |
C149Y |
probably benign |
Het |
| Or2t48 |
A |
T |
11: 58,420,342 (GRCm39) |
S157T |
possibly damaging |
Het |
| Or52n3 |
C |
T |
7: 104,530,721 (GRCm39) |
T269I |
probably benign |
Het |
| Or5an11 |
T |
G |
19: 12,246,365 (GRCm39) |
I257S |
possibly damaging |
Het |
| Or8i2 |
A |
G |
2: 86,852,607 (GRCm39) |
F94L |
probably damaging |
Het |
| Pcdh1 |
A |
C |
18: 38,336,085 (GRCm39) |
Y44* |
probably null |
Het |
| Pcdhb6 |
A |
T |
18: 37,467,640 (GRCm39) |
D187V |
probably damaging |
Het |
| Pclo |
A |
G |
5: 14,727,001 (GRCm39) |
|
probably benign |
Het |
| Pdcl3 |
T |
A |
1: 39,034,836 (GRCm39) |
I80K |
possibly damaging |
Het |
| Pde12 |
A |
T |
14: 26,390,022 (GRCm39) |
V229E |
probably benign |
Het |
| Plcg1 |
A |
G |
2: 160,590,008 (GRCm39) |
E142G |
probably benign |
Het |
| Plxnb1 |
A |
G |
9: 108,930,125 (GRCm39) |
|
probably null |
Het |
| Pnpla1 |
A |
G |
17: 29,097,508 (GRCm39) |
I225V |
probably benign |
Het |
| Polr2f |
A |
G |
15: 79,028,805 (GRCm39) |
|
probably benign |
Het |
| Prob1 |
A |
G |
18: 35,787,364 (GRCm39) |
S297P |
possibly damaging |
Het |
| Qsox2 |
A |
C |
2: 26,110,970 (GRCm39) |
S132A |
probably benign |
Het |
| Rab19 |
T |
A |
6: 39,365,095 (GRCm39) |
Y118* |
probably null |
Het |
| Rfwd3 |
C |
T |
8: 112,014,874 (GRCm39) |
R326Q |
probably damaging |
Het |
| Rptn |
T |
C |
3: 93,304,445 (GRCm39) |
S593P |
possibly damaging |
Het |
| Septin11 |
T |
C |
5: 93,304,783 (GRCm39) |
I200T |
probably damaging |
Het |
| Slc10a4 |
T |
A |
5: 73,173,491 (GRCm39) |
|
probably benign |
Het |
| Slc9c1 |
A |
T |
16: 45,422,324 (GRCm39) |
I1130F |
probably benign |
Het |
| Slit3 |
C |
T |
11: 35,520,659 (GRCm39) |
R599C |
probably damaging |
Het |
| Snx19 |
C |
T |
9: 30,344,662 (GRCm39) |
P622L |
probably damaging |
Het |
| Sspo |
T |
C |
6: 48,471,782 (GRCm39) |
L50P |
probably damaging |
Het |
| St8sia1 |
A |
T |
6: 142,822,453 (GRCm39) |
C137S |
probably damaging |
Het |
| Syt11 |
G |
C |
3: 88,669,259 (GRCm39) |
T211S |
possibly damaging |
Het |
| Tanc1 |
A |
C |
2: 59,621,153 (GRCm39) |
Y324S |
probably damaging |
Het |
| Tas2r136 |
T |
C |
6: 132,754,753 (GRCm39) |
I125V |
possibly damaging |
Het |
| Tbc1d15 |
A |
T |
10: 115,046,130 (GRCm39) |
W458R |
probably damaging |
Het |
| Tecta |
G |
T |
9: 42,270,597 (GRCm39) |
T1237N |
probably damaging |
Het |
| Tmco3 |
G |
A |
8: 13,368,866 (GRCm39) |
V573M |
possibly damaging |
Het |
| Tmem212 |
A |
T |
3: 27,938,961 (GRCm39) |
M175K |
probably benign |
Het |
| Traf6 |
A |
G |
2: 101,527,084 (GRCm39) |
H278R |
probably benign |
Het |
| Trerf1 |
T |
A |
17: 47,652,092 (GRCm39) |
|
noncoding transcript |
Het |
| Ttn |
A |
C |
2: 76,576,988 (GRCm39) |
V24635G |
probably damaging |
Het |
| Ush1c |
A |
T |
7: 45,858,655 (GRCm39) |
D544E |
probably damaging |
Het |
| Usp47 |
C |
T |
7: 111,685,307 (GRCm39) |
T586M |
probably damaging |
Het |
| Vmn2r1 |
T |
A |
3: 63,989,163 (GRCm39) |
M34K |
probably benign |
Het |
| Vmn2r102 |
T |
A |
17: 19,897,770 (GRCm39) |
W262R |
probably damaging |
Het |
| Wasf3 |
C |
T |
5: 146,403,769 (GRCm39) |
A293V |
probably benign |
Het |
| Xrn2 |
A |
G |
2: 146,903,436 (GRCm39) |
Q812R |
probably benign |
Het |
| Zc3h7b |
T |
C |
15: 81,652,230 (GRCm39) |
I10T |
probably damaging |
Het |
| Zfp747 |
A |
T |
7: 126,973,249 (GRCm39) |
L307Q |
probably damaging |
Het |
| Zfp777 |
A |
T |
6: 48,020,824 (GRCm39) |
F266Y |
probably damaging |
Het |
|
| Other mutations in Tet2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00341:Tet2
|
APN |
3 |
133,193,846 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL00401:Tet2
|
APN |
3 |
133,172,643 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01528:Tet2
|
APN |
3 |
133,186,059 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02053:Tet2
|
APN |
3 |
133,194,284 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02142:Tet2
|
APN |
3 |
133,185,900 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02512:Tet2
|
APN |
3 |
133,175,069 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03148:Tet2
|
APN |
3 |
133,187,124 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL03182:Tet2
|
APN |
3 |
133,177,159 (GRCm39) |
nonsense |
probably null |
|
|
IGL03371:Tet2
|
APN |
3 |
133,173,312 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
P0022:Tet2
|
UTSW |
3 |
133,192,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
P0023:Tet2
|
UTSW |
3 |
133,192,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
P0031:Tet2
|
UTSW |
3 |
133,185,963 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0012:Tet2
|
UTSW |
3 |
133,182,319 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0012:Tet2
|
UTSW |
3 |
133,182,319 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0463:Tet2
|
UTSW |
3 |
133,192,427 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0522:Tet2
|
UTSW |
3 |
133,172,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0593:Tet2
|
UTSW |
3 |
133,193,870 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0600:Tet2
|
UTSW |
3 |
133,173,486 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0600:Tet2
|
UTSW |
3 |
133,173,363 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0698:Tet2
|
UTSW |
3 |
133,173,145 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0723:Tet2
|
UTSW |
3 |
133,173,045 (GRCm39) |
missense |
probably benign |
|
|
R0726:Tet2
|
UTSW |
3 |
133,173,945 (GRCm39) |
missense |
probably benign |
|
|
R0747:Tet2
|
UTSW |
3 |
133,173,231 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1006:Tet2
|
UTSW |
3 |
133,182,362 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1382:Tet2
|
UTSW |
3 |
133,182,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1455:Tet2
|
UTSW |
3 |
133,179,406 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1550:Tet2
|
UTSW |
3 |
133,175,280 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1647:Tet2
|
UTSW |
3 |
133,191,641 (GRCm39) |
missense |
probably benign |
|
|
R1662:Tet2
|
UTSW |
3 |
133,172,613 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1738:Tet2
|
UTSW |
3 |
133,187,148 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1749:Tet2
|
UTSW |
3 |
133,185,892 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1869:Tet2
|
UTSW |
3 |
133,187,202 (GRCm39) |
splice site |
probably null |
|
|
R1887:Tet2
|
UTSW |
3 |
133,193,094 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1937:Tet2
|
UTSW |
3 |
133,194,399 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1939:Tet2
|
UTSW |
3 |
133,194,399 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1940:Tet2
|
UTSW |
3 |
133,194,399 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1997:Tet2
|
UTSW |
3 |
133,192,350 (GRCm39) |
nonsense |
probably null |
|
|
R2082:Tet2
|
UTSW |
3 |
133,191,488 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2084:Tet2
|
UTSW |
3 |
133,193,528 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R2215:Tet2
|
UTSW |
3 |
133,192,362 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2321:Tet2
|
UTSW |
3 |
133,192,100 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2873:Tet2
|
UTSW |
3 |
133,192,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3439:Tet2
|
UTSW |
3 |
133,172,592 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3783:Tet2
|
UTSW |
3 |
133,185,124 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3894:Tet2
|
UTSW |
3 |
133,175,238 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3916:Tet2
|
UTSW |
3 |
133,191,816 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3966:Tet2
|
UTSW |
3 |
133,193,418 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4457:Tet2
|
UTSW |
3 |
133,191,324 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4633:Tet2
|
UTSW |
3 |
133,191,310 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4646:Tet2
|
UTSW |
3 |
133,193,843 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4647:Tet2
|
UTSW |
3 |
133,193,843 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4648:Tet2
|
UTSW |
3 |
133,193,843 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4691:Tet2
|
UTSW |
3 |
133,191,844 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4805:Tet2
|
UTSW |
3 |
133,173,076 (GRCm39) |
missense |
probably benign |
0.32 |
|
R4829:Tet2
|
UTSW |
3 |
133,182,381 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4901:Tet2
|
UTSW |
3 |
133,172,805 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4975:Tet2
|
UTSW |
3 |
133,192,520 (GRCm39) |
unclassified |
probably benign |
|
|
R5004:Tet2
|
UTSW |
3 |
133,193,140 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5075:Tet2
|
UTSW |
3 |
133,192,667 (GRCm39) |
missense |
probably benign |
|
|
R5137:Tet2
|
UTSW |
3 |
133,182,326 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5324:Tet2
|
UTSW |
3 |
133,191,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5590:Tet2
|
UTSW |
3 |
133,182,241 (GRCm39) |
splice site |
probably null |
|
|
R5854:Tet2
|
UTSW |
3 |
133,193,646 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5856:Tet2
|
UTSW |
3 |
133,192,401 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5865:Tet2
|
UTSW |
3 |
133,192,860 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5879:Tet2
|
UTSW |
3 |
133,193,721 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R5935:Tet2
|
UTSW |
3 |
133,194,296 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6012:Tet2
|
UTSW |
3 |
133,172,542 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6075:Tet2
|
UTSW |
3 |
133,177,196 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R6181:Tet2
|
UTSW |
3 |
133,193,520 (GRCm39) |
nonsense |
probably null |
|
|
R6188:Tet2
|
UTSW |
3 |
133,186,087 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6339:Tet2
|
UTSW |
3 |
133,192,178 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6612:Tet2
|
UTSW |
3 |
133,193,096 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6923:Tet2
|
UTSW |
3 |
133,185,102 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6934:Tet2
|
UTSW |
3 |
133,188,998 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7076:Tet2
|
UTSW |
3 |
133,172,784 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7155:Tet2
|
UTSW |
3 |
133,175,352 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7184:Tet2
|
UTSW |
3 |
133,179,391 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7200:Tet2
|
UTSW |
3 |
133,192,953 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7459:Tet2
|
UTSW |
3 |
133,186,050 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7504:Tet2
|
UTSW |
3 |
133,193,100 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7524:Tet2
|
UTSW |
3 |
133,185,990 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7613:Tet2
|
UTSW |
3 |
133,172,509 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7653:Tet2
|
UTSW |
3 |
133,192,146 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7691:Tet2
|
UTSW |
3 |
133,192,610 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7770:Tet2
|
UTSW |
3 |
133,186,056 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7807:Tet2
|
UTSW |
3 |
133,192,302 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7813:Tet2
|
UTSW |
3 |
133,179,404 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7978:Tet2
|
UTSW |
3 |
133,193,426 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8055:Tet2
|
UTSW |
3 |
133,173,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8164:Tet2
|
UTSW |
3 |
133,172,895 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8236:Tet2
|
UTSW |
3 |
133,193,547 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8755:Tet2
|
UTSW |
3 |
133,194,039 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8962:Tet2
|
UTSW |
3 |
133,193,804 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9009:Tet2
|
UTSW |
3 |
133,193,360 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9014:Tet2
|
UTSW |
3 |
133,172,949 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9128:Tet2
|
UTSW |
3 |
133,175,374 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9166:Tet2
|
UTSW |
3 |
133,173,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9190:Tet2
|
UTSW |
3 |
133,187,147 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9344:Tet2
|
UTSW |
3 |
133,175,115 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9360:Tet2
|
UTSW |
3 |
133,192,903 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9471:Tet2
|
UTSW |
3 |
133,191,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9488:Tet2
|
UTSW |
3 |
133,193,103 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9534:Tet2
|
UTSW |
3 |
133,173,689 (GRCm39) |
nonsense |
probably null |
|
|
R9557:Tet2
|
UTSW |
3 |
133,191,566 (GRCm39) |
missense |
probably benign |
|
|
R9621:Tet2
|
UTSW |
3 |
133,193,767 (GRCm39) |
nonsense |
probably null |
|
|
R9644:Tet2
|
UTSW |
3 |
133,193,064 (GRCm39) |
nonsense |
probably null |
|
|
R9719:Tet2
|
UTSW |
3 |
133,191,803 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
X0021:Tet2
|
UTSW |
3 |
133,192,056 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
X0066:Tet2
|
UTSW |
3 |
133,194,134 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTACAGAGCCTTGCGTTTGTTTCC -3'
(R):5'- TCAGGCAAAGCTCGAAGTTCCC -3'
Sequencing Primer
(F):5'- CCGTTTGCATCCTTCGGAATC -3'
(R):5'- GCTCGAAGTTCCCTAAAGATTC -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation