Incidental Mutation 'R1732:Nwd1'
| ID |
199394 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nwd1
|
| Ensembl Gene |
ENSMUSG00000048148 |
| Gene Name |
NACHT and WD repeat domain containing 1 |
| Synonyms |
A230063L24Rik |
| MMRRC Submission |
039764-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.186)
|
| Stock # |
R1732 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
73372865-73443508 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to G
at 73393463 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Cysteine
at position 242
(S242C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124804
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000093427]
[ENSMUST00000160443]
[ENSMUST00000161254]
[ENSMUST00000161557]
[ENSMUST00000228312]
|
| AlphaFold |
A6H603 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000093427
AA Change: S242C
PolyPhen 2
Score 0.821 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000091135
Gene: ENSMUSG00000048148
AA Change: S242C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
45 |
55 |
N/A |
INTRINSIC |
|
low complexity region
|
279 |
292 |
N/A |
INTRINSIC |
|
Pfam:AAA_16
|
312 |
457 |
7.3e-8 |
PFAM |
|
Pfam:NACHT
|
336 |
511 |
1.3e-12 |
PFAM |
|
WD40
|
857 |
896 |
1.31e-3 |
SMART |
|
WD40
|
899 |
938 |
7.97e-8 |
SMART |
|
Blast:WD40
|
941 |
985 |
2e-15 |
BLAST |
|
WD40
|
988 |
1028 |
2.05e1 |
SMART |
|
Blast:WD40
|
1037 |
1073 |
2e-9 |
BLAST |
|
Blast:WD40
|
1073 |
1110 |
4e-10 |
BLAST |
|
WD40
|
1118 |
1156 |
5.97e-1 |
SMART |
|
WD40
|
1160 |
1198 |
6.6e1 |
SMART |
|
WD40
|
1245 |
1283 |
5.3e1 |
SMART |
|
WD40
|
1286 |
1326 |
2.13e1 |
SMART |
|
WD40
|
1340 |
1375 |
1.06e2 |
SMART |
|
WD40
|
1377 |
1416 |
3.5e-4 |
SMART |
|
WD40
|
1421 |
1461 |
2.66e0 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160443
|
| SMART Domains |
Protein: ENSMUSP00000124446
Gene: ENSMUSG00000048148
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
45 |
55 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000160912
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000161254
AA Change: S242C
PolyPhen 2
Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000124804
Gene: ENSMUSG00000048148
AA Change: S242C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
45 |
55 |
N/A |
INTRINSIC |
|
low complexity region
|
279 |
292 |
N/A |
INTRINSIC |
|
low complexity region
|
319 |
329 |
N/A |
INTRINSIC |
|
Pfam:NACHT
|
336 |
511 |
2.1e-12 |
PFAM |
|
WD40
|
857 |
896 |
1.31e-3 |
SMART |
|
WD40
|
899 |
938 |
7.97e-8 |
SMART |
|
Blast:WD40
|
941 |
985 |
1e-15 |
BLAST |
|
WD40
|
988 |
1028 |
2.05e1 |
SMART |
|
Blast:WD40
|
1037 |
1073 |
2e-9 |
BLAST |
|
Blast:WD40
|
1073 |
1110 |
3e-10 |
BLAST |
|
WD40
|
1118 |
1156 |
2.49e-1 |
SMART |
|
WD40
|
1203 |
1241 |
5.3e1 |
SMART |
|
WD40
|
1244 |
1284 |
2.13e1 |
SMART |
|
WD40
|
1298 |
1333 |
1.06e2 |
SMART |
|
WD40
|
1335 |
1374 |
3.5e-4 |
SMART |
|
WD40
|
1379 |
1419 |
2.66e0 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161386
|
| SMART Domains |
Protein: ENSMUSP00000123737
Gene: ENSMUSG00000048148
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
45 |
55 |
N/A |
INTRINSIC |
|
low complexity region
|
279 |
292 |
N/A |
INTRINSIC |
|
low complexity region
|
319 |
329 |
N/A |
INTRINSIC |
|
Pfam:NACHT
|
336 |
511 |
1.2e-12 |
PFAM |
|
WD40
|
857 |
896 |
1.31e-3 |
SMART |
|
WD40
|
899 |
938 |
7.97e-8 |
SMART |
|
Blast:WD40
|
941 |
984 |
1e-13 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161557
|
| SMART Domains |
Protein: ENSMUSP00000125470
Gene: ENSMUSG00000048148
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
45 |
55 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000163026
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000228312
AA Change: S283C
PolyPhen 2
Score 0.944 (Sensitivity: 0.80; Specificity: 0.95)
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.1%
- 20x: 91.6%
|
| Validation Efficiency |
99% (78/79) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is thought to be a cytosolic protein and predicted to contain a NACHT domain and multiple WD40 repeats. Increased expression of this gene was observed in some prostate cancer cell lines. Knocking down expression of this gene results in decreased androgen receptor protein levels, indicating that this gene may be important in modulating androgen receptor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 73 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
C |
A |
12: 71,265,995 (GRCm39) |
Q1445K |
probably benign |
Het |
| Acacb |
A |
T |
5: 114,328,148 (GRCm39) |
M303L |
possibly damaging |
Het |
| Actl9 |
T |
C |
17: 33,652,096 (GRCm39) |
V52A |
probably damaging |
Het |
| Adam7 |
T |
C |
14: 68,735,899 (GRCm39) |
T781A |
probably benign |
Het |
| Agpat4 |
T |
C |
17: 12,435,615 (GRCm39) |
V293A |
probably benign |
Het |
| Ank1 |
T |
A |
8: 23,601,479 (GRCm39) |
|
probably benign |
Het |
| Atp1a1 |
C |
A |
3: 101,492,115 (GRCm39) |
G587V |
probably damaging |
Het |
| Avpr1b |
T |
C |
1: 131,527,992 (GRCm39) |
F172L |
probably damaging |
Het |
| Bmp1 |
A |
T |
14: 70,723,705 (GRCm39) |
D710E |
possibly damaging |
Het |
| Cep126 |
A |
T |
9: 8,099,762 (GRCm39) |
I924N |
probably benign |
Het |
| Chek2 |
G |
T |
5: 111,019,968 (GRCm39) |
A517S |
probably benign |
Het |
| Cmbl |
A |
T |
15: 31,588,378 (GRCm39) |
E165D |
probably damaging |
Het |
| Cntnap3 |
A |
T |
13: 64,888,626 (GRCm39) |
|
probably null |
Het |
| Col1a1 |
A |
T |
11: 94,835,241 (GRCm39) |
|
probably benign |
Het |
| Ctbp2 |
T |
C |
7: 132,600,653 (GRCm39) |
M624V |
possibly damaging |
Het |
| Cwc15 |
A |
G |
9: 14,421,543 (GRCm39) |
D203G |
probably benign |
Het |
| Cyld |
C |
T |
8: 89,458,295 (GRCm39) |
|
probably benign |
Het |
| Cyp3a57 |
A |
T |
5: 145,302,455 (GRCm39) |
I84F |
probably damaging |
Het |
| Dennd3 |
T |
A |
15: 73,409,267 (GRCm39) |
|
probably benign |
Het |
| Desi2 |
A |
C |
1: 178,084,217 (GRCm39) |
|
probably benign |
Het |
| Dmxl1 |
T |
A |
18: 50,026,511 (GRCm39) |
L1873* |
probably null |
Het |
| Dmxl1 |
T |
A |
18: 50,036,055 (GRCm39) |
H2359Q |
probably benign |
Het |
| Ephb4 |
A |
G |
5: 137,370,440 (GRCm39) |
N880S |
possibly damaging |
Het |
| F10 |
T |
C |
8: 13,100,764 (GRCm39) |
L214P |
probably damaging |
Het |
| F5 |
G |
A |
1: 164,001,719 (GRCm39) |
V141M |
probably damaging |
Het |
| Fam135a |
A |
T |
1: 24,065,734 (GRCm39) |
S1022T |
possibly damaging |
Het |
| Fam13b |
A |
T |
18: 34,620,187 (GRCm39) |
N232K |
probably benign |
Het |
| Fyco1 |
T |
C |
9: 123,648,157 (GRCm39) |
E1259G |
probably benign |
Het |
| Gak |
A |
T |
5: 108,724,448 (GRCm39) |
D1087E |
probably benign |
Het |
| Gm7138 |
A |
T |
10: 77,612,682 (GRCm39) |
|
probably benign |
Het |
| Gm8674 |
T |
A |
13: 50,055,962 (GRCm39) |
|
noncoding transcript |
Het |
| Gpr25 |
A |
G |
1: 136,187,866 (GRCm39) |
V249A |
probably benign |
Het |
| Hcn3 |
T |
C |
3: 89,055,426 (GRCm39) |
H607R |
probably damaging |
Het |
| Hdac4 |
T |
A |
1: 91,875,257 (GRCm39) |
T905S |
probably benign |
Het |
| Itgad |
T |
C |
7: 127,804,279 (GRCm39) |
S86P |
probably benign |
Het |
| Itgb4 |
G |
T |
11: 115,879,744 (GRCm39) |
R632L |
probably damaging |
Het |
| Kcnb2 |
A |
T |
1: 15,779,979 (GRCm39) |
T284S |
probably benign |
Het |
| Klhl22 |
T |
A |
16: 17,594,888 (GRCm39) |
M339K |
probably damaging |
Het |
| Lonrf2 |
G |
A |
1: 38,852,357 (GRCm39) |
P165S |
probably benign |
Het |
| Mybpc2 |
C |
A |
7: 44,163,099 (GRCm39) |
V484L |
probably benign |
Het |
| Noa1 |
A |
T |
5: 77,454,221 (GRCm39) |
V473E |
probably benign |
Het |
| Or55b10 |
C |
A |
7: 102,143,247 (GRCm39) |
C245F |
probably damaging |
Het |
| Or7e174 |
A |
G |
9: 20,012,796 (GRCm39) |
H247R |
probably damaging |
Het |
| Otof |
A |
T |
5: 30,543,815 (GRCm39) |
W535R |
probably damaging |
Het |
| Peg3 |
T |
C |
7: 6,712,084 (GRCm39) |
E1046G |
possibly damaging |
Het |
| Phldb2 |
T |
C |
16: 45,577,529 (GRCm39) |
E1132G |
probably damaging |
Het |
| Phtf2 |
A |
T |
5: 20,994,625 (GRCm39) |
|
probably null |
Het |
| Plce1 |
G |
T |
19: 38,705,282 (GRCm39) |
A896S |
possibly damaging |
Het |
| Prim1 |
T |
C |
10: 127,851,193 (GRCm39) |
Y26H |
probably damaging |
Het |
| Prr12 |
T |
A |
7: 44,697,780 (GRCm39) |
T712S |
unknown |
Het |
| Psme4 |
G |
A |
11: 30,798,105 (GRCm39) |
R1366H |
probably benign |
Het |
| Ptpdc1 |
T |
C |
13: 48,740,021 (GRCm39) |
E409G |
probably benign |
Het |
| Rabep1 |
A |
G |
11: 70,795,467 (GRCm39) |
N274S |
probably damaging |
Het |
| Rbm14 |
A |
G |
19: 4,853,495 (GRCm39) |
S296P |
probably benign |
Het |
| Rec114 |
A |
G |
9: 58,560,389 (GRCm39) |
S206P |
probably damaging |
Het |
| Rps6ka1 |
A |
T |
4: 133,587,381 (GRCm39) |
Y531N |
probably damaging |
Het |
| Slc28a2 |
T |
C |
2: 122,280,239 (GRCm39) |
|
probably benign |
Het |
| Slc34a1 |
A |
G |
13: 55,561,233 (GRCm39) |
H566R |
probably benign |
Het |
| Slc9c1 |
A |
G |
16: 45,373,291 (GRCm39) |
T290A |
probably benign |
Het |
| Smarcc1 |
T |
A |
9: 110,014,888 (GRCm39) |
|
probably benign |
Het |
| Srp54b |
T |
A |
12: 55,299,544 (GRCm39) |
|
probably null |
Het |
| Stambpl1 |
C |
G |
19: 34,204,121 (GRCm39) |
N70K |
probably damaging |
Het |
| Synj1 |
T |
C |
16: 90,761,118 (GRCm39) |
K710E |
probably damaging |
Het |
| Tenm3 |
T |
A |
8: 48,763,669 (GRCm39) |
D795V |
probably damaging |
Het |
| Tgm2 |
T |
C |
2: 157,976,277 (GRCm39) |
Y149C |
probably damaging |
Het |
| Tmem151a |
C |
A |
19: 5,132,895 (GRCm39) |
A104S |
probably damaging |
Het |
| Top1mt |
A |
G |
15: 75,538,100 (GRCm39) |
|
probably null |
Het |
| Tpgs1 |
T |
A |
10: 79,511,428 (GRCm39) |
L190Q |
possibly damaging |
Het |
| Triobp |
T |
A |
15: 78,851,428 (GRCm39) |
H527Q |
possibly damaging |
Het |
| Tspan2 |
A |
G |
3: 102,676,193 (GRCm39) |
I197V |
probably damaging |
Het |
| Ube3b |
A |
G |
5: 114,525,506 (GRCm39) |
I76V |
probably benign |
Het |
| Vmn1r32 |
A |
T |
6: 66,530,285 (GRCm39) |
S164T |
probably benign |
Het |
| Zfp607a |
G |
T |
7: 27,577,884 (GRCm39) |
C318F |
probably damaging |
Het |
|
| Other mutations in Nwd1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00159:Nwd1
|
APN |
8 |
73,397,705 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01294:Nwd1
|
APN |
8 |
73,438,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01298:Nwd1
|
APN |
8 |
73,388,959 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01333:Nwd1
|
APN |
8 |
73,393,439 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01371:Nwd1
|
APN |
8 |
73,401,743 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02244:Nwd1
|
APN |
8 |
73,434,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02579:Nwd1
|
APN |
8 |
73,434,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02608:Nwd1
|
APN |
8 |
73,394,003 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02632:Nwd1
|
APN |
8 |
73,394,082 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02893:Nwd1
|
APN |
8 |
73,394,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03010:Nwd1
|
APN |
8 |
73,414,688 (GRCm39) |
splice site |
probably benign |
|
|
R0017:Nwd1
|
UTSW |
8 |
73,436,053 (GRCm39) |
splice site |
probably benign |
|
|
R0066:Nwd1
|
UTSW |
8 |
73,438,484 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0066:Nwd1
|
UTSW |
8 |
73,438,484 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0505:Nwd1
|
UTSW |
8 |
73,388,965 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0511:Nwd1
|
UTSW |
8 |
73,408,633 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0612:Nwd1
|
UTSW |
8 |
73,394,308 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0681:Nwd1
|
UTSW |
8 |
73,388,965 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0763:Nwd1
|
UTSW |
8 |
73,397,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0905:Nwd1
|
UTSW |
8 |
73,436,077 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1136:Nwd1
|
UTSW |
8 |
73,424,397 (GRCm39) |
splice site |
probably benign |
|
|
R1483:Nwd1
|
UTSW |
8 |
73,383,714 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1630:Nwd1
|
UTSW |
8 |
73,393,657 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R1724:Nwd1
|
UTSW |
8 |
73,438,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1885:Nwd1
|
UTSW |
8 |
73,431,622 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1973:Nwd1
|
UTSW |
8 |
73,431,590 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R2393:Nwd1
|
UTSW |
8 |
73,389,055 (GRCm39) |
missense |
probably benign |
|
|
R2926:Nwd1
|
UTSW |
8 |
73,393,640 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3706:Nwd1
|
UTSW |
8 |
73,393,744 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3916:Nwd1
|
UTSW |
8 |
73,394,439 (GRCm39) |
nonsense |
probably null |
|
|
R3917:Nwd1
|
UTSW |
8 |
73,394,439 (GRCm39) |
nonsense |
probably null |
|
|
R4153:Nwd1
|
UTSW |
8 |
73,408,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4426:Nwd1
|
UTSW |
8 |
73,393,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4435:Nwd1
|
UTSW |
8 |
73,414,764 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4522:Nwd1
|
UTSW |
8 |
73,397,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4622:Nwd1
|
UTSW |
8 |
73,393,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4659:Nwd1
|
UTSW |
8 |
73,421,949 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4694:Nwd1
|
UTSW |
8 |
73,393,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4837:Nwd1
|
UTSW |
8 |
73,383,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4844:Nwd1
|
UTSW |
8 |
73,393,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4906:Nwd1
|
UTSW |
8 |
73,398,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5041:Nwd1
|
UTSW |
8 |
73,431,683 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5183:Nwd1
|
UTSW |
8 |
73,397,714 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5416:Nwd1
|
UTSW |
8 |
73,393,322 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5553:Nwd1
|
UTSW |
8 |
73,431,604 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5670:Nwd1
|
UTSW |
8 |
73,419,745 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5699:Nwd1
|
UTSW |
8 |
73,429,602 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5722:Nwd1
|
UTSW |
8 |
73,401,872 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5762:Nwd1
|
UTSW |
8 |
73,397,542 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5778:Nwd1
|
UTSW |
8 |
73,419,745 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5992:Nwd1
|
UTSW |
8 |
73,380,201 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6163:Nwd1
|
UTSW |
8 |
73,388,814 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6164:Nwd1
|
UTSW |
8 |
73,388,814 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6165:Nwd1
|
UTSW |
8 |
73,388,814 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6212:Nwd1
|
UTSW |
8 |
73,421,950 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6443:Nwd1
|
UTSW |
8 |
73,388,994 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R6865:Nwd1
|
UTSW |
8 |
73,383,690 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6928:Nwd1
|
UTSW |
8 |
73,408,653 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6944:Nwd1
|
UTSW |
8 |
73,380,162 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6979:Nwd1
|
UTSW |
8 |
73,394,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7060:Nwd1
|
UTSW |
8 |
73,393,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7102:Nwd1
|
UTSW |
8 |
73,421,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7265:Nwd1
|
UTSW |
8 |
73,419,556 (GRCm39) |
missense |
probably benign |
0.29 |
|
R7343:Nwd1
|
UTSW |
8 |
73,438,410 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7391:Nwd1
|
UTSW |
8 |
73,389,046 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7424:Nwd1
|
UTSW |
8 |
73,401,801 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7438:Nwd1
|
UTSW |
8 |
73,434,458 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7487:Nwd1
|
UTSW |
8 |
73,393,266 (GRCm39) |
missense |
unknown |
|
|
R7502:Nwd1
|
UTSW |
8 |
73,434,021 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7883:Nwd1
|
UTSW |
8 |
73,393,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8235:Nwd1
|
UTSW |
8 |
73,438,314 (GRCm39) |
frame shift |
probably null |
|
|
R8282:Nwd1
|
UTSW |
8 |
73,431,580 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8672:Nwd1
|
UTSW |
8 |
73,394,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8716:Nwd1
|
UTSW |
8 |
73,388,908 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8755:Nwd1
|
UTSW |
8 |
73,394,192 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8793:Nwd1
|
UTSW |
8 |
73,419,704 (GRCm39) |
missense |
probably benign |
|
|
R8890:Nwd1
|
UTSW |
8 |
73,438,484 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9072:Nwd1
|
UTSW |
8 |
73,422,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9073:Nwd1
|
UTSW |
8 |
73,422,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9257:Nwd1
|
UTSW |
8 |
73,397,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9582:Nwd1
|
UTSW |
8 |
73,421,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9665:Nwd1
|
UTSW |
8 |
73,401,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0067:Nwd1
|
UTSW |
8 |
73,393,884 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
Z1176:Nwd1
|
UTSW |
8 |
73,398,928 (GRCm39) |
missense |
not run |
|
|
Z1177:Nwd1
|
UTSW |
8 |
73,436,087 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Nwd1
|
UTSW |
8 |
73,422,015 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
Z1177:Nwd1
|
UTSW |
8 |
73,393,256 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTTTCCCAGAAGTACCTCTCAGGC -3'
(R):5'- CCTGGTGGTCCAAAGAGAACCAAG -3'
Sequencing Primer
(F):5'- CCTCAGTGACTGTGATGGCTC -3'
(R):5'- CAGAAGACCTTGGTAGACTCTGTG -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation