Incidental Mutation 'R1734:Mettl9'
ID 199572
Institutional Source Beutler Lab
Gene Symbol Mettl9
Ensembl Gene ENSMUSG00000030876
Gene Name methyltransferase like 9
Synonyms 0610012D09Rik, Drev
MMRRC Submission 039766-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # R1734 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 120633668-120677552 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 120647064 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 57 (Y57N)
Ref Sequence ENSEMBL: ENSMUSP00000033163 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033163] [ENSMUST00000207351]
AlphaFold Q9EPL4
Predicted Effect probably damaging
Transcript: ENSMUST00000033163
AA Change: Y57N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000033163
Gene: ENSMUSG00000030876
AA Change: Y57N

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
low complexity region 39 50 N/A INTRINSIC
Pfam:DREV 56 317 1.4e-142 PFAM
Pfam:Methyltransf_23 123 289 2.7e-12 PFAM
Pfam:Methyltransf_12 150 236 9.1e-10 PFAM
Pfam:Methyltransf_11 150 238 9.4e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207332
Predicted Effect probably benign
Transcript: ENSMUST00000207351
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208157
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208652
Meta Mutation Damage Score 0.9651 question?
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 97.0%
  • 10x: 95.5%
  • 20x: 92.9%
Validation Efficiency 98% (59/60)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm4 A T 4: 144,396,596 (GRCm39) C379S probably benign Het
Abca13 T C 11: 9,535,460 (GRCm39) C4695R probably benign Het
Actr10 T A 12: 71,008,770 (GRCm39) V401E probably benign Het
Adamts16 G A 13: 70,927,637 (GRCm39) probably benign Het
Aimp1 A T 3: 132,380,557 (GRCm39) I59K probably damaging Het
Alms1 T A 6: 85,618,532 (GRCm39) probably null Het
Anln A T 9: 22,262,251 (GRCm39) S947T possibly damaging Het
Atp2c1 T C 9: 105,291,854 (GRCm39) T733A probably damaging Het
BC049715 C T 6: 136,817,306 (GRCm39) P182L probably damaging Het
Cblb T C 16: 52,006,603 (GRCm39) probably benign Het
Cep295 C T 9: 15,252,179 (GRCm39) E397K probably damaging Het
Ces4a G A 8: 105,864,729 (GRCm39) G69S probably damaging Het
Chac1 A T 2: 119,183,939 (GRCm39) L180F probably damaging Het
Cherp A T 8: 73,223,932 (GRCm39) probably null Het
Ckap4 A G 10: 84,363,738 (GRCm39) S442P probably benign Het
Clstn3 G A 6: 124,413,773 (GRCm39) probably benign Het
Crb2 T A 2: 37,683,668 (GRCm39) C1057S probably damaging Het
Dact2 T C 17: 14,416,901 (GRCm39) D433G probably benign Het
Dnah6 G A 6: 73,021,744 (GRCm39) T3526M probably damaging Het
Ethe1 A G 7: 24,307,809 (GRCm39) T210A probably benign Het
Fat2 A G 11: 55,172,197 (GRCm39) S2839P probably benign Het
Fbxl7 T C 15: 26,543,735 (GRCm39) Y304C probably damaging Het
Gad1-ps A T 10: 99,281,637 (GRCm39) noncoding transcript Het
Grm3 C T 5: 9,639,742 (GRCm39) R101K probably benign Het
Hspa12b A G 2: 130,980,456 (GRCm39) Y125C possibly damaging Het
Il10ra T C 9: 45,167,241 (GRCm39) T437A probably benign Het
Itprid2 G A 2: 79,488,166 (GRCm39) V750M probably damaging Het
Jcad T C 18: 4,674,526 (GRCm39) F763L probably damaging Het
Map3k10 T C 7: 27,357,540 (GRCm39) D746G probably damaging Het
Nav2 G A 7: 49,225,468 (GRCm39) E1803K probably damaging Het
Nol11 G A 11: 107,066,449 (GRCm39) S447L possibly damaging Het
Or14a256 C T 7: 86,265,425 (GRCm39) V143M probably benign Het
Osbpl1a T C 18: 12,921,373 (GRCm39) probably null Het
Pde6a A G 18: 61,419,036 (GRCm39) N804S probably damaging Het
Pepd A T 7: 34,730,851 (GRCm39) D301V probably benign Het
Piwil2 A T 14: 70,663,954 (GRCm39) probably null Het
Plec C T 15: 76,070,418 (GRCm39) V931M probably damaging Het
Prrc2a A G 17: 35,369,683 (GRCm39) S1877P possibly damaging Het
Retreg2 G T 1: 75,119,630 (GRCm39) probably null Het
Slc7a11 G A 3: 50,326,795 (GRCm39) Q489* probably null Het
Sned1 G A 1: 93,187,490 (GRCm39) D256N probably damaging Het
Sphkap G A 1: 83,255,236 (GRCm39) R838* probably null Het
Spmip9 T A 6: 70,890,645 (GRCm39) Q49L probably benign Het
Syce2 G A 8: 85,613,776 (GRCm39) E168K probably benign Het
Tmem260 G T 14: 48,746,550 (GRCm39) V609L probably benign Het
Trim35 A G 14: 66,546,778 (GRCm39) D515G probably damaging Het
Tspan5 T C 3: 138,603,901 (GRCm39) Y131H probably damaging Het
Ttbk2 T C 2: 120,586,319 (GRCm39) I466V probably benign Het
Ttn T C 2: 76,576,157 (GRCm39) D24912G probably damaging Het
Utp20 A T 10: 88,603,323 (GRCm39) N1843K probably damaging Het
Vmn1r20 A G 6: 57,409,285 (GRCm39) R204G probably damaging Het
Vps18 A T 2: 119,124,423 (GRCm39) Q450L probably benign Het
Zbtb4 A G 11: 69,667,289 (GRCm39) E198G probably benign Het
Other mutations in Mettl9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00491:Mettl9 APN 7 120,651,336 (GRCm39) missense probably damaging 1.00
IGL01723:Mettl9 APN 7 120,651,492 (GRCm39) missense possibly damaging 0.67
PIT4402001:Mettl9 UTSW 7 120,656,440 (GRCm39) missense probably damaging 0.99
R0401:Mettl9 UTSW 7 120,675,536 (GRCm39) missense probably damaging 1.00
R1004:Mettl9 UTSW 7 120,675,460 (GRCm39) missense probably benign 0.00
R5574:Mettl9 UTSW 7 120,647,093 (GRCm39) missense probably benign 0.03
R7913:Mettl9 UTSW 7 120,675,524 (GRCm39) missense probably damaging 1.00
R8913:Mettl9 UTSW 7 120,675,539 (GRCm39) missense probably damaging 1.00
R9446:Mettl9 UTSW 7 120,675,531 (GRCm39) missense possibly damaging 0.77
Z1177:Mettl9 UTSW 7 120,656,553 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGAAGTCATGCCTGAGGAAGGATTTTG -3'
(R):5'- AACACCTTCTCCGGGTAGTTCCAC -3'

Sequencing Primer
(F):5'- CCTGAGGAAGGATTTTGTACTTG -3'
(R):5'- CCAGCCAGATTTCTCAATGCTG -3'
Posted On 2014-05-23