Incidental Mutation 'R1736:Map3k11'
ID 199749
Institutional Source Beutler Lab
Gene Symbol Map3k11
Ensembl Gene ENSMUSG00000004054
Gene Name mitogen-activated protein kinase kinase kinase 11
Synonyms Mlk3, 2610017K16Rik
MMRRC Submission 039768-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.340) question?
Stock # R1736 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 5738770-5752893 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 5747429 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 555 (D555G)
Ref Sequence ENSEMBL: ENSMUSP00000004156 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004156]
AlphaFold Q80XI6
Predicted Effect probably benign
Transcript: ENSMUST00000004156
AA Change: D555G

PolyPhen 2 Score 0.336 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000004156
Gene: ENSMUSG00000004054
AA Change: D555G

DomainStartEndE-ValueType
low complexity region 11 36 N/A INTRINSIC
SH3 45 105 6.79e-19 SMART
TyrKc 118 377 6.83e-81 SMART
coiled coil region 398 444 N/A INTRINSIC
low complexity region 467 476 N/A INTRINSIC
low complexity region 593 610 N/A INTRINSIC
low complexity region 614 632 N/A INTRINSIC
low complexity region 676 697 N/A INTRINSIC
low complexity region 759 778 N/A INTRINSIC
low complexity region 786 805 N/A INTRINSIC
low complexity region 809 820 N/A INTRINSIC
Meta Mutation Damage Score 0.0910 question?
Coding Region Coverage
  • 1x: 97.6%
  • 3x: 96.9%
  • 10x: 95.2%
  • 20x: 92.0%
Validation Efficiency 97% (57/59)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted or spontaneous mutation display a pattern of dark red stripes of thin dorsal epithelium during pre-wean development, and necrotic dental pulp has been reported for the spontaneous mutant. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts16 G A 13: 70,927,637 (GRCm39) probably benign Het
Adcy3 A G 12: 4,250,998 (GRCm39) N586D possibly damaging Het
Ak6 T A 13: 100,791,689 (GRCm39) probably null Het
Ankrd66 T C 17: 43,854,409 (GRCm39) D41G probably benign Het
Atp8b2 G A 3: 89,860,001 (GRCm39) P339S probably damaging Het
Cacna1d C T 14: 29,811,820 (GRCm39) V1297I probably damaging Het
Cbl A T 9: 44,064,192 (GRCm39) D781E possibly damaging Het
Cep295 C T 9: 15,252,179 (GRCm39) E397K probably damaging Het
Ces4a G A 8: 105,864,729 (GRCm39) G69S probably damaging Het
Clint1 A G 11: 45,797,004 (GRCm39) probably null Het
Col6a3 A G 1: 90,706,781 (GRCm39) Y2111H unknown Het
Csnk1g1 A G 9: 65,927,197 (GRCm39) probably null Het
Dse A T 10: 34,029,145 (GRCm39) N648K probably damaging Het
Dsp A G 13: 38,376,966 (GRCm39) K1584E probably benign Het
Ezh2 A T 6: 47,553,594 (GRCm39) M41K probably damaging Het
Fscn2 G A 11: 120,258,852 (GRCm39) G466S probably damaging Het
Garin5b A G 7: 4,761,153 (GRCm39) S520P probably damaging Het
Gm15217 A G 14: 46,620,663 (GRCm39) probably benign Het
Gm9696 T C 3: 59,879,696 (GRCm39) noncoding transcript Het
Gosr2 G A 11: 103,570,076 (GRCm39) Q162* probably null Het
Hectd4 T A 5: 121,487,593 (GRCm39) H3529Q possibly damaging Het
Klf7 C A 1: 64,118,372 (GRCm39) R75L possibly damaging Het
Kmt2c A T 5: 25,495,525 (GRCm39) I4074K probably damaging Het
Ly6g2 G A 15: 75,089,569 (GRCm39) G26R probably damaging Het
Mindy2 A G 9: 70,538,312 (GRCm39) I341T probably damaging Het
Mrnip G A 11: 50,067,718 (GRCm39) probably null Het
Muc5b G A 7: 141,412,844 (GRCm39) C1930Y unknown Het
Nfatc3 T G 8: 106,805,482 (GRCm39) I109S probably damaging Het
Npas1 G T 7: 16,208,541 (GRCm39) A112D probably benign Het
Npffr2 T A 5: 89,715,925 (GRCm39) I84N probably damaging Het
Nxph4 T A 10: 127,362,465 (GRCm39) H142L probably damaging Het
Otud4 T A 8: 80,378,294 (GRCm39) probably benign Het
Per3 A G 4: 151,093,705 (GRCm39) probably null Het
Pigr G A 1: 130,769,540 (GRCm39) R117Q possibly damaging Het
Plec C T 15: 76,070,418 (GRCm39) V931M probably damaging Het
Prex2 T A 1: 11,160,108 (GRCm39) probably benign Het
Sall4 G A 2: 168,594,555 (GRCm39) P420L probably benign Het
Sap30bp A G 11: 115,855,046 (GRCm39) K252R probably damaging Het
Sec63 T A 10: 42,703,914 (GRCm39) Y692* probably null Het
Sema3e C T 5: 14,260,390 (GRCm39) T181M probably damaging Het
Sf3b3 T C 8: 111,540,464 (GRCm39) I986V probably benign Het
Shisa4 A T 1: 135,299,700 (GRCm39) Y194* probably null Het
Slc17a6 G A 7: 51,311,333 (GRCm39) probably benign Het
Smg1 T G 7: 117,765,190 (GRCm39) probably null Het
Smim7 C T 8: 73,324,849 (GRCm39) G9R probably damaging Het
Spata31d1d C T 13: 59,874,311 (GRCm39) G1075R probably benign Het
Sphkap G A 1: 83,255,236 (GRCm39) R838* probably null Het
Stag3 T C 5: 138,302,771 (GRCm39) probably benign Het
Tbce A G 13: 14,184,227 (GRCm39) I217T possibly damaging Het
Tpk1 G A 6: 43,588,284 (GRCm39) P27S probably benign Het
Tsc22d1 A G 14: 76,655,797 (GRCm39) I2V probably benign Het
Tulp4 T G 17: 6,283,490 (GRCm39) V1173G possibly damaging Het
Uchl1 T C 5: 66,834,417 (GRCm39) probably null Het
Ugt2b38 T A 5: 87,571,492 (GRCm39) Q180L probably benign Het
Other mutations in Map3k11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02017:Map3k11 APN 19 5,747,651 (GRCm39) missense possibly damaging 0.91
IGL02581:Map3k11 APN 19 5,750,834 (GRCm39) missense probably benign
pow UTSW 19 5,750,622 (GRCm39) missense probably benign 0.03
yow UTSW 19 5,747,429 (GRCm39) missense probably benign 0.34
R0130:Map3k11 UTSW 19 5,740,843 (GRCm39) missense probably damaging 1.00
R0193:Map3k11 UTSW 19 5,745,874 (GRCm39) missense probably damaging 0.99
R1621:Map3k11 UTSW 19 5,740,834 (GRCm39) missense probably damaging 1.00
R1791:Map3k11 UTSW 19 5,745,600 (GRCm39) nonsense probably null
R3500:Map3k11 UTSW 19 5,740,275 (GRCm39) start codon destroyed probably benign 0.08
R3836:Map3k11 UTSW 19 5,740,831 (GRCm39) missense possibly damaging 0.71
R3892:Map3k11 UTSW 19 5,752,311 (GRCm39) missense probably benign 0.13
R4303:Map3k11 UTSW 19 5,740,852 (GRCm39) missense probably damaging 1.00
R4513:Map3k11 UTSW 19 5,752,238 (GRCm39) missense probably damaging 0.97
R4613:Map3k11 UTSW 19 5,747,499 (GRCm39) missense probably damaging 0.98
R4613:Map3k11 UTSW 19 5,747,498 (GRCm39) missense probably benign 0.18
R4631:Map3k11 UTSW 19 5,740,941 (GRCm39) missense probably benign 0.30
R4780:Map3k11 UTSW 19 5,740,966 (GRCm39) missense probably damaging 0.99
R5213:Map3k11 UTSW 19 5,740,669 (GRCm39) missense probably damaging 0.99
R5266:Map3k11 UTSW 19 5,750,622 (GRCm39) missense probably benign 0.03
R5372:Map3k11 UTSW 19 5,740,990 (GRCm39) missense probably damaging 1.00
R5736:Map3k11 UTSW 19 5,746,739 (GRCm39) missense probably damaging 1.00
R5899:Map3k11 UTSW 19 5,745,937 (GRCm39) critical splice donor site probably null
R6052:Map3k11 UTSW 19 5,747,430 (GRCm39) missense probably benign 0.01
R6388:Map3k11 UTSW 19 5,740,279 (GRCm39) missense probably damaging 0.96
R6623:Map3k11 UTSW 19 5,745,631 (GRCm39) missense probably damaging 0.97
R6975:Map3k11 UTSW 19 5,740,755 (GRCm39) missense possibly damaging 0.91
R7309:Map3k11 UTSW 19 5,740,486 (GRCm39) missense probably damaging 0.99
R7771:Map3k11 UTSW 19 5,740,636 (GRCm39) missense probably damaging 0.99
R7815:Map3k11 UTSW 19 5,745,667 (GRCm39) missense possibly damaging 0.89
R8988:Map3k11 UTSW 19 5,752,166 (GRCm39) missense probably damaging 1.00
R9130:Map3k11 UTSW 19 5,746,038 (GRCm39) missense possibly damaging 0.69
R9502:Map3k11 UTSW 19 5,740,624 (GRCm39) missense probably damaging 1.00
X0025:Map3k11 UTSW 19 5,746,223 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- ATGGATCGGCCTTTTGACCATACC -3'
(R):5'- GTCTCCTGGAAAGGGAACATGCTTG -3'

Sequencing Primer
(F):5'- ggtcgtttctttgtagccttg -3'
(R):5'- CTCTAAAGAGTAGAACGCCAGG -3'
Posted On 2014-05-23