Incidental Mutation 'R0088:Tmem266'
ID 20014
Institutional Source Beutler Lab
Gene Symbol Tmem266
Ensembl Gene ENSMUSG00000032313
Gene Name transmembrane protein 266
Synonyms AI118078
MMRRC Submission 038375-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R0088 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 9
Chromosomal Location 55234197-55345629 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 55344613 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 415 (D415G)
Ref Sequence ENSEMBL: ENSMUSP00000034862 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034862] [ENSMUST00000085754]
AlphaFold Q8BZB3
Predicted Effect probably damaging
Transcript: ENSMUST00000034862
AA Change: D415G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000034862
Gene: ENSMUSG00000032313
AA Change: D415G

DomainStartEndE-ValueType
low complexity region 16 27 N/A INTRINSIC
transmembrane domain 95 117 N/A INTRINSIC
transmembrane domain 137 159 N/A INTRINSIC
transmembrane domain 172 191 N/A INTRINSIC
low complexity region 260 283 N/A INTRINSIC
low complexity region 298 309 N/A INTRINSIC
low complexity region 381 396 N/A INTRINSIC
low complexity region 423 439 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000085754
SMART Domains Protein: ENSMUSP00000082906
Gene: ENSMUSG00000032313

DomainStartEndE-ValueType
transmembrane domain 30 52 N/A INTRINSIC
transmembrane domain 72 94 N/A INTRINSIC
low complexity region 195 218 N/A INTRINSIC
low complexity region 233 244 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130465
Meta Mutation Damage Score 0.4164 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.7%
  • 20x: 90.8%
Validation Efficiency 82% (32/39)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 T C 8: 25,404,083 (GRCm39) K243R probably damaging Het
Akap9 C A 5: 4,011,946 (GRCm39) T883K probably benign Het
Arhgap5 G T 12: 52,563,331 (GRCm39) D101Y probably damaging Het
Bnc1 T G 7: 81,628,246 (GRCm39) N39T possibly damaging Het
Carnmt1 T A 19: 18,655,217 (GRCm39) H123Q probably benign Het
Cdh24 T C 14: 54,871,171 (GRCm39) D92G probably damaging Het
Eomes A G 9: 118,307,741 (GRCm39) E5G probably damaging Het
Eqtn T C 4: 94,808,227 (GRCm39) T192A probably damaging Het
Fam110c T C 12: 31,125,217 (GRCm39) V393A probably damaging Het
Fbll1 C A 11: 35,688,967 (GRCm39) A99S possibly damaging Het
Il1rl2 A T 1: 40,404,213 (GRCm39) I445F possibly damaging Het
Ipo8 T C 6: 148,703,434 (GRCm39) T400A probably benign Het
Iqsec3 T C 6: 121,450,248 (GRCm39) E92G probably damaging Het
Itpr2 C T 6: 146,142,683 (GRCm39) V1679M probably benign Het
Kif2a G A 13: 107,111,940 (GRCm39) A478V probably damaging Het
Lingo4 A G 3: 94,309,340 (GRCm39) S93G probably benign Het
Mrpl37 A G 4: 106,921,621 (GRCm39) S203P possibly damaging Het
Ndel1 A C 11: 68,724,246 (GRCm39) S242R probably damaging Het
Nfatc3 T A 8: 106,854,574 (GRCm39) M1036K possibly damaging Het
Ngrn T C 7: 79,914,203 (GRCm39) I118T probably damaging Het
Or10d5 A G 9: 39,861,671 (GRCm39) V132A probably benign Het
Pex10 A T 4: 155,154,955 (GRCm39) S236C probably damaging Het
Phkb T G 8: 86,669,020 (GRCm39) probably null Het
Pklr A G 3: 89,049,215 (GRCm39) Y187C probably damaging Het
Plekhh1 A C 12: 79,102,140 (GRCm39) E403D probably benign Het
Pls1 T C 9: 95,677,821 (GRCm39) K22E possibly damaging Het
Prdm2 G A 4: 142,861,524 (GRCm39) H589Y possibly damaging Het
Rabggtb C A 3: 153,614,467 (GRCm39) R230L probably damaging Het
Rsph4a A G 10: 33,785,349 (GRCm39) E420G probably benign Het
Sdk2 T C 11: 113,717,912 (GRCm39) N1484S possibly damaging Het
St8sia3 T A 18: 64,400,056 (GRCm39) V17E possibly damaging Het
Sult6b2 T A 6: 142,743,675 (GRCm39) N117I probably damaging Het
Thbs2 T C 17: 14,901,963 (GRCm39) T422A possibly damaging Het
Tnfrsf21 C T 17: 43,349,104 (GRCm39) H239Y probably benign Het
Ttyh2 G T 11: 114,581,081 (GRCm39) G107C probably damaging Het
Ubr4 A G 4: 139,168,125 (GRCm39) D2835G probably damaging Het
Zranb3 T C 1: 127,904,199 (GRCm39) D540G probably benign Het
Other mutations in Tmem266
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01726:Tmem266 APN 9 55,342,486 (GRCm39) missense probably benign 0.12
IGL03366:Tmem266 APN 9 55,344,517 (GRCm39) missense probably benign 0.06
R0418:Tmem266 UTSW 9 55,344,697 (GRCm39) missense probably benign 0.06
R0497:Tmem266 UTSW 9 55,288,168 (GRCm39) splice site probably null
R0763:Tmem266 UTSW 9 55,322,239 (GRCm39) missense probably damaging 1.00
R1657:Tmem266 UTSW 9 55,325,292 (GRCm39) missense probably damaging 1.00
R3617:Tmem266 UTSW 9 55,307,918 (GRCm39) missense probably damaging 0.99
R4235:Tmem266 UTSW 9 55,325,391 (GRCm39) missense probably damaging 0.99
R4767:Tmem266 UTSW 9 55,288,025 (GRCm39) missense probably damaging 1.00
R5587:Tmem266 UTSW 9 55,344,850 (GRCm39) missense probably damaging 1.00
R5732:Tmem266 UTSW 9 55,288,120 (GRCm39) missense probably damaging 1.00
R5783:Tmem266 UTSW 9 55,305,087 (GRCm39) missense probably damaging 1.00
R6193:Tmem266 UTSW 9 55,344,493 (GRCm39) missense probably benign 0.01
R6943:Tmem266 UTSW 9 55,284,851 (GRCm39) start gained probably benign
R7459:Tmem266 UTSW 9 55,303,883 (GRCm39) missense unknown
R9167:Tmem266 UTSW 9 55,322,231 (GRCm39) missense probably damaging 1.00
R9502:Tmem266 UTSW 9 55,344,973 (GRCm39) missense probably damaging 0.96
X0063:Tmem266 UTSW 9 55,288,033 (GRCm39) missense probably benign 0.00
Z1177:Tmem266 UTSW 9 55,344,754 (GRCm39) missense possibly damaging 0.70
Z1177:Tmem266 UTSW 9 55,305,051 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACCTCTCTGGCCTTCAAAGTGACG -3'
(R):5'- GTTGAACAGACTCACCCTATGCTCC -3'

Sequencing Primer
(F):5'- ggaggcaaaagcaggcag -3'
(R):5'- TCTGGACTGAGCCCAGTG -3'
Posted On 2013-04-11